Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Curr Issues Mol Biol. 2024 Jan 22;46(1):934-947. doi: 10.3390/cimb46010060.
ABSTRACT
The present study investigated the association of genetic predisposition for white matter hyperintensities (WMHs) with incident amnestic mild cognitive impairment (aMCI) or Alzheimer’s disease (AD), as well as whether such an association was influenced by age, sex, and cognitive reserve. Overall, 537 individuals without aMCI or dementia at baseline were included. Among them, 62 individuals developed aMCI/AD at follow up. Genetic propensity to WMH was estimated using a polygenic risk score for WMHs (PRS WMH). The association of PRS WMH with aMCI/AD incidence was examined using COX models. A higher PRS WMH was associated with a 47.2% higher aMCI/AD incidence (p = 0.015) in the fully adjusted model. Subgroup analyses showed significant results in the older age group, in which individuals with a higher genetic predisposition for WMHs had a 3.4-fold higher risk for developing aMCI/AD at follow up (p < 0.001), as well as in the lower cognitive reserve (CR, proxied by education years) group, in which individuals with a higher genetic predisposition for WMHs had an over 2-fold higher risk (p = 0.013). Genetic predisposition for WMHs was associated with aMCI/AD incidence, particularly in the group of participants with a low CR. Thus, CR might be a modifier in the relationship between genetic predisposition for WMHs and incident aMCI/AD.
PMID:38275674 | DOI:10.3390/cimb46010060
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer’s Disease: Results from the HELIAD Study
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Neuroticism polygenic risk predicts conversion from mild cognitive impairment to Alzheimer's disease by impairing inferior parietal surface area Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study Is White Matter Hyperintensity Burden Associated with Cognitive and Motor Impairment in Patients with Parkinson's Disease? A Systematic Review and Meta-Analysis The relationship between cortical thickness and white matter hyperintensities in mid to late life Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Adults without Dementia Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population? Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease Automatic detection of cognitive impairment in patients with white matter hyperintensity and causal analysis of related factors using artificial intelligence of MRI Serum albumin and white matter hyperintensities Visual search for real-world scenes in patients with Alzheimer's disease and amnestic mild cognitive impairment Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns Novel Panel of Long Noncoding RNAs as Diagnostic Biomarkers for Amnestic Mild Cognitive Impairment in Peripheral Blood Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer's disease Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men Differences between Alzheimer's disease and mild cognitive impairment using brain networks from magnetic resonance texture analysis Cerebrovascular Effects of Sildenafil in Small Vessel Disease: The OxHARP Trial Combining neuropsychological assessment and structural neuroimaging to identify early Alzheimer's disease in a memory clinic cohort Genetic and polygenic investigation of heart rate variability to identify biomarkers associated with Anxiety disorders Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment Association of whole-person eigen-polygenic risk scores with Alzheimer's disease Association of whole-person eigen-polygenic risk scores with Alzheimer's disease Lifestyle and genetic predisposition are associated with incident irritable bowel syndrome: A population-based prospective cohort study Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression Complex relationships of socioeconomic status with vascular and Alzheimer's pathways on cognition Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease Association between loneliness and cognitive function, and brain volume in community-dwelling elderly Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes Validation of a polygenic risk score for frailty in the Lothian Birth Cohort 1936 and English longitudinal study of ageing Associations between polygenic risk scores for cardiometabolic phenotypes and adolescent depression and body dissatisfaction Snoring and risk of dementia: a prospective cohort and Mendelian randomization study Perivascular Spaces, Diffusivity Along Perivascular Spaces, and Free Water in Cerebral Small Vessel Disease Association and prediction of Life's Essential 8 score, genetic susceptibility with MCI, dementia, and MRI indices: A prospective cohort study Elevated plasma neurofilament light was associated with multi-modal neuroimaging features in Alzheimer's disease signature regions and predicted future tau deposition Association of cognitive reserve with transitions across cognitive states and death in older adults: A 15-year follow-up study Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy Genetic risk of type 2 diabetes modifies the association between lifestyle and glycemic health at 5 years postpartum among high-risk women Hemispheric asymmetries in hippocampal volume related to memory in left and right temporal variants of frontotemporal degeneration Diabetes accelerates Alzheimer's disease progression in the first year post mild cognitive impairment diagnosis Fractional Anisotropy is a More Sensitive Diagnostic Biomarker Than Mean Kurtosis for Patients with Parkinson Disease with Cognitive Dysfunction: A Diffusional Kurtosis Map Tract-Based Spatial Statistics Study Polygenic risk of social isolation behavior and its influence on psychopathology and personality Polygenic risk of social isolation behavior and its influence on psychopathology and personality Hidden dangers: Does multisensory impairments accompanying visual impairment increase dementia risk Towards cascading genetic risk in Alzheimer's disease Vitamin D, Alzheimer's disease and related dementia Impact of long-term white matter hyperintensity changes on mobility and dexterity Association between household size and risk of incident dementia in the UK Biobank study Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment Insomnia Polygenic Component on Attention Deficit-Hyperactivity Disorder: Exploring this Association Using Genomic Data from Brazilian Families Patterns of cognitive domain abnormalities enhance discrimination of dementia risk prediction: The ARIC study Predictive models of Alzheimer's disease dementia risk in older adults with mild cognitive impairment: a systematic review and critical appraisal
