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Epigenetic Regulation of Neural Activity in the Depressed Brain: The Two Faces of the Histone Deacetylase SIRT1

22 August 2024

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Biol Psychiatry. 2024 Sep 15;96(6):e7-e9. doi: 10.1016/j.biopsych.2024.07.006.

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PMID:39168543 | DOI:10.1016/j.biopsych.2024.07.006

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Carmelo Aquilina
Response to workplace aggression in forensic and secure mental health services: Investigating staff confidence, associated factors, and training needs 10 September 2024
Australasian Psychiatry, Ahead of Print. ObjectiveTo evaluate forensic and secure mental health services (FSMHS) staff’s confidence in managing workplace aggression, identify associated factors, and explore their workplace aggression prevention training needs.MethodsThrough an online survey, staff rated their experience of workplace aggression, perceived effectiveness of current training, and confidence in responding to workplace aggression, and described […]
Wei He
Mostly harmless? Clinical practice guidelines need further consideration of psychotherapy adverse effects 7 September 2024
Australasian Psychiatry, Ahead of Print. The Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines on mood disorders recommend psychotherapy as foundational care for patients with acute depression with minimal discussion of any potential adverse effects. Randomised controlled trial evidence on psychotherapy adverse effects is limited. This is problematic because clinicians must balance […]
Stephen Allison

Evaluating counselling skills of community health workers for pregnant adolescents in Limpopo province 30 July 2024
Background: Adolescent pregnancy carries significant global ramifications. Community health workers (CHWs) play a role in empowering adolescents through counselling skills, thereby promoting informed decision-making for better outcomes.Aim: The study aims to evaluate the counselling skills of CHWs in their efforts to support pregnant adolescents (PA) in Limpopo province.Setting: The research was carried out with CHWs in the Mopani […]
Rakgadi G. Malapela
Cannabis use among hospitalised adolescents before and after decriminalisation in South Africa 26 July 2024
Background: Cannabis is the most widely used substance worldwide, and its use is much higher among adolescents. However, adolescents are at higher risk of negative sequelae secondary to this use, including the possible development of mental disorders. On 31 March 2017, the South African High Court ruled that cannabis use by an adult in a private […]
Michelle C. Swartz
The prevalence of anxiety in pregnant women at Chris Hani Baragwanath Academic Hospital 23 July 2024
Background: Non-psychotic mental disorders are common during the perinatal period. In South Africa, there are few studies on antenatal anxiety and these results vary. Antenatal anxiety does not only add to the burden of perinatal co-morbidity but has subsequent immediate and long-term effects on the mother, birth outcomes and her offspring.Aim: The aim of this study was […]
Lisha Narayan

Nicotine dependence and incident psychiatric disorders: prospective evidence from US national study 11 September 2024
Molecular Psychiatry, Published online: 11 September 2024; doi:10.1038/s41380-024-02748-6Nicotine dependence and incident psychiatric disorders: prospective evidence from US national study
Guillaume Airagnes
Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine 11 September 2024
Molecular Psychiatry, Published online: 11 September 2024; doi:10.1038/s41380-024-02734-yLarge-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine
Mihai Avram
Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder 10 September 2024
Molecular Psychiatry, Published online: 10 September 2024; doi:10.1038/s41380-024-02690-7Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder
Anira Escrichs

Plaudits for logits in sensory neuroscience
A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful examination of their choices. In this issue of , Carandini flips the script, showing how it can model how the brain makes sensory choices.A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful […]
Impacts beyond the brain: Unraveling molecular mechanisms linking psychiatric, metabolic, and inflammatory conditions
By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the publication by Nakanishi et al. provides new insight to how primary brain deficiency impacts physiological systems beyond the brain.By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the […]
Keep calm and carry H3K27me1 off
In this issue of , Torres-Berrío et al. show that stress-susceptible mice exhibit elevated H3K27me1 levels in nucleus accumbens neurons due to the action of the SUZ12 VEFS domain, strengthening the link between specific epigenetic changes and long-lasting stress-induced social, emotional, and cognitive alterations.In this issue of , Torres-Berrío et al. show that stress-susceptible mice exhibit elevated […]

Social identity processes as a vehicle for therapeutic success in psychedelic treatment 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00302-5In this Perspective, authors overview the ‘social cure’ model employing group contexts, identity, and connections and argue for its use as a therapeutic framework for psychedelic treatment.
Martha Newson
Associated transcriptional, brain and clinical variations in schizophrenia 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00306-1This study examining blood transcriptomic, neuroimaging and clinical data in people with schizophrenia shows a relationship between individual variations in gene transcription, brain structure and cognitive performance.
Long-Biao Cui
Found in translation — translational science in mental health research 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00319-wTranslational science is often characterized metaphorically, as bridging the gaps among multidisciplinary research areas. However, in reality, translational work is often separate or excluded from clinical research. Integrating elements of translational and clinical work into more general mental health research is key to innovation and progress.

