Evidence
J Subst Use. 2024;29(4):487-494. doi: 10.1080/14659891.2023.2202760. Epub 2023 May 10.
ABSTRACT
BACKGROUND AND OBJECTIVE: Cannabis Use Disorder (CUD) has no FDA approved treatment. Serotonin-2c (5HT2c) agonists have preclinical and human laboratory evidence for potential efficacy for CUD. We assessed the tolerability and effects of lorcaserin (5HT2c agonist) on CUD.
METHODS: In a 10-week, open label, uncontrolled trial, the tolerability of lorcaserin was tested in outpatients with CUD. Adverse events (AE) were assessed weekly. Cannabis use was assessed twice weekly by the Timeline follow-back and quantitative urine metabolites.
RESULTS: 17 participants enrolled, and 14 received medication. Participants’ average age was 35 years; majority were male (N=12). The medication was well tolerated in males. There were no serious adverse events (SAE). The most common AE’s were headache/migraine (N=4, all females), anorexia (N=3), and irritability (N=2). Participants decreased their frequency of cannabis use significantly (p < 0.001), adjusted for baseline use. By the end of the trial, participants decreased by 1.76 (SE=0.47) cannabis using days/week. Average daily amount of cannabis and urine THC metabolite levels did not change significantly.
CONCLUSIONS: Lorcaserin was well tolerated in males but not females suggesting possible sex differences. Future trials of other 5HT2c agonists (lorcaserin was withdrawn at the request of the FDA) should consider longer dose titration phases.
TRIAL REGISTRATION: NCT02932215.
PMID:39021751 | PMC:PMC11250997 | DOI:10.1080/14659891.2023.2202760
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Open Label Pilot of Lorcaserin (a serotonin 2C-receptor agonist) for Cannabis Use Disorder
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- The Indirect Influence of Cannabis Use Disorder Symptoms on PTSD Symptom Severity Through Psychological Inflexibility
- Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients With Schizophrenia and Cannabis Use Disorder
- The role of sleep in the link between cannabis use and memory function: evidence from a cross-sectional study
- Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California
- Exposure to maternal cannabis use disorder and risk of autism spectrum disorder in offspring: A data linkage cohort study
- "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression
- The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats
- Disrupted dynamic brain functional connectivity in male cocaine use disorder: Hyperconnectivity, strongly-connected state tendency, and links to impulsivity and borderline traits
- Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI
- Cannabis use and its association with psychopathological symptoms in a Swiss adult population: a cross-sectional analysis
- Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans
- Virtual reality cue-exposure therapy in reducing cocaine craving: the Promoting Innovative COgnitive behavioral therapy for Cocaine use disorder (PICOC) study protocol for a randomized controlled trial
- Trends in cannabis use in New Jersey: Effects of COVID-19 and cannabis legalization
- Effects of self- and experimenter-administered cocaine on subsequent ethanol drinking in rhesus monkeys
- Acute Cannabis Administration Transiently Reduces Mitochondrial DNA in Young Adults: Findings from a Secondary Analysis of a Double-Blind, Placebo-Controlled, Randomized Clinical Trial
- Acute Cannabis Administration Transiently Reduces Mitochondrial DNA in Young Adults: Findings from a Secondary Analysis of a Double-Blind, Placebo-Controlled, Randomized Clinical Trial
- Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
- Changes in modes of cannabis consumption pre- and post-legalization and their correlates among adults in Ontario, Canada: 2017-2022
- Trofinetide for the treatment of Rett syndrome: Results from the open-label extension LILAC study
- Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis
- Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis
- Simultaneous cannabis and psychedelic use among festival and concert attendees in Colorado: characterizing enhancement and adverse reactions using mixed methods
- The effect of cannabis edibles on driving and blood THC
- Three-Year Outcomes of 6-Month Paliperidone Palmitate in Adults With Schizophrenia: An Open-Label Extension Study of a Randomized Clinical Trial