Evidence Blueprint
Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer’s Disease: Results from the HELIAD Study
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer’s Disease: Results from the HELIAD Study
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Neuroticism polygenic risk predicts conversion from mild cognitive impairment to Alzheimer's disease by impairing inferior parietal surface area Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study Is White Matter Hyperintensity Burden Associated with Cognitive and Motor Impairment in Patients with Parkinson's Disease? A Systematic Review and Meta-Analysis Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia The relationship between cortical thickness and white matter hyperintensities in mid to late life Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Adults without Dementia Early detection of white matter hyperintensities using SHIVA-WMH detector Verbal fluency patterns associated with the amnestic conversion from mild cognitive impairment to dementia Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: The COSMIC consortium Three-dimensional identification of microvascular pathology and neurovascular inflammation in severe white matter hyperintensity: a case report Correlation between white matter hyperintensity and delusional symptoms in Alzheimer's disease White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population? Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study Strategic Lacunes Associated With Mild Cognitive Impairment in Rural Chinese Older Adults: A Population-Based Study Automatic segmentation of white matter hyperintensities in T2-FLAIR with AQUA: a comparative validation study against conventional methods Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease Automatic detection of cognitive impairment in patients with white matter hyperintensity and causal analysis of related factors using artificial intelligence of MRI Serum albumin and white matter hyperintensities Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress Visual search for real-world scenes in patients with Alzheimer's disease and amnestic mild cognitive impairment Polygenic effects on the risk of Alzheimer's disease in the Japanese population Evaluation of the NIH Toolbox Odor Identification Test across normal cognition, amnestic mild cognitive impairment, and dementia due to Alzheimer's disease Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia Association of long-term exposure to various ambient air pollutants, lifestyle, and genetic predisposition with incident cognitive impairment and dementia Prevalence, cognitive characteristics, and influencing factors of amnestic mild cognitive impairment among older adults residing in an urban community in Chengdu, China Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns The polygenic basis of relapse after a first episode of schizophrenia Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle-Aged Individuals Without Stroke or Dementia Neuroticism and white matter hyperintensities Impairment of delayed recall as a predictor of amnestic mild cognitive impairment development in normal older adults: a 7-year of longitudinal cohort study in Shanghai Novel Panel of Long Noncoding RNAs as Diagnostic Biomarkers for Amnestic Mild Cognitive Impairment in Peripheral Blood White matter hyperintensities in bipolar disorder: systematic review and meta-analysis White matter hyperintensities in bipolar disorder: systematic review and meta-analysis The relationship between social cognitive processes and behavior changes in people with amnestic mild cognitive impairment or dementia using the Edinburgh Social Cognition Test (ESCoT) Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity Association of cognitive reserve with the risk of dementia in the UK Biobank: role of polygenic factors Hybrid PET/MRI with Flutemetamol and FDG in Alzheimer's Disease Clinical Continuum Investigating the association between a history of depression and biomarkers of Alzheimer's disease, cerebrovascular disease, and neurodegeneration in patients with dementia Vascular Burden Moderates the Relationship Between ADHD and Cognition in Older Adults Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function Characteristic early changes of Glu and Cho in brain regions affected by different types of subjective cognitive decline and their clinical significance Effect of Pathway-Specific Polygenic Risk Scores for Alzheimer's Disease (AD) on Rate of Change in Cognitive Function and AD-Related Biomarkers Among Asymptomatic Individuals Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study Contributions of Cerebral White Matter Hyperintensities to Postural Instability in Aging with and without Alcohol Use Disorder Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth Distress Symptoms of Old Age and Mild Cognitive Impairment are Two Distinct Dimensions in Older Adults Without Major Depression White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer's disease Theory of mind in mild cognitive impairment and Parkinson's disease: The role of memory impairment Eye movement patterns during viewing face images with neutral expressions in patients with early-stage Alzheimer's disease and amnestic mild cognitive impairment Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers Circuit-based neuromodulation enhances delayed recall in amnestic mild cognitive impairment Family History of AD/Dementia, Polygenic Risk Score for AD, and Parkinson's Disease FDG-PET markers of heterogeneity and different risk of progression in amnestic MCI Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals