Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Alzheimers Res Ther. 2024 Jul 5;16(1):152. doi: 10.1186/s13195-024-01501-z.
ABSTRACT
Alzheimer’s Disease (AD) is characterized by structural and functional dysfunction involving the Default Mode Network (DMN), for which the Precuneus (PC) is a key node. We proposed a randomized double-blind pilot study to determine neurobiological changes after 24 weeks of PC-rTMS in patients with mild-to-moderate AD. Sixteen patients were randomly assigned to SHAM or PC-rTMS, and received an intensive 2-weeks course with daily rTMS sessions, followed by a maintenance phase in which rTMS has been applied once a week. Before and after the treatment structural and functional MRIs were collected. Our results showed macro- and micro-structural preservation in PC-rTMS compared to SHAM-rTMS group after 24 weeks of treatment, correlated to an increase of functional connectivity (FC) within the PC in the PC-rTMS group. Even if preliminary, these results trigger the possibility of using PC-rTMS to arrest atrophy progression by manipulating distributed network connectivity patterns.
PMID:38970141 | DOI:10.1186/s13195-024-01501-z
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer’s disease patients: a pilot study
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study Effectiveness of Personalized Hippocampal Network-Targeted Stimulation in Alzheimer Disease: A Randomized Clinical Trial Effects of repetitive transcranial magnetic stimulation of the right inferior parietal lobe on the body image perception in anorexia nervosa: A pilot randomized controlled study Early efficacy of rTMS intervention at week 2 predicts subsequent responses at week 24 in schizophrenia in a randomized controlled trial Right Ventrolateral and Left Dorsolateral 10 Hz Transcranial Magnetic Stimulation as an Add-On Treatment for Bipolar I and II Depression: a Double-Blind, Randomised, Three-Arm, Sham-Controlled Study Assessing the effectiveness of high frequency repetitive transcranial magnetic stimulation for post-mastectomy pain in breast cancer patients: A randomized controlled trial Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder Efficacy of MRI-guided rTMS for post-traumatic stress disorder by modulating amygdala activity: study protocol for a randomised controlled trial A Pilot Study of High-Frequency Transcranial Magnetic Stimulation for Bipolar Depression The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis Functional and structural abnormalities of thalamus in individuals at early stage of schizophrenia Functional and structural abnormalities of thalamus in individuals at early stage of schizophrenia Assessing the impact of repetitive transcranial magnetic stimulation on effective connectivity in autism spectrum disorder: An initial exploration using TMS-EEG analysis Altered blood parameters in "major depression" patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study Altered blood parameters in "major depression" patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia The efficacy of low frequency repetitive transcial magnetic stimulation for treating auditory verbal hallucinations in schizophrenia: Insights from functional gradient analyses The efficacy of low frequency repetitive transcial magnetic stimulation for treating auditory verbal hallucinations in schizophrenia: Insights from functional gradient analyses Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial Effect of Acupuncture for Methadone Reduction : A Randomized Clinical Trial Brain stimulation therapeutics Brain stimulation therapeutics Adapted Home-Based Exercises in Dementia: An Exploratory Pre-post Pilot and Feasibility Study Repetitive Transcranial Magnetic Stimulation Improves Hippocampal N-Acetlaspartate Levels and Visual Memory Scores in Alzheimer's Disease Gray matter volume of functionally relevant primary motor cortex is causally related to learning a hand motor task Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn's Disease Characteristics of the Structural Connectivity in Patients with Brain Injury and Chronic Health Symptoms: A Pilot Study Efficacy of repetitive transcranial magnetic stimulation on post-stroke cognitive impairment: A systematic and a network meta-analysis Effects of Low-Level Light Therapy on Resting-State Connectivity Following Moderate Traumatic Brain Injury: Secondary Analyses of a Double-blinded Placebo-controlled Study Effects of Low-Level Light Therapy on Resting-State Connectivity Following Moderate Traumatic Brain Injury: Secondary Analyses of a Double-blinded Placebo-controlled Study Structural and functional imaging features of cognitive phenotypes in pediatric multiple sclerosis Non-pharmacological interventions for improving language and communication in people with primary progressive aphasia Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear Low-frequency repetitive transcranial magnetic stimulation alleviates abnormal behavior