Evidence
Front Psychiatry. 2024 Aug 20;15:1414776. doi: 10.3389/fpsyt.2024.1414776. eCollection 2024.
ABSTRACT
Bipolar disorder is a chronic disorder characterized by fluctuations in mood state and energy and recurrent episodes of mania/hypomania and depression. Bipolar disorder may be regarded as a neuro-progressive disorder in which repeated mood episodes may lead to cognitive decline and dementia development. In the current review, we employed genome-wide association studies to comprehensively investigate the genetic variants associated with bipolar disorder and dementia. Thirty-nine published manuscripts were identified: 20 on bipolar disorder and 19 on dementia. The results showed that the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A were overlapping between patients with bipolar disorder and dementia. In conclusion, the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A may be associated with the neuro-progression of bipolar disorder to dementia. Further genetic studies are needed to comprehensively clarify the role of genes in cognitive decline and the development of dementia in patients with bipolar disorder.
PMID:39228919 | PMC:PMC11368786 | DOI:10.3389/fpsyt.2024.1414776
Estimated reading time: 3 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
The genetic association between bipolar disorder and dementia: a qualitative review
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Bipolar disorder and Lewy body dementia: case report and literature review
- How to treat major depressive disorder with shorter-duration hypomanic episodes? A case report
- Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones-The Circadian Rhythm for Mood (CRM) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial
- Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones-The Circadian Rhythm for Mood (CRM) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial
- Severe psychiatric disorders are associated with increased risk of dementia
- Clinical and sociodemographic characteristics associated with relapse following electroconvulsive therapy for bipolar disorder
- Patterns of Immune Dysregulation in Bipolar Disorder
- Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study
- Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study
- Mood Disorder Questionnaire Positivity in Systemic Lupus Erythematosus and Other Chronic Diseases including Screen Bipolar Disorders or Rhythm and Energy Dysregulation Syndromes (DYMERS)
- Effectiveness of Agomelatine in Generalized Anxiety Disorder Comorbid to Bipolar 1 Disorder in a Male Adolescent Patient
- Lithium and the risk of fractures in patients with bipolar disorder: A population-based cohort study
- Quality of life in older adults with mood states associated with bipolar disorder: A secondary analysis of the English longitudinal study of ageing data
- Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes
- Serum Vitamin D, Mania and Depression-Related Scores: A Comparison among Mixed Bipolar, Mania, and Healthy Subjects
- The impact of treating parental bipolar disorder and schizophrenia on their children's mental health and wellbeing: an empty systematic review
- The impact of treating parental bipolar disorder and schizophrenia on their children's mental health and wellbeing: an empty systematic review
- Causal role of immune cells in bipolar disorder: a Mendelian randomization study
- Independent inheritance of cognition and bipolar disorder in a family sample
- Sleep quality predicts future mood symptoms in adolescents with bipolar disorder
- Bipolar Disorder: From Pathophysiology to Treatment
- Inflammatory and Oxidative Stress Biomarkers in Children and Adolescents with Bipolar Disorder - a Systematic Review and Meta-Analysis
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Hippocampus and amygdala volumes are reduced in patients with schizoaffective disorder
- Research on clinical aspects of bipolar disorder: A review of Indian studies
- The role of oxidative stress in the pathomechanism of major mood disorders: a narrative review with a special focus on uric acid
- The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity
- Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder
- Theory of mind abilities during the course of bipolar disorder: A longitudinal study using mixed models
- The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity
- The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity
- Whole genome sequencing study of identical twins discordant for psychosis
- Exploring Temporal Relationships Between Anxiety, Mood and Mental Imagery in Patients With Bipolar Disorder: A Network Analysis
