Evidence
Natl Sci Rev. 2023 Dec 8;10(11):nwad312. doi: 10.1093/nsr/nwad312. eCollection 2023 Nov.
ABSTRACT
Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric disorder that affects ∼2%-3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors (SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. Brain imaging showed that monkeys with SMBs had larger gray matter (GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor (human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.
PMID:38152386 | PMC:PMC10751879 | DOI:10.1093/nsr/nwad312
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Effects of self- and experimenter-administered cocaine on subsequent ethanol drinking in rhesus monkeys
- Evaluation of [(18)F]fluoroestradiol and ChRERalpha as a gene expression PET reporter system in rhesus monkey brain
- Evaluation of [18F]fluoroestradiol and ChRERα as a gene expression PET reporter system in rhesus monkey brain
- A comparison of rapid rule-learning strategies in humans and monkeys
- Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17
- Larger putamen in individuals at risk and with manifest bipolar disorder
- Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure
- Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner
- Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models
- Nipah virus-associated neuropathology in African green monkeys during acute disease and convalescence
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey
- Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation
- Parental mental disorders in patients with comorbid schizophrenia and obsessive-compulsive disorder: a nationwide family-link study
- The genetics of trichotillomania and excoriation disorder: A systematic review
- Abnormal structure and function of white matter in obsessive-compulsive disorder
- Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders
- A Novel Quadrant Spatial Assay Reveals Environmental Preference in Mouse Spontaneous and Parental Behaviors
- Examining the association between posttraumatic stress disorder and sexual risk-taking in dually diagnosed adolescents
- The universe is asymmetric, the mouse brain too
- The universe is asymmetric, the mouse brain too
- MED13 Gene Mutation Related to Autism Spectrum Disorder: A Case Report
- Estimating the total variance explained by whole-brain imaging for zero-inflated outcomes
- Estimating the total variance explained by whole-brain imaging for zero-inflated outcomes
- Deciphering social traits and pathophysiological conditions from natural behaviors in common marmosets
- Protocol for extracellular recordings in the external globus pallidus of the behaving/awake monkey
- Protocol for extracellular recordings in the external globus pallidus of the behaving/awake monkey
- A panel network analysis of posttraumatic stress disorder and obsessive-compulsive disorder symptoms across the perinatal period
- Scoping Review of Acceptance and Commitment Therapy for Obsessive-Compulsive Disorder in Iran
- Psilocybin in pharmacotherapy of obsessive-compulsive disorder
- Illusory light drives pupil responses in primates
- iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders
- iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders
- Evolutionary and biomedical implications of sex differences in the primate brain transcriptome
- Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice
- Words Matter: Debunking Stereotypes About OCD
- CSF1R-Related Disorder: Prevalence of CSF1R Variants and Their Clinical Significance in the UK Population
- Unintentional poisoning exposures: how does modeling the opening of child-resistant containers influence children's behaviors?
- Cognitive behavioral phenotyping of DSCAM heterozygosity as a model for autism spectrum disorder
- Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
- Incidental Gliosis in the Central Nervous System of Control Nonhuman Primates and Rats
- Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response
- A panel discussion on AI for science: the opportunities, challenges and reflections
- Decreased gray matter volume in the anterior cerebellar of attention deficit/hyperactivity disorder comorbid oppositional defiant disorder children with associated cerebellar-cerebral hyperconnectivity: insights from a combined structural MRI…
- Regular cannabis use modulates gamma activity in brain regions serving motor control
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Macaca mulatta)
- Resting-state functional connectivity of amygdala subregions across different symptom subtypes of obsessive-compulsive disorder patients
- Neuronal Activity in Gustatory Cortex during Economic Choice
- Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study
- Correlation of Comorbidities and Variability of Tics in Children with Chronic Tic Disorder
- Structural changes in eloquent cortex secondary to glioma in sensorimotor area
- Incidence of Panic Disorder Diagnoses After Celebrity Disclosures of Panic Disorder in South Korea
- Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study
- Child Maltreatment, Mental Health Disorders, and Health Risk Behaviors in People With Diverse Gender Identities
- Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism
- Engagement in binge eating and fasting associated with poorer sleep quality in an online sample of adults
- Motor-sensory biases are associated with cognitive and social abilities in humans
- Motor-sensory biases are associated with cognitive and social abilities in humans
- Sexually Transmitted Diseases and Attention-Deficit/Hyperactivity Disorder: A Systematic Literature Review
Evidence Blueprint
Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not?
- Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis
- Deep learning-based activity recognition and fine motor identification using 2D skeletons of cynomolgus monkeys
- Local structural and functional MRI markers of compulsive behaviors and obsessive-compulsive disorder diagnosis within striatum-based circuits
- Effects of self- and experimenter-administered cocaine on subsequent ethanol drinking in rhesus monkeys
- Repetitive Behaviors in Autism and Obsessive-Compulsive Disorder: A Systematic Review
- Forebrain EAAT3 overexpression increases susceptibility to amphetamine-induced repetitive behaviors
- Two multimodal neuroimaging subtypes of obsessive-compulsive disorder disclosed by semi-supervised machine learning
- Two multimodal neuroimaging subtypes of obsessive-compulsive disorder disclosed by semi-supervised machine learning
- Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
- A closer look to neural pathways and psychopharmacology of obsessive compulsive disorder
- Evaluation of [(18)F]fluoroestradiol and ChRERalpha as a gene expression PET reporter system in rhesus monkey brain
- Evaluation of [18F]fluoroestradiol and ChRERα as a gene expression PET reporter system in rhesus monkey brain
- A comparison of rapid rule-learning strategies in humans and monkeys
- Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys
- The Parallel Pandemic: A Systematic Review on the Effects of the COVID-19 Pandemic on OCD among Children and Adolescents
- Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics
- Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17
- Tracking a moving visual target in the rhesus monkey: Influence of the occurrence frequency of the target path
- Characterizing the personality and gray matter volume of chimpanzees that exhibit autism-related socio-communicative phenotypes
- Gray matter morphological abnormities are constrained by normal structural covariance network in OCD
- Defining repetitive behaviours in frontotemporal dementia
- Obsessive-Compulsive Disorder (OCD): A Comprehensive Review of Diagnosis, Comorbidities, and Treatment Approaches
- Comparative anatomy of the dentate mossy cells in non-human primates: their spatial distributions and axonal projections compared with mouse mossy cells
- The Development of Socially Directed Attention: An Functional Magnetic Resonance Imaging Study in Infant Monkeys
- Neural correlates of risk taking in patients with obsessive-compulsive disorder during risky decision-making
- Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations
- Larger putamen in individuals at risk and with manifest bipolar disorder
- Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure
- Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci
- Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner
- Assessment of Comorbid Obsessive-Compulsive Disorder and Posttraumatic Stress Disorder
- Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models
- Hyperconnecitivity between dorsal attention and frontoparietal networks predicts treatment response in obsessive-compulsive disorder
- Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice
- "This Is a Disease" and "Disease Has No Sin": Discourse Constructions of Individuals With Obsessive-Compulsive Disorder With Regard to Being Diagnosed
- The shared genetic risk factors between Tourette syndrome and obsessive-compulsive disorder
- Generation of mitochondrial replacement monkeys by female pronucleus transfer
- Theta and Gamma Activity Differences in Obsessive-Compulsive Disorder and Panic Disorder: Insights from Resting-State EEG with eLORETA
- Nipah virus-associated neuropathology in African green monkeys during acute disease and convalescence
- Tales from the life and lab of a female social neuroscientist
- Obsessive-compulsive disorder following severe traumatic brain injury
- Dorsal striatal functional connectivity and repetitive behaviour dimensions in children and youth with neurodevelopmental disorders
- Gray matter volume of functionally relevant primary motor cortex is causally related to learning a hand motor task
- Comparative transcriptome analysis between rhesus macaques ( Macaca mulatta) and crab-eating macaques ( M. fascicularis)
- Hedonic eating, obesity, and addiction result from increased neuropeptide Y in the nucleus accumbens during human brain evolution
- Altered neural anticipation of reward and loss but not receipt in adolescents with obsessive-compulsive disorder
- A 28-Year-Old Man with Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder, and Dissociative Identity Disorder Responding to Aripiprazole Augmentation of Clomipramine Combined with Psychoeducation and Exposure and Response Prevention
- Clinical Advances in Treatment Strategies for Obsessive-compulsive Disorder in Adults
- Chronic GCPII (glutamate-carboxypeptidase-II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey
- Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention-deficit/hyperactivity disorder
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Human brain computing and brain-inspired intelligence
- Intensive exposure treatment for obsessive compulsive disorder in old age.
- Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study
- Absence of eye position effects in the early auditory cortex of monkeys
- Insight in obsessive-compulsive disorder: conception, clinical characteristics, neuroimaging, and treatment
- Predictive spread of obsessive-compulsive disorder pathology using the network diffusion model
- Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking
- Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD)