LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans

14 August 2024

Evidence

Diabetes Obes Metab. 2024 Aug 14. doi: 10.1111/dom.15850. Online ahead of print.

ABSTRACT

AIM: Liver-expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study the association between fasting LEAP2 and anthropometric and metabolic traits, feeding behaviour, LEAP2 genetic variants and blood cell DNA methylation status; and (c) to ascertain postprandial changes in LEAP2 after high protein intake and the association with feeding behaviour and food intake.

METHODS: Anthropometric and behavioural measures, genotyping, methylation profiling, plasma glucose and LEAP2 concentrations were assessed in 327 females and males. A subgroup of 123 participants received an ad libitum high-protein meal, and postprandial LEAP2 concentration and behavioural measures were assessed.

RESULTS: LEAP2 concentration was higher in participants with OW/OB (p < 0.001) and in females (p < 0.001), and was associated with LEAP2 single nucleotide polymorphisms rs765760 (p = 0.012) and rs803223 (p = 0.019), but not with LEAP2 methylation status. LEAP2 concentration was directly related to glycaemia (p = 0.001) and fullness (p = 0.003) in participants with normal weight, whereas it was associated with body mass index (p = 0.018), waist circumference (p = 0.014) and motor impulsivity in participants with OW/OB (p = 0.005). A negative association with reward responsiveness was observed in participants with OW/OB (p = 0.023). LEAP2 concentration was inversely associated with food intake (p = 0.034) and decreased after a high-protein meal (p < 0.001), particularly in women (p = 0.002).

CONCLUSION: Increased LEAP2 in participants with OW/OB is associated with behavioural characteristics of obesity. Our results show sexual dimorphism in LEAP2 concentration before and after food intake and highlight the role of LEAP2 in feeding regulation.

PMID:39140219 | DOI:10.1111/dom.15850

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American Journal of Psychiatry, Volume 181, Issue 9, Page 793-794, September 01, 2024.
Donel M. Martin

August Issues of APA Journals Cover New Research on PTSD, Suicide, Personal Recovery, Eating Disorders, and More
psychiatry.org
July Issues of APA Journals Cover New Research on Pharmacogenomics, ADHD Medication Use, Associations Between Mental Health and Cardiometabolic Complications Later in Life, and More
psychiatry.org
APA Statement on the Police Killing of Sonya Massey 1 September 2024
The July 7 killing of Sonya Massey by former sheriff’s deputy Sean Grayson is a disturbing and horrifying tragedy that should never have happened. Law enforcement, when visiting the home of anyone with reported mental health concerns, should be trained and prepared to respond to these individuals with care and empathy, not violence and harm
APAPsychiatric

Prevalence of Common Child Mental Health Disorders Using Administrative Health Data and Parent Report in a Prospective Community-Based Cohort from Alberta, Canada: Prévalence des troubles communs de santé mentale de l’enfant à l’aide des données de santé administratives et des rapports des parents dans une cohorte prospective communautaire d’Alberta, Canada 22 August 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveKnowing the prevalence of mental health difficulties in young children is critical for early identification and intervention. In the current study, we examine the agreement among three different data sources estimating the prevalence of diagnoses for attention deficit hyperactivity disorder (ADHD) and emotional disorders (i.e., anxiety or […]
N. Racine
Urinary Retention Following Electro-Convulsive Therapy Under General Mask Anesthesia 21 August 2024
The Canadian Journal of Psychiatry, Ahead of Print.
Anthony A Stephenson
An Epidemiological Study of Physical–Mental Multimorbidity in Youth: Une étude épidémiologique de la morbidité physique-mentale chez les jeunes 16 August 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveThis epidemiological study estimated the lifetime prevalence of chronic physical illness (i.e., an illness that lasted or was expected to last ≥6 months) and 6-month prevalence of mental disorder and multimorbidity (i.e., ≥1 physical illness and ≥1 mental disorder) in youth. Associations between physical illness and mental […]
Shannon V. Reaume

Mostly harmless? Clinical practice guidelines need further consideration of psychotherapy adverse effects 7 September 2024
Australasian Psychiatry, Ahead of Print. The Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines on mood disorders recommend psychotherapy as foundational care for patients with acute depression with minimal discussion of any potential adverse effects. Randomised controlled trial evidence on psychotherapy adverse effects is limited. This is problematic because clinicians must balance […]
Stephen Allison
A reflection on mental health education for pacific clinicians 7 September 2024
Australasian Psychiatry, Ahead of Print. ObjectivesTo review the challenges to developing and sustaining the Pacific mental health workforce for future planning.ConclusionEmerging from a colonial mental health service and training paradigm, contemporary Pacific Island Countries and Territories confront significant workforce education and training challenges that require solutions relevant to regional circumstances.
Odille Chang
The Thought Broadcast: The importance of psychiatric journal clubs 6 September 2024
Australasian Psychiatry, Ahead of Print.

