Evidence
Can J Cardiol. 2024 Apr 3:S0828-282X(24)00293-9. doi: 10.1016/j.cjca.2024.03.025. Online ahead of print.
ABSTRACT
Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying vascular etiology. In this review, we examine recent genetic advancements in our understanding of VaD, encompassing a range of methodologies including genome-wide association studies (GWAS), polygenic risk scores (PRS), heritability estimates, and family studies for monogenic disorders revealing the complex and heterogeneous nature of the disease. We report well-known genetic associations and highlight potential pathways and mechanisms implicated in VaD and its pathological risk factors, including stroke, cerebral small vessel diseases and cerebral amyloid angiopathy. Moreover, we discuss important modifiable risk factors such as hypertension, diabetes, and dyslipidemia, emphasizing the importance of a multifactorial approach in prevention, treatment, and understanding the genetic basis of VaD. Lastly, we outline several areas of scientific advancements to improve clinical care, highlighting that large-scale collaborative efforts, together with an integromics approach can enhance the robustness of genetic discoveries. Indeed, understanding the genetics of VaD and its pathophysiological risk factors hold the potential to redefine VaD based on molecular mechanisms and generate novel diagnostic, prognostic, and therapeutic tools.
PMID:38579965 | DOI:10.1016/j.cjca.2024.03.025
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Genetic Determinants of Vascular Dementia
🌐 90 Days
VR Related Evidence Matrix
- Vascular Dementia: From Pathobiology to Emerging Perspectives
- Executive Dysfunction in Patients Undergoing Chronic Haemodialysis Treatment: A Possible Symptom of Vascular Dementia
- Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
- Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms
- Association of whole-person eigen-polygenic risk scores with Alzheimer's disease
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages
- Association of whole-person eigen-polygenic risk scores with Alzheimer's disease
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study
- Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise
- Small-vessel disease in the brain
- The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Postural control characteristics in Alzheimer's disease, dementia with Lewy bodies, and vascular dementia
- Blood-based Biomarkers of Cerebral Small Vessel Disease
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Pathophysiology of cerebral small vessel disease: a journey through recent discoveries
- Motoric cognitive risk syndrome as a predictor of adverse health outcomes: A systematic review and meta-analysis
- Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
- Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study
- Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
- Advancing Fairness in Cardiac Care: Strategies for Mitigating Bias in Artificial Intelligence Models within Cardiology
- Ion transporter cascade, reactive astrogliosis and cerebrovascular diseases
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Genome-wide characterization of circulating metabolic biomarkers
- Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci
- Identifying genetic differences between bipolar disorder and major depression through multiple GWAS
- Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study
- Lifestyle and genetic predisposition are associated with incident irritable bowel syndrome: A population-based prospective cohort study
- Dementias Platform UK: Bringing genetics into life
- Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample
- A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
- A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
- Microvascular burden and long-term risk of stroke and dementia in type 2 diabetes mellitus
- Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
- Stroke in the Time of Circadian Medicine
- Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review
- Gastroesophageal reflux disease with 6 neurodegenerative and psychiatric disorders: Genetic correlations, causality, and potential molecular mechanisms
- The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease
- Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2)
- Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease
- Association Between Triglyceride Glucose Index with Cognitive Impairment and Dementia in Adult Population: A Meta-Analysis
- The Role of NRF2 in Cerebrovascular Protection: Implications for Vascular Cognitive Impairment and Dementia (VCID)
- Improving genetic risk modeling of dementia from real-world data in underrepresented populations
- Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
- Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction
- Binary Nano-inhalant Formulation of Icariin Enhances Cognitive Function in Vascular Dementia via BDNF/TrkB Signaling and Anti-inflammatory Effects
- Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study
- Genome-wide association study identifies new loci associated with OCD
- Utility of learning ratio scores from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Memory Test in distinguishing patterns of cognitive decline in veterans referred for neuropsychological evaluation
- Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption
- Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology
- Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
- Association between household size and risk of incident dementia in the UK Biobank study
- Experimental laboratory models as tools for understanding modifiable dementia risk
- CO2 cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid, and tau proteins
Evidence Blueprint
Genetic Determinants of Vascular Dementia
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Genetic Determinants of Vascular Dementia
🌐 365 Days
VR Related Evidence Matrix
- Vascular Dementia: From Pathobiology to Emerging Perspectives
- Executive Dysfunction in Patients Undergoing Chronic Haemodialysis Treatment: A Possible Symptom of Vascular Dementia
- Oligodendrocytes play a critical role in white matter damage of vascular dementia
- Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
- Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer's disease and experimental chronic cerebral hypoperfusion
- Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms
- Association between pre-dementia psychiatric diagnoses and all-cause dementia is independent from polygenic dementia risks in the UK Biobank
- Deep learning applications in vascular dementia using neuroimaging
- Cerebrovascular Hemodynamics in Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Transcranial Doppler Studies
- Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
- Association of whole-person eigen-polygenic risk scores with Alzheimer's disease
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages
- Association of whole-person eigen-polygenic risk scores with Alzheimer's disease
- Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia: Dementia Series
- Vascular Cognitive Impairment - Past, Present, and Future Challenges
- Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders
- Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study
- Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease
- Polygenic risk associations with clinical characteristics and recurrence of Dupuytren's disease
- Associations between antipsychotics exposure and dementia risk: A prospective cohort study of 415,100 participants
- Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise
- Integration of metabolomics and network pharmacology technology to explain the effect mechanisms of Danggui Buxue decoction in vascular dementia
- Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial Dysfunction and Associated Vascular Dementia
- Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia
- Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder
- Small-vessel disease in the brain
- The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
- Language Impairment in Vascular Dementia: A Clinical Review
- Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes
- Investigation of genetic determinants of cognitive change in later life
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Xinshubao tablet rescues cognitive dysfunction in a mouse model of vascular dementia: Involvement of neurogenesis and neuroinflammation
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Postural control characteristics in Alzheimer's disease, dementia with Lewy bodies, and vascular dementia
- Cerebral microinfarcts revisited: Detection, causes, and clinical relevance
- Blood-based Biomarkers of Cerebral Small Vessel Disease
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease
- Trans-ancestry meta-analysis of genome wide association studies of inhibitory control
- Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health
- Association of cognitive reserve with the risk of dementia in the UK Biobank: role of polygenic factors
- A polygenic risk score for predicting racial and genetic susceptibility to prurigo nodularis
- Identification of differentially expressed exosome proteins in serum as potential biomarkers for cognitive impairments in cerebral small vessel disease
- Pathophysiology of cerebral small vessel disease: a journey through recent discoveries
- Mismatch negativity and polygenic risk scores for schizophrenia and bipolar disorder
- Deregulation of the Glymphatic System in Alzheimer's Disease: Genetic and Non-Genetic Factors
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia
- Sleep Characteristics and Risk of Stroke and Dementia: An Observational and Mendelian Randomization Study
- Association evaluations of oral anticoagulants with dementia risk based on genomic and real-world data
- Motoric cognitive risk syndrome as a predictor of adverse health outcomes: A systematic review and meta-analysis
- Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta-analysis
- Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
- Atrial fibrillation and dementia: not everything is clear…
- Use of big data and machine learning algorithms to extract possible treatment targets in neurodevelopmental disorders
- Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia
- Genetic correlation, shared loci, but no causality between bipolar disorder and inflammatory bowel disease: A genome-wide pleiotropic analysis
- Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk
- Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study