Oxytocin decreases alcohol self-administration in male baboons 11 September 2024
Translational Psychiatry, Published online: 11 September 2024; doi:10.1038/s41398-024-03076-7Oxytocin decreases alcohol self-administration in male baboons
Mary R. Lee
Testing the causal relationship of fat and sugar intake with depression and cortisol: a Mendelian Randomisation study 10 September 2024
Translational Psychiatry, Published online: 10 September 2024; doi:10.1038/s41398-024-03089-2Testing the causal relationship of fat and sugar intake with depression and cortisol: a Mendelian Randomisation study
Matylda Buczkowska
MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy 10 September 2024
Translational Psychiatry, Published online: 10 September 2024; doi:10.1038/s41398-024-03075-8MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy
Yao-Bo Li

The relationship between corticospinal excitability and structural integrity in stroke patients 6 September 2024
BackgroundEvaluation of the structural integrity and functional excitability of the corticospinal tract (CST) is likely to be important in predicting motor recovery after stroke. Previous reports are inconsistent regarding a possible link between CST structure and CST function in this setting. This study aims to investigate the structure-function relationship of the CST at the acute […]
Daghsen, L., Checkouri, T., Wittwer, A., Valabregue, R., Galanaud, D., Lejeune, F.-X., Doulazmi, M., Lamy, J.-C., Pouget, P., Roze, E., Rosso, C.
Intermediate HTT CAG repeats worsen disease severity in amyotrophic lateral sclerosis 6 September 2024
IntroductionRecent research has indicated a connection between amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), an inherited neurological condition caused by a trinucleotide CAG repeat expansion within exon 1 of the Huntingtin gene (HTT; MIM:613004).1 The same pathogenic CAG repeat expansions (40 or more CAG repeats) observed in patients with HD have been identified in […]
Grassano, M., Canosa, A., DAlfonso, S., Corrado, L., Brodini, G., Koumantakis, E., Cugnasco, P., Manera, U., Vasta, R., Palumbo, F., Mazzini, L., Gallone, S., Moglia, C., Dewan, R., Chia, R., Ding, J., Dalgard, C., Gibbs, R. J., Scholz, S., Calvo, A., Traynor, B., Chio, A.
Prognosis prediction and immunotherapy optimisation for cryptogenic new-onset refractory status epilepticus 5 September 2024
BackgroundCryptogenic new-onset refractory status epilepticus (cNORSE) currently lacks comprehensive knowledge regarding its clinical dynamics, prognostic factors and treatment guidance. Here we present the longitudinal clinical profiles, predictive factors for outcomes and the optimal duration of immunotherapy in patients with cNORSE.MethodsThis retrospective secondary endpoint analysis investigated patients with cNORSE identified from a prospective autoimmune encephalitis cohort […]
Jang, Y., Ahn, S. H., Park, K.-I., Jang, B.-S., Lee, H. S., Bae, J.-H., Lee, Y., Sunwoo, J.-S., Jun, J.-S., Kim, K. T., Mon, S. Y., You, J. H., Kim, T.-J., Shin, H., Han, D., Cho, Y. W., Dubey, D., Chu, K., Lee, S. K., Lee, S.-T.

Mendelian randomization: causal inference leveraging genetic data 19 April 2024
Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for […]
Chen, Lane G.
Interventions targeting social determinants of mental disorders and the Sustainable Development Goals: a systematic review of reviews 25 March 2024
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review […]
Oswald, Tassia Kate
Do metacognitive therapies for schizophrenia-spectrum disorders work? A meta-analytic investigation 21 March 2024
Recent reviews and meta-analyses of metacognitive therapy for schizophrenia-spectrum disorder (SSD) have included uncontrolled studies, single-session interventions, and/or analyses limited to a single form of metacognitive therapy. We sought to evaluate the efficacy of metacognitive therapies more broadly based on controlled trials (CT) of sustained treatments. We conducted a pre-registered meta-analysis of controlled trials that […]
Melville, Grace

A national evaluation of a multi‐modal, blended, digital intervention integrated within Australian youth mental health services 12 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
M. Alvarez‐Jimenez, J. Nicholas, L. Valentine, P. Liu, S. Mangelsdorf, S. Baker, T. Gilbertson, G. O'Loughlin, C. McEnery, P. D. McGorry, J. F. Gleeson, S. P. Cross
Relationship between nonexercise activity and mood in patients with eating disorders 8 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Robin Olfermann, Sabine Schlegel, Anna Vogelsang, Ulrich Ebner‐Priemer, Almut Zeeck, Markus Reichert
The impact of sex in the effectiveness of functional remediation in bipolar disorder 7 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Maria Serra‐Navarro, Derek Clougher, Brisa Solé, Jose Sánchez‐Moreno, Ana González‐Pinto, Esther Jiménez, Benedikt L. Amann, Vicent Balanzá‐Martínez, Rafael Tabarés‐Seisdedos, Celso Arango, Vivian Accardo, María Paz García‐Portilla, Ángela Ibáñez, José Manuel Crespo, José Luis Ayuso‐Mateos, Silvia Amoretti, Carla Torrent, Anabel Martínez‐Aran, Eduard Vieta, CIBERSAM Functional Remediation Group

