Evidence
Sci Rep. 2023 Aug 22;13(1):13706. doi: 10.1038/s41598-023-40838-7.
ABSTRACT
While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR.
PMID:37607967 | DOI:10.1038/s41598-023-40838-7
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Lipidomic signature of stroke recurrence after transient ischemic attack
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial
- Determinants of adherence to post-stroke/transient ischemic attack secondary prevention medications: A cohort study
- Association between Serum Vitamin D Level and Acute Ischemic Stroke
- Stroke in a Young Patient Due to Moyamoya Disease
- Carotid atherosclerotic plaque microcalcification is independently associated with recurrent neurovascular events: a pilot study
- Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial
- Timing of oral anticoagulants initiation for atrial fibrillation after acute ischemic stroke: A systematic review and meta-analysis
- Circulating Chemokines and Short- and Long-Term Outcomes After Ischemic Stroke
- Stroke and Stroke-Like Episodes: Recurrent Manifestations in GLUT1 Deficiency Syndrome
- Stroke Risk After Emergency Department Treat-and-Release Visit for a Fall
- Circulating levels of neurofilament light chain as a biomarker of infarct and white matter hyperintensity volumes after ischemic stroke
- Altered Intrinsic Brain Activity in Ischemic Stroke Patients Assessed Using the Percent Amplitude of a Fluctuation Method
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
- Embolic Stroke of Undetermined Source: New Data and New Controversies on Cardiac Monitoring and Anticoagulation
- Adaptive Metabolic Responses Facilitate Blood-Brain Barrier Repair in Ischemic Stroke via BHB-Mediated Epigenetic Modification of ZO-1 Expression
- Type 1 Myocardial Infarction in Patients With Acute Ischemic Stroke
- Comparison of vascular risk profile and clinical outcomes among patients with central (branch) retinal artery occlusion versus amaurosis fugax
- Establishing the distribution of cerebrovascular resistance using computational fluid dynamics and 4D flow MRI
- Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke: current evidence and future perspectives
- Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research
- Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE
- Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC
- Patent Foramen Ovale Closure in Older Patients With Stroke: Patient Selection for Trial Feasibility
- Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
- Contrast Staining in Noninfarcted Tissue after Endovascular Treatment of Acute Ischemic Stroke
- Latent class analysis and longitudinal development trajectory study of psychological distress in patients with stroke: a study protocol
- Stroke and Transient Ischemic Attack
- Early Rhythm Control and Incident Dementia in Patients With Atrial Fibrillation and Prior Stroke
- Relationship Between Carotid Web Morphology on CT Angiography and Stroke: A Pooled Multicenter Analysis
- Incidence and Influencing Factors of Anxiety and Depression in Individuals with Acute Ischemic Stroke: A Retrospective Study
- The volume of steal phenomenon is associated with neurological deterioration in patients with large-vessel occlusion minor stroke not eligible for thrombectomy
- A review of methamphetamine use and stroke in the young
- Prestroke Cognitive Impairment: Frequency and Association With Premorbid Neuropsychiatric, Functional, and Neuroimaging Features
- Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions
- Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis
- Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis
- Time From Hospital Arrival Until Endovascular Thrombectomy and Patient-Reported Outcomes in Acute Ischemic Stroke
- Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial
- Metabolic Dysfunction-Associated Steatotic Liver Disease in Severe Obesity and Concordance Between Invasive (Biopsy) and Non-Invasive (OWLiver®) Diagnoses
- Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
- Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
- Ultra-early navigated transcranial magnetic stimulation for perioperative stroke: anatomo-functional report
- Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults
- Interrupting Effect of Social Distancing on Ischemic Heart Disease, Asthma, Stroke, and Suicide Attempt Patients by PM(2.5) Exposure
- Usefulness of Mirogabalin in Central Neuropathic Pain After Stroke: Post Hoc Analysis of a Phase 3 Study by Stroke Type and Location
- An exploratory study on lipidomic profiles in a cohort of individuals with posttraumatic stress disorder
- Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes
- A promising frontier: targeting NETs for stroke treatment breakthroughs
- Evaluating psychological distress associated with life events under the traumatic experience threshold in patients with major depressive and bipolar disorder
- Diagnostic test accuracy of assessment tools for detecting delirium in patients with acute stroke: commentary of a systematic review
- Hemodynamic Stroke: Emerging Concepts, Risk Estimation, and Treatment
- A Systematic Review and Meta-Analysis on the Identification of Predictors Associated With Insomnia or Sleep Disturbance in Post-stroke Patients
- Robust Ensemble of Two Different Multimodal Approaches to Segment 3D Ischemic Stroke Segmentation Using Brain Tumor Representation Among Multiple Center Datasets
- Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core
- The Burden of Stroke in Neonates Undergoing Congenital Heart Surgery: A Large Multicenter Analysis
- Exploring shared molecular signatures and regulatory mechanisms in nonalcoholic steatohepatitis and inflammatory bowel disease using integrative bioinformatics analysis
- Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial
- Understanding the family burden and caregiver role in stroke rehabilitation: insights from a retrospective study
- Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis
- Non-alcoholic fatty liver disease increases the risk of biochemical recurrence in high-grade metastatic prostate cancer patients
- Outcomes and Recurrence Rate of Esophageal Varices after Endoscopic Treatment in Patients with Alcoholic Cirrhosis and Viral Cirrhosis