Evaluating counselling skills of community health workers for pregnant adolescents in Limpopo province 30 July 2024
Background: Adolescent pregnancy carries significant global ramifications. Community health workers (CHWs) play a role in empowering adolescents through counselling skills, thereby promoting informed decision-making for better outcomes.Aim: The study aims to evaluate the counselling skills of CHWs in their efforts to support pregnant adolescents (PA) in Limpopo province.Setting: The research was carried out with CHWs in the Mopani […]
Rakgadi G. Malapela
Cannabis use among hospitalised adolescents before and after decriminalisation in South Africa 26 July 2024
Background: Cannabis is the most widely used substance worldwide, and its use is much higher among adolescents. However, adolescents are at higher risk of negative sequelae secondary to this use, including the possible development of mental disorders. On 31 March 2017, the South African High Court ruled that cannabis use by an adult in a private […]
Michelle C. Swartz
The prevalence of anxiety in pregnant women at Chris Hani Baragwanath Academic Hospital 23 July 2024
Background: Non-psychotic mental disorders are common during the perinatal period. In South Africa, there are few studies on antenatal anxiety and these results vary. Antenatal anxiety does not only add to the burden of perinatal co-morbidity but has subsequent immediate and long-term effects on the mother, birth outcomes and her offspring.Aim: The aim of this study was […]
Lisha Narayan

Peering into the mind: unraveling schizophrenia’s secrets using models 8 September 2024
Molecular Psychiatry, Published online: 08 September 2024; doi:10.1038/s41380-024-02728-wPeering into the mind: unraveling schizophrenia’s secrets using models
João V. Nani
A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder 6 September 2024
Molecular Psychiatry, Published online: 06 September 2024; doi:10.1038/s41380-024-02719-xA systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder
Marion M. Friske
Impaired macroautophagy confers substantial risk for intellectual disability in children with autism spectrum disorders 6 September 2024
Molecular Psychiatry, Published online: 06 September 2024; doi:10.1038/s41380-024-02741-zImpaired macroautophagy confers substantial risk for intellectual disability in children with autism spectrum disorders
Ahrom Ham

Plaudits for logits in sensory neuroscience
A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful examination of their choices. In this issue of , Carandini flips the script, showing how it can model how the brain makes sensory choices.A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful […]
Impacts beyond the brain: Unraveling molecular mechanisms linking psychiatric, metabolic, and inflammatory conditions
By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the publication by Nakanishi et al. provides new insight to how primary brain deficiency impacts physiological systems beyond the brain.By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the […]
Keep calm and carry H3K27me1 off
In this issue of , Torres-Berrío et al. show that stress-susceptible mice exhibit elevated H3K27me1 levels in nucleus accumbens neurons due to the action of the SUZ12 VEFS domain, strengthening the link between specific epigenetic changes and long-lasting stress-induced social, emotional, and cognitive alterations.In this issue of , Torres-Berrío et al. show that stress-susceptible mice exhibit elevated […]

Social identity processes as a vehicle for therapeutic success in psychedelic treatment 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00302-5In this Perspective, authors overview the ‘social cure’ model employing group contexts, identity, and connections and argue for its use as a therapeutic framework for psychedelic treatment.
Martha Newson
Associated transcriptional, brain and clinical variations in schizophrenia 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00306-1This study examining blood transcriptomic, neuroimaging and clinical data in people with schizophrenia shows a relationship between individual variations in gene transcription, brain structure and cognitive performance.
Long-Biao Cui
Found in translation — translational science in mental health research 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00319-wTranslational science is often characterized metaphorically, as bridging the gaps among multidisciplinary research areas. However, in reality, translational work is often separate or excluded from clinical research. Integrating elements of translational and clinical work into more general mental health research is key to innovation and progress.

Testing the causal relationship of fat and sugar intake with depression and cortisol: a Mendelian Randomisation study 10 September 2024
Translational Psychiatry, Published online: 10 September 2024; doi:10.1038/s41398-024-03089-2Testing the causal relationship of fat and sugar intake with depression and cortisol: a Mendelian Randomisation study
Matylda Buczkowska
MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy 10 September 2024
Translational Psychiatry, Published online: 10 September 2024; doi:10.1038/s41398-024-03075-8MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy
Yao-Bo Li
Exposure to an acute stress impaired the metabolic plasticity of resilient rats by enhancing fatty acid β-oxidation in the ventral hippocampus 10 September 2024
Translational Psychiatry, Published online: 10 September 2024; doi:10.1038/s41398-024-03080-xExposure to an acute stress impaired the metabolic plasticity of resilient rats by enhancing fatty acid β-oxidation in the ventral hippocampus
Paola Brivio

The relationship between corticospinal excitability and structural integrity in stroke patients 6 September 2024
BackgroundEvaluation of the structural integrity and functional excitability of the corticospinal tract (CST) is likely to be important in predicting motor recovery after stroke. Previous reports are inconsistent regarding a possible link between CST structure and CST function in this setting. This study aims to investigate the structure-function relationship of the CST at the acute […]
Daghsen, L., Checkouri, T., Wittwer, A., Valabregue, R., Galanaud, D., Lejeune, F.-X., Doulazmi, M., Lamy, J.-C., Pouget, P., Roze, E., Rosso, C.
Intermediate HTT CAG repeats worsen disease severity in amyotrophic lateral sclerosis 6 September 2024
IntroductionRecent research has indicated a connection between amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), an inherited neurological condition caused by a trinucleotide CAG repeat expansion within exon 1 of the Huntingtin gene (HTT; MIM:613004).1 The same pathogenic CAG repeat expansions (40 or more CAG repeats) observed in patients with HD have been identified in […]
Grassano, M., Canosa, A., DAlfonso, S., Corrado, L., Brodini, G., Koumantakis, E., Cugnasco, P., Manera, U., Vasta, R., Palumbo, F., Mazzini, L., Gallone, S., Moglia, C., Dewan, R., Chia, R., Ding, J., Dalgard, C., Gibbs, R. J., Scholz, S., Calvo, A., Traynor, B., Chio, A.
Prognosis prediction and immunotherapy optimisation for cryptogenic new-onset refractory status epilepticus 5 September 2024
BackgroundCryptogenic new-onset refractory status epilepticus (cNORSE) currently lacks comprehensive knowledge regarding its clinical dynamics, prognostic factors and treatment guidance. Here we present the longitudinal clinical profiles, predictive factors for outcomes and the optimal duration of immunotherapy in patients with cNORSE.MethodsThis retrospective secondary endpoint analysis investigated patients with cNORSE identified from a prospective autoimmune encephalitis cohort […]
Jang, Y., Ahn, S. H., Park, K.-I., Jang, B.-S., Lee, H. S., Bae, J.-H., Lee, Y., Sunwoo, J.-S., Jun, J.-S., Kim, K. T., Mon, S. Y., You, J. H., Kim, T.-J., Shin, H., Han, D., Cho, Y. W., Dubey, D., Chu, K., Lee, S. K., Lee, S.-T.

Mendelian randomization: causal inference leveraging genetic data 19 April 2024
Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for […]
Chen, Lane G.
Interventions targeting social determinants of mental disorders and the Sustainable Development Goals: a systematic review of reviews 25 March 2024
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review […]
Oswald, Tassia Kate
Do metacognitive therapies for schizophrenia-spectrum disorders work? A meta-analytic investigation 21 March 2024
Recent reviews and meta-analyses of metacognitive therapy for schizophrenia-spectrum disorder (SSD) have included uncontrolled studies, single-session interventions, and/or analyses limited to a single form of metacognitive therapy. We sought to evaluate the efficacy of metacognitive therapies more broadly based on controlled trials (CT) of sustained treatments. We conducted a pre-registered meta-analysis of controlled trials that […]
Melville, Grace

Relationship between nonexercise activity and mood in patients with eating disorders 8 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Robin Olfermann, Sabine Schlegel, Anna Vogelsang, Ulrich Ebner‐Priemer, Almut Zeeck, Markus Reichert
The impact of sex in the effectiveness of functional remediation in bipolar disorder 7 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Maria Serra‐Navarro, Derek Clougher, Brisa Solé, Jose Sánchez‐Moreno, Ana González‐Pinto, Esther Jiménez, Benedikt L. Amann, Vicent Balanzá‐Martínez, Rafael Tabarés‐Seisdedos, Celso Arango, Vivian Accardo, María Paz García‐Portilla, Ángela Ibáñez, José Manuel Crespo, José Luis Ayuso‐Mateos, Silvia Amoretti, Carla Torrent, Anabel Martínez‐Aran, Eduard Vieta, CIBERSAM Functional Remediation Group
Childhood maltreatment and outcomes following electroconvulsive therapy in adults with depression 5 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Ana Jelovac, Christopher Mohan, Emma Whooley, Anna Igoe, Cathal McCaffrey, Declan M. McLoughlin

Anti‐epileptic drug use and subsequent degenerative dementia occurrence 10 September 2024
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 10, Issue 3, July‐September 2024.
Naoki Ikegaya, Honoka Nakamura, Yutaro Takayama, Yohei Miyake, Takahiro Hayashi, Masaki Sonoda, Mitsuru Sato, Kensuke Tateishi, Jun Suenaga, Masao Takaishi, Yu Kitazawa, Misako Kunii, Hiroki Abe, Tomoyuki Miyazaki, Tetsuaki Arai, Manabu Iwasaki, Takayuki Abe, Tetsuya Yamamoto
Barriers for bariatric surgery in provincial New Zealand: a qualitative analysis 10 September 2024
ANZ Journal of Surgery, EarlyView.
Henry Witcomb Cahill, Matthew McGuinness, Ian Bissett, Christopher Harmston
Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS‐induced Depressive‐Like Behaviors 10 September 2024
Advanced Healthcare Materials, EarlyView.
Minzi Ju, Zhongkun Zhang, Feng Gao, Gang Chen, Sibo Zhao, Dan Wang, Huijuan Wang, Yanpeng Jia, Ling Shen, Yonggui Yuan, Honghong Yao

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Evolving Perspectives on Wellness and Stress
Renewing the Teaching of Clinical Reasoning in Psychiatry: An Opportunity for Advancing Mental Health Training and Care
Assaults and Microaggressions Against Psychiatric Residents: Findings from a US Survey
Psychiatric physicians may experience higher rates of assault than those in other fields. For many reasons, residents may be especially vulnerable. This study updates rates of assaults among US psychiatry residents as well as the reporting rates and emotional effects of these incidents. Little data exists to examine rates of microaggressions against psychiatry residents.A cross-sectional […]

Acute Augmentations to Psychological Therapies in Eating Disorders: A Systematic Review and Meta-Analysis
The purpose of this systematic review and meta-analysis was to examine the use and efficacy of acute augmentation therapies in eating disorders.A meta-analysis addressing this topic across psychological disorders found augmentation significantly improved therapy outcome with strongest findings for augmentations targeting biological mechanisms; however, only one study examined eating disorders.Our systematic review identified 29 studies […]
Health Equity and Perinatal Mental Health
Pregnancy and the postpartum period are vulnerable times to experience psychiatric symptoms. Our goal was to describe existing inequities in perinatal mental health, especially across populations, geography, and in the role of childbirth.People of color are at an increased risk for perinatal mental health difficulties and more likely to experience neglect, poor communication, and racial […]
Harnessing Immersive Virtual Reality: A Comprehensive Scoping Review of its Applications in Assessing, Understanding, and Treating Eating Disorders
Immersive Virtual Reality (IVR) has shown promise in the assessment, understanding, and treatment of eating disorders (EDs), providing a dynamic platform for clinical innovation. This scoping review aims to synthesize the recent advancements and applications of IVR in addressing these complex psychological disorders.This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols, […]