Dual trajectories of supportive coparenting and father involvement: Parental predictors and influences 12 September 2024
Family Relations, EarlyView.
SuJung Park, Melissa A. Barnett, Ann M. Mastergeorge
Social determinants of health on attitudes toward childbearing among women with multiple sclerosis: A cross‐sectional study 12 September 2024
Brain and Behavior, Volume 14, Issue 9, September 2024.
Nahid Abbasi Khoshsirat, Romina Mokaram, Zohreh Mahmoodi, Ehsan Shahrestanaki, Nooshin Ghavidel
Cognitive resilience to Alzheimer's disease characterized by cell‐type abundance 12 September 2024
Alzheimer's &Dementia, EarlyView.
Nicholas O'Neill, Thor D. Stein, Oluwatosin A. Olayinka, Jenny A. Empawi, Junming Hu, Tong Tong, Xiaoling Zhang, Lindsay A. Farrer

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Evolving Perspectives on Wellness and Stress
Renewing the Teaching of Clinical Reasoning in Psychiatry: An Opportunity for Advancing Mental Health Training and Care
Assaults and Microaggressions Against Psychiatric Residents: Findings from a US Survey
Psychiatric physicians may experience higher rates of assault than those in other fields. For many reasons, residents may be especially vulnerable. This study updates rates of assaults among US psychiatry residents as well as the reporting rates and emotional effects of these incidents. Little data exists to examine rates of microaggressions against psychiatry residents.A cross-sectional […]

Acute Augmentations to Psychological Therapies in Eating Disorders: A Systematic Review and Meta-Analysis
The purpose of this systematic review and meta-analysis was to examine the use and efficacy of acute augmentation therapies in eating disorders.A meta-analysis addressing this topic across psychological disorders found augmentation significantly improved therapy outcome with strongest findings for augmentations targeting biological mechanisms; however, only one study examined eating disorders.Our systematic review identified 29 studies […]
Health Equity and Perinatal Mental Health
Pregnancy and the postpartum period are vulnerable times to experience psychiatric symptoms. Our goal was to describe existing inequities in perinatal mental health, especially across populations, geography, and in the role of childbirth.People of color are at an increased risk for perinatal mental health difficulties and more likely to experience neglect, poor communication, and racial […]
Harnessing Immersive Virtual Reality: A Comprehensive Scoping Review of its Applications in Assessing, Understanding, and Treating Eating Disorders
Immersive Virtual Reality (IVR) has shown promise in the assessment, understanding, and treatment of eating disorders (EDs), providing a dynamic platform for clinical innovation. This scoping review aims to synthesize the recent advancements and applications of IVR in addressing these complex psychological disorders.This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols, […]

Editorial introductions
No abstract available
journals.lww.com
Sex and gender differences in cancer in individuals with severe mental disorders
Purpose of review Although cancer incidence is similar between individuals with severe mental disorders (SMD) and the general population (GP), survival rates are lower, particularly in those with schizophrenia. While the scientific and medical communities acknowledge sex differences in cancer mechanisms, including risk factors and cancer types, less is known about sex and gender disparities […]
Bajić, Žarko; Vuk-Pisk, Sandra; Filipčić, Igor; Šimunović Filipčić, Ivona
The role of human involvement and support in digital mental health interventions for people with schizophrenia spectrum disorders: a critical review
Purpose of review Schizophrenia spectrum disorders (SDD) are characterized by a complex array of psychosis symptoms, and typically require ongoing and long-term support, including pharmacological and nonpharmacological management. Digital mental health interventions (DMHIs) have been suggested as a novel therapeutic approach to enable low-cost, scalable improvements in quality of care for adults living with SSD. […]
Arnautovska, Urska; Milton, Alyssa; Trott, Mike; Soole, Rebecca; Siskind, Dan

Daily-life reactivity and emotion regulation in children with social anxiety disorder
Prominent models of adult social anxiety disorder emphasize the role of hyperreactivity and emotion regulation (ER) difficulties. However, it is unclear whether these factors are relevant in childhood, a critical period for the development of this disorder. We used ecological momentary assessment with mobile phones to assess daily-life emotional reactivity and use and effectiveness of […]
Correlates of treatment-seeking in DSM-5 generalized anxiety disorder: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions‐III
47 % of those with lifetime GAD received therapy or medication for GAD.PTSD, depression, and panic disorder were associated with treatment seeking.Fatigue, panic attacks, reassurance seeking, and interpersonal avoidance were also related. Generalized Anxiety Disorder (GAD) presents a significant personal and societal burden and is associated with chronic medical comorbidities and markedly lower quality of life. […]
Scaling up psychological interventions into the daily lives of patients with anxiety and related disorders

Parent‐child interaction at age 5 months: genetic and environmental contributions and associations with later socio‐communicative development 11 September 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Irzam Hardiansyah, Petra Warreyn, Angelica Ronald, Mark J. Taylor, Terje Falck‐Ytter
The interplay of maternal and paternal postpartum depressive symptoms with children's internalizing and externalizing symptoms from childhood to adolescence: does socioeconomic status matter? A longitudinal cohort study 10 September 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Myriam Clément, Marilyn N. Ahun, Massimiliano Orri, Tina C. Montreuil, Martin St‐André, Catherine M. Herba, Gregory Moullec, Sylvana M Côté
Optimization of self‐ or parent‐reported psychiatric phenotypes in longitudinal studies 9 September 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Franjo Ivankovic, Sharon Johnson, James Shen, Jeremiah M. Scharf, Carol A. Mathews

