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Iosifina Foskolou, PhD, is a group leader at Sanquin Institute (Amsterdam), specialising in T cell metabolism and cancer immunotherapy. Her lab focuses on improving T cell immunotherapies against solid tumours by better understanding the environments immune cells face in both the tumour microenvironment and lymphoid tissues.
Iosifina holds a DPhil in Oncology from the University of Oxford, where she studied the effects of low oxygen (hypoxia) in solid tumours. She has extensive postdoctoral experience at both Cambridge University and the Karolinska Institute, where she investigated how metabolism can improve cancer immunotherapy.
Iosifina has a robust academic background, and her work has been widely published in peer-reviewed journals, with key papers on T cell function, metabolism, and anti-tumour immunity. Throughout her career, she has secured numerous grants, including a Marie Sklodowska Curie post-doctoral Fellowship.
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Imaging-based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision From dendritic cells to inflammatory bowel disease CAR-T lymphocyte-based cell therapies; mechanistic substantiation, applications and biosafety enhancement with suicide genes: new opportunities to melt side effects Perspectives in collective cell migration - moving forward Advances in manufacturing chimeric antigen receptor immune cell therapies Unravelling the tumor microenvironment of gastric cancer peritoneal metastase Mitophagy, from genetics to biology, and back (rescheduled date) Study reveals previously unknown genetic causes of colorectal cancer CIMT 2024: Report on the 21st Annual Meeting of the Association for Cancer Immunotherapy Immune cell infiltration and inflammatory landscape in primary brain tumours Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation Rare Driver Mutations in Advanced, Oncogene-Addicted Non-Small Cell Lung Cancer: A North Italian, Real-World, Registry Experience The Role of CD4+T Cells in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade Unravelling the diagnostic pathology and molecular biomarkers in lung cancer EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages Characterizing the immune tumor microenvironment in ALK fusion-positive lung cancer: state-of-the-art and therapeutical implications Cutaneous Oncology: Strategies for Melanoma Prevention, Diagnosis, and Therapy Yasuní in Oxford: Linking Local and Global Struggles Against Extractivism Epigenetics: at the apex of innate immune memory Targeting the Hippo pathway to prevent radioresistance brain metastases from the lung (Review) The Evaluation of the N-cadherin Promoter's ability to Block EMT by Specific Expression of Diphtheria Toxin in EMT-induced A549 Cell Lines Myeloid derived suppressor cells and macrophages in regulation of immune response in cancer and tumor progression Deep learning-based risk stratification of preoperative breast biopsies using digital whole slide images Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma Gut Macrophages Modulate Body-First Synucleinopathies Multiple aspects of matrix stiffness in cancer progression Overexpression of an Engineered SerpinB9 Enhances Allogeneic T-Cell Persistence and Efficacy Novel therapeutic agents in clinical trials: emerging approaches in cancer therapy Novel therapeutic agents in clinical trials: emerging approaches in cancer therapy Follow up of breast cancer GWAS through drug repositioning and CRISPR screens Single-Cell Data Analysis Reveals Critical Hepatic Cells Subpopulations in the Progression of Non-alcoholic Fatty Liver Disease to Non-Alcoholic Steatohepatitis Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours A novel artificial intelligence network to assess the prognosis of gastrointestinal cancer to immunotherapy based on genetic mutation features Pivotal role of intestinal cholesterol and nuclear receptor LXR in metabolic liver steatohepatitis and hepatocarcinoma Immune signature and therapeutic approach of natural killer cell in chronic liver disease and hepatocellular carcinoma Cancer therapy-related cardiac dysfunction and the role of cardiovascular imaging: systemic review and opinion paper from the Working Group on Cardio-Oncology of the Korean Society of Cardiology Avalanche burial pathophysiology - a unique combination of hypoxia, hypercapnia and hypothermia CHG Lunchtime Lab Talks: Professor Christopher Buckley (Kennedy) Germ Cell Nuclear Factor: from reproductive to craniofacial development Small States at the heart of the EU: The case of Andorra Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment A case series of non-small cell lung cancer patients with EGFR or HER2 exon 20 insertion in Li Fraumeni syndrome A case series of non-small cell lung cancer patients with EGFR or HER2 exon 20 insertion in Li Fraumeni syndrome Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage Integrated analysis of the role of PR/SET domain 14 in gastric cancer Integrated analysis of the role of PR/SET domain 14 in gastric cancer Microbiome and pancreatic cancer: time to think about chemotherapy 3D bioprinting of an in vitro hepatoma microenvironment model: establishment, evaluation, and anticancer drug testing Targeting LINC070974 inhibits lung adenocarcinoma cell proliferation and progression by interacting with Y-box binding protein 1 Protocol