Evidence
Asian J Psychiatr. 2024 Jun 27;99:104137. doi: 10.1016/j.ajp.2024.104137. Online ahead of print.
ABSTRACT
Executive impairment in schizophrenia is common, but the mechanism remains unclear. This is the first study to use simultaneously functional near-infrared spectroscopy (fNIRS) to monitor the hemodynamic response in schizophrenia during the MATRICS Consensus Cognitive Battery (MCCB). Here, we monitored relative changes in oxyhemoglobin concentration in the medial prefrontal cortex (mPFC) during Trail Making Test, Symbol Coding Test and Mazes Test of the MCCB in 63 patients (29 females) with schizophrenia and 32 healthy controls (15 females). Results showed that patients with schizophrenia scored lower than healthy controls on all three tests (P < 0.001), but mPFC activation was significantly higher during the test (P < 0.03). Higher activation of the mPFC may reflect abnormal information processing in schizophrenia. In addition, the results also showed sex differences in hemodynamic activation during the task in patients with schizophrenia, and fNIRS has the potential to be a clinical adjunct to screening for cognitive function in schizophrenia.
PMID:38959836 | DOI:10.1016/j.ajp.2024.104137
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
- Altered functional connectivity subserving expressed emotion environments in schizophrenia: An fNIRS study
- Longitudinal changes in cognitive function in early psychosis: a meta-analysis with the MATRICS consensus cognitive battery (MCCB)
- Longitudinal changes in cognitive function in early psychosis: a meta-analysis with the MATRICS consensus cognitive battery (MCCB)
- Association between reduced plasma BDNF concentration and MMSE scores in both chronic schizophrenia and mild cognitive impairment
- Relationship of cognitive measures to mRNA levels in lymphocytes from patients with schizophrenia and controls
- Abnormal Global Cortical Responses in Drug-naive Patients with Schizophrenia following Orbitofrontal Cortex Stimulation: A Concurrent TMS-EEG Study
- Abnormal Global Cortical Responses in Drug-naïve Patients with Schizophrenia following Orbitofrontal Cortex Stimulation: A Concurrent TMS-EEG Study
- Sex-differential cognitive performance on MCCB of youth with BD-II depression
- The characteristics of WM in individuals with depressive tendencies: A functional near-infrared spectroscopy (fNIRS) study
- The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies
- mGluR5 Positive Allosteric Modulation Prevents MK-801 Induced Increases in Extracellular Glutamate in the Rat Medial Prefrontal Cortex
- Discriminative analysis of schizophrenia and major depressive disorder using fNIRS
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Peak alpha frequency in schizophrenia, bipolar disorder, and healthy volunteers: Associations with visual information processing and cognition
- Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study
- Compensatory thickening of cortical thickness in early stage of schizophrenia
- Compensatory thickening of cortical thickness in early stage of schizophrenia
- Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia
- Measuring Cognitive Impairments Associated With Schizophrenia in Clinical Practice: Overview of Current Challenges and Future Opportunities
- Impact of lifetime stressor exposure on neuroenergetics in schizophrenia spectrum disorders
- Impact of lifetime stressor exposure on neuroenergetics in schizophrenia spectrum disorders
- Effect of gamma-tACS on prefrontal hemodynamics in bipolar disorder: A functional near-infrared study
- Adolescent stress differentially modifies dopamine and norepinephrine release in the medial prefrontal cortex of adult rats
- Attenuated frontotemporal brain activation during cognitive tasks is associated with lower succinate dehydrogenase protein levels in patients with major depressive disorder
- The neural compensation phenomenon in schizophrenia with mild attention deficits during working memory task
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Impulsivity and inhibitory control in deficit and non-deficit schizophrenia
- Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia
- Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study
- Prefrontal brain activity and self-injurious behavior in adolescents with major depressive disorder: A functional near-infrared spectroscopy (fNIRS) study
- Cognitive Impairments in Drug-Naive Patients With First-Episode Negative Symptom-Dominant Psychosis
- Cognitive Impairments in Drug-Naive Patients With First-Episode Negative Symptom-Dominant Psychosis
- Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia
- Revisiting Rorschach test and Minnesota Multiphasic Personality Inventory-II patterns in Kraepelinian vs. DSM-wise Schizophrenia: How They Differ and What It Means for Diagnosis
- Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder
- Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke
- Sex differences in aberrant functional connectivity of three core networks and subcortical networks in medication-free adolescent-onset major depressive disorder
- Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools for Schizophrenia Assessment: Multisite Usability Study
- Global functional connectivity reorganization reflects cognitive processing speed deficits and fatigue in multiple sclerosis
- Clozapine treatment and astrocyte activity in treatment resistant schizophrenia: A proton magnetic resonance spectroscopy study
- Gender differences in cognitive improvements after two months of atypical antipsychotic treatment in first episode schizophrenia
- Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
- Elevated intrinsic cortical curvature in treatment-resistant schizophrenia: Evidence of structural deformation in functional connectivity areas and comparison with alternate indices of structure
- Abnormal Temporal Window of Integration in Auditory Sensory Memory in Schizophrenia
- Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction
- Inhibition of prefrontal cortex parvalbumin interneurons mitigates behavioral and physiological sequelae of chronic stress in male mice
- Revisiting Cognitive Deficits in Outpatients with Psychotic Disorders: A Transdiagnostic Comparison of Cognitive Performance While Accounting for Putative Confounding Factors
- Trustworthiness judgments and pupil-size in individuals with schizophrenia
- Protein Profiles and Novel Molecular Biomarkers of Schizophrenia Based on 4D-DIA Proteomics
- Minor physical anomalies in schizophrenia and first-degree relatives in comparison to healthy controls: A systematic review and meta-analysis
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Comparison of microRNA expression levels in patients with schizophrenia before and after electroconvulsive therapy
- The relationship between peripheral immune cell markers and cognitive functions in patients with schizophrenia
- Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables
- Toxoplasma gondii infection positively associated with schizophrenia: Evidences from UK Biobank cohort and case-controlled studies
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
- Evaluation of inflammatory markers obtained from complete blood count in different stages of schizophrenia
Evidence Blueprint
Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Increased and sex-differentiated medial prefrontal cortex activation during the MATRICS Consensus Cognitive Battery in schizophrenia: A fNIRS study
- The MATRICS consensus cognitive battery for the assessment of cognitive impairment in schizotypal personality disorder
- The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study
- The relationship between inflammatory markers, clinical characteristics, and cognitive performance in drug-naïve patients with schizophrenia
- Altered functional connectivity subserving expressed emotion environments in schizophrenia: An fNIRS study
- Longitudinal changes in cognitive function in early psychosis: a meta-analysis with the MATRICS consensus cognitive battery (MCCB)
- Longitudinal changes in cognitive function in early psychosis: a meta-analysis with the MATRICS consensus cognitive battery (MCCB)
- Investigating amplitude of low-frequency fluctuation and possible links with cognitive impairment in childhood and adolescence onset schizophrenia: a correlation study
- A comparative study of cognitive function in young patients with bipolar disorder with and without non-suicidal self-injury
- Sex-specific associations of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in patients with drug-naive schizophrenia
- Association between reduced plasma BDNF concentration and MMSE scores in both chronic schizophrenia and mild cognitive impairment
- Relationship of cognitive measures to mRNA levels in lymphocytes from patients with schizophrenia and controls
- Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia
- Abnormal Global Cortical Responses in Drug-naive Patients with Schizophrenia following Orbitofrontal Cortex Stimulation: A Concurrent TMS-EEG Study
- Abnormal Global Cortical Responses in Drug-naïve Patients with Schizophrenia following Orbitofrontal Cortex Stimulation: A Concurrent TMS-EEG Study
- Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia
- Sex-differential cognitive performance on MCCB of youth with BD-II depression
- The characteristics of WM in individuals with depressive tendencies: A functional near-infrared spectroscopy (fNIRS) study
- Lower complement C1q levels in first-episode psychosis and in schizophrenia
- Transcriptional signatures of the whole-brain voxel-wise resting-state functional network centrality alterations in schizophrenia
- The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies
- Immune dysregulation is associated with symptom dimensions and cognitive deficits in schizophrenia: accessible evidence from complete blood count
- mGluR5 Positive Allosteric Modulation Prevents MK-801 Induced Increases in Extracellular Glutamate in the Rat Medial Prefrontal Cortex
- Discriminative analysis of schizophrenia and major depressive disorder using fNIRS
- Further clarification of cognitive processes of prospective memory in schizophrenia by comparing eye-tracking and ecologically-valid measurements
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Lower plasma tumor necrosis factor-alpha is associated with symptomatic remission in patients with schizophrenia
- Peak alpha frequency in schizophrenia, bipolar disorder, and healthy volunteers: Associations with visual information processing and cognition
- Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia
- Gray matter matters: Cognitive stability and flexibility in schizophrenia spectrum disorder
- Cognitive deficits profiles in the first-episode of schizophrenia, clinical high risk of psychosis, and genetically high-risk of psychosis
- Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study
- Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum
- Compensatory thickening of cortical thickness in early stage of schizophrenia
- The Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS): a validation study
- Compensatory thickening of cortical thickness in early stage of schizophrenia
- ASD and ADHD: Divergent activating patterns of prefrontal cortex in executive function tasks?
- Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia
- The identification of novel schizophrenia-related metabolites using untargeted lipidomics
- Measuring Cognitive Impairments Associated With Schizophrenia in Clinical Practice: Overview of Current Challenges and Future Opportunities
- Abnormal static and dynamic local functional connectivity in first-episode schizophrenia: A resting-state fMRI study
- Impact of lifetime stressor exposure on neuroenergetics in schizophrenia spectrum disorders
- Impact of lifetime stressor exposure on neuroenergetics in schizophrenia spectrum disorders
- Cerebro-cerebellar gray matter abnormalities associated with cognitive impairment in patients with recent-onset and chronic schizophrenia
- Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia
- Effect of gamma-tACS on prefrontal hemodynamics in bipolar disorder: A functional near-infrared study
- Adolescent stress differentially modifies dopamine and norepinephrine release in the medial prefrontal cortex of adult rats
- Attenuated frontotemporal brain activation during cognitive tasks is associated with lower succinate dehydrogenase protein levels in patients with major depressive disorder
- The neural compensation phenomenon in schizophrenia with mild attention deficits during working memory task
- Anxiety symptoms without depression are associated with cognitive control network (CNN) dysfunction: An fNIRS study
- The evaluation study for social cognition measures in Japan: Psychometric properties, relationships with social function, and recommendations
- Exploring the link between functional connectivity of ventral tegmental area and physical fitness in schizophrenia and healthy controls
- Prefrontal oxygenation varies as a function of response inhibition performance in healthy participants but not in youth with non-suicidal self-injury
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
- Impulsivity and inhibitory control in deficit and non-deficit schizophrenia
- Imaging the Vesicular Acetylcholine Transporter in Schizophrenia: a PET study using [18F]-VAT
- Abnormal connectivity and activation during audiovisual speech perception in schizophrenia
- Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia
- Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study
- Prefrontal brain activity and self-injurious behavior in adolescents with major depressive disorder: A functional near-infrared spectroscopy (fNIRS) study
- Cognitive Impairments in Drug-Naive Patients With First-Episode Negative Symptom-Dominant Psychosis