Int J Psychiatry Clin Pract. 2024 Aug 18:1-4. doi: 10.1080/13651501.2024.2391301. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate the effectiveness and safety of long-term use of silexan in patients with a wide range of anxiety disorders.

METHODS: A retrospective chart review was conducted on 50 patients diagnosed with various anxiety disorders who were prescribed silexan. The primary outcomes measured included the resolution of anxiety symptoms, changes in Generalized Anxiety Disorder-7 (GAD-7) scores, and Clinical Global Impressions-Improvement (CGI-I) scores. The duration of silexan use and any reported adverse events were also recorded.

RESULTS: Silexan effectively resolved anxiety symptoms in 35 patients, with 24 out of 25 patients who received silexan for more than 12 weeks showing significant improvement. Median GAD-7 and CGI-I scores decreased significantly (p<0.001). By the end of the follow-up period, 46% of patients had minimal anxiety and 24% had mild anxiety. No adverse events were reported during the study period.

CONCLUSIONS: Long-term use of silexan is feasible, safe, and effective in managing a wide range of anxiety disorders in real-world clinical settings.

PMID:39154289 | DOI:10.1080/13651501.2024.2391301