Free Neuropathol. 2021 Jan 12;2:2-1. doi: 10.17879/freeneuropathology-2021-3166. eCollection 2021 Jan.
ABSTRACT
Key requirements for the validity of a neuropathological study are the inclusion of large numbers of biopsy or autopsy cases and proper controls, the rigorous classification of the basic neuropathology and the selection of the most suitable technologies for investigation. Whether the studies are performed with the fanciest, new, and state of the art technology or with rather conventional methodology is of minor importance. Following these criteria, a spectrum of neuropathological studies has been published in 2020, which provides new insights on important questions related to neurological disease. They include the pathological substrate of brain disease in COVID-19 infected patients, the nature of the adaptive and innate inflammatory response, or the type and mechanisms of tissue injury and repair in multiple sclerosis, and diagnostically relevant or mechanistic new insights into antibody-mediated diseases of the central nervous system. Other studies describe in detail the dynamic changes of brain inflammation in patients with trisomy 21 as a disease model for Alzheimer’s disease, or the presence and consequences of vascular comorbidities in a chronic inflammatory disease, such as multiple sclerosis. All these contributions have provided important, highly relevant clues for basic and translational neuroscience.
J Neurooncol. 2024 Jun 21. doi: 10.1007/s11060-024-04744-w. Online ahead of print.ABSTRACTPURPOSE: This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs).METHODS: This...
J Neurooncol. 2024 Jun 21. doi: 10.1007/s11060-024-04744-w. Online ahead of print.ABSTRACTPURPOSE: This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs).METHODS: This...
Front Neurosci. 2024 Jun 5;18:1422912. doi: 10.3389/fnins.2024.1422912. eCollection 2024.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of motor neurons characterized by muscle weakness, muscle...
Ann Rheum Dis. 2024 Jun 20:ard-2024-225773. doi: 10.1136/ard-2024-225773. Online ahead of print.ABSTRACTOBJECTIVES: Autoantibodies targeting intracellular proteins are common in various autoimmune diseases. In the context...
Neurobiol Dis. 2024 Jun 18:106571. doi: 10.1016/j.nbd.2024.106571. Online ahead of print.ABSTRACTLeucine-rich repeat kinase 2 (LRRK2) is the most common gene responsible for familial Parkinson's disease...
Acta Neuropathol Commun. 2024 Jun 21;12(1):101. doi: 10.1186/s40478-024-01817-9.ABSTRACTWithin the past decade, incremental integration of molecular characteristics into the classification of central nervous system neoplasms increasingly...
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