Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Birth Defects Res. 2024 Jul;116(7):e2379. doi: 10.1002/bdr2.2379.
ABSTRACT
BACKGROUND: Autism spectrum disorder (ASD) is the fastest-growing child neuropsychiatric condition. Cognitive dysfunctions such as memory impairments are experienced by patients along with social disturbances and repetitive/stereotypic movements. We have used the radial arm maze (RAM), for measurement of working and reference memory errors in an animal model of autism. In addition, the potential effects of agmatine, an endogenous NMDA antagonist, on RAM performance and autistic-like behaviors were assessed.
METHODS: Autism was modeled by valproic acid (VPA) administration at gestational Day 12.5. Autism-associated behaviors in male offspring were examined in an open field test (OFT) and three-chambered test (TCT) on postnatal days 50-51. Thereafter, the animals were trained in the RAM (PND 55) until they attained the criteria of 80% correct choices during five consecutive trials. Forty-eight hours after the acquisition of criteria, agmatine was injected 30 min before subsequent behavioral testing, which included the retention phase of the RAM, OFT, and TCT.
RESULTS: VPA-treated and intact rats showed the same performance in RAM, and acute injection of agmatine rescued social and anxiety-like behavior induced by VPA without the effect on RAM.
CONCLUSION: In a rat model of autism, spatial learning, and memory did not change. Agmatine rescued social and anxiety-like behavior in autistic animals.
PMID:38958465 | DOI:10.1002/bdr2.2379
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Effects of agmatine on radial-arm maze memory performance and autistic-like behaviors in a male rat model of autism
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Administration of Atosiban, an Oxytocin Receptor Antagonist, Ameliorates Autistic-like Behaviors in a Female Rat Model of Valproic Acid-induced Autism The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism Supplementation with stigma maydis polysaccharide attenuates autism-like behaviors and improves gut function in valproic acid-induced autism model male rats Comparison of predictive validity of two Autism Spectrum Disorder Rat Models: Behavioural investigations Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Low-frequency repetitive transcranial magnetic stimulation alleviates abnormal behavior in valproic acid rat model of autism through rescuing synaptic plasticity and inhibiting neuroinflammation Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism Reversal of electrophysiological and behavioral deficits mediated by 5-HT7 receptor upregulation following LP-211 treatment in an autistic-like rat model induced by prenatal valproic acid exposure Protective effects of selegiline against amyloid beta-induced anxiety-like behavior and memory impairment Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention Adolescent Treadmill Exercise Enhances Hippocampal Brain-Derived Neurotrophic Factor (BDNF) Expression and Improves Cognition in Autism-Modeled Rats Adolescent Treadmill Exercise Enhances Hippocampal Brain-Derived Neurotrophic Factor (BDNF) Expression and Improves Cognition in Autism-Modeled Rats Practice is the best of all instructors-Effects of enactment encoding and episodic future thinking on prospective memory performance in high-functioning adults with autism spectrum disorder Cognitive behavioral phenotyping of DSCAM heterozygosity as a model for autism spectrum disorder Amelioration of propionic acid-induced autism spectrum disorder in rats through dapagliflozin: The role of IGF-1/IGFBP-3 and the Nrf2 antioxidant pathway Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway Taurine Improved Autism-Like Behaviours and Defective Neurogenesis of the Hippocampus in BTBR Mice through the PTEN/mTOR/AKT Signalling Pathway THE ALPHA1A ANTAGONIST TAMSULOSIN IMPAIRS MEMORY ACQUISITION, CONSOLIDATION AND RETRIEVAL IN A NOVEL OBJECT RECOGNITION TASK IN MICE Prenatal 1-Nitropyrene Exposure Causes Autism-Like Behavior Partially by Altering DNA Hydroxymethylation in Developing Brain Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring's prefrontal cortex A snapshot on introspection of autism spectrum disorder Interactions of methamphetamine and REM sleep deprivation on behavioral performance in adult and adolescent rats Autism Spectrum Disorders: Etiology, Epidemiology, and Challenges for Public Health Disruptions in reproductive health, sex hormonal profiles, and hypothalamic hormone receptors content in females of the C58/J mouse model of autism Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B(6) metabolism Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B(6) metabolism Gestational administration of aqueous leaf extract of Jatropha tanjorensis alleviated postpartum emotional and cognitive dysfunction in rats (Wistar strain) Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation Vaporized Δ9-tetrahydrocannabinol exposure in utero has negative effects on attention in a dose- and sex-dependent manner Healthy Prenatal Dietary Pattern and Offspring Autism Quality of Life and Its Associated Correlates of Parents of Children on the Autism Spectrum in Singapore Exposure to maternal cannabis use disorder and risk of autism spectrum disorder in offspring: A data linkage cohort study Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders Social communication and restricted, repetitive behavior as assessed with a diagnostic tool for autism (ADOS-2) in women with anorexia nervosa Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters Repetitive Behaviors in Autism and Obsessive-Compulsive Disorder: A Systematic Review Effect of Osteopathic Manipulation in an Autism Spectrum Child With Speech Impairment and Attention Deficit: A Case Report Effects of Sex Differences and Combined Use of Clozapine on Initial Dosage Optimization of Valproic Acid in Patients with Bipolar Disorder Antihypertensive treatment during pregnancy induces long-term changes in gut microbiota and the behaviors of the attention deficit hyperactivity disorder offspring Changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes Dexmedetomidine attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal flora A Simple Tube Escape Assay to Test Learning and Memory in Zebrafish with Minimized Habituation A Simple Tube Escape Assay to Test Learning and Memory in Zebrafish with Minimized Habituation Treatment of Aggressive Behavior and Agitation in an 11-Year-Old Boy with Co-Occurring Autism and ADHD: A Case Report and Literature Review on the Use of Intravenous Valproate in Emergency Psychiatry Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression Family-Centric Applied Behavior Analysis Facilitates Improved Treatment Utilization and Outcomes Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior Deficits Memory strategies in autistic and older adults Co-administration of sub-effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockade of the NMDA receptor in rats Indulging Curiosity: Preliminary Evidence of an Anxiolytic-like Effect of Castor Oil and Ricinoleic Acid Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression Telehealth-delivered parent-based sleep-focused intervention for insomnia in preschool children with autism spectrum disorder: A randomized controlled study Stabilizing Axin leads to optic nerve hypoplasia in a mouse model of autism