- Exploring Temporal Relationships Between Anxiety, Mood and Mental Imagery in Patients With Bipolar Disorder: A Network Analysis
- Homocysteine levels in first-episode patients with psychiatric disorders
- Genetic neurodevelopmental clustering and dyslexia
- Genetic neurodevelopmental clustering and dyslexia
- Beyond the Window of Risk? The Dutch Bipolar Offspring Study: 22-Year Follow-Up
- The Current Progress of Psychiatric Genomics
- The research landscape of bipolar disorder in Germany: productive, but underfunded
- The Effect of Lithium Variation Coefficient on the Risk of Attack in Patients with Bipolar Disorder: A Pilot Study
- Misperceiving Momentum: Computational Mechanisms of Biased Striatal Reward Prediction Errors in Bipolar Disorder
- Misperceiving Momentum: Computational Mechanisms of Biased Striatal Reward Prediction Errors in Bipolar Disorder
- Mapping review of register-based cohort studies of bipolar disorder
- Seasonality and sun exposure in incidence of major depression, bipolar disorder, and first-time use of antidepressant medication
- MicroRNAs as potential diagnostic biomarkers for bipolar disorder
- Novel targets and therapies of metformin in dementia: old drug, new insights
- Practice Guidelines for Bipolar Disorder by the JSMD (Japanese Society of Mood Disorders)
- Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History
- A grounded theory on acceptance of diagnosis as a pathway to recovery in bipolar disorder
- Genetic biomarkers of cognitive impairment and dementia of potential interest in CKD patients
- Features of cognitive impairment in bipolar affective disorder
- Risk of adverse pregnancy, delivery and neonatal outcomes associated with bipolar disorder and prenatal use of mood stabilizers: A population-based cohort study
- Risk of adverse pregnancy, delivery and neonatal outcomes associated with bipolar disorder and prenatal use of mood stabilizers: A population-based cohort study
- Longitudinal Interplay Between Alcohol Use, Mood, and Functioning in Bipolar Spectrum Disorders
- Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies
- The link between alterations in circadian rhythms and lipid metabolism in bipolar disorder: the lipid droplets hypothesis
- Group psychoeducation for patients with bipolar disorder: a retrospective study on effectiveness in delaying relapse episodes and intensity
- Pharmacological Treatment of Binge Eating Disorder and Frequent Comorbid Diseases
- The status of MRI databases across the world focused on psychiatric and neurological disorders
- The status of MRI databases across the world focused on psychiatric and neurological disorders
- Prevalence and risk factors for depression in factitious disorder: a systematic review
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
Evidence Blueprint
The genetic association between bipolar disorder and dementia: a qualitative review
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
The genetic association between bipolar disorder and dementia: a qualitative review
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states
- Bipolar disorder and Lewy body dementia: case report and literature review
- How to treat major depressive disorder with shorter-duration hypomanic episodes? A case report
- Impact of cognitive reserve on bipolar disorder: a systematic review
- Investigating the increased risk of schizophrenia and bipolar disorders in relatives of ADHD probands using colocalization analysis of common genetic variants
- A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder
- Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones-The Circadian Rhythm for Mood (CRM) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial
- Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones-The Circadian Rhythm for Mood (CRM) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial
- Severe psychiatric disorders are associated with increased risk of dementia
- Clinical and sociodemographic characteristics associated with relapse following electroconvulsive therapy for bipolar disorder
- A bibliometric and visual analysis of cognitive function in bipolar disorder from 2012 to 2022
- Bipolar disorder and the gut microbiota: a bibliometric analysis
- Bipolar disorder and the gut microbiota: a bibliometric analysis
- Patterns of Immune Dysregulation in Bipolar Disorder
- Managing the Dual Diagnosis Dilemma of Bipolar Disorder and Substance Abuse in Clinical Settings
- Comparing the metabolic pathways of different clinical phases of bipolar disorder through metabolomics studies
- Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics
- Progress and Implications from Genetic Studies of Bipolar Disorder
- Effects of CACNA1C and ANK3 on cognitive function in patients with bipolar disorder
- Understanding Bipolar Disorder: Risk Factors & Protective Measures
- Neuroprogression in bipolar disorder: why right is wrong
- Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder
- Limited evidence of autocorrelation signaling upcoming affective episodes: a 12-month e-diary study in patients with bipolar disorder
- Bipolar Patient-Specific In Vitro Diagnostic Test Reveals Underlying Cardiac Arrhythmia Phenotype Caused by Calcium Channel Genetic Risk Factor
- Dysregulation of mood, energy, and social rhythms syndrome (DYMERS): A working hypothesis
- Factors associated with self-perceived treatment-resistance in bipolar disorder
- Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study
- Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study
- Associations between benign paroxysmal positional vertigo and seven mental disorders: a two-sample Mendelian randomization study
- Mood Disorder Questionnaire Positivity in Systemic Lupus Erythematosus and Other Chronic Diseases including Screen Bipolar Disorders or Rhythm and Energy Dysregulation Syndromes (DYMERS)
- Effectiveness of Agomelatine in Generalized Anxiety Disorder Comorbid to Bipolar 1 Disorder in a Male Adolescent Patient
- From Unipolar to Bipolar: The Diagnostic Evolution in an Elderly Man
- The effect of age on emotion processing in individuals with mood disorders and in healthy individuals
- The effect of age on emotion processing in individuals with mood disorders and in healthy individuals
- Evidence for mood instability in patients with bipolar disorder: Applying multilevel hidden Markov modeling to intensive longitudinal ecological momentary assessment data
- Lithium and the risk of fractures in patients with bipolar disorder: A population-based cohort study
- Occurrence of postpartum manic or mixed episodes in women with bipolar I disorder: A systematic review and meta-analysis
- Investigating light sensitivity in bipolar disorder (HELIOS-BD)
- Catatonia and melancholia interface: exploring a new paradigm for evaluation and treatment. A case series and literature review
- Mental illness and pulmonary tuberculosis: a bidirectional two-sample Mendelian randomization study
- Lipid and Glucose Profile across Different Mental Disorders
- Quality of life in older adults with mood states associated with bipolar disorder: A secondary analysis of the English longitudinal study of ageing data
- Early warning signals observed in motor activity preceding mood state change in bipolar disorder
- Dissecting the impact of complement component 4A in bipolar disorder
- Bipolar disorders and schizophrenia: discrete disorders?
- Bipolar disorders and schizophrenia: discrete disorders?
- Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes
- Serum Vitamin D, Mania and Depression-Related Scores: A Comparison among Mixed Bipolar, Mania, and Healthy Subjects
- The impact of treating parental bipolar disorder and schizophrenia on their children's mental health and wellbeing: an empty systematic review
- The impact of treating parental bipolar disorder and schizophrenia on their children's mental health and wellbeing: an empty systematic review
- Reduced heart rate variability during mania in a repeated naturalistic observational study
- Biomarkers of bipolar disorder based on metabolomics: A systematic review
- Alcohol use disorders in patients with bipolar disorder: a systematic review and meta-analysis
- Alcohol use disorders in patients with bipolar disorder: a systematic review and meta-analysis
- Causal role of immune cells in bipolar disorder: a Mendelian randomization study
- Independent inheritance of cognition and bipolar disorder in a family sample
- Hemodynamics and arrhythmia disorder caused by lithium poisoning: A case report
- Zuranolone - synthetic neurosteroid in treatment of mental disorders: narrative review
- Sleep quality predicts future mood symptoms in adolescents with bipolar disorder
- A Novel Unsupervised Machine Learning Approach to Assess Postural Dynamics in Euthymic Bipolar Disorder
- Bipolar Disorder: From Pathophysiology to Treatment
- Adaption and validation of the Rwandese version of the Mood Disorder Questionnaire for the screening of bipolar disorder
- The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis
- Inflammatory and Oxidative Stress Biomarkers in Children and Adolescents with Bipolar Disorder - a Systematic Review and Meta-Analysis