Can J Cardiol. 2024 Apr 3:S0828-282X(24)00293-9. doi: 10.1016/j.cjca.2024.03.025. Online ahead of print.
ABSTRACT
Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying vascular etiology. In this review, we examine recent genetic advancements in our understanding of VaD, encompassing a range of methodologies including genome-wide association studies (GWAS), polygenic risk scores (PRS), heritability estimates, and family studies for monogenic disorders revealing the complex and heterogeneous nature of the disease. We report well-known genetic associations and highlight potential pathways and mechanisms implicated in VaD and its pathological risk factors, including stroke, cerebral small vessel diseases and cerebral amyloid angiopathy. Moreover, we discuss important modifiable risk factors such as hypertension, diabetes, and dyslipidemia, emphasizing the importance of a multifactorial approach in prevention, treatment, and understanding the genetic basis of VaD. Lastly, we outline several areas of scientific advancements to improve clinical care, highlighting that large-scale collaborative efforts, together with an integromics approach can enhance the robustness of genetic discoveries. Indeed, understanding the genetics of VaD and its pathophysiological risk factors hold the potential to redefine VaD based on molecular mechanisms and generate novel diagnostic, prognostic, and therapeutic tools.
J Nutr Biochem. 2024 Jun 28:109675. doi: 10.1016/j.jnutbio.2024.109675. Online ahead of print.ABSTRACTThe developing brain is sensitive to the impacts of early-life nutritional intake. This study...
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Heart Lung. 2024 Jun 29;68:116-125. doi: 10.1016/j.hrtlng.2024.06.009. Online ahead of print.ABSTRACTBACKGROUND: Factors associated with cardiovascular complications of COVID-19 remain understudied.OBJECTIVES: Here we investigate the occurrence...
Chem Pharm Bull (Tokyo). 2024;72(7):630-637. doi: 10.1248/cpb.c23-00027.ABSTRACTAlzheimer's disease (AD) is the leading cause of senile dementia, and the rapid increase in the frequency of AD...
Chem Pharm Bull (Tokyo). 2024;72(7):618-629. doi: 10.1248/cpb.c23-00464.ABSTRACTAlzheimer's disease (AD) is a common form of dementia. Although the causal mechanisms of AD are not fully understood,...
Int J Geriatr Psychiatry. 2024 Jul;39(7):e6118. doi: 10.1002/gps.6118.ABSTRACTBACKGROUND: Rates of dementia are increasing in migrant populations, however, there is evidence that they remain underrepresented in...
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