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Prophylactic efficacy of ketamine, but not the low-trapping NMDA receptor antagonist AZD6765, against stress-induced maladaptive behavior and 4E-BP1-related synaptic protein synthesis impairment
🌐 90 Days
VR Related Evidence Matrix
- Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice
- Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice
- Edaravone dexborneol attenuates cognitive impairment in a rat model of vascular dementia by inhibiting hippocampal oxidative stress and inflammatory responses and modulating the NMDA receptor signaling pathway
- Use of Quantitative Electroencephalography to Inform Age- and Sex-Related Differences in NMDA Receptor Function Following MK-801 Administration
- Postnatal hypofunction of N-methyl-D-aspartate receptors alters perforant path synaptic plasticity and filtering and impairs dentate gyrus-mediated spatial discrimination
- Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticity in adult male rats
- Voltage tunes mGlu5 receptor function, impacting synaptic transmission
- Serotonin Signaling through Lipid Membranes
- Neurophysiological evidence that frontoparietal connectivity and GABA-A receptor changes underpin the antidepressant response to ketamine
- Ketamine Infusion in a Resistant Obsessive-Compulsive Disorder Patient in Bangladesh with Severe Suicidal Ideation: A Case Report
- Ketamine Infusion in a Resistant Obsessive-Compulsive Disorder Patient in Bangladesh with Severe Suicidal Ideation: A Case Report
- Sleep need driven oscillation of glutamatergic synaptic phenotype
- Sleep need driven oscillation of glutamatergic synaptic phenotype
- µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
- a-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
- Particulate matter (PM(10)) exacerbates on MK-801-induced schizophrenia-like behaviors through the inhibition of ERK-CREB-BDNF signaling pathway
- Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- New pharmacotherapies to tackle the unmet needs in bipolar disorder: a focus on acute suicidality
- Subcutaneous ketamine reduces suicide risk and improves functioning in depression: A proof-of-concept study
- Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus
- SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity
- The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
- Dual-step pharmacological intervention for traumatic-like memories: implications from D-cycloserine and cannabidiol or clonidine in male and female rats
- Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
- Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
- mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS
- Ligand-gated ion channels as potential biomarkers for ADT-mediated cognitive decline in prostate cancer patients
- Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia
- Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia
- Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review
- Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review
- Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
- Low-frequency repetitive transcranial magnetic stimulation alleviates abnormal behavior in valproic acid rat model of autism through rescuing synaptic plasticity and inhibiting neuroinflammation
- Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours
- Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner
- Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner
- Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics?
- GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation
- Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl3-induced zebrafish (Danio rerio) model of Alzheimer's disease
- Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome
- Dexmedetomidine attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal flora
- Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy
- Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
- Cannabidiol and it fluorinate analog PECS-101 reduces hyperalgesia and allodynia in trigeminal neuralgia via TRPV1 receptors
- Role of NLRP3 inflammasome in prevention and treatment of cognitive impairment-related diseases and traditional Chinese medicine intervention: a review
- Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study
- Extrasynaptic localization is essential for α5GABAA receptor modulation of dopamine system function
- Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice
- Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons
- Electrophysiological Phenotypes of Hippocampal Synaptic and Network Functions in Cannabinoid Receptor 2 Knockout Mice
- NK3R signalling in the posterodorsal medial amygdala is involved in stress-induced suppression of pulsatile LH secretion in female mice
- In vitro evaluation of PET radiotracers for imaging synaptic density, the acetylcholine transporter, AMPA-tarp-γ8 and muscarinic M4 receptors in Alzheimer's disease
- Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Integration of Microfluidic Devices with Microelectrode Arrays to Functionally Assay Amyloid-β-Induced Synaptotoxicity
- Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects?
