Evidence
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J Int Med Res. 2024 Jun;52(6):3000605241258473. doi: 10.1177/03000605241258473.
ABSTRACT
The aim of this short narrative review was to evaluate the existing literature regarding the clinical use of ketamine among individuals with dementia, especially those with behavioral disturbances. PubMed, Cochrane, and Ovid (Embase, APA PsycINFO, and MEDLINE) databases were searched for abstracts using the search terms “ketamine” AND “dementia.” Only articles describing the use of ketamine in individuals with dementia were included. Articles that did not include individuals with dementia, did not use ketamine, were published in a non-English language, primarily described animal studies, or were reviews were excluded. Three case reports met the inclusion criteria. One described the use of subcutaneous ketamine for depression, one described the use of intramuscular ketamine for acute agitation, and one described the use of S-ketamine as anesthesia during electroconvulsive therapy for depression and catatonia. No significant adverse effects were reported in any of the cases. Although the use of ketamine in the treatment of depression and agitation associated with dementia has potential, the current evidence remains limited. High-quality prospective studies are needed to confirm the observations of these case reports before ketamine can be used to treat behavioral disturbances in individuals with dementia.
PMID:38907362 | DOI:10.1177/03000605241258473
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Ketamine for catatonia: A novel treatment for an old clinical challenge? A systematic review of the evidence Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? A meta-analysis of the effects of ketamine on suicidal ideation in depression patients The Pharmacological Management of Ketamine Use Disorder: A Systematic Review Elder Abuse in Older Adults With Dementia: Protective Factors and Adverse Effects Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression Exploring the influence of weather variability and climate change on health outcomes in people living with dementia: A scoping review protocol Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions Neglect of older adults living with dementia in family caregiving: A dimensional concept analysis Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study Cognitive changes in patients with unipolar TRD treated with IV ketamine: A systematic review Cognitive changes in patients with unipolar TRD treated with IV ketamine: A systematic review Widespread reductions in cortical thickness following ketamine abuse Ketamine in the effective management of chronic pain, depression, and posttraumatic stress disorder for Veterans: A meta-analysis and systematic review Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? (Revisited) Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? (Revisited) Non-Pharmacological Interventions in the Management of Dementia-Related Psychosis: A Systematic Review and Meta-Analysis What's New in Dementia Risk Prediction Modelling? An Updated Systematic Review Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression A randomised, open-label, pragmatic pilot comparison of oral and intravenous ketamine in treatment-resistant depression A randomised, open-label, pragmatic pilot comparison of oral and intravenous ketamine in treatment-resistant depression Diabetes mellitus and risk of incident dementia in APOE e4 carriers: an updated meta-analysis The current status of apathy in patients with dementia and its factors: A systematic review Effectiveness of interventions to prevent abuse in people living with dementia in community settings: A systematic review Association of Dementia with Adverse Outcomes in Older Patients with Acute Myocardial Infarction in the ICU Psychosis detection in dementia: a systematic review of diagnostic test accuracy studies Subanesthetic S-ketamine does not acutely alter striatal dopamine transporter binding in healthy Sprague Dawley female rats A Systematic Review on Ketamine and Esketamine for Treatment-Resistant Depression and Suicidality in Adolescents: A New Hope? Improvement in depressive symptoms in a patient with severe and enduring anorexia nervosa and comorbid major depressive disorder using psychotherapy-assisted IV ketamine : a case report A replication study using the World Health Organization pharmacovigilance database (VigiBase®) to evaluate whether an association between ketamine and esketamine and alcohol and substance misuse exists Out-of-hospital paramedic interactions with people living with dementia: a scoping review Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies Usability of web-based tools designed for communication and decision-making in dementia: Systematic review and design brief Non-improvement predicts subsequent non-response to repeated-dose intravenous ketamine for depression: a re-analysis of a 2-week open-label study in patients with unipolar and bipolar depression Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors Mentalising imagery therapy for family dementia caregivers: protocol for a scoping review Correlates of Mild Behavioral Impairment in Older Adults: Protocol for a Scoping Review Correlates of Mild Behavioral Impairment in Older Adults: Protocol for a Scoping Review Role of Electroconvulsive Therapy, Ketamine Infusion, and Deep Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression: A Case Report Heat-related illness and dementia: a study integrating epidemiological and experimental evidence Effects of Low-Dose Ketamine Infusion on the Positive and Negative Domains of Hopelessness and Suicidal Thoughts Alcohol Use Disorder and Dementia: A Review Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3beta interaction Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression Barriers and facilitators to diagnosing dementia in migrant populations: A systematic review of European health professionals' perspectives Denial of Desire for Death in Dementia: Why Is Dementia Excluded from Australian Voluntary Assisted Dying Legislation? 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Association between chronic pain and dementia: a systematic review and meta-analysis Risk of Dementia in Parkinson's Disease: A Systematic Review and Meta-Analysis Risk of Dementia in Parkinson's Disease: A Systematic Review and Meta-Analysis A Meta-Synthesis on Sexuality in Persons with Dementia Mapped Using the Model of Human Occupation Suicidal ideation following ketamine prescription in patients with recurrent major depressive disorder: a nation-wide cohort study Suicidal ideation following ketamine prescription in patients with recurrent major depressive disorder: a nation-wide cohort study Predicting treatment response to ketamine in treatment-resistant depression using auditory mismatch negativity: Study protocol Oral ketamine effects on dynamics of functional network connectivity in patients treated for chronic suicidality Obsessive-Compulsive Symptoms in Dementia: Scoping Review of Pathological Changes Technology Usability for People Living With Dementia: Concept Analysis Examining the Relationships Between Indoor Environmental Quality Parameters Pertaining to Light, Noise, Temperature, and Humidity and the Behavioral and Psychological Symptoms of People Living With Dementia: Scoping Review Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis Using AI-Based Technologies to Help Nurses Detect Behavioral Disorders: Narrative Literature Review
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Is there evidence for using ketamine among individuals with dementia?
