Evidence
Sci Rep. 2024 Jul 9;14(1):15855. doi: 10.1038/s41598-024-66871-8.
ABSTRACT
Dendritic spines are the postsynaptic compartments of excitatory synapses, however, a substantial subset of spines additionally receives inhibitory input. In such dually innervated spines (DiSs), excitatory long-term potentiation (LTP) mechanisms are suppressed, but can be enabled by blocking tonic inhibitory GABAB receptor signaling. Here we show that LTP mechanisms at DiSs are also enabled by two other excitatory LTP stimuli. In hippocampal neurons, these chemical LTP (cLTP) stimuli induced robust movement of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) to DiSs. Such synaptic CaMKII accumulation is an essential LTP mechanism at singly innervated spines (SiSs). Indeed, CaMKII accumulation at DiSs was also accompanied by other readouts for successful LTP induction: spine growth and surface insertion of GluA1. Thus, DiSs are capable of the same LTP mechanisms as SiSs, although induction of these mechanism additionally requires either reduced inhibitory signaling or increased excitatory stimulation. This additional regulation may provide further computational control.
PMID:38982271 | DOI:10.1038/s41598-024-66871-8
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Induction of LTP mechanisms in dually innervated dendritic spines
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Induction of LTP mechanisms in dually innervated dendritic spines
- Artificial fluorescent sensor reveals pre-synaptic NMDA receptors switch cholecystokinin release and LTP in the hippocampus
- Astrocyte D1/D5 dopamine receptors govern non-Hebbian long-term potentiation at sensory synapses onto lamina I spinoparabrachial neurons
- Sex-specific mechanisms underlie long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens
- Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology
- Ab peptide enhances GluA1 internalization via lipid rafts in Alzheimer's-related hippocampal LTP dysfunction
- A Methodology for Specific Disruption of Microtubule Polymerization into Dendritic Spines
- Optimizing GABAA receptor antagonism for the induction of long-term potentiation in the mouse and rat dentate gyrus in vitro
- Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus
- Trans-synaptic association of vesicular zinc transporter 3 and Shank3 supports synapse-specific dendritic spine structure and function in mouse auditory cortex
- The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons
- G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia
- Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice
- Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
- PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior
- The low and high doses administration of lutein improves memory and synaptic plasticity impairment through different mechanisms in a rat model of vascular dementia
- Cognitive integrity in Non-Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines
- Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
- CXCL10 impairs synaptic plasticity was modulated by cGAS-STING pathway after stroke in mice
- Improved DiOlistic labelling technique for neurons in situ: Detailed visualisation of dendritic spines and concurrent histochemical-detection in fixed tissue
- Morphological heterogeneity of neurons in the human central amygdaloid nucleus
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex
- Modulation of structural and functional plasticity in the hippocampus across the murine estrous cycle
- Synapse-specific trapping of SNARE machinery proteinsin the anesthetized Drosophila brain
- CaMKII activity and metabolic imbalance-related neurological diseases: Focus on vascular dysfunction, synaptic plasticity, amyloid beta accumulation, and lipid metabolism
- Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice
- Androgen transition and management of hereditary angioedema long-term prophylaxis in real life: a single-center case series
- Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy
- Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
- Calcineurin and CK2 reciprocally regulate synaptic AMPA receptor phenotypes via α2δ-1 in spinal excitatory neurons
- Enhanced synaptic inhibition in the dorsolateral geniculate nucleus in a mouse model of glaucoma
- Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex
- Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex
- The mechanics of correlated variability in segregated cortical excitatory subnetworks
- Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
- Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
- Critically Assessing the Unanswered Questions of How, Where, and When to Induce Plasticity in the Posttraumatic Stress Disorder Network with Transcranial Magnetic Stimulation
- Presynaptic structural and functional plasticity are coupled by convergent Rap1 signaling
- Regulator of G Protein Signaling 14 protein expression profile in the adult mouse brain
- Postnatal hypofunction of N-methyl-D-aspartate receptors alters perforant path synaptic plasticity and filtering and impairs dentate gyrus-mediated spatial discrimination
- Developmental activity-based anorexia alters hippocampal non-genomic stress response and induces structural instability and spatial memory impairment in female rats
- Integrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise
- Different states of synaptic vesicle priming explain target cell type-dependent differences in neurotransmitter release
- Historical review: The golden age of the Golgi method in human neuropathology
- Stress and inflammation target dorsolateral prefrontal cortex function: Neural mechanisms underlying weakened cognitive control
- Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2
- Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice
- Fast inhibition slows and desynchronizes mouse auditory efferent neuron activity
- Persistent Interruption in Parvalbumin Positive Inhibitory Interneurons: Biophysical and Mathematical Mechanisms
- Effect of electroacupuncture stimulation of "Sibai"(ST2) and "Quanliao"(SI18) on excitatory neurons of sensorimotor cortex in mice
- Effect of electroacupuncture stimulation of "Sibai"(ST2) and "Quanliao"(SI18) on excitatory neurons of sensorimotor cortex in mice
- Calcium channel signalling at neuronal endoplasmic reticulum-plasma membrane junctions
- Calcium channel signalling at neuronal endoplasmic reticulum-plasma membrane junctions
- Neuron type-specific optogenetic stimulation for differential stroke recovery in chronic capsular infarct
- Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders
- Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice
- Cocaine disrupts action flexibility via glucocorticoid receptors
- Cocaine disrupts action flexibility via glucocorticoid receptors
- Distinct roles of excitatory and inhibitory neurons in the medial prefrontal cortex in the expression and reconsolidation of methamphetamine-associated memory in male mice
- Neural mechanism of non-adaptive cognitive emotion regulation in patients with non-suicidal self-injury
- Oxytocin ameliorates cognitive impairments by attenuating excitation/inhibition imbalance of neurotransmitters acting on parvalbumin interneurons in a mouse model of sepsis-associated encephalopathy
- Identification of dental implant systems from low-quality and distorted dental radiographs using AI trained on a large multi-center dataset
- TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing
- Regulation of the mouse ventral tegmental area by melanin-concentrating hormone
Evidence Blueprint
Induction of LTP mechanisms in dually innervated dendritic spines
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Induction of LTP mechanisms in dually innervated dendritic spines
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Induction of LTP mechanisms in dually innervated dendritic spines
- The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis
- Artificial fluorescent sensor reveals pre-synaptic NMDA receptors switch cholecystokinin release and LTP in the hippocampus
- The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling
- Astrocyte D1/D5 dopamine receptors govern non-Hebbian long-term potentiation at sensory synapses onto lamina I spinoparabrachial neurons
- Sex-specific mechanisms underlie long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens
- Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology
- D-Cycloserine enhances the bidirectional range of NMDAR-dependent hippocampal synaptic plasticity
- Ab peptide enhances GluA1 internalization via lipid rafts in Alzheimer's-related hippocampal LTP dysfunction
- BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation
- A Methodology for Specific Disruption of Microtubule Polymerization into Dendritic Spines
- Optimizing GABAA receptor antagonism for the induction of long-term potentiation in the mouse and rat dentate gyrus in vitro
- Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory
- Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus
- Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling
- Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal CA1 neurons of rats
- Trans-synaptic association of vesicular zinc transporter 3 and Shank3 supports synapse-specific dendritic spine structure and function in mouse auditory cortex
- Functional inhibition of katanin affects synaptic plasticity
- Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus
- Estradiol receptors inhibit long-term potentiation in the dorsomedial striatum
- Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning
- The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons
- Acute adolescent morphine exposure improves dark avoidance memory and enhances long-term potentiation of ventral hippocampal CA1 during adulthood in rats
- Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene
- G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia
- Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice
- Three-dimensional visualization and analysis of dendritic spines in human brain tissue
- Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
- PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior
- Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain
- Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms
- The low and high doses administration of lutein improves memory and synaptic plasticity impairment through different mechanisms in a rat model of vascular dementia
- The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling
- Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice
- Cognitive integrity in Non-Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines
- Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
- DiGeorge syndrome critical region gene 2 (DGCR2), a schizophrenia risk gene, regulates dendritic spine development through cell adhesion
- Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer's disease
- CXCL10 impairs synaptic plasticity was modulated by cGAS-STING pathway after stroke in mice
- cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission
- Improved DiOlistic labelling technique for neurons in situ: Detailed visualisation of dendritic spines and concurrent histochemical-detection in fixed tissue
- Impaired monoamine neural system in the mPFC of SHRSP/Ezo as an animal model of attention-deficit/hyperactivity disorder
- Maladaptive plasticity induced by morphine is mediated by hippocampal astrocytic Connexin-43
- Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease
- GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo
- Comparative effects of the alcoholic extract of Terminalia chebula and crocin on stress‑induced anxiety‑like behavior and memory impairment in male rats
- Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticity in adult male rats
- Morphological heterogeneity of neurons in the human central amygdaloid nucleus
- Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex
- Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density
- Modulation of structural and functional plasticity in the hippocampus across the murine estrous cycle
- Synapse-specific trapping of SNARE machinery proteinsin the anesthetized Drosophila brain
- Electrophysiological Phenotypes of Hippocampal Synaptic and Network Functions in Cannabinoid Receptor 2 Knockout Mice
- Combination Therapy with Platelet-Rich Plasma and Epidermal Neural Crest Stem Cells Increases Treatment Efficacy in Vascular Dementia
- CaMKII activity and metabolic imbalance-related neurological diseases: Focus on vascular dysfunction, synaptic plasticity, amyloid beta accumulation, and lipid metabolism
- Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice
- MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior
- Androgen transition and management of hereditary angioedema long-term prophylaxis in real life: a single-center case series
- Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons
- LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors
- Presynaptic kainate receptors onto somatostatin interneurons are recruited by activity throughout development and contribute to cortical sensory adaptation
- Postsynaptic cell type and synaptic distance do not determine efficiency of monosynaptic rabies virus spread measured at synaptic resolution
- Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders