Evidence
Neurol Clin Pract. 2024 Dec;14(6):e200361. doi: 10.1212/CPJ.0000000000200361. Epub 2024 Aug 30.
ABSTRACT
BACKGROUND: Approximately 6.9 million American individuals have Alzheimer dementia and 50% have mild disease. Lecanemab, an approved antiamyloid antibody, is associated with modest reduction in functional decline in patients with mild dementia or mild cognitive impairment. In Clarity-AD, 239 (26.6%) of patients experienced amyloid-related imaging abnormalities (ARIAs) overall (i.e., ARIAs associated with hemorrhages or edema). The complexity of treatment and risks of adverse events necessitate a multidisciplinary collaborative approach.
RECENT FINDINGS: With limited treatment options, lecanemab approval generated significant interest among clinicians, patients, and families. Lecanemab treatment requires biweekly infusions along with ongoing imaging tests, laboratory monitoring, patient assessment, drug interaction screening, and cognitive function monitoring. Processes to support patient selection, access, and safety are important given the monitoring requirements and total cost of care.
IMPLICATIONS FOR PRACTICE: The planning process for lecanemab can serve as a blueprint to support safe and effective management of therapeutic innovation in neurology and other areas.
PMID:39229480 | PMC:PMC11368232 | DOI:10.1212/CPJ.0000000000200361
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Lecanemab Planning: Blueprint for Safe and Effective Management of Complex Therapies
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome
- Development of disease-modifying therapies against Alzheimer's disease
- A Framework for Best Practices and Readiness in the Advent of Anti-Amyloid Therapy for Early Alzheimer's Disease in Asia
- Role of Neurologists in Dementia Practice
- Amyloid-related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid-modifying therapy
- Predicting Cognitive Decline in Amyloid-Positive Patients With Mild Cognitive Impairment or Mild Dementia
- Alzheimer's disease and its treatment-yesterday, today, and tomorrow
- Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias
- The Black Book of Psychotropic Dosing and Monitoring
- Characterizing the clinical heterogeneity of early symptomatic Alzheimer's disease: a data-driven machine learning approach
- Characterizing the clinical heterogeneity of early symptomatic Alzheimer's disease: a data-driven machine learning approach
- Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
- Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
- Fractional Anisotropy is a More Sensitive Diagnostic Biomarker Than Mean Kurtosis for Patients with Parkinson Disease with Cognitive Dysfunction: A Diffusional Kurtosis Map Tract-Based Spatial Statistics Study
- Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
- Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
- Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
- Caregivers' and Health Care Providers' Cultural Perceptions of and Experiences With Latino Patients With Dementia
- Outcomes of Patients With Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease at 3 and 5 Years After Diagnosis
- Vegetable-first eating habits are associated with a reduced risk of mild cognitive impairment in elderly diabetic patients
- Association of Seizure Control With Cognition in People With Normal Cognition and Mild Cognitive Impairment
- Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease
- The Health and Economic Burden of Ozone Pollution on Alzheimer's Disease and Mild Cognitive Impairment in China
- Management of older adults with diabetes mellitus: Perspective from geriatric medicine
- Association of the Area Deprivation Index With Dementia Basic Workup and Diagnosis in Central and Western Virginia: A Cross-Sectional Study
- Neuropsychological and neuroanatomical underpinnings of the face pareidolia errors on the noise pareidolia test in patients with mild cognitive impairment and dementia due to Lewy bodies
- Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease
- Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease
- The Alzheimer's Disease Neuroimaging Initiative Clinical Core
- Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns
- Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns
- Association of Heart Failure With Cognitive Decline and Development of Mild Cognitive Impairment and Dementia
- Differences between Alzheimer's disease and mild cognitive impairment using brain networks from magnetic resonance texture analysis
- Lecanemab: Benefits of Alzheimer's drug are "just too small" to justify cost, says NICE
- APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy
- Diabetes accelerates Alzheimer's disease progression in the first year post mild cognitive impairment diagnosis
- Genetic biomarkers of cognitive impairment and dementia of potential interest in CKD patients
- The Associations of Sensory Impairment With 10-Year Risk of Dementia and Alzheimer's Disease: The Health and Retirement Study, 2010-2020
- Correction: Updated safety results from phase 3 lecanemab study in early Alzheimer's disease
