Evidence
Mov Disord Clin Pract. 2024 Sep 13. doi: 10.1002/mdc3.14206. Online ahead of print.
ABSTRACT
BACKGROUND: Family history of Parkinson’s disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.
OBJECTIVES: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).
METHODS: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.
RESULTS: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.
CONCLUSIONS: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.
PMID:39269187 | DOI:10.1002/mdc3.14206
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Family History in Parkinson’s Disease: A National Cross-Sectional Study
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Family history of psychiatric conditions and development of siblings of children with autism
- Young-Onset Alzheimer Dementia Due to a Novel Pathogenic Presenilin 1 Variant Initially Misdiagnosed as Autoimmune Encephalitis
- Young-Onset Alzheimer Dementia Due to a Novel Pathogenic Presenilin 1 Variant Initially Misdiagnosed as Autoimmune Encephalitis
- Family history of cancer and lung cancer: Utility of big data and artificial intelligence for exploring the role of genetic risk
- Exploring first-degree family history in a cohort of Portuguese Alzheimer's disease patients: population evidence for X-chromosome linked and recessive inheritance of risk factors
- Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia
- Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan
- Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan
- Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study
- The Epidemiological, Clinical, and Therapeutic Profile of Bipolar Patients in Eastern Morocco
- An Exploratory Case-Control Study for Mitochondrial DNA G10398A in Bipolar I Disorder Patients with a Family History of Affective Disorders
- Parental History of Memory Impairment and β-Amyloid in Cognitively Unimpaired Older Adults
- A systematic review of eating disorders and family functioning
- Autosomal Recessive Guanosine Triphosphate Cyclohydrolase I Deficiency: Redefining the Phenotypic Spectrum and Outcomes
- Examining the association of familial and social stress, trauma, and support on mood, anxiety, and behavioral symptoms and diagnoses in youth at risk for bipolar disorder and controls
- Identification of a pathogenic mutation in ARPP21 in patients with amyotrophic lateral sclerosis
- Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson's Disease
- Relationship between family history of mandatory boarding school experiences and suicide risk in US reservation-based Native American youth: a cross-sectional analysis
- Screening and early treatment for osteoporosis: Who are we missing under age 65?
- Exploration of Risk Factors for Language Regression According to Parent Reports in Turkish Children with Autism Spectrum Disorder
- Clinical Manifestations
- Dystonia in a Patient with Genetically Proven Salih Ataxia Due to a Novel Truncating Variant: Expanding the Genotypic and Phenotypic Spectrum
- Risk Factors of Alcohol Use Disorders Among Inpatients with Schizophrenia: An Institutional-Based Cross-sectional Survey
- Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study
- Subclinical hypomanic experiences in young adults after sleep deprivation are independent of depressive disorders, chronotype or 5-HTTLPR polymorphism
- A Germline ZFX Missense Variant in a Patient With Primary Hyperparathyroidism
- A Germline ZFX Missense Variant in a Patient With Primary Hyperparathyroidism
- Medulloblastomas with ELP1 pathogenic variants: A weakly penetrant syndrome with a restricted spectrum in a limited age window
- The family alliance as a facilitator of therapeutic change in systemic relational psychotherapy for borderline personality disorder: A case study
- A case report about anorexia nervosa and ischemic stroke: what can we learn?
- Brain-derived neurotrophic factor and C-reactive protein (CRP) biomarkers in suicide attempter and non-attempter major depression disorder (MDD) patients
- Antisocial personality disorder and determinants among prisoners in South Gondar zone correctional institutions, Northwest Ethiopia: An institution-based cross-sectional study
- Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial
- Systematic Review of the Cost of Illness of Parkinson's Disease from a Societal Perspective
- Poor Concordance Between Intensive Care Unit Patients' and Family Members' Patient Dignity Inventory Scores Despite Communication of Dignity-Related Distress
- Functional Movement Disorder as a Prodromal Symptom of Parkinson's Disease-Clinical and Pathophysiological Insights
- Polysomnogram Findings and Psychosocial and Academic Concerns in Children With Cleft Palate With or Without Cleft Lip
- Care burden and associated factors among caregivers of patients with bipolar type I disorder
- The role of MiRNA-34 family in different signaling pathways and its therapeutic options
- Life and Death: A Multicenter Study Evaluating Cardiologists' Approach to Difficult Conversations with Fontan Patients and Families
- Prediction of Future Parkinson Disease Using Plasma Proteins Combined With Clinical-Demographic Measures
- Prediction of Future Parkinson Disease Using Plasma Proteins Combined With Clinical-Demographic Measures
- Longitudinal Analysis of Cancer Family Caregiver Perception of Sleep Difficulty During Home Hospice
- Nurses' Experiences of the Prerequisites for Implementing Family-Centered Care to Prevent Pediatric Delirium
- Risk factors for attempted suicide in non-psychotic patients with suicidal ideation
- Risk factors for attempted suicide in non-psychotic patients with suicidal ideation
- Natural history and progression of metabolic dysfunction-associated steatotic liver disease
- Risk factors for suicidal behavior in patients hospitalized for adjustment disorders
- Clinical Intervention Strategies and Family Dynamics in Adolescent Eating Disorders: A Scoping Review for Enhancing Early Detection and Outcomes
- Clinical Intervention Strategies and Family Dynamics in Adolescent Eating Disorders: A Scoping Review for Enhancing Early Detection and Outcomes
- Using polygenic scores in combination with symptom rating scales to identify attention-deficit/hyperactivity disorder
- The relationship between sleep disturbance and aggressive behaviour among community-dwelling schizophrenia patients: a moderated mesomeric effect model
- Retinal Changes in Double-Antibody Seronegative Neuromyelitis Optica Spectrum Disorders
- Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer's disease and a history of traumatic brain injury
- Unveiling metabolic dysfunction-associated fatty liver disease: Knowledge gaps and attitudes among Lebanese university students
- Use of Clozapine in persons with a history of seizures: A retrospective study
- Anxiety and depression among hypertensive patients during the COVID-19 pandemic: A cross-sectional study from Kathmandu Metropolitan, Nepal
- Houston, We Have AI Problem! Quality Issues with Neuroimaging-Based Artificial Intelligence in Parkinson's Disease: A Systematic Review
- Acute symptomatic seizures in patients with recurrent ischemic stroke: A multicentric study
- Arrest History and Health Among U.S. Sexual and Gender Minority Youth, 2022
- Arrest History and Health Among U.S. Sexual and Gender Minority Youth, 2022
- Delirium Mediated the Association Between a History of Falls and Short-Term Mortality Risk in Critically Ill Ischemic Stroke Patients
- Nicotine dependence and incident psychiatric disorders: prospective evidence from US national study
- Survey on diagnosis of post-brain injury "higher brain dysfunction" in patients with cognitive impairment. Family/caregiver response
Evidence Blueprint
Family History in Parkinson’s Disease: A National Cross-Sectional Study
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Family History in Parkinson’s Disease: A National Cross-Sectional Study
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Family History of AD/Dementia, Polygenic Risk Score for AD, and Parkinson's Disease
- Factors associated with perceived helpfulness and use of mental health websites by Australian young adults with a family history of mental illness
- Gerstmann-Sträussler-Scheinker Disease Presenting as Late-Onset Slowly Progressive Spinocerebellar Ataxia, and Comparative Case Series with Neuropathology
- Longitudinal associations between psychedelic use and psychotic symptoms in the United States and United Kingdom
- Meta-analysis of a family history of diabetes in schizophrenia
- Early onset Parkinson's disease in the cycle of 3,4-methylenedioxymethamphetamine and substance use: a case report
- Influencing Factors on the Efficacy of Aerobic Exercise Therapy in Depression: A Single-Centre Cross-Sectional Study
- Family history of psychiatric conditions and development of siblings of children with autism
- Young-Onset Alzheimer Dementia Due to a Novel Pathogenic Presenilin 1 Variant Initially Misdiagnosed as Autoimmune Encephalitis
- Young-Onset Alzheimer Dementia Due to a Novel Pathogenic Presenilin 1 Variant Initially Misdiagnosed as Autoimmune Encephalitis
- Family history of cancer and lung cancer: Utility of big data and artificial intelligence for exploring the role of genetic risk
- Delay discounting and family history of psychopathology in children ages 9-11
- Exploring first-degree family history in a cohort of Portuguese Alzheimer's disease patients: population evidence for X-chromosome linked and recessive inheritance of risk factors
- Association of type 2 diabetes with family history of diabetes, diabetes biomarkers, mental and physical disorders in a Kenyan setting
- Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia
- Neural activations during cognitive and affective theory of mind processing in healthy adults with a family history of alcohol use disorder
- Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan
- Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan
- Parkinson's Disease Associated with G2019S LRRK2 Mutations without Lewy Body Pathology
- Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study
- Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years
- Impact of a family history of mental disorders on the characteristics of patients with early psychosis
- The Epidemiological, Clinical, and Therapeutic Profile of Bipolar Patients in Eastern Morocco
- Heterogeneity in families with ATTRV30M amyloidosis: a historical and longitudinal Portuguese case study impact for genetic counselling
- Neural response to threat and reward among young adults at risk for alcohol use disorder
- An Exploratory Case-Control Study for Mitochondrial DNA G10398A in Bipolar I Disorder Patients with a Family History of Affective Disorders
- Correction to "Gerstmann-Straussler-Scheinker Disease Presenting as Late-Onset Slowly Progressive Spinocerebellar Ataxia, and Comparative Case Series with Neuropathology"
- Parental History of Memory Impairment and β-Amyloid in Cognitively Unimpaired Older Adults
- Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families
- Clinical Effects of Cannabis Use in First-Episode Acute Psychotic Patients
- Validity of the DSM-5 Mixed Features Specifier Interview
- A systematic review of eating disorders and family functioning
- Validity of the DSM-5 Mixed Features Specifier Interview
- How to Use the New European Academy of Neurology/Movement Disorder Society European Section Guideline for Invasive Therapies in Parkinson's Disease
- The effects of family support and smartphone-derived homestay on daily mood and depression among sexual and gender minority adolescents
- Staging's determinants in early intervention youth: a retrospective study
- Young people at risk for developing bipolar disorder: Two-year findings from the multicenter prospective, naturalistic Early-BipoLife study
- Levodopa-Induced Dyskinesias are Frequent and Impact Quality of Life in Parkinson's Disease: A 5-Year Follow-Up Study
- BCL11B-Related Dystonia: Further Evidence of an Emerging Cause of Childhood-Onset Generalized Dystonia
- Aceruloplasminemia: Unique Clinical and MRI Findings in a Patient with a Novel Frameshift Mutation
- Autosomal Recessive Guanosine Triphosphate Cyclohydrolase I Deficiency: Redefining the Phenotypic Spectrum and Outcomes
- Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation
- Relevance of antinuclear antibody in diagnosis and characteristics of multiple sclerosis
- Examining the association of familial and social stress, trauma, and support on mood, anxiety, and behavioral symptoms and diagnoses in youth at risk for bipolar disorder and controls
- Identification of a pathogenic mutation in ARPP21 in patients with amyotrophic lateral sclerosis
- Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson's Disease
- Caregiver and family functioning after pediatric disorder of consciousness: telephone-based outcome assessment
- DPF2-related Coffin-Siris syndrome type 7 in two generations
- Psychedelic use and psychiatric risks
- Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research
- Relationship between family history of mandatory boarding school experiences and suicide risk in US reservation-based Native American youth: a cross-sectional analysis
- The Intergenerational Transfer of Mental Disorders: A Population-Based Multigenerational Linkage Study: Le transfert intergénérationnel des troubles mentaux : une étude sur les liens multigénérationnels basée sur la population
- A Case of NEDMAGA: Neurodevelopmental Disorder with Movement Abnormalities, Abnormal Gait, and Autistic Features
- Neurophysiological Analysis of Cortical Myoclonic Tremor and Excessive Startle in ARHGEF9 Deficiency
- Predictive factors for postoperative delirium in thoracic surgery
- Serum signature of antibodies to toxoplasma gondii, rubella virus, and cytomegalovirus in females with bipolar disorder: A cross-sectional study
- Functional Alterations in Patients with Bipolar Disorder and Their Unaffected First-Degree Relatives: Insight from Genetic, Epidemiological, and Neuroimaging Data
- Screening and early treatment for osteoporosis: Who are we missing under age 65?
- Celebration of the 300th Anniversary of the Regius Chair in History: 'What is History Now?'
- Exploration of Risk Factors for Language Regression According to Parent Reports in Turkish Children with Autism Spectrum Disorder
- Cortical and subcortical structural differences in psychostimulant-free ADHD youth with and without a family history of bipolar I disorder: a cross-sectional morphometric comparison
- User experience of a family health history chatbot: A quantitative analysis
- The impact of comorbid premenstrual syndrome or premenstrual dysphoric disorder on the clinical characteristics of bipolar disorder among Han Chinese women
- From random to precise: updated colon cancer screening and surveillance for inflammatory bowel disease