Reply: Interpreting early default mode network dysfunction across the Alzheimer’s disease Spectrum
AI Summary
Early Default Mode Network (DMN) dysfunction is detectable across preclinical and prodromal Alzheimer's, reflecting synaptic and network vulnerability rather than isolated regional atrophy.
Methodological heterogeneity, including imaging modalities, preprocessing and head motion, complicates interpretation of DMN changes across studies and cohorts.
Harmonised longitudinal imaging and biomarker integration are required to validate DMN metrics as early diagnostic markers and targets for intervention.
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