Temporal dynamic brain-heart interaction alterations associated with suicidal ideation in major depressive disorder
AI Summary
Temporal dynamic brain-heart interaction (TD-BHI) alterations distinguish MDD with suicidal ideation: increased in parietal lobes and decreased in right parietal lobes.
TD-BHI values correlate significantly with attention/vigilance and sleep quality in MDDSI patients, linking physiological interactions to cognition and sleep disturbances.
Ensemble learning using TD-BHI discriminated MDDSI from MDDNSI with AUC 0.825, indicating TD-BHI as a potential diagnostic biomarker.
BMC Psychiatry. 2026 May 12. doi: 10.1186/s12888-026-08153-3. Online ahead of print.
ABSTRACT
BACKGROUND: Previous studies have indicated abnormal brain activation or heart rate variability in patients with major depressive disorder (MDD). Suicidal ideation, as one of the main concerns of MDD, is a serious public health problem. However, the interactions between brain and heart of MDD patients with and without suicidal ideation remain largely unknown.
METHODS: In this study, resting-state EEG and ECG data were simultaneously collected from 42 healthy controls (HCs), 69 MDD patients with suicidal ideation (MDDSI), and 39 MDD patients without suicidal ideation (MDDNSI). We proposed a novel methodology for analyzing temporal dynamic brain-heart interactions (TD-BHI). Then, we calculated the correlations between abnormalities of TD-BHI and cognitive performance, as well as sleep quality. Finally, we assessed the ability of TD-BHI to distinguish MDDSI patients.
RESULTS: We found that the TD-BHI values in the MDDSI group significantly increased in the parietal lobes and decreased in the right parietal lobes, compared with those in the HCs group. Additionally, the attention/vigilance score of the MATRICS consensus cognitive battery (MCCB) and the Pittsburgh sleep quality index scores were significantly correlated with the TD-BHI values in the MDDSI group. The ensemble learning model based on TD-BHI achieved an AUC of 0.825 in distinguishing MDDSI from MDDNSI patients.
CONCLUSION: Distinct abnormalities of TD-BHI may mediate suicidal ideation in MDD patients and can serve as a reliable biomarker for the diagnosis of MDDSI patients.
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