Evidence
Am J Psychiatry. 2023 May 1;180(5):340-347. doi: 10.1176/appi.ajp.20230172.
ABSTRACT
Over the past decade, psychedelic compounds have emerged as potentially transformative therapeutics for a variety of intractable neuropsychiatric conditions. However, historically most of the basic science has utilized these compounds as probes to interrogate various endogenous neurotransmitter systems-mainly the serotonin 5-HT2A receptor. With the renewed interest in utilizing these compounds as therapeutics and the explosion in clinical trials, psychedelics have been purported to treat many neuropsychiatric disorders, including depression, cluster headaches, migraines, anxiety, and obsessive-compulsive disorder. It is therefore imperative to understand the biology and pharmacology behind their therapeutic mechanisms as well as expose any potential pitfalls in their widespread use as treatments. This review covers the latest advances in understanding the biological mechanisms, the newest efforts in drug discovery, and potential pitfalls when it comes to utilizing this class of compounds as emerging therapeutics.
PMID:37122272 | DOI:10.1176/appi.ajp.20230172
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Psychedelics as Transformative Therapeutics
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Prescription digital therapeutics: An emerging treatment option for negative symptoms in schizophrenia
- Prescription digital therapeutics: An emerging treatment option for negative symptoms in schizophrenia
- Integrating Polygenic Scores and Phenotypic Data to Understand Psychiatric Outcomes
- The Influence of Stakeholder Interests on Safety Outcome Reporting in Psychedelic Research and Implications for Science Communication
- Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?
- The Role of Atypicals With Regard to Weight Gain in Bipolar Disorder Treatment
- Drug repurposing for cancer
- Drug repurposing for cancer
- The More Things Change .
- Suicide in Black Females
- Network Connection Issues in ADHD
- ADHD and ASD: Time to Split or Lump?
- Advances in Understanding Schizophrenia, ADHD, and ASD
- Multi-target drugs for Alzheimer's disease
- Suicide in Black Females: Response to Mattes
- PTSD, Phobias, Suicide Attempts, and Psychiatric Vulnerabilities
- Neuromelanin-Sensitive MRI: A Biomarker for Treatment-Resistant Schizophrenia?
- Cognitive Remediation in Schizophrenia Spectrum Illness: Evidence for Treatment Persistence
- Decoding Sex Differences in PTSD Heritability: A Comprehensive Twin Study
- Aligning Stem Cell Models and Postmortem Studies to Query Striatal Neurodevelopment in Schizophrenia
- The Invisible Children: Is the Glass Half Full or Half Empty?
- The Invisible Children: Is the Glass Half Full or Half Empty?
- Attitudes toward psychedelics and psychedelic-assisted therapy among potential mental health service users and the general population in Australia
- Natural product pharmacology: the British Journal of Pharmacology perspective
- Therapeutic modulation of the kynurenine pathway in severe mental illness and comorbidities: A potential role for serotonergic psychedelics
- Assessing the Effects of Thiazole-Carboxamide Derivatives on the Biophysical Properties of AMPA Receptor Complexes as a Potential Neuroprotective Agent
- Assessing the Effects of Thiazole-Carboxamide Derivatives on the Biophysical Properties of AMPA Receptor Complexes as a Potential Neuroprotective Agent
- Stutterers' experiences on classic psychedelics: A preliminary self-report study
- High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters
- Neurobiology and Treatment of Posttraumatic Stress Disorder
- Psilocybin for clinical indications: A scoping review
- Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments: Safety, Efficacy, Limitations and Challenges
- Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments: Safety, Efficacy, Limitations and Challenges
- Do classic psychedelics increase the risk of seizures? A scoping review
- Do classic psychedelics increase the risk of seizures? A scoping review
- Therapeutic potential of Bergenin in the management of neurological-based diseases and disorders
- International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology
- International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology
- XOB: A novel phenylalkylamine antagonist of 5-HT2A receptors and voltage-gated sodium channels
- Cryo-EM structures elucidate the multiligand receptor nature of megalin
- AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1
- Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits
- Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis
- Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness
- Network Pharmacology and Molecular Docking Integrated with Molecular Dynamics Simulations Investigate the Pharmacological Mechanism of Yinchenhao Decoction in the Treatment of Non-alcoholic Fatty Liver Disease
- Network Pharmacology and Molecular Docking Integrated with Molecular Dynamics Simulations Investigate the Pharmacological Mechanism of Yinchenhao Decoction in the Treatment of Non-alcoholic Fatty Liver Disease
- Curcumin and nano-curcumin applications in psychiatric disorders
- Current state of clinical ultrasound neuromodulation
- Current state of clinical ultrasound neuromodulation
- Dietary glycation compounds - implications for human health
- Effects and safety of transcranial direct current stimulation on multiple health outcomes: an umbrella review of randomized clinical trials
- Neuroprotective compounds alter the expression of genes coding for proteins related to mitochondrial function in activated microglia
- Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease
- Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor
- How to treat subsyndromal anxiety disorder - practical recommendations for implementation in primary care
- Therapeutic Potential of Psychedelic Drugs: Navigating High Hopes, Strong Claims, Weak Evidence, and Big Money
- Generative design of compounds with desired potency from target protein sequences using a multimodal biochemical language model
- Apollo Therapeutics and Oxford University enter into drug discovery and development collaboration
- A Comprehensive Collection of Pain and Opioid Use Disorder Compounds for High-Throughput Screening and Artificial Intelligence-Driven Drug Discovery
- Psychopharmacology Review for Eating Disorders Among Children, Adolescents, and Adults
- Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets
- Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets
- Carvedilol increases seizure resistance in a mouse model of SCN8A-derived epilepsy
Evidence Blueprint
Psychedelics as Transformative Therapeutics
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Psychedelics as Transformative Therapeutics
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Structural pharmacology and therapeutic potential of 5-methoxytryptamines
- Structural pharmacology and therapeutic potential of 5-methoxytryptamines
- Psychedelic Therapy: A Primer for Primary Care Clinicians-The Strengths, Weaknesses, Opportunities, and Threats of Psychedelic Therapeutics
- Psychedelic Drugs or Hallucinogens: Exploring Their Medicinal Potential
- Perceptual Modifying Compounds and Their Potential Therapeutic Applications in Neuropsychiatric Disorders
- Bedside to bench: the outlook for psychedelic research
- The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
- Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence
- Psychedelics for Alzheimer's Disease-Related Dementia: Unveiling Therapeutic Possibilities and Pathways
- Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
- Classical psychedelics in psychiatry - renaissance of interest and therapeutic perspectives
- Multimodal Neuroimaging of the Effect of Serotonergic Psychedelics on the Brain
- Substance Use Disorders Are Psychiatric Disorders
- RNA therapeutics for neurological disease
- Rethinking the First Episode of Schizophrenia: Identifying Convergent Mechanisms During Development and Moving Toward Prediction
- New Insights Into Psychotic Disorders
- The First Large GWAS Meta-Analysis for Postpartum Depression
- Adversity and Resilience, Postpartum Depression, Suicide, and Racial/Ethnic Disparities
- Seeking New Solutions Addressing Structural Racism, Childhood Trauma, Suicidal Behaviors Across Sexual Orientations, and Postpartum Depression
- Psychedelia: The interplay of music and psychedelics
- Correction to Guintivano et al
- Sexual Orientation and Suicidal Behavior: Is It Getting Better?
- Predicting Conversion to Psychosis Using Machine Learning: Are We There Yet?
- Perinatal Mental Health: Advances and Opportunities
- Another Step Toward the Prediction of Antipsychotic Treatment Response Using Functional Connectivity
- Trends in Suicide Among Black Women in the United States, 1999-2020
- Past Is Prologue: Ethical Issues in Pediatric Psychedelics Research and Treatment
- A Mental Health Crisis and Call to Action: Increasing Trends in Suicide Among Black Women in the United States
- Prescription digital therapeutics: An emerging treatment option for negative symptoms in schizophrenia
- Prescription digital therapeutics: An emerging treatment option for negative symptoms in schizophrenia
- Cardiovascular safety of psychedelic medicine: current status and future directions
- Integrating Polygenic Scores and Phenotypic Data to Understand Psychiatric Outcomes
- The Influence of Stakeholder Interests on Safety Outcome Reporting in Psychedelic Research and Implications for Science Communication
- The bodily self from psychosis to psychedelics
- Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
- 4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase
- The Developmental Trajectory to Cannabis Use Disorder
- The Developmental Trajectory to Cannabis Use Disorder
- Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?
- The Role of Atypicals With Regard to Weight Gain in Bipolar Disorder Treatment
- Psychedelics and neonihilism: connectedness in a meaningless world
- The Influence of Parenting on Callous-Unemotional Traits and the Implications for the Causes and Treatment of Conduct Disorder
- Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis
- Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis
- In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials
- The Influence of Parenting on Callous-Unemotional Traits and the Implications for the Causes and Treatment of Conduct Disorder
- Pharmacology of platelet immune receptors: mechanisms of activation and development of therapeutics
- Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics?
- Novel neurosteroid therapeutics for post-partum depression: perspectives on clinical trials, program development, active research, and future directions
- Drug repurposing for cancer
- Drug repurposing for cancer
- The More Things Change .
- Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders
- Suicide in Black Females
- Network Connection Issues in ADHD
- Predicting Conversion to Psychosis: What Lies Beyond the Biomarkers?
- Methamphetamine-Induced Psychosis and Schizophrenia: A Call for Special Attention
- ADHD and ASD: Time to Split or Lump?
- Advances in Understanding Schizophrenia, ADHD, and ASD
- Multi-target drugs for Alzheimer's disease
- Suicide in Black Females: Response to Mattes
- PTSD, Phobias, Suicide Attempts, and Psychiatric Vulnerabilities
- Neuromelanin-Sensitive MRI: A Biomarker for Treatment-Resistant Schizophrenia?