Am J Psychiatry. 2023 May 1;180(5):340-347. doi: 10.1176/appi.ajp.20230172.
ABSTRACT
Over the past decade, psychedelic compounds have emerged as potentially transformative therapeutics for a variety of intractable neuropsychiatric conditions. However, historically most of the basic science has utilized these compounds as probes to interrogate various endogenous neurotransmitter systems-mainly the serotonin 5-HT2A receptor. With the renewed interest in utilizing these compounds as therapeutics and the explosion in clinical trials, psychedelics have been purported to treat many neuropsychiatric disorders, including depression, cluster headaches, migraines, anxiety, and obsessive-compulsive disorder. It is therefore imperative to understand the biology and pharmacology behind their therapeutic mechanisms as well as expose any potential pitfalls in their widespread use as treatments. This review covers the latest advances in understanding the biological mechanisms, the newest efforts in drug discovery, and potential pitfalls when it comes to utilizing this class of compounds as emerging therapeutics.
BMC Pregnancy Childbirth. 2024 Sep 6;24(1):582. doi: 10.1186/s12884-024-06735-1.ABSTRACTBACKGROUND: Despite its known benefits, breastfeeding rates among mothers with perinatal mental health conditions are staggeringly low. Systematic...
Psychol Med. 2024 Sep 6:1-14. doi: 10.1017/S0033291724001375. Online ahead of print.ABSTRACTBACKGROUND: Although numerous studies have examined the effects of psychological treatments for obsessive-compulsive disorder (OCD),...
J Neural Transm (Vienna). 2024 Sep 4. doi: 10.1007/s00702-024-02816-9. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is a heterogenous autoimmune-mediated disease of the central nervous system...
Ann Acad Med Singap. 2024 Aug 29;53(8):471-480. doi: 10.47102/annals-acadmedsg.202496.ABSTRACTINTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) is used for treatment-resistant major depressive disorder (MDD) and obsessive-compulsive disorder...
J Family Med Prim Care. 2024 Aug;13(8):3031-3037. doi: 10.4103/jfmpc.jfmpc_13_24. Epub 2024 Jul 26.ABSTRACTBACKGROUND: The global increasing prevalence of obsessive-compulsive disorders and symptoms among various age...
Turk Psikiyatri Derg. 2024 Fall;35(3):248-250. doi: 10.5080/u26945.ABSTRACTSelf-mutilation attempts are common in psychiatric practice. One form of self-harm, genital self-mutilation (GSM), is less common but may...
This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
Privacy & Cookies Policy
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.