Free Neuropathol. 2023 May 8;4:4-8. doi: 10.17879/freeneuropathology-2023-4701. eCollection 2023 Jan.
ABSTRACT
Several advances in the field of neurodevelopmental diseases (NDDs) have been reported by 2022. Of course, NDDs comprise a diverse group of disorders, most of which with different aetiologies. However, owing to the development and consolidation of technological approaches, such as proteomics and RNA-sequencing, and to the improvement of brain organoids along with the introduction of artificial intelligence (AI) for biodata analysis, in 2022 new aetiological mechanisms for some NDDs have been proposed. Here, we present hints of some of these findings. For instance, centrioles regulate neuronal migration and could be behind the aetiology of periventricular heterotopia; also, the accumulation of misfolded proteins could explain the neurological effects in COVID-19 patients; and, autism spectrum disorders (ASD) could be the expression of altered cortical arealization. We also cover other interesting aspects as the description of a new NDD characterized by deregulation of genes involved in stress granule (SG) assemblies, or the description of a newly discovered neural progenitor that explains the different phenotypes of tumours and cortical tubers in tuberous sclerosis complex (TSC) disease; and how it is possible to decipher the aetiology of sudden unexplained death in childhood (SUDC) or improve the diagnosis of cortical malformations using formalin-fixed paraffin-embedded samples.
Childs Nerv Syst. 2024 Jun 21. doi: 10.1007/s00381-024-06493-7. Online ahead of print.ABSTRACTBACKGROUND: Children with metopic synostosis have been found to have more neurocognitive and behavioral...
J Dev Behav Pediatr. 2024 Jun 21. doi: 10.1097/DBP.0000000000001293. Online ahead of print.ABSTRACTOBJECTIVE: Medical providers report barriers that prevent them from discussing sexual health with...
J Sex Res. 2024 Jun 21:1-16. doi: 10.1080/00224499.2024.2365273. Online ahead of print.ABSTRACTAdults entering college, especially autistic individuals, may have a higher likelihood of unwanted or...
PCN Rep. 2024 Jun 18;3(2):e212. doi: 10.1002/pcn5.212. eCollection 2024 Jun.ABSTRACTAIM: Given the escalating prevalence of autism spectrum disorder (ASD), the persistent paucity of child psychiatrists...
PCN Rep. 2024 Jun 18;3(2):e212. doi: 10.1002/pcn5.212. eCollection 2024 Jun.ABSTRACTAIM: Given the escalating prevalence of autism spectrum disorder (ASD), the persistent paucity of child psychiatrists...
Front Psychiatry. 2024 Jun 6;15:1403476. doi: 10.3389/fpsyt.2024.1403476. eCollection 2024.ABSTRACTBACKGROUND: Social isolation during critical periods of development is associated with alterations in behavior and neuronal circuitry....
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