Evidence
Sci Rep. 2023 Aug 22;13(1):13706. doi: 10.1038/s41598-023-40838-7.
ABSTRACT
While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR.
PMID:37607967 | DOI:10.1038/s41598-023-40838-7
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Lipidomic signature of stroke recurrence after transient ischemic attack
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Subtype-Specific Association of Mitochondrial DNA Copy Number With Poststroke/TIA Outcomes in 10 241 Patients in China
- Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer's Disease Neuroimaging Initiative cohort
- Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study
- Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial
- Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial
- Timing of oral anticoagulants initiation for atrial fibrillation after acute ischemic stroke: A systematic review and meta-analysis
- Circulating Chemokines and Short- and Long-Term Outcomes After Ischemic Stroke
- Secondary stroke prevention in people with atrial fibrillation: treatments and trials
- Risk of Recurrent Stroke and Mortality Among Black and White Patients With Poststroke Depression
- Total Tau Protein Mediates the Association of Ischemic Cerebrovascular Disease with Cognitive Decline
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Biomarker profiling to determine clinical impact of microRNAs in cognitive disorders
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
- Embolic Stroke of Undetermined Source: New Data and New Controversies on Cardiac Monitoring and Anticoagulation
- A comprehensive review for artificial intelligence on neuroimaging in rehabilitation of ischemic stroke
- Adaptive Metabolic Responses Facilitate Blood-Brain Barrier Repair in Ischemic Stroke via BHB-Mediated Epigenetic Modification of ZO-1 Expression
- Type 1 Myocardial Infarction in Patients With Acute Ischemic Stroke
- Service delivery in acute ischemic stroke patients: Does sex matter?
- Comparison of vascular risk profile and clinical outcomes among patients with central (branch) retinal artery occlusion versus amaurosis fugax
- Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study
- Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke: current evidence and future perspectives
- Predicting ischemic stroke patients' prognosis changes using machine learning in a nationwide stroke registry
- Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research
- Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE
- Lipidomic Analysis of Liver and Adipose Tissue in a High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice Model Reveals Alterations in Lipid Metabolism by Weight Loss and Aerobic Exercise
- Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC
- Patent Foramen Ovale Closure in Older Patients With Stroke: Patient Selection for Trial Feasibility
- Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes
- Small-vessel disease in the brain
- Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
- Exploring shared molecular signatures and regulatory mechanisms in nonalcoholic steatohepatitis and inflammatory bowel disease using integrative bioinformatics analysis
- Contrast Staining in Noninfarcted Tissue after Endovascular Treatment of Acute Ischemic Stroke
- Remote Ischemic Conditioning in Stroke Recovery
- Validation of the de Morton mobility index (DEMMI) among acute stroke patients aged ≥65 years: a register study
- Dysphagia after stroke: research advances in treatment interventions
- Early Rhythm Control and Incident Dementia in Patients With Atrial Fibrillation and Prior Stroke
- Stroke and Transient Ischemic Attack
- Relationship Between Carotid Web Morphology on CT Angiography and Stroke: A Pooled Multicenter Analysis
- The volume of steal phenomenon is associated with neurological deterioration in patients with large-vessel occlusion minor stroke not eligible for thrombectomy
- Incidence and Influencing Factors of Anxiety and Depression in Individuals with Acute Ischemic Stroke: A Retrospective Study
- Non-adaptive cognitive emotion regulation mediates the relationship between disease uncertainty and acute stress disorder in patients with ischaemic stroke
- A review of methamphetamine use and stroke in the young
- Prestroke Cognitive Impairment: Frequency and Association With Premorbid Neuropsychiatric, Functional, and Neuroimaging Features
- Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation
- Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions
- Time From Hospital Arrival Until Endovascular Thrombectomy and Patient-Reported Outcomes in Acute Ischemic Stroke
- Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial
- Interrupting Effect of Social Distancing on Ischemic Heart Disease, Asthma, Stroke, and Suicide Attempt Patients by PM(2.5) Exposure
- Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults
- A promising frontier: targeting NETs for stroke treatment breakthroughs
- Diagnostic test accuracy of assessment tools for detecting delirium in patients with acute stroke: commentary of a systematic review
- Hemodynamic Stroke: Emerging Concepts, Risk Estimation, and Treatment
- Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
- A Systematic Review and Meta-Analysis on the Identification of Predictors Associated With Insomnia or Sleep Disturbance in Post-stroke Patients
- Our experience with blast and gunshot induced traumatic vascular injuries at Somalia's major vascular referral center
- Our experience with blast and gunshot induced traumatic vascular injuries at Somalia's major vascular referral center
- Interaction between central nervous system and immune system after ischemic stroke and its therapeutic significance of traditional Chinese medicine
- Robust Ensemble of Two Different Multimodal Approaches to Segment 3D Ischemic Stroke Segmentation Using Brain Tumor Representation Among Multiple Center Datasets
- Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core
- Proteome-wide Mendelian randomization identifies potential therapeutic targets for nonalcoholic fatty liver diseases
- The Burden of Stroke in Neonates Undergoing Congenital Heart Surgery: A Large Multicenter Analysis
- A Deep Auto-Optimized Collaborative Learning (DACL) model for disease prognosis using AI-IoMT systems
