Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Cureus. 2024 Mar 12;16(3):e56044. doi: 10.7759/cureus.56044. eCollection 2024 Mar.
ABSTRACT
The aim of this systematic literature review was to investigate the role of the cerebellum in the affective symptoms observed in patients with bipolar disorder. The present systematic literature review included clinical studies conducted from 2013-2023 among adult populations with bipolar I and II disorders, along with their specifiers. With regard to cerebellar pathology, it was found that those with bipolar disorder performed worse than their healthy counterparts in their ability to comprehend the mental states of others and in identifying negative mental states. Additionally, individuals with bipolar disorder had reduced gray matter loss in regions such as lobules I-IX, crus I, and crus II, different functional activation patterns of the thalamus, striatum, and hippocampus on functional magnetic resonance imaging (fMRI), and increased cortical thickness. Cerebro-cerebellar functional connectivities were altered in patients with bipolar disorder. The effects of lamotrigine and lithium on cerebellar volume and abnormalities are also discussed in this paper. The present systematic literature review illustrates the emerging involvement of the cerebellum in bipolar disorder and its affective symptoms and paves the way for future research and a better understanding of bipolar disorder.
PMID:38606213 | PMC:PMC11008919 | DOI:10.7759/cureus.56044
![Google](https://www.google.com/images/branding/googlelogo/2x/googlelogo_light_color_92x30dp.png)
![Google Keep](https://www.gstatic.com/images/branding/product/1x/keep_48dp.png)
![Share on Linkedin](https://psychiatryai.com/wp-content/uploads/2023/10/linkedin-logo-png-2048-1.png)
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Cool Evidence: Engaging Young People and Students in Real-World Evidence
![](/wp-content/uploads/2024/04/bd462cc11bcf0bd0d0d6f1d0f8b7cd04-modified-1.png)
Real-Time Evidence Search [Psychiatry]
![](/wp-content/uploads/2024/04/pubmed.png)
AI Research
![](/wp-content/uploads/2024/05/Il5nR_nf_400x400-modified-1.png)
Role of the Cerebellum in Bipolar Disorder: A Systematic Literature Review
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Alcohol Dependence Syndrome With Bipolar Affective Disorder and Hypomanic Current Episode: A Case Report Schizencephaly Associated With Bipolar Affective Disorder Trends and Prevalence of Psychotropic Medication Use in Children and Adolescents in the Period Between 2013 and 2023: A Systematic Review Trends and Prevalence of Psychotropic Medication Use in Children and Adolescents in the Period Between 2013 and 2023: A Systematic Review Revisiting Eye Movement Desensitization and Reprocessing Therapy for Post-traumatic Stress Disorder: A Systematic Review and Discussion of the American Psychological Association's 2017 Recommendations Managing the Dual Diagnosis Dilemma of Bipolar Disorder and Substance Abuse in Clinical Settings Antecedents of major depressive, bipolar, and psychotic disorders: a systematic review and meta-analysis of prospective studies The Effects of Ayahuasca on Psychological Disorders: A Systematic Literature Review Efficacy of life goals collaborative care for bipolar disorder: A systematic review Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review The Types of Psychosocial Factors Associated with Suicidality Outcomes for People Living with Bipolar Disorder: A Scoping Review Knee Buckling as an Atypical Adverse Effect of Clozapine: A Case Report A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell models Bipolar disorder and the gut microbiota: a bibliometric analysis Bipolar disorder and the gut microbiota: a bibliometric analysis Exploring the Effects of Major Depressive Disorder on Daily Occupations and the Impact of Psychotherapy: A Literature Review Cerebellar dysconnectivity in schizophrenia and bipolar disorder is associated with cognitive and clinical variables Childhood neglect, the neglected trauma. A systematic review and meta-analysis of its prevalence in psychiatric disorders Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis Childhood neglect, the neglected trauma. A systematic review and meta-analysis of its prevalence in psychiatric disorders The Role of Artificial Intelligence in Identifying Depression and Anxiety: A Comprehensive Literature Review Catatonia and melancholia interface: exploring a new paradigm for evaluation and treatment. A case series and literature review The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review Echocardiographic evaluation of myocardial strain in bipolar disorder across different phases: A comparative study with healthy controls Bipolar Disorder Predisposition in a Greek Male With β-Thalassemia Trait: External Factors, Including COVID-19, and Other Clinical Implications Bipolar Disorder Predisposition in a Greek Male With beta-Thalassemia Trait: External Factors, Including COVID-19, and Other Clinical Implications Mental health interventions for individuals with serious mental illness in the criminal legal system: a systematic review Oral health of people with emotional disorders: A systematic review and meta-analysis A bibliometric and visual analysis of cognitive function in bipolar disorder from 2012 to 2022 Exploring the Role of Serum Hydrogen Sulphide (H2S) Levels in Manic Depressive Psychosis in Terms of Its Association, Diagnostic Ability, and Severity Prediction: Findings From a Tertiary Care Center in North Bengal Cognition in Bipolar Disorder: An Update for Clinicians Cognition in Bipolar Disorder: An Update for Clinicians Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder Investigating light sensitivity in bipolar disorder (HELIOS-BD) Intensive Care Unit (ICU)-Related Post-traumatic Stress Disorder: A Literature Review Intensive Care Unit (ICU)-Related Post-traumatic Stress Disorder: A Literature Review The clinical significance of emotional urgency in bipolar disorder: a scoping review Investigating the increased risk of schizophrenia and bipolar disorders in relatives of ADHD probands using colocalization analysis of common genetic variants The effectiveness of savouring interventions on well-being in adult clinical populations: A protocol for a systematic review Bipolar disorders and schizophrenia: discrete disorders? Bipolar disorders and schizophrenia: discrete disorders? Factors associated with sexual dysfunction in patients with bipolar disorder The emerging neuroimmune hypothesis of bipolar disorder: An updated overview of neuroimmune and microglial findings Larger putamen in individuals at risk and with manifest bipolar disorder Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder: a high-risk study in the Chinese population Time matters for mental health: a systematic review of quantitative studies on time perspective in psychiatric populations Obsessive-Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review Adaption and validation of the Rwandese version of the Mood Disorder Questionnaire for the screening of bipolar disorder Remission of Clozapine-Induced Hepatotoxicity Following a Switch to Olanzapine Augmented with Haloperidol: A Case Report and Literature Review The efficacy of lamotrigine in bipolar disorder: A systematic review and meta-analysis The efficacy of lamotrigine in bipolar disorder: A systematic review and meta-analysis Mediterranean Diet and Mental Health in Children and Adolescents: A Systematic Review Eating disorders among international migrants: a systematic review and meta-analysis Being a child of a parent with a diagnosis of schizophrenia or bipolar disorder: A qualitative study A Case of Severely Impaired Consciousness and Convulsions From Attempted Suicide by Ingesting Triflumizole Emulsion: Clinical Features and Literature Review Mapping prodromal symptoms in patients with bipolar disorder: A network perspective Associations between soluble urokinase plasminogen activator receptor (suPAR) concentration and psychiatric disorders - A systematic review and meta-analysis Lipid and Glucose Profile across Different Mental Disorders A two-year longitudinal evaluation of the impact of the COVID-19 pandemic on pre-existing mental health service attenders Functional Impairment, Attachment, and Affective Temperaments in Euthymic Patients with Bipolar Disorder Comment on: Systematic review and meta-analysis of retinal microvascular caliber in bipolar disorder, major depressive disorder, and schizophrenia Suicide Assessment and Prevention in Bipolar Disorder: How Current Evidence Can Inform Clinical Practice
Evidence Blueprint
Role of the Cerebellum in Bipolar Disorder: A Systematic Literature Review
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
![](https://psychiatryai.com/wp-content/uploads/2023/04/psychiatryai_com.webp)
Role of the Cerebellum in Bipolar Disorder: A Systematic Literature Review
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
Alcohol Dependence Syndrome With Bipolar Affective Disorder and Hypomanic Current Episode: A Case Report Schizencephaly Associated With Bipolar Affective Disorder Cannabis use and its relationship with bipolar disorder: A systematic review and meta-analysis The prevalence and odds of bipolar disorder in women with polycystic ovary syndrome (PCO) disease: a systematic review and meta-analysis The Relationship Between Religious Coping and Internalized Stigma Among Patients With Bipolar Disorder Effectiveness of Brexpiprazole in a Patient With Bipolar Disorder and Comorbid Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia: A Case Report Alcohol use disorders in patients with bipolar disorder: a systematic review and meta-analysis Alcohol use disorders in patients with bipolar disorder: a systematic review and meta-analysis Trends and Prevalence of Psychotropic Medication Use in Children and Adolescents in the Period Between 2013 and 2023: A Systematic Review Trends and Prevalence of Psychotropic Medication Use in Children and Adolescents in the Period Between 2013 and 2023: A Systematic Review Revisiting Eye Movement Desensitization and Reprocessing Therapy for Post-traumatic Stress Disorder: A Systematic Review and Discussion of the American Psychological Association's 2017 Recommendations Negative Impacts of Psychiatric Medications on Oral Health: A Literature Review Managing the Dual Diagnosis Dilemma of Bipolar Disorder and Substance Abuse in Clinical Settings Differences in facial emotion recognition between bipolar disorder and other clinical populations: A systematic review and meta-analysis Antecedents of major depressive, bipolar, and psychotic disorders: a systematic review and meta-analysis of prospective studies The Effects of Ayahuasca on Psychological Disorders: A Systematic Literature Review The Role of Ketamine in the Treatment of Bipolar Depression: A Scoping Review Case report and systematic review of cerebellar vermis alterations in psychosis Efficacy of life goals collaborative care for bipolar disorder: A systematic review Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset The Types of Psychosocial Factors Associated with Suicidality Outcomes for People Living with Bipolar Disorder: A Scoping Review Advances in functional MRI research in bipolar disorder: from the perspective of mood states Knee Buckling as an Atypical Adverse Effect of Clozapine: A Case Report Impact of cognitive reserve on bipolar disorder: a systematic review Clinical features in co-occuring obsessive-compulsive disorder and bipolar disorder: A systematic review and meta-analysis Effects of the COVID-19 Pandemic on University Students' Mental Health: A Literature Review Prevalence of Psychiatric Illness Among Keratoconus Patients Factors associated with self-perceived treatment-resistance in bipolar disorder Behçet Disease and Bipolar Disorder: A Case Report and Review A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder Evaluation of Efficacy of Cannabis Use in Patients With Attention Deficit Hyperactivity Disorder: A Systematic Review Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell models From Unipolar to Bipolar: The Diagnostic Evolution in an Elderly Man Bipolar disorder and the gut microbiota: a bibliometric analysis Bipolar disorder and the gut microbiota: a bibliometric analysis A Clinical Suspicion of Quetiapine-Induced Psychosis: A Case Report and Literature Review Alpha-2 Agonists in Children and Adolescents With Post-traumatic Stress Disorder: A Systematic Review Correlations between multimodal neuroimaging and peripheral inflammation in different subtypes and mood states of bipolar disorder: a systematic review Hypokalemic Hypophosphatemic Thyrotoxic Periodic Paralysis Associated with Bipolar Disorder Therapy Gender differences in suicide among patients with bipolar disorder: A systematic review and meta-analysis Buspirone in Autism Spectrum Disorder: A Systematic Review Effect of Periodontal Disease on Alzheimer's Disease: A Systematic Review When Addressing Trauma Makes a Difference: A Case Report of Undiagnosed Complex Post-traumatic Stress Disorder Effectiveness and safety of second-generation antipsychotics for psychiatric disorders apart from schizophrenia: A systematic review and meta-analysis A Systematic Review of Misdiagnosis of Pediatric Bipolar Disorder: Assessments and Recommendations The relationship between childhood interpersonal and non-interpersonal trauma and autobiographical memory: a systematic review Status of Type II vs. Type I Bipolar Disorder: Systematic Review with Meta-Analyses Psychological Testing in a Complex Case: Psychosis in Co-occurring PTSD, Gender Dysphoria, and Bipolar Disorder Exploring the Effects of Major Depressive Disorder on Daily Occupations and the Impact of Psychotherapy: A Literature Review Cerebellar dysconnectivity in schizophrenia and bipolar disorder is associated with cognitive and clinical variables Can Brain-Derived Neurotrophic Factor Be Considered a Biomarker for Bipolar Disorder? An Analysis of the Current Evidence Childhood neglect, the neglected trauma. A systematic review and meta-analysis of its prevalence in psychiatric disorders Exploration of Psychiatry Residents' Attitudes toward Patients with Substance Use Disorder, Bipolar Disorder and Schizophrenia in Saudi Arabia Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis Childhood neglect, the neglected trauma. A systematic review and meta-analysis of its prevalence in psychiatric disorders A comparison of recurrence rates after discontinuation of second-generation antipsychotic long-acting injectable versus corresponding oral antipsychotic in the maintenance treatment of bipolar disorder: A systematic review The Role of Artificial Intelligence in Identifying Depression and Anxiety: A Comprehensive Literature Review Heart rate variability (HRV) as a way to understand associations between the autonomic nervous system (ANS) and affective states: A critical review of the literature Occurrence of postpartum manic or mixed episodes in women with bipolar I disorder: A systematic review and meta-analysis Catatonia and melancholia interface: exploring a new paradigm for evaluation and treatment. A case series and literature review Bipolar Disorder Due to Traumatic Brain Injury: A Case Report The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review