Editorial introductions
No abstract available
journals.lww.com
Sex and gender differences in cancer in individuals with severe mental disorders
Purpose of review Although cancer incidence is similar between individuals with severe mental disorders (SMD) and the general population (GP), survival rates are lower, particularly in those with schizophrenia. While the scientific and medical communities acknowledge sex differences in cancer mechanisms, including risk factors and cancer types, less is known about sex and gender disparities […]
Bajić, Žarko; Vuk-Pisk, Sandra; Filipčić, Igor; Šimunović Filipčić, Ivona
The role of human involvement and support in digital mental health interventions for people with schizophrenia spectrum disorders: a critical review
Purpose of review Schizophrenia spectrum disorders (SDD) are characterized by a complex array of psychosis symptoms, and typically require ongoing and long-term support, including pharmacological and nonpharmacological management. Digital mental health interventions (DMHIs) have been suggested as a novel therapeutic approach to enable low-cost, scalable improvements in quality of care for adults living with SSD. […]
Arnautovska, Urska; Milton, Alyssa; Trott, Mike; Soole, Rebecca; Siskind, Dan

Daily-life reactivity and emotion regulation in children with social anxiety disorder
Little is known about maintaining factors of child social anxiety disorder (SAD).High daily-life reactivity and use of suppression are specific to child SAD.Maladaptive emotion regulation predicts trait social anxiety one year later.Treatment should put more focus on reducing maladaptive emotion regulation. Prominent models of adult social anxiety disorder emphasize the role of hyperreactivity and emotion […]
Correlates of treatment-seeking in DSM-5 generalized anxiety disorder: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions‐III
Generalized Anxiety Disorder (GAD) presents a significant personal and societal burden and is associated with chronic medical comorbidities and markedly lower quality of life. Effective treatments exist, less than half of individuals with lifetime GAD will ever seek psychotherapeutic or pharmacological treatment. A thorough understanding of the factors that influence treatment seeking for GAD is […]
Scaling up psychological interventions into the daily lives of patients with anxiety and related disorders

Optimization of self‐ or parent‐reported psychiatric phenotypes in longitudinal studies 9 September 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Franjo Ivankovic, Sharon Johnson, James Shen, Jeremiah M. Scharf, Carol A. Mathews
Behavioral characteristics of toddlers later identified with an autism diagnosis, ADHD symptoms, or combined autism and ADHD symptoms 3 September 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Naomi O. Davis, Reginald Lerebours, Rachel E. Aiello, Kimberly L.H. Carpenter, Scott Compton, Lauren Franz, Scott H. Kollins, Maura Sabatos‐DeVito, Marina Spanos, Geraldine Dawson
Practitioner Review: Treatments for young people who self‐harm – challenges and recommendations for research and clinical practice 28 August 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Katrina Witt, Anne Stewart, Keith Hawton

Elder abuse and neglect, novel factors affecting depression risk, SARS-CoV-2 Omicron-induced anxiety, and provider flourishing in pediatric palliative care 7 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print.
Harold G. Koenig
Red kratom and red corvette: A case of mania induced by kratom withdrawal 6 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. Background: Kratom, derived from the Mitragyna speciose, a plant native to Southeast Asia, is a substance that is gaining popularity in the United States as a self-medication tool for opiate withdrawal and pain management. Its active compounds, mitragynine, and 7-hydroxymitragynine, interact with various receptors in the […]
Mohammmad Abidali
Psychotropic medication and hepatobiliary health: Ultrasound observations on patients with schizophrenia 5 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveThis study sought to examine the association between antipsychotic drug use and hepatobiliary health based on serum markers and ultrasound observations on a sample of patients with schizophrenia compared to age and gender matched healthy controls.MethodsThe 120 patients with schizophrenia and 60 control subjects had […]
Linlin Yue

Research landscape analysis on dual diagnosis of substance use and mental health disorders: key contributors, research hotspots, and emerging research topics 30 August 2024
Substance use disorders (SUDs) and mental health disorders (MHDs) are significant public health challenges with far-reaching consequences on individuals and society. Dual diagnosis, the coexistence of SUDs and...
Waleed M. Sweileh
Association between rTMS-induced changes in inflammatory markers and improvement in psychiatric diseases: a systematic review 27 August 2024
Repetitive transcranial magnetic stimulation (rTMS) has recently gained relevance in treating different psychiatric disorders. Limited evidence suggests that the beneficial effects of rTMS on psychopathology c...
Bruno Pedraz-Petrozzi, Shrabon Insan, Moritz Spangemacher, Jonathan Reinwald, Eva Kathrin Lamadé, Maria Gilles, Michael Deuschle and Alexander Sartorius
Maternal depression and early childhood development among children aged 24–59 months: the mediating effect of responsive caregiving 20 August 2024
This study examined whether maternal depression is related to Early Childhood Developmental (ECD) delay among children by quantifying the mediating contribution of responsive caregiving. We used data from 1235...
Siyu Zou, Xinye Zou, Ruolin Zhang, Kefan Xue, Angela Y. Xiao, Mo Zhou, Ziyuan Fu and Hong Zhou