Evidence Blueprint
Effects of agmatine on radial-arm maze memory performance and autistic-like behaviors in a male rat model of autism
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Effects of agmatine on radial-arm maze memory performance and autistic-like behaviors in a male rat model of autism
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Effects of music on cognitive behavioral impairments in both sex of adult rats exposed prenatally to valproic acid Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers Agmatine ameliorates valproic acid-induced depletion of parvalbumin-positive neuron Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate Administration of Atosiban, an Oxytocin Receptor Antagonist, Ameliorates Autistic-like Behaviors in a Female Rat Model of Valproic Acid-induced Autism Autistic-like behaviors are attenuated by agmatine consumption during pregnancy: Assessment of oxidative stress profile and histopathological changes in the prefrontal cortex and CA1 region of the hippocampus The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of autism Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of orexin receptor Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism Sex-related beneficial effects of exercise on cardiac function and rhythm in autistic rats Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats Investigating the effect of exposure to monosodium glutamate during pregnancy on development of autism in male rat offspring Supplementation with stigma maydis polysaccharide attenuates autism-like behaviors and improves gut function in valproic acid-induced autism model male rats Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice Comparison of predictive validity of two Autism Spectrum Disorder Rat Models: Behavioural investigations Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Low-frequency repetitive transcranial magnetic stimulation alleviates abnormal behavior in valproic acid rat model of autism through rescuing synaptic plasticity and inhibiting neuroinflammation Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice Benefits of bone marrow mesenchymal stem cells compared to their conditioned medium in valproic acid-induced autism in rats Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid Low prepulse inhibition predicts lower social interaction, impaired spatial working memory, reference memory and cognitive flexibility in genetically heterogeneous rats Reversal of electrophysiological and behavioral deficits mediated by 5-HT7 receptor upregulation following LP-211 treatment in an autistic-like rat model induced by prenatal valproic acid exposure Environmental exposure to chlorpyrifos during gestation, APOE polymorphism and the risk on autistic-like behaviors Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder Protective effects of selegiline against amyloid beta-induced anxiety-like behavior and memory impairment Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention Zebrafish embryonically exposed to valproic acid present impaired retinal development and sleep behavior Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism Adolescent Treadmill Exercise Enhances Hippocampal Brain-Derived Neurotrophic Factor (BDNF) Expression and Improves Cognition in Autism-Modeled Rats Adolescent Treadmill Exercise Enhances Hippocampal Brain-Derived Neurotrophic Factor (BDNF) Expression and Improves Cognition in Autism-Modeled Rats Oral calcium and vitamin D supplements differentially alter exploratory, anxiety-like behaviors and memory in male rats Practice is the best of all instructors-Effects of enactment encoding and episodic future thinking on prospective memory performance in high-functioning adults with autism spectrum disorder Cognitive behavioral phenotyping of DSCAM heterozygosity as a model for autism spectrum disorder Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats Reversing valproic acid-induced autism-like behaviors through a combination of low-frequency repeated transcranial magnetic stimulation and superparamagnetic iron oxide nanoparticles MA-5 ameliorates autism-like behavior in mice prenatally exposed to valproic acid The olfactory working memory capacity paradigm: A more sensitive and robust method of assessing cognitive function in male 5XFAD mice Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats Bacteroides is increased in an autism cohort and induces autism-relevant behavioral changes in mice in a sex-dependent manner A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut-brain axis The Relationship between the Autistic Traits and Everyday Memory Processing in Adults with Autism Spectrum Disorder and Healthy Adults Amelioration of propionic acid-induced autism spectrum disorder in rats through dapagliflozin: The role of IGF-1/IGFBP-3 and the Nrf2 antioxidant pathway The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model Female mice prenatally exposed to valproic acid exhibit complex and prolonged social behavior deficits Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: obligatory role of hippocampal GPR55 receptors Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism Biodistribution of Agmatine to Brain and Spinal Cord Following Systemic Delivery KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism Self-processing and social functioning in autistic preschoolers Ameliorating effect of pioglitazone on prenatal valproic acid-induced behavioral and neurobiological abnormalities in autism spectrum disorder in rats Quetiapine and Valproic Acid-induced Central Hypothyroidism in a Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case Report Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats The Notch1/Hes1 pathway regulates Neuregulin 1/ErbB4 and participates in microglial activation in rats with VPA-induced autism Comparative effects of the alcoholic extract of Terminalia chebula and crocin on stress‑induced anxiety‑like behavior and memory impairment in male rats Investigating the Effects of Valproic acid on Placental Epigenetic Modifications and Development in the CD-1 Mouse Model