in valproic acid rat model of autism through rescuing synaptic plasticity and inhibiting neuroinflammation Neuroimaging and plasma evidence of early white matter loss in Parkinson's disease with poor outcomes Effect of acupuncture for temporomandibular disorders: a randomized clinical trial Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models Repetitive transcranial magnetic stimulation in central post-stroke pain: a meta-analysis and systematic review of randomized controlled trials Changes of brain functional network in Alzheimer's disease and frontotemporal dementia: a graph-theoretic analysis Modulation of dlPFC function and decision-making capacity by repetitive transcranial magnetic stimulation in methamphetamine use disorder Functional connectivity is linked to working memory differences in children with reading learning disability Altered individual gray matter structural covariance networks in early abstinence patients with alcohol dependence Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns EEG coherences of the default mode network among patients comorbid with major depressive disorder and anxiety symptoms NG2-Glia Cause Diabetic Blood-Brain Barrier Disruption by Secreting MMP-9 NG2-Glia Cause Diabetic Blood-Brain Barrier Disruption by Secreting MMP-9 A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer's disease using resting-state functional network connectivity Decreased gray matter volume in the anterior cerebellar of attention deficit/hyperactivity disorder comorbid oppositional defiant disorder children with associated cerebellar-cerebral hyperconnectivity: insights from a combined structural MRI… Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions High-definition transcranial direct current stimulation (HD-tDCS) in major depressive disorder with anxious distress-a study protocol for a double-blinded randomized sham-controlled trial Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies Unstructured Group Support Enhances Compliance to Pharmacological Treatment by Improving Social Cognition in Patients with Bipolar Disorder: A Pilot fMRI Study Spatial and temporal pattern of structure-function coupling of human brain connectome with development
Evidence Blueprint
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer’s disease patients: a pilot study
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer’s disease patients: a pilot study
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study Effectiveness of Personalized Hippocampal Network-Targeted Stimulation in Alzheimer Disease: A Randomized Clinical Trial Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations A preliminary randomized controlled trial of repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex in treatment seeking participants with cannabis use disorder Effects of repetitive transcranial magnetic stimulation of the right inferior parietal lobe on the body image perception in anorexia nervosa: A pilot randomized controlled study Multimodal workflows optimally predict response to repetitive transcranial magnetic stimulation in patients with schizophrenia: a multisite machine learning analysis Early efficacy of rTMS intervention at week 2 predicts subsequent responses at week 24 in schizophrenia in a randomized controlled trial The effect of repetitive transcranial magnetic stimulation on the negative symptoms of chronic schizophrenia and serum brain-derived neurotrophic factor Psychomotor Slowing in Psychosis and Inhibitory Repetitive Transcranial Magnetic Stimulation: A Randomized Clinical Trial Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial Repetitive transcranial magnetic stimulation can improve negative symptoms and/or neurocognitive impairments in the first psychosis episode: A randomized controlled trial Rich-club reorganization of white matter structural network in schizophrenia patients with auditory verbal hallucinations following 1 Hz rTMS treatment Exploring morphological similarity and randomness in Alzheimer's disease using adjacent grey matter voxel-based structural analysis Right Ventrolateral and Left Dorsolateral 10 Hz Transcranial Magnetic Stimulation as an Add-On Treatment for Bipolar I and II Depression: a Double-Blind, Randomised, Three-Arm, Sham-Controlled Study Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sham-controlled trial Lack of effects of eight-week left dorsolateral prefrontal theta burst stimulation on white matter macro/microstructure and connection in autism Predictive role of impulsivity, anxiety, and depression in the efficacy of intermittent theta burst transcranial magnetic stimulation modalities for treating methamphetamine use disorder: A randomized clinical trial The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study Disrupted white matter structural networks in individuals with alcohol dependence Assessing the effectiveness of high frequency repetitive transcranial magnetic stimulation for post-mastectomy