Sexual Orientation Microaggression Rating Scale (SOMRS): Development and association with alliance ruptures. 8 August 2024
Sexual minority clients report experiencing frequent microaggressions during therapy, however, therapists may not recognize those microaggressions or may be reluctant to self-report them. The main aim of the present study was thus to develop an observational measure of in-session therapist-committed microaggressions related to the sexual orientation of sexual minority individuals (e.g., those who identify as […]
Should we feel the same? Mutual recognition and congruence between therapist and client regarding ruptures and repairs. 8 July 2024
The pattern of rupture and repair within therapeutic alliances has been associated with improved outcome. The present study adds to this body of research by examining rupture and repair from a dyadic perspective. First, we examined the relationship between mutual recognition of ruptures, rupture intensity, and client ratings of session helpfulness. We then examined client–therapist […]
Preventing dropout in spiritually integrated psychotherapies: What are the effective methods of attending to clients’ spirituality? 30 May 2024
The purpose of this study was to examine associations between clinicians’ use of varying types of spiritual interventions in the first session of spiritually integrated psychotherapies (SIPs) and clients’ likelihood of returning for a second session. In total, 154 practitioners of SIPs from 33 settings in a practice-research network reported on their implementation of different […]

Ongoing Teacher Support for Data-Based Individualization: A Meta-Analysis and Synthesis 6 September 2024
Journal of Learning Disabilities, Ahead of Print. Although data-based individualization (DBI) has positive effects on learning outcomes for students with learning difficulties, this framework can be difficult for teachers to implement due to its complexity and contextual barriers. The first aim of this synthesis was to investigate the effects of ongoing professional development (PD) support […]
Emma Shanahan
A Family-Based Intervention for Early Elementary Students With Reading and Behavioral Difficulties: A Pilot Study 2 August 2024
Journal of Learning Disabilities, Ahead of Print. We created and tested a family-based intervention with families of children in Grades 1 and 2 with reading and behavioral difficulties to investigate its impact on text comprehension. Developed with input from parents, reading experts, and behavior specialists, Family-RISE (Reading Intervention with Supports for Engagement) integrates evidence-based practices […]
Garrett J. Roberts
Assessing Beliefs About Intrinsic and Extrinsic Determinants of SLD: Evaluating the Factor Structure of a Novel Instrument 26 July 2024
Journal of Learning Disabilities, Ahead of Print. Schools conduct comprehensive psychoeducational evaluations to identify students with specific learning disabilities (SLDs) and determine whether they qualify for special education services. This decision-making process is complex and research has documented many factors influencing SLD identification decisions. One such factor may be decision-makers’ beliefs about the underlying causes […]
Courtenay A. Barrett

Staff Perceptions of Mental Health Relapse Prevention Support in a Specialist Mental Health Service in an Intellectual Disability Setting 10 September 2024
British Journal of Learning Disabilities, EarlyView.
Shannon Sinnott, Cliodhna O'Donovan, Suzanne Guerin
Item reduction of the “Support Intensity Scale” for people with intellectual disabilities, using machine learning 19 August 2024
British Journal of Learning Disabilities, EarlyView.
Félix González‐Carrasco, Felipe Espinosa Parra, Izaskun Álvarez‐Aguado, Sebastián Ponce Olguín, Vanessa Vega Córdova, Miguel Roselló‐Peñaloza
Culturally adaptive healthcare for people with a learning disability from an ethnic minority background: A qualitative synthesis 12 August 2024
British Journal of Learning Disabilities, EarlyView.
Christina Roberts, Nicola Ditzel, Nicola Cooper‐Moss, Katie Umbleby, Umesh Chauhan

Autism spectrum disorder, radicalization, and violence: a forensic perspective 30 August 2024
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Julian A.C. Gojer Kayla M. Gaw Kaileigh M. Chretien a Integrated Forensic Program, Royal Ottawa Mental Health Center and Institute of Mental Health Research, ON, Canadab Sexual Behaviours Clinic, Royal Ottawa Mental Health Center and Institute of Mental Health Research, ON, Canadac Integrated Forensic Program (IFP), Royal Ottawa Mental Health Center, ON, Canada
Childhood onset violence and early onset schizophrenia. A molecular diagnosis of 15q13.2-13.3 duplication syndrome and the effects on insight and engagement 28 August 2024
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Ed Silva Department missing for affiliation Rathbone Low Secure Unit, Rathbone Hospital, Mersey Care NHS FT, Liverpool, UK
Statement of Retraction: See think act: the need to rethink and refocus on relational security 19 August 2024
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Therapeutic and non-therapeutic practices in the child justice system in Kenya: A therapeutic jurisprudence perspective
Child justice systems are specialized jurisdictions set up for the purpose of providing justice related services to children. In an effort to resolve many of the systemic injustices expereinced by justice involved children, Kenya recently legislated the Children Act 2022. This new law is viewed as a paradigm shift from previous children acts as it […]
Forensic criteria, clinical and theoretical issues of the indication of court-ordered treatment: A comparative survey among experts in forensic psychiatry and sentencing judges in France
Following the French law n° 98–468 of 17 June 1998 relative to the prevention of sexual offenses and the protection of minors, social and judicial follow-up and court-ordered treatment were introduced with the aim of reinforcing the prevention of recidivism. Court-ordered treatment is one of the possible obligatory measures provided for by social and judicial […]
Editorial Board

