Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Psychiatry Res Neuroimaging. 2024 Jun 13;342:111848. doi: 10.1016/j.pscychresns.2024.111848. Online ahead of print.
ABSTRACT
The purpose of this study was to assess the functional connectivity of the posterior cingulate cortex in autism spectrum disorder (ASD). We used resting-state functional magnetic resonance imaging (rsfMRI) brain scans of adolescents diagnosed with ASD and a neurotypical control group. The Autism Brain Imaging Data Exchange (ABIDE) consortium was utilized to acquire data from the University of Michigan (145 subjects) and data from the New York University (183 subjects). The posterior cingulate cortex showed reduced connectivity with the anterior cingulate cortex for the ASD group compared to the control group. These two brain regions have previously both been linked to ASD symptomology. Specifically, the posterior cingulate cortex has been associated with behavioral control and executive functions, which appear to be responsible for the repetitive and restricted behaviors (RRB) in ASD. Our findings support previous data indicating a neurobiological basis of the disorder, and the specific functional connectivity changes involving the posterior cingulate cortex and anterior cingulate cortex may be a potential neurobiological biomarker for the observed RRBs in ASD.
PMID:38896910 | DOI:10.1016/j.pscychresns.2024.111848
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Functional connectivity of the posterior cingulate cortex in autism spectrum disorder
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice Analysis of changes in intrinsic neural timescales in male smoking addicts based on whole brain resting-state functional magnetic resonance imaging Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Sex differences in aberrant functional connectivity of three core networks and subcortical networks in medication-free adolescent-onset major depressive disorder Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN-LSTM model Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN-LSTM model Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder Altered intra- and inter-network connectivity in autism spectrum disorder Functional connectivity of the sensorimotor cerebellum in autism: associations with sensory over-responsivity Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles T1w/T2w ratio maps identify children with autism spectrum disorder and the relationships between myelin-related changes and symptoms Autism-associated brain differences can be observed in utero using MRI Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression Uncovering Effects of Schizophrenia upon a Maximally Significant, Minimally Complex Subset of Default Mode Network Connectivity Features Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders Deep Canonical Correlation Fusion Algorithm Based on Denoising Autoencoder for ASD Diagnosis and Pathogenic Brain Region Identification Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping Structural and functional neural patterns among sub-threshold bulimia nervosa: Abnormalities in dorsolateral prefrontal cortex and orbitofrontal cortex Effects of bilateral tDCS over DLPFC on response inhibition, craving, and brain functional connectivity in Internet gaming disorder: A randomized, double-blind, sham-controlled trial with fMRI Correlations between developmental trajectories of brain functional connectivity, neurocognitive functions, and clinical symptoms in patients with attention-deficit hyperactivity disorder Correlations between developmental trajectories of brain functional connectivity, neurocognitive functions, and clinical symptoms in patients with attention-deficit hyperactivity disorder The mediating role of trait impulsivity in the relation between cue-induced craving and functional connectivity within the salience network among abstinent patients with methamphetamine use disorder Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety Assessing the impact of repetitive transcranial magnetic stimulation on effective connectivity in autism spectrum disorder: An initial exploration using TMS-EEG analysis Predicting individual autistic symptoms for patients with autism spectrum disorder using interregional morphological connectivity Increased ventral anterior insular connectivity to sports betting availability indexes problem gambling Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features Correlation between autistic traits and brain functional connectivity in preschoolers with autism spectrum disorder: a resting state MEG study Age-atypical brain functional networks in autism spectrum disorder: a normative modeling approach Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study Whole-brain intrinsic functional connectivity predicts symptoms and functioning in early psychosis Four Streams Within the Prefrontal Cortex: Integrating Structural and Functional Connectivity BrainDAS: Structure-aware domain adaptation network for multi-site brain network analysis In vivo translocator protein in females with autism spectrum disorder: a pilot study Coactivation pattern analysis reveals altered whole-brain functional transient dynamics in autism spectrum disorder Dynamic graph transformer network via dual-view connectivity for autism spectrum disorder identification Dynamic graph transformer network via dual-view connectivity for autism spectrum disorder identification The multiscale topological organization of the functional brain network in adolescent PTSD Functional connectivity is linked to working memory differences in children with reading learning disability Brain perfusion SPECT in dementia: what radiologists should know Abnormal Insula Network Characteristics in Panic Disorder Cortical-cerebellar circuits changes in preschool ASD children by multimodal MRI Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder The relationship between the resting state functional connectivity and social cognition in schizophrenia: Results from the Italian Network for Research on Psychoses Anhedonia as a potential transdiagnostic phenotype with immune-related changes in recent onset mental health disorders Developmental changes in prefrontal cortex activation in children with or without autism spectrum traits on near-infrared spectroscopy Leveraging the adolescent brain cognitive development study to improve behavioral prediction from neuroimaging in smaller replication samples Leveraging the adolescent brain cognitive development study to improve behavioral prediction from neuroimaging in smaller replication samples Brain Abnormalities in Schizophrenia: A Comparative Imagistic Study Associations of tau, Aβ, and brain volume of the Papez circuit with cognition in Alzheimer's disease The effects of cannabis abstinence on cognition and resting state network activity in people with multiple sclerosis: A preliminary study Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination Decreased brain iron deposition based on quantitative susceptibility mapping correlates with reduced neurodevelopmental status in children with autism spectrum disorder A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood Autism spectrum disorders detection based on multi-task transformer neural network Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder Mapping early brain-body interactions: associations of fetal heart rate variation with newborn brainstem, hypothalamic, and dorsal anterior cingulate cortex functional connectivity Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders
Evidence Blueprint
Functional connectivity of the posterior cingulate cortex in autism spectrum disorder
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Functional connectivity of the posterior cingulate cortex in autism spectrum disorder
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Subcortical-cortical white matter connectivity in adults with autism spectrum disorder and schizophrenia patients Structural and functional changes of anterior cingulate cortex subregions in migraine without aura: relationships with pain sensation and pain emotion Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia Functional Connectivity of the Anterior Cingulate Cortex and the Right Anterior Insula Differentiates between Major Depressive Disorder, Bipolar Disorder and Healthy Controls Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice Analysis of changes in intrinsic neural timescales in male smoking addicts based on whole brain resting-state functional magnetic resonance imaging Relationship between abnormal intrinsic functional connectivity of subcortices and autism symptoms in high-functioning adults with autism spectrum disorder Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Towards an accurate autism spectrum disorder diagnosis: multiple connectome views from fMRI data Connectome-wide structure-function coupling models implicate polysynaptic alterations in autism Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth Amygdala functional connectivity in borderline personality disorder Resolving heterogeneity in dynamics of synchronization stability within the salience network in autism spectrum disorder Connectivity differences between inferior frontal gyrus and mentalizing network in autism as compared to developmental coordination disorder and non-autistic youth Motor performance and functional connectivity between the posterior cingulate cortex and supplementary motor cortex in bipolar and unipolar depression Autism Spectrum Disorder Detection by Hybrid Convolutional Recurrent Neural Networks from Structural and Resting State Functional MRI Images Sex differences in aberrant functional connectivity of three core networks and subcortical networks in medication-free adolescent-onset major depressive disorder Disentangling the individual-shared and individual-specific subspace of altered brain functional connectivity in autism spectrum disorder Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN-LSTM model Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN-LSTM model Modulation of resting-state networks following repetitive transcranial alternating current stimulation of the dorsolateral prefrontal cortex Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder Early life stress and body-mass-index modulate brain connectivity in alcohol use disorder Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder Intrinsic network abnormalities in children with autism spectrum disorder: an independent component analysis Altered intra- and inter-network connectivity in autism spectrum disorder Global MEG Resting State Functional Connectivity in Children with Autism and Sensory Processing Dysfunction Functional connectivity of the sensorimotor cerebellum in autism: associations with sensory over-responsivity Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles Posterior cingulate cortex spontaneous activity associated with motor response inhibition in patients with obsessive-compulsive disorder: A resting-state fMRI study Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program Advances in DTI studies for diagnoses and treatment of obsessive-compulsive disorder Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder Relationship between autism and brain cortex surface area: genetic correlation and a two-sample Mendelian randomization study Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sham-controlled trial T1w/T2w ratio maps identify children with autism spectrum disorder and the relationships between myelin-related changes and symptoms Conditional Variational Autoencoder for Functional Connectivity Analysis of Autism Spectrum Disorder Functional Magnetic Resonance Imaging Data: A Comparative Study Design and methodology for a proof of mechanism study of individualized neuronavigated continuous Theta burst stimulation for auditory processing in adolescents with autism spectrum disorder Association between urban upbringing and functional brain connectivity in schizophrenia A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry Autism-associated brain differences can be observed in utero using MRI Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression Parent-child interaction related to brain functional alterations and development outcomes in autism spectrum disorder: A study based on resting state-fMRI Altered interhemispheric functional connectivity in patients with obsessive-compulsive disorder and its potential in therapeutic response prediction Sports game intervention aids executive function enhancement in children with autism - An fNIRS study Functional connectivity in rumination: a systematic review of magnetic resonance imaging studies Uncovering Effects of Schizophrenia upon a Maximally Significant, Minimally Complex Subset of Default Mode Network Connectivity Features Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study ALERT: Atlas-Based Low Estimation Rank Tensor Approach to Detect Autism Spectrum Disorder Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury Intrinsic functional connectivity between the anterior insular and retrosplenial cortex as a moderator and consequence of cocaine self-administration in rats Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder Diagnostic Classification of ASD Using Fractal Functional Connectivity of fMRI and Logistic Regression Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea Confounding Effects on the Performance of Machine Learning Analysis of Static Functional Connectivity Computed from rs-fMRI Multi-site Data I know why the caged bird sings: Greater ventromedial prefrontal cortex to right amygdala associated with elevated HRV in distress tolerant versus intolerant individuals ASD and ADHD: Divergent activating patterns of prefrontal cortex in executive function tasks? Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders