The role of MAOA gene expression in human aggressive behaviors

Wiad Lek. 2025;78(11):2263-2272. doi: 10.36740/WLek/211871.

ABSTRACT

OBJECTIVE: Aim: To identify whether the association between MAOA gene expression and exposure to antisocial outcomes.

PATIENTS AND METHODS: Materials and Methods: A hundred and eighty samples (100 depressed patients going to psychiatric clinics and 80 healthy) of males and females were involved in the present study. Gene expression was performed for patients and controls using the real-time PCR technique to compare the expression of the MAOA gene when exposed to different types and levels of trauma.

RESULTS: Results: The results show a decrease in the expression activity of the MAOA gene in most patients. The data revealed that males have a lower expression of the MAOA gene than females. There were no significant differences down-regulated in the folding expression 2-ΔΔCt of MAOA gene in patients who were prone to trauma exposure (missing someone, domestic violence, exposure to community violence, alcohol abuse, physical abuse, and sexual abuse). In terms of marital status, there was no significant upregulation of fold changes in the expression of the MAOA gene recorded in the patient group (2-ΔΔCt = 1.3, 1.3, and 1.5) when compared with the healthy group (2-ΔΔCt = 1).

CONCLUSION: Conclusions: Our results suggest that the MAOA gene controls aggression and its effect on trauma history and levels.

PMID:41518161 | DOI:10.36740/WLek/211871