Evidence Blueprint
Lipidomic signature of stroke recurrence after transient ischemic attack
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Lipidomic signature of stroke recurrence after transient ischemic attack
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Subtype-Specific Association of Mitochondrial DNA Copy Number With Poststroke/TIA Outcomes in 10 241 Patients in China
- The relationship of small vessel disease burden on cerebral and regional brain atrophy rates and cognitive performance over one year of follow-up after transient ischemic attack
- Rapid outpatient transient ischemic attack clinic and stroke service activity during the SARS-CoV-2 pandemic: a multicenter time series analysis
- Posttraumatic Stress Disorder Is Associated With Elevated Risk of Incident Stroke and Transient Ischemic Attack in Women Veterans
- Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA
- Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer's Disease Neuroimaging Initiative cohort
- One-Year Outcomes of Early Therapy With Ticagrelor vs Clopidogrel in CYP2C19 Loss-of-Function Carriers With Stroke or TIA Trial
- Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study
- Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial
- Clinical Features and Voxel-Based-Symptom-Lesion Mapping of Silent Aspiration in Acute Infratentorial Stroke
- Early histopathological changes of secondary degeneration in the spinal cord after total MCA territory stroke
- Screening for health-related quality of life and its determinants in Fabry disease: A cross-sectional multicenter study
- Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial
- Pre-stroke and early post-stroke apathy is associated with increased risk of dementia 3 months after stroke
- Do stroke services still show sex differences? A multicenter study
- Timing of oral anticoagulants initiation for atrial fibrillation after acute ischemic stroke: A systematic review and meta-analysis
- Circulating Chemokines and Short- and Long-Term Outcomes After Ischemic Stroke
- Pericyte Microvesicles as Plasma Biomarkers Reflecting Brain Microvascular Signaling in Patients With Acute Ischemic Stroke
- Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study
- Stroke analysis and recognition in functional near-infrared spectroscopy signals using machine learning methods
- Current practice and attitudes of stroke physicians towards rhythm-control therapy for stroke prevention: results of an international survey
- Evaluation of the functional outcome and mobility of patients after stroke depending on their cognitive state
- Drivers of Chronic Pathology Following Ischemic Stroke: A Descriptive Review
- Development and validation of a machine learning-based prognostic risk stratification model for acute ischemic stroke
- Secondary stroke prevention in people with atrial fibrillation: treatments and trials
- Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage
- Risk of Recurrent Stroke and Mortality Among Black and White Patients With Poststroke Depression
- Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine non-alcoholic steatohepatitis
- Association between cardiovascular diseases and dementia among various age groups: a population-based cohort study in older adults
- Autism Spectrum Disorder in Children With Perinatal Ischemic Stroke Varies by Stroke Type
- CA-UNet Segmentation Makes a Good Ischemic Stroke Risk Prediction
- Total Tau Protein Mediates the Association of Ischemic Cerebrovascular Disease with Cognitive Decline
- Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Biomarker profiling to determine clinical impact of microRNAs in cognitive disorders
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
- Embolic Stroke of Undetermined Source: New Data and New Controversies on Cardiac Monitoring and Anticoagulation
- Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study
- Chagas disease stroke and associated risk factors: A case-control study
- A comprehensive review for artificial intelligence on neuroimaging in rehabilitation of ischemic stroke
- Vagus Nerve Stimulation in Ischemic Stroke
- Hybrid surgery can improve neurocognitive function in patients with internal carotid artery occlusion
- Comparing the contribution of each clinical indicator in predictive models trained on 980 subacute stroke patients: a retrospective study
- Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke
- Predicting new-onset post-stroke depression from real-world data using machine learning algorithm
- A new insight into the role of pericytes in ischemic stroke
- Adaptive Metabolic Responses Facilitate Blood-Brain Barrier Repair in Ischemic Stroke via BHB-Mediated Epigenetic Modification of ZO-1 Expression
- Incidence and influencing factors of post-stroke cognitive impairment in convalescent young patients with first-ever stroke
- Characterizing the profiles of patients with acute concussion versus prolonged post-concussion symptoms in Ontario
- Type 1 Myocardial Infarction in Patients With Acute Ischemic Stroke
- Distinct changes in serum metabolites and lipid species in the onset and progression of NAFLD in Obese Chinese
- Comparative transcriptome findings reveal the neuroinflammatory network and potential biomarkers to early detection of ischemic stroke
- Transient Middle Cerebral Artery Occlusion Model of Stroke
- Does ICU admission dysphagia independently contribute to delirium risk in ischemic stroke patients? Results from a cohort study
- Association between dysphagia and symptoms of depression and anxiety after ischemic stroke
- Association between dysphagia and symptoms of depression and anxiety after ischemic stroke
- Anticoagulation in acute ischemic stroke patients with mechanical heart valves: To bridge or not with heparin. The ESTREM study
- M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH
- Service delivery in acute ischemic stroke patients: Does sex matter?
- Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study
- Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study
- Comparison of vascular risk profile and clinical outcomes among patients with central (branch) retinal artery occlusion versus amaurosis fugax