Elder abuse and neglect, novel factors affecting depression risk, SARS-CoV-2 Omicron-induced anxiety, and provider flourishing in pediatric palliative care 7 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print.
Harold G. Koenig
Red kratom and red corvette: A case of mania induced by kratom withdrawal 6 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. Background: Kratom, derived from the Mitragyna speciose, a plant native to Southeast Asia, is a substance that is gaining popularity in the United States as a self-medication tool for opiate withdrawal and pain management. Its active compounds, mitragynine, and 7-hydroxymitragynine, interact with various receptors in the […]
Mohammmad Abidali
Psychotropic medication and hepatobiliary health: Ultrasound observations on patients with schizophrenia 5 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveThis study sought to examine the association between antipsychotic drug use and hepatobiliary health based on serum markers and ultrasound observations on a sample of patients with schizophrenia compared to age and gender matched healthy controls.MethodsThe 120 patients with schizophrenia and 60 control subjects had […]
Linlin Yue

Research landscape analysis on dual diagnosis of substance use and mental health disorders: key contributors, research hotspots, and emerging research topics 30 August 2024
Substance use disorders (SUDs) and mental health disorders (MHDs) are significant public health challenges with far-reaching consequences on individuals and society. Dual diagnosis, the coexistence of SUDs and...
Waleed M. Sweileh
Association between rTMS-induced changes in inflammatory markers and improvement in psychiatric diseases: a systematic review 27 August 2024
Repetitive transcranial magnetic stimulation (rTMS) has recently gained relevance in treating different psychiatric disorders. Limited evidence suggests that the beneficial effects of rTMS on psychopathology c...
Bruno Pedraz-Petrozzi, Shrabon Insan, Moritz Spangemacher, Jonathan Reinwald, Eva Kathrin Lamadé, Maria Gilles, Michael Deuschle and Alexander Sartorius
Maternal depression and early childhood development among children aged 24–59 months: the mediating effect of responsive caregiving 20 August 2024
This study examined whether maternal depression is related to Early Childhood Developmental (ECD) delay among children by quantifying the mediating contribution of responsive caregiving. We used data from 1235...
Siyu Zou, Xinye Zou, Ruolin Zhang, Kefan Xue, Angela Y. Xiao, Mo Zhou, Ziyuan Fu and Hong Zhou

Sexual Orientation Microaggression Rating Scale (SOMRS): Development and association with alliance ruptures. 8 August 2024
Sexual minority clients report experiencing frequent microaggressions during therapy, however, therapists may not recognize those microaggressions or may be reluctant to self-report them. The main aim of the present study was thus to develop an observational measure of in-session therapist-committed microaggressions related to the sexual orientation of sexual minority individuals (e.g., those who identify as […]
Should we feel the same? Mutual recognition and congruence between therapist and client regarding ruptures and repairs. 8 July 2024
The pattern of rupture and repair within therapeutic alliances has been associated with improved outcome. The present study adds to this body of research by examining rupture and repair from a dyadic perspective. First, we examined the relationship between mutual recognition of ruptures, rupture intensity, and client ratings of session helpfulness. We then examined client–therapist […]
Preventing dropout in spiritually integrated psychotherapies: What are the effective methods of attending to clients’ spirituality? 30 May 2024
The purpose of this study was to examine associations between clinicians’ use of varying types of spiritual interventions in the first session of spiritually integrated psychotherapies (SIPs) and clients’ likelihood of returning for a second session. In total, 154 practitioners of SIPs from 33 settings in a practice-research network reported on their implementation of different […]

Ongoing Teacher Support for Data-Based Individualization: A Meta-Analysis and Synthesis 6 September 2024
Journal of Learning Disabilities, Ahead of Print. Although data-based individualization (DBI) has positive effects on learning outcomes for students with learning difficulties, this framework can be difficult for teachers to implement due to its complexity and contextual barriers. The first aim of this synthesis was to investigate the effects of ongoing professional development (PD) support […]
Emma Shanahan
A Family-Based Intervention for Early Elementary Students With Reading and Behavioral Difficulties: A Pilot Study 2 August 2024
Journal of Learning Disabilities, Ahead of Print. We created and tested a family-based intervention with families of children in Grades 1 and 2 with reading and behavioral difficulties to investigate its impact on text comprehension. Developed with input from parents, reading experts, and behavior specialists, Family-RISE (Reading Intervention with Supports for Engagement) integrates evidence-based practices […]
Garrett J. Roberts
Assessing Beliefs About Intrinsic and Extrinsic Determinants of SLD: Evaluating the Factor Structure of a Novel Instrument 26 July 2024
Journal of Learning Disabilities, Ahead of Print. Schools conduct comprehensive psychoeducational evaluations to identify students with specific learning disabilities (SLDs) and determine whether they qualify for special education services. This decision-making process is complex and research has documented many factors influencing SLD identification decisions. One such factor may be decision-makers’ beliefs about the underlying causes […]
Courtenay A. Barrett

