Can J Cardiol. 2024 Apr 3:S0828-282X(24)00293-9. doi: 10.1016/j.cjca.2024.03.025. Online ahead of print.
ABSTRACT
Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying vascular etiology. In this review, we examine recent genetic advancements in our understanding of VaD, encompassing a range of methodologies including genome-wide association studies (GWAS), polygenic risk scores (PRS), heritability estimates, and family studies for monogenic disorders revealing the complex and heterogeneous nature of the disease. We report well-known genetic associations and highlight potential pathways and mechanisms implicated in VaD and its pathological risk factors, including stroke, cerebral small vessel diseases and cerebral amyloid angiopathy. Moreover, we discuss important modifiable risk factors such as hypertension, diabetes, and dyslipidemia, emphasizing the importance of a multifactorial approach in prevention, treatment, and understanding the genetic basis of VaD. Lastly, we outline several areas of scientific advancements to improve clinical care, highlighting that large-scale collaborative efforts, together with an integromics approach can enhance the robustness of genetic discoveries. Indeed, understanding the genetics of VaD and its pathophysiological risk factors hold the potential to redefine VaD based on molecular mechanisms and generate novel diagnostic, prognostic, and therapeutic tools.
Methods. 2024 Jun 23:S1046-2023(24)00159-2. doi: 10.1016/j.ymeth.2024.06.009. Online ahead of print.ABSTRACTDiOlistic labelling is a robust, unbiased ballistic method that utilises lipophilic dyes to morphologically label neurons....
BMC Geriatr. 2024 Jun 25;24(1):554. doi: 10.1186/s12877-024-05151-6.ABSTRACTBACKGROUND: The ageing population and the rise of persons with dementia (PWD) living at home have increased the need...
BMC Geriatr. 2024 Jun 26;24(1):558. doi: 10.1186/s12877-024-05136-5.ABSTRACTBACKGROUND: Quantifying the informal caregiver burden is important for understanding the risk factors associated with caregiver overload and for...
BMC Neurosci. 2024 Jun 25;25(1):28. doi: 10.1186/s12868-024-00878-9.ABSTRACTBACKGROUND AND AIM: Diabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of...
BMC Genomics. 2024 Jun 25;25(1):633. doi: 10.1186/s12864-024-10534-5.ABSTRACTHuntington's disease (HD) is a dominantly inherited neurodegenerative disorder featured by abnormal movements, arising from the extensive neuronal loss...
Sci Rep. 2024 Jun 25;14(1):14666. doi: 10.1038/s41598-024-65094-1.ABSTRACTDue to its involvement in physiological and pathological processes, histone deacetylase 6 (HDAC6) is considered a promising pharmaceutical target...
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