Faithful and fearful: Does religion promote or reduce fear of crime in Germany?
This article complements existing victimological studies on religion by investigating whether religion promotes or reduces fear of crime in Germany. According to the generalized insecurity approach and the theory of social production functions, religion and fear of crime are linked via secularization-induced diffuse insecurities. It is expected that different facets of religion are tied to […]
Moral foundations in gender violence cases decided in Portuguese courts
Gender violence encompasses a multitude of morally problematic psychological, physical, and sexual behaviors that, in most countries, constitute criminal offenses. In this study, we investigate the association between moral foundations (, , , , and ) and punitive responses to gender violence offenses. Our case study focuses on gender violence in Portugal, a country in […]
Comparing the criminal careers of organized crime offenders in Italy and the Netherlands
The concept of organized crime has dynamically evolved, with researchers contending that it is a social construct or an umbrella concept encompassing different empirical manifestations. Scholars have often suggested classifying organized crime groups into those involved in “racketeering” or “governing” and those engaged in “transit crime” or “trading.” However, these propositions were never assessed at […]

The longitudinal associations between nonviolent/violent stressful life events, moral disengagement, and online aggression in Chinese young people through the lens of general aggression model. 18 July 2024
Objective: Online aggression (OA) in Chinese university students is a public health concern. Drawing on the general aggression model (GAM), this study examines the extent to which nonviolent and violent stressful life events predict OA through altering moral cognition (i.e., moral disengagement). It also examines whether the two types of stressful life events interactively predict […]
Adolescent relationship violence: Should pushes and hits always be considered violent? 18 July 2024
Objective: Research on adolescent relationship violence often involves having adolescents report on physically forceful acts, such as pushes and hits, that have occurred in the context of dating relationships. The present study compares: (a) adolescents who reported having experienced acts of physical force by a dating partner and attributed it solely to playfulness (playful only); […]
Internalized heterosexism magnifies the association of hazardous or harmful alcohol use on intimate partner violence perpetration rates of sexual minority and same-sex-attracted men. 20 June 2024
Objective: To test whether internalized heterosexism, a form of minority stress, heightens the effect of hazardous or harmful alcohol use on frequency of intimate partner violence (IPV) perpetration among sexual minority and same-sex-attracted men. Method: We recruited participants online via Amazon Mechanical Turk (MTurk). Inclusion criteria were adult cisgender men living in the United States […]

Expanding our understanding of long‐term trends in alcohol abstention and consumption in England (2001–19) using two age–period–cohort approaches 10 September 2024
Addiction, Volume 119, Issue 10, Page 1726-1736, October 2024.
Magdalena Opazo Breton, Madeleine Henney, Inge Kersbergen, Alan Brennan, John Holmes
Predictors of alcohol and other drug treatment completion among young people accessing residential and community‐based treatment: A retrospective analysis of routinely collected service data 10 September 2024
Addiction, Volume 119, Issue 10, Page 1813-1825, October 2024.
Megan Wells, Peter J. Kelly, Lauren Mullaney, Mei Lin Lee, Robert Stirling, Sarah Etter, Briony Larance
Systematic review and meta‐analyses of cytisine to support tobacco cessation 10 September 2024
Addiction, Volume 119, Issue 10, Page 1713-1725, October 2024.
Cheneal Puljević, Daniel Stjepanović, Isabel Meciar, Heewon Kang, Gary Chan, Kylie Morphett, Hollie Bendotti, Garry Kunwar, Coral Gartner

A pilot study of “AKBAY” self-help intervention for university students with moderate symptoms of depression and anxiety 9 September 2024
Depression and anxiety are common mental health issues among young adults, particularly exacerbated by the COVID-19 pandemic. Research indicates a notable increase in global prevalence rates, especially in this demographic. Despite their prevalence, factors like stigma, cost and limited accessibility often prevent individuals from seeking professional help. Therefore, there is a pressing need for innovative […]
Sherna Bangalan
Defining mental health literacy: a systematic literature review and educational inspiration 2 September 2024
This paper aims to explore how the term “mental health literacy” (MHL) is defined and understand the implications for public mental health and educational interventions. An extensive search was conducted by searching PubMed, ERIC, PsycINFO, Scopus and Web of Science. Keywords such as “mental health literacy” and “definition” were used. The publication year ranges from […]
Shengnan Zeng
Representing the experiences of charity peer leaders facilitating well-being interventions to their peers using process evaluation methodology (Part 2) 2 September 2024
This paper aims to build on Part 1 which generated a theory representing the experiences of charity peer leaders facilitating well-being interventions (Burns, 2024). This study (Part 2) examines the process of peers [1] becoming peer leaders using the generated theory. Following the Medical Research Council Process Evaluation Framework (Moore et al, 2015), the methods […]
Jenny Burns

Mortality in the Victorian asylum: was it so high? Standardised Mortality Rate compared with historical methods 9 August 2024
History of Psychiatry, Ahead of Print. Mortality is closely linked to age, sex, and social and historical context. Standardised Mortality Rates (SMR) address these contextual factors by comparing mortality in a population under study with that in people of the same age and sex, the same period in history and from a similar cultural context. […]
Charlotte Richardson
The notion of excessive childhood restlessness in Spain at the beginning of the twentieth century 27 July 2024
History of Psychiatry, Ahead of Print. This study delves into the historical documentation from 1900 to 1936 by Spanish doctors and educators concerning children’s hyperactivity. By focusing on medical perspectives of the time, we aim to explore the conceptualisation of childhood phenomenology within the context of significant international literature of that era. The publications of […]
Joana Escamilla Lerner
Empathy or sympathy: a necessary distinction? 23 July 2024
History of Psychiatry, Ahead of Print. As a deeply hybrid discipline, psychiatry demands research that tackles the concepts constituting it and its objects. This is an essential prerequisite to empirical studies, the validity of which are directly dependent on a clear understanding of the underlying concepts. Empathy and sympathy are concepts used variably and inconsistently […]
Ivana S Marková