- Towards a natural treatment for mania: red onion husk extract modulates neuronal resilience, redox signalling, and glial activation
- Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment
- Mechanisms underlying memory impairment induced by fructose
Evidence Blueprint
Prophylactic efficacy of ketamine, but not the low-trapping NMDA receptor antagonist AZD6765, against stress-induced maladaptive behavior and 4E-BP1-related synaptic protein synthesis impairment
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More Evidence
Prophylactic efficacy of ketamine, but not the low-trapping NMDA receptor antagonist AZD6765, against stress-induced maladaptive behavior and 4E-BP1-related synaptic protein synthesis impairment
🌐 365 Days
VR Related Evidence Matrix
- Oxidative stress responses and their alterations in the Nrf2-NMDA receptor pathway in the brain of suicide victims
- Ketamine, an Old-New Drug: Uses and Abuses
- Evaluation of Midazolam-Ketamine-Allopregnanolone Combination Therapy against Cholinergic-Induced Status Epilepticus in Rats
- Ketamine use in pediatric depression: A systematic review
- Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist
- Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice
- Vagus nerve stimulation (VNS) modulates synaptic plasticity in the rat infralimbic cortex via Trk-B receptor activation to reduce drug-seeking
- Environmental enrichment improves social isolation-induced memory impairment: The possible role of ITSN1-Reelin-AMPA receptor signaling pathway
- Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice
- Exploring the Molecular Targets for the Antidepressant and Antisuicidal Effects of Ketamine Enantiomers by Using Network Pharmacology and Molecular Docking
- Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats
- Edaravone dexborneol attenuates cognitive impairment in a rat model of vascular dementia by inhibiting hippocampal oxidative stress and inflammatory responses and modulating the NMDA receptor signaling pathway
- Use of Quantitative Electroencephalography to Inform Age- and Sex-Related Differences in NMDA Receptor Function Following MK-801 Administration
- eIF4E phosphorylation mediated LPS induced depressive-like behaviors via ameliorated neuroinflammation and dendritic loss
- cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission
- Postnatal hypofunction of N-methyl-D-aspartate receptors alters perforant path synaptic plasticity and filtering and impairs dentate gyrus-mediated spatial discrimination
- GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring
- A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice
- Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticity in adult male rats
- Voltage tunes mGlu5 receptor function, impacting synaptic transmission
- Dorsal hippocampal CA1 NMDA receptors mediate the interactive effects of quetiapine and lithium on memory retention in male rats
- Serotonin Signaling through Lipid Membranes
- Neurophysiological evidence that frontoparietal connectivity and GABA-A receptor changes underpin the antidepressant response to ketamine
- Metabotropic glutamate receptor 2 expression is chronically elevated in male rats with post-traumatic stress disorder related behavioral traits following repetitive low-level blast exposure
- Ketamine Infusion in a Resistant Obsessive-Compulsive Disorder Patient in Bangladesh with Severe Suicidal Ideation: A Case Report
- Ketamine Infusion in a Resistant Obsessive-Compulsive Disorder Patient in Bangladesh with Severe Suicidal Ideation: A Case Report
- Ketamine alleviates fear memory and spatial cognition deficits in a PTSD rat model via the BDNF signaling pathway of the hippocampus and amygdala
- Acute administration of the NMDA receptor antagonists ketamine and MK-801 reveals dysregulation of glutamatergic signalling and sensorimotor gating in the Sapap3 knockout mouse model of compulsive-like behaviour
- Sleep need driven oscillation of glutamatergic synaptic phenotype
- Sleep need driven oscillation of glutamatergic synaptic phenotype
- Effect of Cerebralcare Granule® combined with memantine on Alzheimer's disease
- (R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication
- µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
- Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats
- Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease
- a-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
- Chronic psychosocial stress triggers microglial-/macrophage-induced inflammatory responses leading to neuronal dysfunction and depressive-related behavior
- Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive-compulsive behaviors in mice
- Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
- Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis
- Cold nociception as a measure of hyperalgesia during spontaneous heroin withdrawal in mice
- Comparative effects of the alcoholic extract of Terminalia chebula and crocin on stress‑induced anxiety‑like behavior and memory impairment in male rats
- Particulate matter (PM(10)) exacerbates on MK-801-induced schizophrenia-like behaviors through the inhibition of ERK-CREB-BDNF signaling pathway
- Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
- Geniposide improves depression-like behavior in prenatal stress male offspring through restoring HPA axis- and glucocorticoid receptor-associated dysfunction
- Hippocampal BAIAP2 prevents chronic mild stress-induced depression-like behaviors in mice
- Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism
- Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression
- Genomic glucocorticoid receptor effects guide acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in rats
- GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
- Liraglutide Reduces Alcohol Consumption, Anxiety, Memory Impairment, and Synapse Loss in Alcohol Dependent Mice
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- NMDA receptor-mediated Ca2+ signaling: Impact on cell cycle regulation and the development of neurodegenerative diseases and cancer
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression
- The role of lateral habenula NMDA receptors in tramadol-induced conditioning
- New pharmacotherapies to tackle the unmet needs in bipolar disorder: a focus on acute suicidality
- Subcutaneous ketamine reduces suicide risk and improves functioning in depression: A proof-of-concept study
- The anterior cingulate cortex is critical for acute stress-induced hypersensitivity in mice
- Possible involvement of FFAR1 signaling in mouse emotional behaviors through the regulation of brain monoamine releases
- Ketamine ameliorates activity-based anorexia of adolescent female mice through changes in GluN2B-containing NMDA receptors at postsynaptic cytoplasmic locations of pyramidal neurons and interneurons of medial prefrontal cortex
- 11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E2 /ERβ signaling pathways
- Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus
- NLRP3-GSDMD-dependent IL-1β secretion from microglia mediates learning and memory impairment in a chronic intermittent hypoxia-induced mouse model