- Home-based transcranial direct current stimulation in bipolar depression: an open-label treatment study of clinical outcomes, acceptability and adverse events
- Measuring Cannabis Reinforcement among Young Adults: A Mixed Methods Examination
- Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal
- Shifts in Motivation to Seek Substance Use Disorder Treatment in Adolescents, Emerging Adults, and Older Adults
- The safety, immunogenicity, and efficacy of heterologous boosting with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: a randomized, open-label, active-controlled phase 3 trial
- Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1
- Electroconvulsive therapy for the acute management of severe agitation in dementia (ECT-AD): A modified study protocol
- From mood to use: Using ecological momentary assessments to examine how anhedonia and depressed mood impact cannabis use in a depressed sample
- Cannabis, Tobacco Use, and COVID-19 Outcomes
- Examining the moderating role of cannabis use on the relationship between alcohol consumption and inflammation in individuals with alcohol use disorder
- An incentive-based text-messaging intervention to reduce maternal alcohol use during pregnancy and lactation in South Africa (MaRISA study): Findings from a single-arm pilot study
- Cannabis in Combat Sports: position statement of the association of ringside physicians
- Pharmacokinetic Bioequivalence and Safety Assessment of Two Venlafaxine Hydrochloride Extended-Release Capsules in Healthy Chinese Subjects Under Fed Conditions: A Randomized, Open-Label, Single-Dose, Crossover Study
- Pharmacokinetic Bioequivalence and Safety Assessment of Two Venlafaxine Hydrochloride Extended-Release Capsules in Healthy Chinese Subjects Under Fed Conditions: A Randomized, Open-Label, Single-Dose, Crossover Study
- A mobile health intervention for emerging adults with regular cannabis use: A micro-randomized pilot trial design protocol
- Cannabis Sativa Oil Promotes Social Interaction and Ultrasonic Communication by Acting on Oxytocin Pathway
- Cannabis Sativa Oil Promotes Social Interaction and Ultrasonic Communication by Acting on Oxytocin Pathway
- Narrative Review of Brivaracetam: Preclinical Profile and Clinical Benefits in the Treatment of Patients with Epilepsy
- Narrative Review of Brivaracetam: Preclinical Profile and Clinical Benefits in the Treatment of Patients with Epilepsy
- An exploratory open-label multicentre phase I/II trial evaluating the safety and efficacy of postnatal or prenatal and postnatal administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of severe osteogenesis…
- "Like the Wild West": Health care provider perspectives on impacts of recreational cannabis legalization on patients and providers at a tertiary psychiatric hospital in Ontario, Canada
- Clozapine as a mood stabiliser for schizoaffective disorder: Effectiveness during a three-month follow-up
- Effects of Cannabis Use on Neurocognition: A Scoping Review of MRI Studies
- Validation of the Spanish version of the multifaceted empathy test: comparison between cannabis use effects and controls in social cognition
- Validation of the Spanish version of the multifaceted empathy test: comparison between cannabis use effects and controls in social cognition
- A randomised, open-label, pragmatic pilot comparison of oral and intravenous ketamine in treatment-resistant depression
- A randomised, open-label, pragmatic pilot comparison of oral and intravenous ketamine in treatment-resistant depression
- Assessment of clinical outcomes in patients with inflammatory arthritis: analysis from the UK Medical Cannabis Registry
- Disulfiram Should Remain Second-line Treatment for Most Patients with Alcohol Use Disorder
- Autologous umbilical cord blood infusion for the treatment of autism in young children: A within-subjects open label study on safety (assessed via caregiver report) and efficacy
- Autologous umbilical cord blood infusion for the treatment of autism in young children: A within-subjects open label study on safety (assessed via caregiver report) and efficacy
- Prenatal Cannabis Exposure and The Risk for Neuropsychiatric Anomalies in the Offspring: A Systematic Review and Meta-Analysis
- Feasibility and Tolerability of Daily Theta Burst Stimulation in Autistic Youth with Intellectual Disabilities and Minimally Speaking Status: A Pilot Double-Blind Randomized Sham-Controlled Trial