Supported accommodations for people with serious mental disorders: Care pathways and predictors of age of entry and length of stay 6 September 2024
International Journal of Social Psychiatry, Ahead of Print. Introduction:Supported accommodations (SAs) are key components of community mental health care, but little is known about residents’ care pathways. This study analysed the care pathways of residents of SAs, and factors associated with their age of entry and length of stay.Methods:A random sample of SAs’ residents in […]
Bárbara Pedrosa
Compassion fatigue and healthcare professionals: Challenges 6 September 2024
International Journal of Social Psychiatry, Ahead of Print.
Dinesh Bhugra
The impact of the 2023 Türkiye-Syria earthquakes on the mental health of children 6 September 2024
International Journal of Social Psychiatry, Ahead of Print. The seismic events that struck southern Turkey and Syria in February 2023, with magnitudes of 7.8 and 7.6 respectively, have significantly impacted the well-being of millions, particularly children and adolescents. This correspondence highlights the psychological repercussions faced by minors in the aftermath of the earthquakes, including anxiety, […]
Sirwan Khalid Ahmed

Contract award criteria in public procurement procedures – The possibility of improving the situation of society from the perspective of the European Union and Poland [version 2; peer review: 1 approved, 1 approved with reservations] 10 September 2024
Background Public tenders are vital for a country’s GDP and citizens’ quality of life, enabling public administration to achieve various goals. Developing and developed countries allocate over 10% of their GDP to public procurement. This highlights the significant societal support public tenders can provide, making it important to consider how they can further benefit society. […]
Mateusz Brzeziński
Assessing the cytotoxicity of phenolic and terpene fractions extracted from Iraqi Prunus arabica against AMJ13 and SK-GT-4 human cancer cell lines [version 3; peer review: 1 approved, 1 approved with reservations] 10 September 2024
Background: Breast and esophageal cancer are the most aggressive and prominent causes of death worldwide. In addition, these cancers showed resistance to current chemotherapy regimens with limited success rates and fatal outcomes. Recently many studies reported the significant cytotoxic effects of phenolic and terpene fractions extracted from various Prunus species against different cancer cell lines. […]
Matin Adil Mahmood
The frailty among suburban elderly population after one-year COVID-19 pandemic in Cirebon Regency, Indonesia [version 3; peer review: 2 approved, 1 approved with reservations] 10 September 2024
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has had significant impacts worldwide, especially among older adults. Frailty is a determinant of susceptibility to morbidity and mortality due to COVID-19 in the elderly. This study aimed to determine frailty status and identify factors associated with the suburban elderly population in Cirebon Regency, Indonesia, after the […]
Ahmad Fariz Malvi Zamzam Zein

How Cannabis Laws and Mental Health Prescription Drugs Are Linked 10 September 2024
(MedPage Today) -- In this video interview, Ashley Bradford, PhD, of the Georgia Institute of Technology School of Public Policy in Atlanta, discusses her new paper in JAMA Network Open, which assessed how cannabis laws were associated with prescription...
Nurse-Supported Cognitive Behavioral Therapy for Insomnia Improved Sleep Outcomes 9 September 2024
(MedPage Today) -- Nurse-supported, self-directed cognitive behavioral therapy (CBT) for insomnia reduced severity scores and improved sleep outcomes, a randomized trial of veterans showed. Among 178 veterans, Insomnia Severity Index scores fell...
Youth With Chronic Pain May Have More Anxiety and Depression 9 September 2024
(MedPage Today) -- Young people with chronic pain also have higher rates of depression and anxiety, according to a systematic review and meta-analysis. In an analysis of 79 studies totaling almost 23,000 youth, the prevalence of anxiety was 34...

Dyslexia and ADHD share genetic links, study shows - Medical Xpress 10 September 2024
Genetic relationships between ten neurodevelopmental and psychiatric disorders. Credit: Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02649 ...
U-M study reveals how propofol affects brain connectivity and consciousness - News-Medical 10 September 2024
... psychiatry and anesthesiology." Zirui Huang, Ph.D., Research Assistant ... Psychiatry. (Subscribe or Preview).
How Adjacent Consent Undermines Sexual Assault Reporting | Psychiatrist.com 10 September 2024
People judge sexual assault victims more harshly and offer less support when the assault follows consensual sexual activity.

Finerenone Reduces T2D Onset in HF With Preserved EF 10 September 2024
In addition to improving heart failure symptoms, finerenone reduced the onset of new type 2 diabetes in patients with mildly reduced or preserved ejection fraction. Medscape Medical News
The ESMO Congress Starts This Week in Barcelona 10 September 2024
One of the world's largest oncology meetings will begin on Friday. Here's what you should know. Medscape Medical News
Human Bird Flu Patient Had No Known Animal Contact 10 September 2024
Investigation into potential exposure remains ongoing, but CDC considers current risk low. Medscape Medical News

Gaza: UN envoy condemns deadly strike on camp in humanitarian zone 10 September 2024
The UN Middle East envoy has strongly condemned deadly airstrikes by the Israeli Defense Forces (IDF) on Tuesday on a densely populated area in an Israeli-designated humanitarian zone in Gaza.
Gaza war continues to shut hundreds of thousands out of class 9 September 2024
Monday would have marked the start of the new school year in Gaza, but the ongoing war continues to deprive hundreds of thousands of children of this fundamental right, UN agencies have warned.
The world must ‘wake up and help Sudan out of the nightmare of conflict’, says WHO’s Tedros 8 September 2024
Sudan’s health system is “near collapse” after 16 months of war have left the country and its people facing what the UN’s top health official described on Sunday as the “perfect storm of crises”, which the world is largely ignoring.