- Differences in cognitive trajectories of dementia: Comparison Alzheimer's disease dementia and Dementia with Lewy bodies in Korean patient cohort
- Eligibility for antiamyloid treatment: preparing for disease-modifying therapies for Alzheimer's disease
- Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis
- Specific and cumulative infection burden and mild cognitive impairment and dementia: A population-based study
- Specific and cumulative infection burden and mild cognitive impairment and dementia: A population-based study
- Altered brain connectivity in mild cognitive impairment is linked to elevated tau and phosphorylated tau, but not to GAP-43 and Amyloid-β measurements: a resting-state fMRI study
- Repurposing antidiabetic drugs for Alzheimer's disease: A review of preclinical and clinical evidence and overcoming challenges
- Implications of treatment duration and frequency for value and cost-effective price of Alzheimer treatments
- Lecanemab: European drug agency rejects Alzheimer's drug amid debate over efficacy and safety
- Adverse effects of methylphenidate for apathy in patients with Alzheimer's disease (ADMET2 trial)
- Correlates of Mild Behavioral Impairment in Older Adults: Protocol for a Scoping Review
- Correlates of Mild Behavioral Impairment in Older Adults: Protocol for a Scoping Review
- Speech-related parameters are sensitive measures of acetylcholinesterase inhibitor therapy in mild Alzheimer's disease
- Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome
- Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome
- Examining the Stability and Predictive Utility of Across- and Within-Domain Intra-Individual Variability in Mild Cognitive Impairment
- Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome
- Efficacy and safety of butylphthalide in patients with mild cognitive impairment: a multicentre, randomised, double-blind, placebo-controlled trial (EBMCI study)
- Cognitive impairment in children and adults with cerebrotendinous xanthomatosis: A French cohort study
- Psychological well-being trajectories preceding incident mild cognitive impairment and dementia
- Tau pathology mediate the plasma biomarkers and cognitive function in patients with mild cognitive impairment
- Dose-response relationship between computerized cognitive training and cognitive improvement
- Treatment of Aggressive Behavior and Agitation in an 11-Year-Old Boy with Co-Occurring Autism and ADHD: A Case Report and Literature Review on the Use of Intravenous Valproate in Emergency Psychiatry
- Acute Kidney Injury and Its Association With Dementia and Specific Dementia Types: Findings From a Population-Based Study in Sweden
- Visual search for real-world scenes in patients with Alzheimer's disease and amnestic mild cognitive impairment
Evidence Blueprint
Lecanemab Planning: Blueprint for Safe and Effective Management of Complex Therapies
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Lecanemab Planning: Blueprint for Safe and Effective Management of Complex Therapies
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease
- Lecanemab Questions
- Updated safety results from phase 3 lecanemab study in early Alzheimer's disease
- The efficacy and safety of lecanemab 10 mg/kg biweekly compared to a placebo in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials
- Comparative efficacy, tolerability and acceptability of donanemab, lecanemab, aducanumab and lithium on cognitive function in mild cognitive impairment and Alzheimer's disease: a systematic review and network meta-analysis
- Lecanemab blocks the effects of the Ab/fibrinogen complex on blood clots and synapse toxicity in organotypic culture
- Proportion of Community-Dwelling Individuals Older Than 70 Years Eligible for Lecanemab Initiation: The Gothenburg H70 Birth Cohort Study
- Proportion of Community-Dwelling Individuals Older Than 70 Years Eligible for Lecanemab Initiation: The Gothenburg H70 Birth Cohort Study
- Apolipoprotein E Genetic Testing in a New Age of Alzheimer Disease Clinical Practice
- Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome
- Development of disease-modifying therapies against Alzheimer's disease
- A Framework for Best Practices and Readiness in the Advent of Anti-Amyloid Therapy for Early Alzheimer's Disease in Asia
- Role of Neurologists in Dementia Practice
- Amyloid-related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid-modifying therapy
- Guidelines for pharmacotherapy in Alzheimer's disease - A primer on FDA-approved drugs
- Predicting Cognitive Decline in Amyloid-Positive Patients With Mild Cognitive Impairment or Mild Dementia
- Alzheimer's disease and its treatment-yesterday, today, and tomorrow
- Estimating demand for potential disease-modifying therapies for Alzheimer's disease in the UK
- Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
- Bayesian meta-analysis of phase 3 results of aducanumab, lecanemab, donanemab, and high-dose gantenerumab in prodromal and mild Alzheimer's disease
- Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias
- Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
- Alzheimer's Drugs APPlication for Down syndrome?