Staff Perceptions of Mental Health Relapse Prevention Support in a Specialist Mental Health Service in an Intellectual Disability Setting 10 September 2024
British Journal of Learning Disabilities, EarlyView.
Shannon Sinnott, Cliodhna O'Donovan, Suzanne Guerin
Item reduction of the “Support Intensity Scale” for people with intellectual disabilities, using machine learning 19 August 2024
British Journal of Learning Disabilities, EarlyView.
Félix González‐Carrasco, Felipe Espinosa Parra, Izaskun Álvarez‐Aguado, Sebastián Ponce Olguín, Vanessa Vega Córdova, Miguel Roselló‐Peñaloza
Culturally adaptive healthcare for people with a learning disability from an ethnic minority background: A qualitative synthesis 12 August 2024
British Journal of Learning Disabilities, EarlyView.
Christina Roberts, Nicola Ditzel, Nicola Cooper‐Moss, Katie Umbleby, Umesh Chauhan

Autism spectrum disorder, radicalization, and violence: a forensic perspective 30 August 2024
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Julian A.C. Gojer Kayla M. Gaw Kaileigh M. Chretien a Integrated Forensic Program, Royal Ottawa Mental Health Center and Institute of Mental Health Research, ON, Canadab Sexual Behaviours Clinic, Royal Ottawa Mental Health Center and Institute of Mental Health Research, ON, Canadac Integrated Forensic Program (IFP), Royal Ottawa Mental Health Center, ON, Canada
Childhood onset violence and early onset schizophrenia. A molecular diagnosis of 15q13.2-13.3 duplication syndrome and the effects on insight and engagement 28 August 2024
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Ed Silva Department missing for affiliation Rathbone Low Secure Unit, Rathbone Hospital, Mersey Care NHS FT, Liverpool, UK
Statement of Retraction: See think act: the need to rethink and refocus on relational security 19 August 2024
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Therapeutic and non-therapeutic practices in the child justice system in Kenya: A therapeutic jurisprudence perspective
Child justice systems are specialized jurisdictions set up for the purpose of providing justice related services to children. In an effort to resolve many of the systemic injustices expereinced by justice involved children, Kenya recently legislated the Children Act 2022. This new law is viewed as a paradigm shift from previous children acts as it […]
Forensic criteria, clinical and theoretical issues of the indication of court-ordered treatment: A comparative survey among experts in forensic psychiatry and sentencing judges in France
Following the French law n° 98–468 of 17 June 1998 relative to the prevention of sexual offenses and the protection of minors, social and judicial follow-up and court-ordered treatment were introduced with the aim of reinforcing the prevention of recidivism. Court-ordered treatment is one of the possible obligatory measures provided for by social and judicial […]
Editorial Board

Faithful and fearful: Does religion promote or reduce fear of crime in Germany?
This article complements existing victimological studies on religion by investigating whether religion promotes or reduces fear of crime in Germany. According to the generalized insecurity approach and the theory of social production functions, religion and fear of crime are linked via secularization-induced diffuse insecurities. It is expected that different facets of religion are tied to […]
Moral foundations in gender violence cases decided in Portuguese courts
Gender violence encompasses a multitude of morally problematic psychological, physical, and sexual behaviors that, in most countries, constitute criminal offenses. In this study, we investigate the association between moral foundations (, , , , and ) and punitive responses to gender violence offenses. Our case study focuses on gender violence in Portugal, a country in […]
Comparing the criminal careers of organized crime offenders in Italy and the Netherlands
The concept of organized crime has dynamically evolved, with researchers contending that it is a social construct or an umbrella concept encompassing different empirical manifestations. Scholars have often suggested classifying organized crime groups into those involved in “racketeering” or “governing” and those engaged in “transit crime” or “trading.” However, these propositions were never assessed at […]

The longitudinal associations between nonviolent/violent stressful life events, moral disengagement, and online aggression in Chinese young people through the lens of general aggression model. 18 July 2024
Objective: Online aggression (OA) in Chinese university students is a public health concern. Drawing on the general aggression model (GAM), this study examines the extent to which nonviolent and violent stressful life events predict OA through altering moral cognition (i.e., moral disengagement). It also examines whether the two types of stressful life events interactively predict […]
Adolescent relationship violence: Should pushes and hits always be considered violent? 18 July 2024
Objective: Research on adolescent relationship violence often involves having adolescents report on physically forceful acts, such as pushes and hits, that have occurred in the context of dating relationships. The present study compares: (a) adolescents who reported having experienced acts of physical force by a dating partner and attributed it solely to playfulness (playful only); […]
Internalized heterosexism magnifies the association of hazardous or harmful alcohol use on intimate partner violence perpetration rates of sexual minority and same-sex-attracted men. 20 June 2024
Objective: To test whether internalized heterosexism, a form of minority stress, heightens the effect of hazardous or harmful alcohol use on frequency of intimate partner violence (IPV) perpetration among sexual minority and same-sex-attracted men. Method: We recruited participants online via Amazon Mechanical Turk (MTurk). Inclusion criteria were adult cisgender men living in the United States […]