to quantify immune cell distribution from the vasculature to the glioma microenvironment on sequential immunofluorescence multiplex images Protocol to quantify immune cell distribution from the vasculature to the glioma microenvironment on sequential immunofluorescence multiplex images Innate immune memory after brain injury drives inflammatory cardiac dysfunction Innate immune memory after brain injury drives inflammatory cardiac dysfunction Therapeutic resurgence of 6-diazo-5-oxo-l-norleucine (DON) through tissue-targeted prodrugs On the mechanisms of brain blood flow regulation during hypoxia Intricate interplay between cell metabolism and necroptosis regulation in metabolic dysfunction-associated steatotic liver disease: A narrative review Single cell metabolomics and targeted proteomic imaging of immune populations
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Understanding and manipulating the T-cell response to peptide-MHC Stem Cell Origin of Cancer: Clinical Implications for Cancer Immunity and Immunotherapy Drilling Down on the Correlates of Tumour Rejection Metabolic diversity of tumor-infiltrating T cells as target for anti-immune therapeutics Integrated single-cell transcriptomics reveals the hypoxia-induced inflammation-cancer transformation in NASH-derived hepatocellular carcinoma Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application Primary brain tumours in adults New funding for development of world's first lung cancer vaccine "How do I get hired outside of academia?!" Ask the Panel of Recruiters Iron metabolism: backfire of cancer cell stemness and therapeutic modalities Imaging-based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids Multi-omics and artificial intelligence predict clinical outcomes of immunotherapy in non-small cell lung cancer patients A replicating LCMV-based vaccine for the treatment of solid tumors New trial to study how the human immune system adapts to ‘tolerate’ malaria parasites Dose-Specific Intratumoral GM-CSF Modulates Breast Tumor Oxygenation and Antitumor Immunity Critical role of the gut microbiota in immune responses and cancer immunotherapy Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision BCKDK Modification Enhances the Anticancer Efficacy of CAR-T Cells by Reprogramming Branched Chain Amino Acid Metabolism Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma T-cells stoop to conquer Differential Immunoexpression of Inhibitory Immune Checkpoint Molecules and Clinicopathological Correlates in Keratoacanthoma, Primary Cutaneous Squamous Cell Carcinoma and Metastases Turning anecdotal irradiation-induced anti-cancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells Music therapy, quality of life and efficacy of immunotherapy for NSCLC Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage IV colorectal cancer From dendritic cells to inflammatory bowel disease Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome CAR-T lymphocyte-based cell therapies; mechanistic substantiation, applications and biosafety enhancement with suicide genes: new opportunities to melt side effects Perspectives in collective cell migration - moving forward Advances in manufacturing chimeric antigen receptor immune cell therapies Unravelling the tumor microenvironment of gastric cancer peritoneal metastase Designing an Algorithmically Enhanced NHS Wilms' tumour gene 1 (WT1) enhances non-small cell lung cancer malignancy and is inhibited by microRNA-498-5p The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells Mitophagy, from genetics to biology, and back (rescheduled date) Oxford-Harrington Rare Disease Centre Launches Pioneering Therapeutics Accelerator to Advance Innovative Treatments for Rare Diseases Metabolic characterisation of transglutaminase 2 inhibitor effects in breast cancer cell lines Study reveals previously unknown genetic causes of colorectal cancer CIMT 2024: Report on the 21st Annual Meeting of the Association for Cancer Immunotherapy Enhanced perfusion following exposure to radiotherapy: A theoretical investigation Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma therapy: Challenges and opportunities Researchers discover how immune cells hunt down cancer around the body Immune cell infiltration and inflammatory landscape in primary brain tumours Cell death Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation Rare Driver Mutations in Advanced, Oncogene-Addicted Non-Small Cell Lung Cancer: A North Italian, Real-World, Registry Experience Careers in International Organisations, Diplomacy & Think Tanks for Researchers Unveiling The Neuropathology Tumour Landscape: 10-Year Statistical Analysis With Global Comparison - Single Centre Experience The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma The Role of CD4+T Cells in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade Unravelling the diagnostic pathology and molecular biomarkers in lung cancer Gamma Delta T Cells: Role in Immunotherapy of Hepatocellular Carcinoma Cell death by phagocytosis Hyperactive Protein Responses and Functional Residuomics of Cilia Dissecting Parkinson's disease with long-read RNA-sequencing Eliciting calcium transients with UV nanosecond laser stimulation in adult patient-derived glioblastoma brain cancer cells in vitro EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability Exploiting pancreatic cancer metabolism: challenges and opportunities