Optimizing Management of Treatment-Resistant Schizophrenia in Japan: Promoting a Refined Clozapine Titration Protocol and Addressing the ‘Clozapine Ceiling’ through Glutamatergic Modulation
AI Summary
Refine clozapine titration protocols in Japan to enhance safety, tolerability and therapeutic response for treatment resistant schizophrenia.
Explore glutamatergic modulation as an adjunctive strategy to overcome the clozapine ceiling and address persistent symptoms.
Implement integrated clinical and policy measures combining titration refinement and glutamatergic approaches to optimise national TRS management.
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