Results from the 2024 Tracking Antimicrobial Resistance Country Self-Assessment Survey (TrACSS): Quadripartite webinar 10 September 2024
Agenda:1. Overview and introduction to the Tracking Antimicrobial Resistance Country Self-Assessment Survey (TrACSS): Anand Balachandran (WHO)2. Results of the 8th round of TrACSS and relevant trends from the previous seven years by sector:- Zlatina Dobreva (WHO): Multisector results and human health related results - Yohane Soko (WOAH): Animal health related results- Ozge Kara (FAO): Food and […]
who.int
Suicide Prevention in Thailand: A whole-of-society approach 10 September 2024
In recent years, Thailand has seen a concerning rise in suicide rates, with a 32% increase in the suicide mortality rate from 2017 to 2022. The highest rates are observed among older individuals (aged 55 and above) , while teenagers (15-19) have the highest rates of suicide attempts. In 2023, there were 31,402 suicide attempts […]
who.int
Suicide prevention in Suriname: strengthening multisectoral collaboration 9 September 2024
who.int

Race, Gender, and Donor Heart Acceptance—Reply 10 September 2024
In Reply Ms Majeed and colleagues pose important questions regarding our study. First, the COVID-19 pandemic had several possible implications for transplant care. To explore these implications, we reexamined the number of donor heart offers until acceptance as in the original article but censored observations after February 29, 2020, to exclude the COVID-19 period. For […]
The Valediction in Poetry and Medicine 10 September 2024
Valedictions are essential in poetry (from those of Catullus to Donne and, in more recent times, from Seamus Heaney to Adrienne Rich), expressing as much devotion and renewal as they do sorrow and the elegiac. So at this difficult moment of transition in medicine, when many physicians are leaving the profession for a variety of […]
Extent of Drug Patents With Terminal Disclaimers and Obviousness-Type Double Patenting Rejections 10 September 2024
This study evaluates the frequency of terminal disclaimers filed by drug patent holders to obviate obviousness-type double patenting rejections associated with drug patent thickets.

RCP showed bias in handling members’ concerns over physician associates, review finds 10 September 2024
The Royal College of Physicians demonstrated “organisational bias” and was dysfunctional in its handling of members’ concerns over physicians associates, a damning review has found.An independent inquiry by the health think tank the King’s Fund into the events surrounding a “painful” and “shocking” RCP extraordinary general meeting on 13 March 2024 was published on Tuesday […]
Matthew Limb
Limit appointments to ensure safe working, GPs advised 10 September 2024
GPs should extend the length of their appointments to 15 minutes, a move which would likely mean reducing the total number of appointments they offer, the BMA General Practitioners Committee for England (GPCE) has advised.1In updated “safe working” guidance published on 6 September GPCE acknowledged that a reduction in appointments would mean non-urgent patients may […]
Elisabeth Mahase
Changing the narrative on suicide: how can the new government deliver its ambition to save lives? 10 September 2024
A year has passed since the publication of a new national suicide prevention strategy for England.1 In that time, the political landscape has shifted and we now have a new government in place, but national data on deaths by suicide are still showing worrying trends.As outlined in last year’s strategy, welcome progress has been made […]
Ella Fuller

How to best convey continuous outcomes in patient decision aids 10 September 2024
IntroductionThe work of transforming scientific publications into tools that can support people in comparing treatments, tests and other interventions has been driven by efforts to support shared decision-making. The International Patient Decision Aids Standards (IPDAS) Collaboration has published many articles that guide this process. IPDAS, and others in this field, have considered the challenges of […]
Elwyn, G., Durand, M. A., Agoritsas, T., Mayer, M.
Development of a competency framework for health technology assessment in India 5 September 2024
IntroductionHealth technology assessment (HTA) has become a key part of assessing evidence to determine which treatments are funded. Early applications were within the centrally funded health systems of high-income countries. Recent years have seen increased use within low-income and middle-income countries, including India.1–6Increased application of HTAs has required corresponding increases in the systems’ resources that […]
Dixon, S., Tyagi, K., Singh, M., Kar, S. S., Bagepally, B. S., Prinja, S., Booth, A., Carroll, C., Sohail, A., Mehndiratta, A.
Pharmacological interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units: a network meta-analysis 3 September 2024
ObjectivesTo assess the efficacy and safety of pharmacological interventions for preventing upper gastrointestinal (GI) bleeding in people admitted to intensive care units (ICUs).Design and settingSystematic review and frequentist network meta-analysis using standard methodological procedures as recommended by Cochrane for screening of records, data extraction and analysis. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) […]
Toews, I., Hussain, S., Nyirenda, J. L. Z., Willis, M. A., Kantorova, L., Slezakova, S., Boltena, M. T., Peter, J. V., Fontes, L. E. S., Klugar, M., Sadeghirad, B., Meerpohl, J. J.

Deaths in prison 10 September 2024
In this country we do not give a death sentence, but for everyone who has taken their life in prison that is exactly what they got - Mark Saunders, whose son Dean died in HMP & YOI Chelmsford in 2016 Below is a breakdown of deaths in prison in England and Wales by calendar year […]
Inquest
Deaths in police custody 10 September 2024
To date there have been 1900 deaths in police custody or otherwise following contact with the police in England & Wales since 1990 Below is a breakdown of deaths in police custody or following other forms of contact with the police, as well as vehicular pursuits and road traffic incidents (RTIs) since 1990, by calendar […]
Inquest
Podcast 6 September 2024
Unlawful Killing: Death, resistance and the fight for justice. Listen now!
Inquest