J Appl Clin Med Phys. 2024 Jul 23:e14472. doi: 10.1002/acm2.14472. Online ahead of print.

ABSTRACT

PURPOSE: This study examines how MRI distortions affect frame-based SRS treatments and assesses the need for clinical distortion corrections.

METHODS: The study included 18 patients with 80 total brain targets treated using frame-based radiosurgery. Distortion within patients’ MRIs were corrected using Cranial Distortion Correction (CDC) software, which utilizes the patient’s CT to alter planning MRIs to reduce inherent intra-cranial distortion. Distortion was evaluated by comparing the original planning target volumes (PTV_ORIG) to targets contoured on corrected MRIs (PTV_CORR). To provide an internal control, targets were also re-contoured on uncorrected (PTV_RECON) MRIs. Additional analysis was done to assess if 1 mm expansions to PTV_ORIG targets would compensate for patient-specific distortions. Changes in target volumes, DICE and JACCARD similarity coefficients, minimum PTV dose (D_min), dose to 95% of the PTV (D95%), and normal tissue receiving 12 Gy (V_12Gy), 10 Gy (V_10Gy), and 5 Gy (V_5Gy) were calculated and evaluated. Student’s t-tests were used to determine if changes in PTV_CORR were significantly different than intra-contouring variability quantified by PTV_RECON.

RESULTS: PTV_RECON and PTV_CORR relative changes in volume were 6.19% ± 10.95% and 1.48% ± 32.92%. PTV_RECON and PTV_CORR similarity coefficients were 0.90 ± 0.08 and 0.73 ± 0.16 for DICE and 0.82 ± 0.12 and 0.60 ± 0.18 for JACCARD. PTV_RECON and PTV_CORR changes in D_min were -0.88% ± 8.77% and -12.9 ± 17.3%. PTV_RECON and PTV_CORR changes in D95% were -0.34% ± 5.89 and -8.68% ± 13.21%. The 1 mm expanded PTV_ORIG targets did not entirely cover 14 of the 80 PTV_CORR targets. Normal tissue changes (V_12Gy, V_10Gy, V_5Gy) calculated with PTV_RECON were (-0.09% ± 7.39%, -0.38% ± 5.67%, -0.08% ± 2.04%) and PTV_CORR were (-2.14% ± 7.34%, -1.42% ± 5.45%, -0.61% ± 1.93%). Except for V_10Gy, all PTV_CORR changes were significantly different (p < 0.05) than PTV_RECON.

CONCLUSION: MRIs used for SRS target delineation exhibit notable geometric distortions that may compromise optimal dosimetric accuracy. A uniform 1 mm expansion may result in geometric misses; however, the CDC algorithm provides a feasible solution for rectifying distortions, thereby enhancing treatment precision.

PMID:39042450 | DOI:10.1002/acm2.14472