- A Rare Case of Stroke in a 76-Year-Old Woman: Left Atrial Papillary Fibroelastoma as the Culprit
- Analysis of the lipidomic profile of vegetable oils and animal fats and changes during aging by UPLC-Q-exactive orbitrap mass spectrometry
Evidence Blueprint
Lipidomic signature of stroke recurrence after transient ischemic attack
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Lipidomic signature of stroke recurrence after transient ischemic attack
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Subtype-Specific Association of Mitochondrial DNA Copy Number With Poststroke/TIA Outcomes in 10 241 Patients in China
- The relationship of small vessel disease burden on cerebral and regional brain atrophy rates and cognitive performance over one year of follow-up after transient ischemic attack
- Rapid outpatient transient ischemic attack clinic and stroke service activity during the SARS-CoV-2 pandemic: a multicenter time series analysis
- Posttraumatic Stress Disorder Is Associated With Elevated Risk of Incident Stroke and Transient Ischemic Attack in Women Veterans
- Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA
- One-Year Outcomes of Early Therapy With Ticagrelor vs Clopidogrel in CYP2C19 Loss-of-Function Carriers With Stroke or TIA Trial
- Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study
- Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial
- Determinants of adherence to post-stroke/transient ischemic attack secondary prevention medications: A cohort study
- Association between Serum Vitamin D Level and Acute Ischemic Stroke
- Stroke in a Young Patient Due to Moyamoya Disease
- Carotid atherosclerotic plaque microcalcification is independently associated with recurrent neurovascular events: a pilot study
- Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer's Disease Neuroimaging Initiative cohort
- Clinical Features and Voxel-Based-Symptom-Lesion Mapping of Silent Aspiration in Acute Infratentorial Stroke
- Screening for health-related quality of life and its determinants in Fabry disease: A cross-sectional multicenter study
- Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial
- Pre-stroke and early post-stroke apathy is associated with increased risk of dementia 3 months after stroke
- Timing of oral anticoagulants initiation for atrial fibrillation after acute ischemic stroke: A systematic review and meta-analysis
- Circulating Chemokines and Short- and Long-Term Outcomes After Ischemic Stroke
- Pericyte Microvesicles as Plasma Biomarkers Reflecting Brain Microvascular Signaling in Patients With Acute Ischemic Stroke
- Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study
- Stroke analysis and recognition in functional near-infrared spectroscopy signals using machine learning methods
- Do stroke services still show sex differences? A multicenter study
- Stroke and Stroke-Like Episodes: Recurrent Manifestations in GLUT1 Deficiency Syndrome
- Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine non-alcoholic steatohepatitis
- Secondary stroke prevention in people with atrial fibrillation: treatments and trials
- Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage
- Risk of Recurrent Stroke and Mortality Among Black and White Patients With Poststroke Depression
- Stroke Risk After Emergency Department Treat-and-Release Visit for a Fall
- Circulating levels of neurofilament light chain as a biomarker of infarct and white matter hyperintensity volumes after ischemic stroke
- Early histopathological changes of secondary degeneration in the spinal cord after total MCA territory stroke
- Autism Spectrum Disorder in Children With Perinatal Ischemic Stroke Varies by Stroke Type
- Altered Intrinsic Brain Activity in Ischemic Stroke Patients Assessed Using the Percent Amplitude of a Fluctuation Method
- Total Tau Protein Mediates the Association of Ischemic Cerebrovascular Disease with Cognitive Decline
- Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis
- Drivers of Chronic Pathology Following Ischemic Stroke: A Descriptive Review
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
- Embolic Stroke of Undetermined Source: New Data and New Controversies on Cardiac Monitoring and Anticoagulation
- Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study
- Chagas disease stroke and associated risk factors: A case-control study
- A comprehensive review for artificial intelligence on neuroimaging in rehabilitation of ischemic stroke
- Adaptive Metabolic Responses Facilitate Blood-Brain Barrier Repair in Ischemic Stroke via BHB-Mediated Epigenetic Modification of ZO-1 Expression
- Incidence and influencing factors of post-stroke cognitive impairment in convalescent young patients with first-ever stroke
- Distinct changes in serum metabolites and lipid species in the onset and progression of NAFLD in Obese Chinese
- CA-UNet Segmentation Makes a Good Ischemic Stroke Risk Prediction
- Transient Middle Cerebral Artery Occlusion Model of Stroke
- Type 1 Myocardial Infarction in Patients With Acute Ischemic Stroke
- Does ICU admission dysphagia independently contribute to delirium risk in ischemic stroke patients? Results from a cohort study
- Association between dysphagia and symptoms of depression and anxiety after ischemic stroke
- Association between dysphagia and symptoms of depression and anxiety after ischemic stroke
- M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH
- Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study
- Service delivery in acute ischemic stroke patients: Does sex matter?
- Evaluation of the functional outcome and mobility of patients after stroke depending on their cognitive state
- Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study
- Symptomatic Carotid Atheroma Inflammation Lumen-stenosis score compared with Oxford and Essen risk scores to predict recurrent stroke in symptomatic carotid stenosis
- Comparison of vascular risk profile and clinical outcomes among patients with central (branch) retinal artery occlusion versus amaurosis fugax
- Depression and anxiety in acute ischemic stroke involving the anterior but not paramedian or inferolateral thalamus
- Establishing the distribution of cerebrovascular resistance using computational fluid dynamics and 4D flow MRI
- Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study
- Vagus Nerve Stimulation in Ischemic Stroke