Evidence
Sci Adv. 2024 Jul 12;10(28):eadk3365. doi: 10.1126/sciadv.adk3365. Epub 2024 Jul 10.
ABSTRACT
It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory consolidation in male mice but not females. Optogenetic excitation of CeM-Tac2 fibers in the BNSTpl exhibited enhanced inhibitory postsynaptic currents in males compared to females. In vivo calcium imaging analysis revealed a sex-dimorphic fear memory engram in the BNSTpl. Furthermore, in humans, the single-nucleotide polymorphism (SNP) in the Tac2 receptor (rs2765) (TAC3R) decreased CeM-BNST connectivity in a fear task, impaired fear memory consolidation, and increased the expression of the TAC3R mRNA in AA-carrier men but not in women. These sex differences in critical neuronal circuits underlying fear memory formation may be relevant to human neuropsychiatric disorders with fear memory alterations such as posttraumatic stress disorder.
PMID:38985873 | DOI:10.1126/sciadv.adk3365
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Sex differences in neural projections of fear memory processing in mice and humans
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
Evidence Blueprint
Sex differences in neural projections of fear memory processing in mice and humans
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Sex differences in neural projections of fear memory processing in mice and humans
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