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Is there evidence for using ketamine among individuals with dementia?
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Exploring the Impact of Music on Response to Ketamine/Esketamine: A Scoping Review Ketamine use in pediatric depression: A systematic review The Efficacy and Safety of Intranasal Formulations of Ketamine and Esketamine for the Treatment of Major Depressive Disorder: A Systematic Review Newer therapies and surgical management of ketamine-induced uropathy: A review Ketamine for mood disorders, anxiety, and suicidality in children and adolescents: a systematic review Ketamine for catatonia: A novel treatment for an old clinical challenge? A systematic review of the evidence Ketamine, an Old-New Drug: Uses and Abuses Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? Are Population-Level Approaches to Dementia Risk Reduction Under-Researched? A Rapid Review of the Dementia Prevention Literature A meta-analysis of the effects of ketamine on suicidal ideation in depression patients Intravenous Ketamine Exacerbating Symptoms of Acute Stress Disorder: A Case Report and Systematized Review of Existing Literature The Pharmacological Management of Ketamine Use Disorder: A Systematic Review Elder Abuse in Older Adults With Dementia: Protective Factors and Adverse Effects Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression Long-term follow-up of participants in ketamine clinical trials for mood disorders Similarities and differences in the prevalence and risk factors of suicidal behavior between caregivers and people with dementia: a systematic review Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects? Current concepts in ketamine therapy in the emergency department Self- and Proxy-Completion of Quality of Life Assessment in Dementia Care: A Review of Reviews Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis Brain-derived neurotrophic factor Val66Met and CYP2B6 polymorphisms as predictors for ketamine effectiveness in patients with treatment-resistant depression Exploring the influence of weather variability and climate change on health outcomes in people living with dementia: A scoping review protocol Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions Neglect of older adults living with dementia in family caregiving: A dimensional concept analysis A scoping review on the psychosocial interventions used in day care service for people living with dementia Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023 Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions Ketamine and its enantiomers for depression: a bibliometric analysis from 2000 to 2023 Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study Depression as a Risk Factor for Dementia: A Meta-Analysis Ketamine for treatment-resistant major depressive disorder: Double-blind active-controlled crossover study Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics? (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality Primitive reflexes and dementia in older adults: a meta-analysis of observational and cohort studies Short-term ketamine use in bipolar depression: a review of the evidence for short-term treatment management So how special is special K? A systematic review and meta-analysis of ketamine for PTSD RCTs Cognitive changes in patients with unipolar TRD treated with IV ketamine: A systematic review Cognitive changes in patients with unipolar TRD treated with IV ketamine: A systematic review Prevalence of orofacial pain in individuals with mild cognitive impairment or dementia: A systematic review and meta-analysis Widespread reductions in cortical thickness following ketamine abuse Impact of intra-operative ketamine on postoperative outcomes in abdominal surgery: a narrative review Impact of intra-operative ketamine on postoperative outcomes in abdominal surgery: a narrative review Current trends in psychotherapies and psychosocial interventions for people with dementia: a scoping review of randomized controlled trials Current trends in psychotherapies and psychosocial interventions for people with dementia: a scoping review of randomized controlled trials Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network Ketamine in the effective management of chronic pain, depression, and posttraumatic stress disorder for Veterans: A meta-analysis and systematic review The impact of perioperative ketamine or esketamine on the subjective quality of recovery after surgery: a meta-analysis of randomised controlled trials Equine-assisted services for people living with dementia: a systematic review Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies Dental decision-making for persons with dementia: A systematic narrative review Protocol for a randomised controlled trial of ketamine versus ketamine and behavioural activation therapy for adults with treatment-resistant depression in the community Dilemmas and support strategies in dementia care: Experiences of case managers in Taiwan Ketamine, Dissociation, and Depression: What is 'Special' About Ketamine? 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