- Prevalence of mild behavioural impairment and its association with cognitive and functional impairment in normal cognition, mild cognitive impairment, and mild Alzheimer's dementia
- How promising are the latest monoclonal antibodies targeting amyloid-β for the treatment of early Alzheimer's disease?
- The Black Book of Psychotropic Dosing and Monitoring
- Diagnosis of Alzheimer's dementia and vehicle driving restriction: a scoping review
- Characterizing the clinical heterogeneity of early symptomatic Alzheimer's disease: a data-driven machine learning approach
- The network structure of cognitive impairment: from Subjective Cognitive Decline to Alzheimer's Disease
- Passive immunotherapy for Alzheimer's disease: challenges & future directions
- A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the 'What', 'How', 'To Whom', and 'How Much' Questions
- A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the 'What', 'How', 'To Whom', and 'How Much' Questions
- Characterizing the clinical heterogeneity of early symptomatic Alzheimer's disease: a data-driven machine learning approach
- Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology
- Comorbidities associated with symptoms of subjective cognitive decline in individuals aged 45-64
- Comparison of Quantitative Hippocampal Volumes and Structured Scoring Scales in Predicting Alzheimer Disease Diagnosis
- Mild Cognitive Impairment Progression and Alzheimer's Disease Risk: A Comprehensive Analysis of 3553 Cases over 203 Months
- Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
- Use of Complementary and Integrative Medicine for Alzheimer's Disease and Cognitive Decline
- Alzheimer's Disease: The Past, Present, and Future of a Globally Progressive Disease
- Elevated Mortality Rate in Patients With Functional Seizures After Diagnosis and Referral
- Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
- Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
- Fractional Anisotropy is a More Sensitive Diagnostic Biomarker Than Mean Kurtosis for Patients with Parkinson Disease with Cognitive Dysfunction: A Diffusional Kurtosis Map Tract-Based Spatial Statistics Study
- Predicting functional decline in aging and Alzheimer's disease with PET-based Braak staging
- Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
- Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
- Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks
- Tau accumulation and its spatial progression across the Alzheimer's disease spectrum
- Impact of incidental synucleinopathy in mild cognitive impairment due to Alzheimer disease
- Caregivers' and Health Care Providers' Cultural Perceptions of and Experiences With Latino Patients With Dementia
- Outcomes of Patients With Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease at 3 and 5 Years After Diagnosis
- Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis
- Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial
- Vegetable-first eating habits are associated with a reduced risk of mild cognitive impairment in elderly diabetic patients
- Association of Seizure Control With Cognition in People With Normal Cognition and Mild Cognitive Impairment
- Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease
- Hypertension and mild cognitive impairment: state-of-the-art review
- Commentary on: physical activity and exercise for mild cognitive impairment and dementia: a collaborative international guideline
- Recent Advances in Fluorescent Theranostics for Alzheimer's Disease: A Comprehensive Survey on Design, Synthesis, and Properties
- The Health and Economic Burden of Ozone Pollution on Alzheimer's Disease and Mild Cognitive Impairment in China
- The Effects of a Nonpharmacological Intervention Practice for Older Adults with Mild Cognitive Impairment and Their Family Caregivers in China
- Management of older adults with diabetes mellitus: Perspective from geriatric medicine
- Association of the Area Deprivation Index With Dementia Basic Workup and Diagnosis in Central and Western Virginia: A Cross-Sectional Study