Effectiveness of mobile smoking cessation treatment with 1‐week nicotine replacement therapy sampling at outdoor smoking hotspots: A cluster randomized controlled trial 11 September 2024
Addiction, EarlyView.
Wan Jia Aaron He, Qi Wang, Ching Han Helen Chan, Tzu Tsun Luk, Man Ping Wang, Siu Chee Sophia Chan, Tai Hing Lam, Yee Tak Derek Cheung
Detection and quantification of synthetic cannabinoids in seven illicitly sourced disposable vapes submitted by an individual presenting to a UK drug and alcohol service 11 September 2024
Addiction, EarlyView.
Sam Craft, Peter Sunderland, Molly F. Millea, Christopher R. Pudney, Oliver B. Sutcliffe, Tom P. Freeman
Implications of the shift to DSM‐5 for alcohol use disorder prevalence estimates in the National Survey on Drug Use and Health 10 September 2024
Addiction, EarlyView.
Allen J. Bailey, Patrick D. Quinn, R. Kathryn McHugh

A pilot study of “AKBAY” self-help intervention for university students with moderate symptoms of depression and anxiety 9 September 2024
Depression and anxiety are common mental health issues among young adults, particularly exacerbated by the COVID-19 pandemic. Research indicates a notable increase in global prevalence rates, especially in this demographic. Despite their prevalence, factors like stigma, cost and limited accessibility often prevent individuals from seeking professional help. Therefore, there is a pressing need for innovative […]
Sherna Bangalan
Defining mental health literacy: a systematic literature review and educational inspiration 2 September 2024
This paper aims to explore how the term “mental health literacy” (MHL) is defined and understand the implications for public mental health and educational interventions. An extensive search was conducted by searching PubMed, ERIC, PsycINFO, Scopus and Web of Science. Keywords such as “mental health literacy” and “definition” were used. The publication year ranges from […]
Shengnan Zeng
Representing the experiences of charity peer leaders facilitating well-being interventions to their peers using process evaluation methodology (Part 2) 2 September 2024
This paper aims to build on Part 1 which generated a theory representing the experiences of charity peer leaders facilitating well-being interventions (Burns, 2024). This study (Part 2) examines the process of peers [1] becoming peer leaders using the generated theory. Following the Medical Research Council Process Evaluation Framework (Moore et al, 2015), the methods […]
Jenny Burns

Mortality in the Victorian asylum: was it so high? Standardised Mortality Rate compared with historical methods 9 August 2024
History of Psychiatry, Ahead of Print. Mortality is closely linked to age, sex, and social and historical context. Standardised Mortality Rates (SMR) address these contextual factors by comparing mortality in a population under study with that in people of the same age and sex, the same period in history and from a similar cultural context. […]
Charlotte Richardson
The notion of excessive childhood restlessness in Spain at the beginning of the twentieth century 27 July 2024
History of Psychiatry, Ahead of Print. This study delves into the historical documentation from 1900 to 1936 by Spanish doctors and educators concerning children’s hyperactivity. By focusing on medical perspectives of the time, we aim to explore the conceptualisation of childhood phenomenology within the context of significant international literature of that era. The publications of […]
Joana Escamilla Lerner
Empathy or sympathy: a necessary distinction? 23 July 2024
History of Psychiatry, Ahead of Print. As a deeply hybrid discipline, psychiatry demands research that tackles the concepts constituting it and its objects. This is an essential prerequisite to empirical studies, the validity of which are directly dependent on a clear understanding of the underlying concepts. Empathy and sympathy are concepts used variably and inconsistently […]
Ivana S Marková

The Mpox outbreak is a public health emergency of international concern: Implications for mental health and global preparedness 11 September 2024
International Journal of Social Psychiatry, Ahead of Print. Background:The Mpox, a zoonotic viral disease that has historically affected Central and West Africa, has been declared a Public Health Emergency of International Concern by the World Health Organization. Rapid transmission and recent dissemination in Africa may imply significant challenges to global health, including mental health.Methods:We reviewed […]
Julio Torales
Caregivers’ depressive symptoms and eating disorder severity in adults with anorexia and bulimia nervosa 11 September 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Negative affectivity of caregivers has been linked to difficulties in the caregiver-patient relationship and it is assumed to contribute to the maintenance of eating disorder (ED) symptoms.Aims:The present study investigated the relationship of patients’ ED symptom severity to patients’ and caregivers’ depressive symptoms, and caregivers’ involvement in […]
Krisztina Kocsis-Bogar
Social and emotional well-being intervention to reduce stress, anxiety, and depression among Ukrainian refugees resettled in Massachusetts 11 September 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Mental health problems are high among refugees due to their traumatic experiences of fleeing war and witnessing disasters and deaths due to violence and conflict. Refugees are exposed to various socio-cultural stressors during their migration journey before, during, and after arriving at the host country, which may […]
Kalpana Poudel-Tandukar

What we know and what should we know about the future of blockchain in finance [version 1; peer review: awaiting peer review] 12 September 2024
Background In response to the transformative impact of blockchain technology on economic and financial landscapes, there is a critical need for a review study that analyses the knowledge landscape from diverse perspectives. Methods This research VOSviewer, and Bibliometrix to undertake a bibliometric analysis of the expanding literature related to blockchain technology within the financial sector. […]
Shikta Singh
An enhanced broadband class-J mode power amplifier for 5G smart meter applications [version 2; peer review: 1 approved, 1 approved with reservations] 12 September 2024
Background: With the tremendous increase in the usage of smart meters for industrial/ household purposes, their implementation is considered a crucial challenge in the Internet of Things (IoT) world, leading to a demand for emerging 5G technology. In addition, a large amount of data has to be communicated by smart meters efficiently, which needs a […]
Nagisetty Sridhar
Comparison of histopathological and triphenyl tetrazolium chloride test in diagnosing myocardial infarction: An autopsy study [version 1; peer review: awaiting peer review] 12 September 2024
Background Sudden and unexpected deaths are increasing drastically. The main cause of sudden death is cardiovascular disease, out of which coronary artery disease predominates forming 80% of the cases. Most of the time, detecting early changes in myocardial infarction during the autopsy is challenging since gross infarct changes do not appear until after 24 to […]
Varun Krishna B

Inpatient CBT Reduces Suicide and Readmissions After Discharge 11 September 2024
(MedPage Today) -- Brief cognitive behavioral therapy (BCBT) sessions adapted for psychiatric inpatients reduced postdischarge suicide attempts and readmission rates, according to a randomized clinical trial. In a trial of 200 participants at...
Local Suicide Risk Factors; Chappell Roan's Bipolar II Disorder; Student Mindfulness 11 September 2024
(MedPage Today) -- Local economic and social conditions like health insurance access, internet, and household income, were tied with suicide risk, according to a new CDC report. The FDA cleared DeepWell Digital Therapeutics' technology that can...
Steroid Use Tied to Diabetes; Suicide Rates Climbing; Legionnaire's Death Toll Rises 11 September 2024
(MedPage Today) -- Note that some links may require registration or subscription. Chronic steroid use more than doubled the risk of type 2 diabetes, a large-scale study showed. (U.S. News & World Report) A novel blood test identified people...

New insights could help prevent psychosis relapses in youth and young adults 12 September 2024
... Psychiatry and a current doctoral student at Boston University. Detecting patterns in delusions. The study, published in Jama Psychiatry, found ...
High doses of some prescription stimulants tied to increased psychosis risk - EurekAlert! 12 September 2024
... Psychiatry. DOI: 10.1176/appi.ajp.20230329. ###. About McLean. McLean Hospital has a continuous commitment to put people first in patient care ...
Triad emergency psychiatrist shares suicide risk factors - WXII 12 12 September 2024
Dr. Laika Simeon-Thompson, the medical director of emergency psychiatry at Atrium Wake Forest Baptist Hospital, says suicide can impact people of ...

Hormone Therapy Can Benefit Women Into Their 80s 12 September 2024
Hormone therapy (HT) can help women manage menopause symptoms into their 80s, and the reasons are varied. MDedge News
Diabetic Complications Increase Risk for Periodontitis 12 September 2024
The coexistence of neuropathy and retinopathy increased the risk for moderate/severe periodontitis, and dyslipidemia had an additive effect. Medscape Medical News
Debate: Should CAR T Best Be Used in Early MM Relapse? 12 September 2024
Judging by Attendees' Votes at the SOHO 2024 Debate, Perhaps Not Medscape Medical News

Mpox: UNHCR launches appeal to support refugees in African countries 11 September 2024
The UN refugee agency, UNHCR, appealed on Wednesday for $21.4 million to urgently scale up health services for forcibly displaced people in African countries impacted by mpox.
Gaza: Six UNRWA staff killed in strikes on school sheltering displaced people 11 September 2024
Six staff members with the UN agency that assists Palestine refugees, UNRWA, were killed in Gaza on Wednesday when two Israeli airstrikes hit a school-turned-shelter and its surroundings.
Gaza: UN envoy condemns deadly strike on camp in humanitarian zone 10 September 2024
The UN Middle East envoy has strongly condemned deadly airstrikes by the Israeli Defense Forces (IDF) on Tuesday on a densely populated area in an Israeli-designated humanitarian zone in Gaza.

Launch of the Global Coalition for Evidence 13 September 2024
The Global Coalition for Evidence will be launched on 13th September during the second Global Evidence Summit in Prague.The COVID-19 pandemic underscored the critical role of evidence-informed decision-making (EIDM), where the rapid uptake and effective implementation of evidence were pivotal in guiding decision-making processes. Accurate and timely translation of evidence remains essential for promoting population […]
who.int
Results from the 2024 Tracking Antimicrobial Resistance Country Self-Assessment Survey (TrACSS): Quadripartite webinar 10 September 2024
Agenda:1. Overview and introduction to the Tracking Antimicrobial Resistance Country Self-Assessment Survey (TrACSS): Anand Balachandran (WHO)2. Results of the 8th round of TrACSS and relevant trends from the previous seven years by sector:- Zlatina Dobreva (WHO): Multisector results and human health related results - Yohane Soko (WOAH): Animal health related results- Ozge Kara (FAO): Food and […]
who.int
Suicide Prevention in Thailand: A whole-of-society approach 10 September 2024
In recent years, Thailand has seen a concerning rise in suicide rates, with a 32% increase in the suicide mortality rate from 2017 to 2022. The highest rates are observed among older individuals (aged 55 and above) , while teenagers (15-19) have the highest rates of suicide attempts. In 2023, there were 31,402 suicide attempts […]
who.int

Race, Gender, and Donor Heart Acceptance—Reply 10 September 2024
In Reply Ms Majeed and colleagues pose important questions regarding our study. First, the COVID-19 pandemic had several possible implications for transplant care. To explore these implications, we reexamined the number of donor heart offers until acceptance as in the original article but censored observations after February 29, 2020, to exclude the COVID-19 period. For […]
The Valediction in Poetry and Medicine 10 September 2024
Valedictions are essential in poetry (from those of Catullus to Donne and, in more recent times, from Seamus Heaney to Adrienne Rich), expressing as much devotion and renewal as they do sorrow and the elegiac. So at this difficult moment of transition in medicine, when many physicians are leaving the profession for a variety of […]
Extent of Drug Patents With Terminal Disclaimers and Obviousness-Type Double Patenting Rejections 10 September 2024
This study evaluates the frequency of terminal disclaimers filed by drug patent holders to obviate obviousness-type double patenting rejections associated with drug patent thickets.

Liraglutide: Weight loss injection is effective in children aged 6-11, study reports 11 September 2024
The weight loss injection liraglutide, branded as Saxenda, effectively reduced body mass index (BMI) in children and was more effective than lifestyle interventions in a small phase 3 trial involving 82 children.1The study, published in the New England Journal of Medicine and funded by the manufacturer Novo Nordisk, saw children aged 6-11 randomly allocated in […]
Elisabeth Mahase
Prostate cancer incidence and mortality in Europe and implications for screening activities: population based study 11 September 2024
In this paper by Vaccarella and colleagues (BMJ 2024;386:e077738, doi:10.1136/bmj-2023-077738, published 4 September 2024), the funding section should have acknowledged the support of the Italian Ministry of Health as well as the independence of the funders. The new statement should read:Funding: DS and LDM were supported by the Italian Association for Cancer Research (grant No […]
Tackling UK’s long term sickness will improve NHS productivity, analysis finds 11 September 2024
A “whole of government” approach to tackling long term sickness and economic inactivity could return as many as 600 000 people to the UK workforce within five years, say analysts.They estimate that this could deliver a £109bn-£177bn boost to the UK’s GDP—equal to 2-3% in 2029—and could “unlock” £35bn-£57bn in fiscal revenue by then.In a […]
Matthew Limb

How to best convey continuous outcomes in patient decision aids 10 September 2024
IntroductionThe work of transforming scientific publications into tools that can support people in comparing treatments, tests and other interventions has been driven by efforts to support shared decision-making. The International Patient Decision Aids Standards (IPDAS) Collaboration has published many articles that guide this process. IPDAS, and others in this field, have considered the challenges of […]
Elwyn, G., Durand, M. A., Agoritsas, T., Mayer, M.
Development of a competency framework for health technology assessment in India 5 September 2024
IntroductionHealth technology assessment (HTA) has become a key part of assessing evidence to determine which treatments are funded. Early applications were within the centrally funded health systems of high-income countries. Recent years have seen increased use within low-income and middle-income countries, including India.1–6Increased application of HTAs has required corresponding increases in the systems’ resources that […]
Dixon, S., Tyagi, K., Singh, M., Kar, S. S., Bagepally, B. S., Prinja, S., Booth, A., Carroll, C., Sohail, A., Mehndiratta, A.
Pharmacological interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units: a network meta-analysis 3 September 2024
ObjectivesTo assess the efficacy and safety of pharmacological interventions for preventing upper gastrointestinal (GI) bleeding in people admitted to intensive care units (ICUs).Design and settingSystematic review and frequentist network meta-analysis using standard methodological procedures as recommended by Cochrane for screening of records, data extraction and analysis. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) […]
Toews, I., Hussain, S., Nyirenda, J. L. Z., Willis, M. A., Kantorova, L., Slezakova, S., Boltena, M. T., Peter, J. V., Fontes, L. E. S., Klugar, M., Sadeghirad, B., Meerpohl, J. J.

Deaths in prison 10 September 2024
In this country we do not give a death sentence, but for everyone who has taken their life in prison that is exactly what they got - Mark Saunders, whose son Dean died in HMP & YOI Chelmsford in 2016 Below is a breakdown of deaths in prison in England and Wales by calendar year […]
Inquest
Deaths in police custody 10 September 2024
To date there have been 1901 deaths in police custody or otherwise following contact with the police in England & Wales since 1990 Below is a breakdown of deaths in police custody or following other forms of contact with the police, as well as vehicular pursuits and road traffic incidents (RTIs) since 1990, by calendar […]
Inquest
Podcast 6 September 2024
Unlawful Killing: Death, resistance and the fight for justice. Listen now!
Inquest