- Treatment of a resistant case of schizoaffective disorder with lumateperone: A case report
- Change in substance use among patients in opioid maintenance treatment: baseline to 1-year follow-up
- Change in substance use among patients in opioid maintenance treatment: baseline to 1-year follow-up
- Safety and tolerability of esketamine nasal spray versus quetiapine extended release in patients with treatment resistant depression
- Safety and tolerability of esketamine nasal spray versus quetiapine extended release in patients with treatment resistant depression
- Epigenetic effects of cannabis: A systematic scoping review of behavioral and emotional symptoms associated with cannabis use and exocannabinoid exposure
Evidence Blueprint
Open Label Pilot of Lorcaserin (a serotonin 2C-receptor agonist) for Cannabis Use Disorder
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Open Label Pilot of Lorcaserin (a serotonin 2C-receptor agonist) for Cannabis Use Disorder
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study
- The Indirect Influence of Cannabis Use Disorder Symptoms on PTSD Symptom Severity Through Psychological Inflexibility
- Executive functions and behavioral economic demand for cannabis among young adults: Indirect associations with cannabis consumption and cannabis use disorder
- Prevalence of Cannabis Use Disorder and Reasons for Use Among Adults in a US State Where Recreational Cannabis Use Is Legal
- Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients With Schizophrenia and Cannabis Use Disorder
- Genome-wide DNA methylation analysis of cannabis use disorder in a veteran cohort enriched for posttraumatic stress disorder
- Evaluating age-related disparities in cannabis-related problems among LGBT+ versus non-LGBT+ adults
- The role of sleep in the link between cannabis use and memory function: evidence from a cross-sectional study
- Predictors of effective therapy among individuals with Cannabis Use Disorder: a review of the literature
- A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset
- Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California
- Resting state functional connectivity in dependent cannabis users: The moderating role of cannabis attitudes
- Emerging pharmacotherapy for the treatment of cannabis use disorder
- Emerging pharmacotherapy for the treatment of cannabis use disorder
- Criminal Justice Referrals to Cannabis Use Disorder Treatment among Adolescents and Young Adults following Recreational Cannabis Legalization in the United States
- Cannabis use disorder and adverse cardiovascular outcomes: A population-based retrospective cohort analysis of adults from Alberta, Canada
- Mobile Intervention to Address Cannabis Use Disorder Among Black Adults: Protocol for a Randomized Controlled Trial
- Effects of sub-chronic nabiximols on biological markers of individuals undergoing a clinical trial for the treatment of cannabis use disorder
- Exposure to maternal cannabis use disorder and risk of autism spectrum disorder in offspring: A data linkage cohort study
- A Systematic Review of the Clinical Effects of Cannabis and Cannabinoids in Posttraumatic Stress Disorder Symptoms and Symptom Clusters
- A preliminary randomized controlled trial of repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex in treatment seeking participants with cannabis use disorder
- A Review of Disparities in Cannabis Use and Cannabis Use Disorder Affecting Sexual and Gender Minority Populations and Evidence for Contributing Factors
- Mental and Physical Health Conditions Among U.S. Veterans with Cannabis Use and Cannabis Use Disorders
- Cannabis and Anxiety: A Critical Review
- Estimate the prevalence of daily caffeine consumption, caffeine use disorder, caffeine withdrawal and perceived harm in Iran: a cross-sectional study
- The economic impact of cannabis use disorder and dementia diagnosis in veterans diagnosed with traumatic brain injury
- The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study
- Incremental Predictive Validity of the Dualistic Model of Passion for Cannabis Use Among College Undergraduate Students With and Without a Cannabis Use Disorder
- Potential effect of antidepressants on remission from cocaine use disorder - A nationwide matched retrospective cohort study