pain in breast cancer patients: A randomized controlled trial Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study Active versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial Studying additive effects of combining rTMS with cognitive control training: a pilot investigation Repetitive Transcranial Magnetic Stimulation With and Without Text4Support for the Treatment of Resistant Depression: Protocol for a Patient-Centered Multicenter Randomized Controlled Pilot Trial Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression Accelerated transcranial magnetic stimulation for psychological distress in advanced cancer: A phase 2a feasibility and preliminary efficacy clinical trial Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder Effects of low-Frequency rTMS combined with risperidone on the gut microbiome in Hospitalized Patients with Chronic Schizophrenia Efficacy of MRI-guided rTMS for post-traumatic stress disorder by modulating amygdala activity: study protocol for a randomised controlled trial The acute effects of repetitive transcranial magnetic stimulation on laminar diffusion anisotropy of neocortical gray matter Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks Optimal Frequency in rTMS for the Management of Chronic Pain: A Network Meta-Analysis of Randomized Controlled Trials A randomized controlled trial of repetitive transcranial magnetic stimulation plus donepezil vs donepezil alone for mild to moderate cognitive impairment due to small vessel cerebrovascular disease The role of repetitive transcranial magnetic stimulation therapy in functional bowel disease Efficacy of rTMS combined with cognitive training in TBI with cognition disorder: a systematic review and meta-analysis Triple network connectivity changes in patients with major depressive disorder versus healthy controls via structural network imaging after electroconvulsive therapy treatment Pattern of Compliance and Efficacy of Repetitive Transcranial Magnetic Stimulation Protocol for Treating Major Depressive Disorder Among Treatment Participants and Completers: A Report From Iran Utility of Repetitive Transcranial Magnetic Stimulation for Chronic Daily Headache Prophylaxis: A Systematic Review and Meta-Analysis The Effect of Deep Repetitive Transcranial Magnetic Stimulation with an H1 Coil on Hopelessness in Patients with Major Depressive Disorder: A Randomized Controlled Trial Changes in neuroactive steroids, neurotrophins and immunological biomarkers after monotherapy 8-week rTMS treatment and their relationship with neurocognitive functions in depression Navigated and individual α-peak-frequency-guided transcranial magnetic stimulation in male patients with treatment-refractory schizophrenia Randomised controlled trial of neurostimulation for symptoms of anorexia nervosa (TRENA study): study protocol A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease Neuroticism and openness exhibit an anti-correlation pattern to dissociable default mode network: using resting connectivity and structural equation modeling analysis Subgenual cingulate connectivity as a treatment predictor during low-frequency right dorsolateral prefrontal rTMS: A concurrent TMS-fMRI study A Pilot Study of High-Frequency Transcranial Magnetic Stimulation for Bipolar Depression Electroconvulsive Therapy Versus Repetitive Transcranial Magnetic Stimulation in Patients With a Depressive Episode: A Register-Based Study Deficits in brain default mode network connectivity mediate the relationship between poor sleep quality and anxiety severity Characterizing typhoon-related posttraumatic stress disorder based on multimodal fusion of structural, diffusion, and functional magnetic resonance imaging Structural neuroplasticity effects of singing in chronic aphasia Structural underpinnings and long-term effects of resilience in Parkinson's disease The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis Comparative efficacy of repetitive transcranial magnetic stimulation protocols for obsessive-compulsive disorder: A network meta-analysis The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study Functional and structural abnormalities of thalamus in individuals at early stage of schizophrenia Functional and structural abnormalities of thalamus in individuals at early stage of schizophrenia Exploiting macro- and micro-structural brain changes for improved Parkinson's disease classification from MRI data Effects of family income on brain functional connectivity in US children: associations with cognition An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes: A Hospital-Based Study in Oman Assessing the impact of repetitive transcranial magnetic stimulation on effective connectivity in autism spectrum disorder: An initial exploration using TMS-EEG analysis Repetitive transcranial magnetic stimulation-induced neuroplasticity and the treatment of psychiatric disorders: state of the evidence and future opportunities