Evidence
Mult Scler. 2024 Sep 5:13524585241271988. doi: 10.1177/13524585241271988. Online ahead of print.
ABSTRACT
BACKGROUND: Cerebrospinal fluid (CSF) oligoclonal bands (OCB) are a diagnostic biomarker in multiple sclerosis (MS). The central vein sign (CVS) is an imaging biomarker for MS that may improve diagnostic accuracy.
OBJECTIVES: The objective of the study is to examine the diagnostic performance of simplified CVS methods in comparison to OCB in participants with clinical or radiological suspicion for MS.
METHODS: Participants from the CentrAl Vein Sign in MS (CAVS-MS) pilot study with CSF testing were included. Select-3 and Select-6 (counting up to three or six CVS+ lesions per scan) were rated on post-gadolinium FLAIR* images. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value for Select-3, Select-6, OCB, and combinations thereof were calculated for MS diagnosis at baseline and at 12 months.
RESULTS: Of 53 participants, 25 were OCB+. At baseline, sensitivity for MS diagnosis was 0.75 for OCB, 0.83 for Select-3, and 0.71 for Select-6. Specificity for MS diagnosis was 0.76 for OCB, 0.48 for Select-3, and 0.86 for Select-6. At 12 months, PPV for MS diagnosis was 0.95 for Select-6 and 1.00 for Select-6 with OCB+ status.
DISCUSSION: Results suggest similar diagnostic performance of simplified CVS methods and OCB. Ongoing studies will refine whether CVS could be used in replacement or in conjunction with OCB.
PMID:39234802 | DOI:10.1177/13524585241271988
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis
- New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign
- Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study
- Diagnostic accuracy of automated Lumipulse plasma pTau-217 in Alzheimer's disease: a real-world study
- The ageing central nervous system in multiple sclerosis: the imaging perspective
- The ageing central nervous system in multiple sclerosis: the imaging perspective
- Co-localization of NCCT hypodensity and CTA spot sign predicts substantial intracerebral hematoma expansion: The Black-&-White sign
- Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer's disease with MRI and CSF biomarkers
- Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay
- Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas
- Multimodal AI Combining Clinical and Imaging Inputs Improves Prostate Cancer Detection
- Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach
- Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice
- Anti-N-methyl-D-aspartate Receptor Encephalitis in Turner Syndrome with 45,X/46,X,idic(X)(p11.4) Mosaics
- Monitoring cognitive functioning in multiple sclerosis will trigger anxiety in patients: Commentary
- A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
- Combined MR quantitative susceptibility mapping and multi-shell diffusion in Parkinson's disease
- The time to include cognition in the multiple sclerosis concept of progression independent from relapse activity is now
- The time to include cognition in the multiple sclerosis concept of progression independent from relapse activity is now
- Phonemic processing is below expectations and linked to word-finding difficulty in multiple sclerosis
- Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care
- Cerebrospinal Fluid-In Gradient of Cortical and Deep Gray Matter Damage in Multiple Sclerosis
- E-BDL: Enhanced Band-Dependent Learning Framework for Augmented Radar Sensing
- Association of CSF alpha-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies
- The diagnosis of ASD with MRI: a systematic review and meta-analysis
- Impact of an AI-Based laparoscopic cholecystectomy coaching program on the surgical performance: a randomized controlled trial
- From cortisol-producing adrenal adenoma to atrial myxoma, through nivolumab-induced hypophysitis: a complicated case report of Carney Complex
- Diagnostic accuracy of artificial intelligence in detecting left ventricular hypertrophy by electrocardiograph: a systematic review and meta-analysis
- Evaluation of cerebrospinal fluid (CSF) and interstitial fluid (ISF) mouse proteomes for the validation and description of Alzheimer's disease biomarkers
- Accelerated musculoskeletal magnetic resonance imaging with deep learning-based image reconstruction at 0.55 T-3 T
- Atypical telencephalic reflux pattern in a cavernous sinus dural AV fistula related to an anatomical variation of the basal vein of Rosenthal
- Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer's disease
- The Evaluation of Clinical Applications for the Detection of the Alzheimer's Disease Biomarker GFAP
- Transitive inference in a clinical childhood sample with a focus on autism spectrum disorder
- Transitive inference in a clinical childhood sample with a focus on autism spectrum disorder
- Dual-source dual-energy CT and deep learning for equivocal lymph nodes on CT images for thyroid cancer
- Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study
- Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria
- A Case of Personality and Behavioral Changes with Frontotemporal and Cerebellar Atrophy on MRI with Corresponding Hypometabolism on FDG-PET
- Utilizing portable electroencephalography to screen for pathology of Alzheimer's disease: a methodological advancement in diagnosis of neurodegenerative diseases
- Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies
- Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies
- Advances in Clinical Application of Cerebrospinal Fluid Circulating Tumor DNA in Leptomeningeal Metastasis of Non-small Cell Lung Cancer
- A high-precision view of intercompartmental drug transport via simultaneous, seconds-resolved, in situ measurements in the vein and brain
- A high-precision view of intercompartmental drug transport via simultaneous, seconds-resolved, in situ measurements in the vein and brain
- Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical Research
- Comparison of lung ultrasound assisted by artificial intelligence to radiology examination in pneumothorax
- Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
- The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice
- The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice
- Utility of shaking chills as a diagnostic sign for bacteremia in adults: a systematic review and meta-analysis
- Utility of shaking chills as a diagnostic sign for bacteremia in adults: a systematic review and meta-analysis
- High levels of neurofilament light and YKL-40 in cerebrospinal fluid are related to poor outcome in ALS
- CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease
- The Cotard Delusion in a Patient With Neuropsychiatric Systemic Lupus Erythematosus: The Challenges of Autoimmune Psychosis
- Autistic adults' perspectives and experiences of diagnostic assessments that include play across the lifespan
- Impact of macular scotoma and tubular vision on oculomotor behavior and performance in visuospatial comparison tasks
- Patients' Attitudes Toward the Use of Artificial Intelligence as a Diagnostic Tool in Radiology in Saudi Arabia: Cross-Sectional Study
- Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model
- Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model
- A systematic review of deep learning-based spinal bone lesion detection in medical images
- DiTA: helping you search for evidence of diagnostic test accuracy in physical therapy
- Can electroencephalography (EEG) identify the different dimensions of pain in fibromyalgia? A pilot study
- Diagnostic Performance of GFAP, UCH-L1, and MAP-2 Within 30 and 60 Minutes of Traumatic Brain Injury
Evidence Blueprint
Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis
- Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis
- Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis
- Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis
- New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign
- Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study
- Obsessive-compulsive symptoms and brain lesions compatible with multiple sclerosis
- Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy
- Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections
- Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes
- Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
- Diagnostic accuracy of automated Lumipulse plasma pTau-217 in Alzheimer's disease: a real-world study
- Sampling Cerebrospinal Fluid and Blood from Lateral Tail Vein in Rats during EEG Recordings
- A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimer's disease
- Artificial intelligence applied to MRI data to tackle key challenges in multiple sclerosis
- Diagnostic effectiveness of deep learning-based MRI in predicting multiple sclerosis: A meta-analysis
- The split apparent diffusion coefficient sign: A novel magnetic resonance imaging biomarker for cortical pathology with possible implications in autoimmune encephalitis
- The significance of cerebrospinal fluid analysis in the differential diagnosis of 564 psychiatric patients: Multiple sclerosis is more common than autoimmune-encephalitis
- The ageing central nervous system in multiple sclerosis: the imaging perspective
- The ageing central nervous system in multiple sclerosis: the imaging perspective
- The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease
- Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP)
- Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis
- Risk of data leakage in estimating the diagnostic performance of a deep-learning-based computer-aided system for psychiatric disorders
- Co-localization of NCCT hypodensity and CTA spot sign predicts substantial intracerebral hematoma expansion: The Black-&-White sign
- Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases
- Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes
- Diagnostic utility of cerebrospinal fluid biomarkers in patients with rapidly progressive dementia
- Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer's disease with MRI and CSF biomarkers
- Clinicopathological and diagnostic imaging findings in a dog with neurocandidiasis
- Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay
- Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer's disease
- Cerebrospinal fluid findings in patients with obsessive-compulsive disorder, Tourette syndrome, and PANDAS: A systematic literature review
- Machine Learning-Derived MRI-Based Neurodegeneration Biomarker for Alzheimer's Disease: A Multi-Database Validation Study
- Clinical value of Alzheimer's disease biomarker testing
- Clinical value of Alzheimer's disease biomarker testing
- CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease
- Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas
- Risk identification for the development of large-artery vasospasm after aneurysmatic subarachnoid hemorrhage - a multivariate, risk-, and location-adjusted prediction model
- Memory performance mediates subjective sleep quality associations with cerebrospinal fluid Alzheimer's disease biomarker levels and hippocampal volume among individuals with mild cognitive symptoms
- Development of a Digital Patient Assistant for the Management of Cyclic Vomiting Syndrome: Patient-Centric Design Study
- Multimodal AI Combining Clinical and Imaging Inputs Improves Prostate Cancer Detection
- Inflammatory cerebrospinal fluid markers in schizophrenia spectrum disorders: A systematic review and meta-analysis of 69 studies with 5710 participants
- Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease
- The additive value of complementing diagnostic idiopathic intracranial hypertension criteria by MRI - an external validation study
- Proximity extension assay in cerebrospinal fluid identifies neurofilament light chain as biomarker of neurodegeneration in sporadic cerebral amyloid angiopathy
- Profiling amyloid-β peptides as biomarkers for cerebral amyloid angiopathy
- CRISPR-Powered Aptasensor for Diagnostics of Alzheimer's Disease
- Hypo-attenuating Berry Sign as a Novel Imaging Marker of Ruptured Aneurysm in Patients with Subarachnoid Hemorrhage; a Diagnostic Accuracy Study
- Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach
- Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice
- Identification of potential disease-associated variants in idiopathic generalized epilepsy using targeted sequencing
- Anti-N-methyl-D-aspartate Receptor Encephalitis in Turner Syndrome with 45,X/46,X,idic(X)(p11.4) Mosaics
- Distinctive Pattern of Metal Deposition in Neurologic Wilson Disease: Insights From 7T Susceptibility-Weighted Imaging
- A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD
- Ubiquity of Synthetic Phenolic Antioxidants in Children's Cerebrospinal Fluid from South China: First Evidence for Their Penetration across the Blood-Cerebrospinal Fluid Barrier
- Clinical and radiological correlates of apathy in multiple sclerosis
- Monitoring cognitive functioning in multiple sclerosis will trigger anxiety in patients: Commentary
- No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache
- The relation of a cerebrospinal fluid profile associated with Alzheimer's disease with cognitive function and neuropsychiatric symptoms in sporadic cerebral amyloid angiopathy
- A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
- Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy
- Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
- Combined MR quantitative susceptibility mapping and multi-shell diffusion in Parkinson's disease