- The effectiveness of mobile-based ecological momentary motivational enhancement therapy in reducing craving and severity of cannabis use disorder: Study protocol for a randomized controlled trial
- Mind it! A mindfulness-based group psychotherapy for substance use disorders in adolescent inpatients
- Absence of Evidence for Sustained Effects of Daily Cannabidiol Administration on Anandamide Plasma Concentration in Individuals with Cocaine Use Disorder: Exploratory Findings from a Randomized Controlled Trial
- Mismatch of Biological and Social Time in Cocaine-Addicted Men
- Dysregulation of Plasma Growth Factors and Chemokines in Cocaine Use Disorder: Implications for Dual Diagnosis with Schizophrenia and Antisocial Personality Disorder in an Exploratory Study
- Use of antipsychotic medication, benzodiazepines, and psychiatric hospitalization in cannabis-related versus cannabis-unrelated schizophrenia - a nationwide, register-based cohort study
- The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study
- Enhanced cannabis timeline followback (EC-TLFB): Comprehensive assessment of cannabis use including standard THC units and validation through biological measures
- CANNABIS USE AND SUICIDE IN NON-AFFECTIVE PSYCHOSIS: A MINI-REVIEW OF RECENT LITERATURE
- "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression
- Tolerability of High-Dose Oral Δ9-THC: Implications for Human Laboratory Study Design
- Development of Mobile Contingency Management for Cannabis Use Reduction
- Antipsychotic Use and Psychiatric Hospitalization in First-Episode Non-affective Psychosis and Cannabis Use Disorder: A Swedish Nationwide Cohort Study
- Effects of Trauma Cue Exposure and Posttraumatic Stress Disorder (PTSD) on Affect and Cannabis Craving in Cannabis Users With Trauma Histories: Use of Expressive Writing as an Online Cue-Reactivity Paradigm: Effets de l'exposition aux signaux…
- Cognitive-behavioral therapies in the management of adolescents with cannabis use disorder (CUD): A systematic review
- The Caffeine Dilemma: Unraveling the Intricate Relationship Between Caffeine Use Disorder, Caffeine Withdrawal Symptoms, and Mental Wellbeing in Adults
- The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats
- Substance Use Disorders and Psychiatric Illness Among Transitional Age Youth Experiencing Homelessness
- Disrupted dynamic brain functional connectivity in male cocaine use disorder: Hyperconnectivity, strongly-connected state tendency, and links to impulsivity and borderline traits
- Clavulanic Acid Decreases Cocaine Cue Reactivity in Addiction-Related Brain Areas, a Randomized fMRI Pilot Study
- Clavulanic Acid Decreases Cocaine Cue Reactivity in Addiction-Related Brain Areas, a Randomized fMRI Pilot Study
- Predictors of abstinence maintenance after cocaine inpatient detoxification: A prospective study
- Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI
- Structural and functional pathology in cocaine use disorder with polysubstance use: A multimodal fusion approach structural-functional pathology in cocaine use disorder
- Longitudinal Associations Between Cannabis Use and Cognitive Impairment in a Clinical Sample of Middle-Aged Adults Using Cannabis for Medical Symptoms
- SAFE-ROCK: A Phase I Trial of an Oral Application of the ROCK Inhibitor Fasudil to Assess Bioavailability, Safety, and Tolerability in Healthy Participants
- 18-Month efficacy and safety analysis of monthly subcutaneous buprenorphine injection for opioid use disorder: Integrated analysis of phase 3 studies
- Intentions to Use Cannabis Postpartum: A Qualitative Study of Pregnant Individuals Who Used Cannabis During Early Pregnancy
- Indirect Associations Between PTSD Symptoms and Cannabis Problems in Young Adults: The Unique Roles of Cannabis Coping Motives and Medicinal Use Orientation
- Association of mental health related quality of life and other factors with treatment seeking for substance use disorders: A comparison of SUDs rooted in legal, partially legal, and illegal substances
- Cannabis use and mood disorders: a systematic review
- Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder
- Factors associated with the use of cannabis for self-medication by adults: data from the French TEMPO cohort study
- Comparison of three magnetic resonance imaging measures of brain iron in healthy and cocaine use disorder participants