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Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression

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Cureus. 2024 Apr 5;16(4):e57654. doi: 10.7759/cureus.57654. eCollection 2024 Apr.

ABSTRACT

Borderline personality disorder (BPD) and treatment-resistant depression (TRD) are common mental disorders that are challenging to treat. Ketamine is an N-methyl-D-aspartate receptor antagonist that has shown promise as a rapid-acting antidepressant when administered intravenously. BPD symptoms have also been demonstrated to improve with repeated intravenous administration of ketamine, and a single case report described improvement in BPD following the intranasal administration of esketamine. We present a case report of a woman with BPD and TRD who responded to treatment with very low-dose sublingual ketamine. Very low-dose sublingual ketamine may be effective for the treatment of psychiatric disorders such as BPD and/or comorbid TRD.

PMID:38707115 | PMC:PMC11070208 | DOI:10.7759/cureus.57654

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Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression

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