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Individualized temporal interference stimulation with theta-burst patterning targeting the BNST in obsessive-compulsive disorder: Two cases

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Individualised temporal interference with theta-burst effectively targeted the BNST using personalised modelling, enabling noninvasive deep stimulation.
Both cases showed clinically meaningful OCD symptom reduction after repeated sessions, including decreased compulsions and improved functioning.
Procedure was well tolerated with no serious adverse events reported, supporting feasibility and need for controlled trials to confirm efficacy.

Asian J Psychiatr. 2026 Jun 14;122:105059. doi: 10.1016/j.ajp.2026.105059. Online ahead of print.

NO ABSTRACT

PMID:42302338 | DOI:10.1016/j.ajp.2026.105059

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