Evidence
J Am Chem Soc. 2024 Mar 22. doi: 10.1021/jacs.3c12908. Online ahead of print.
ABSTRACT
This study presents a global strategy for the transsulfuration of intracellular thiols (RSH) to persulfides (RSSH). Thiiranes comprising fluorenyl/diphenyl and malonate ester moieties directly convert intercellular RSH to low-molecular-weight RSSH in cells. The efficiency of transsulfuration is determined by counting the number of olefins produced as byproducts, providing ratiometric signals for the corresponding persulfide production. Specifically, the direct and rapid protein S-persulfidation by thiirane is validated. Thiiranes are expected to play a crucial role in the study of sulfur signaling.
PMID:38518245 | DOI:10.1021/jacs.3c12908
Add to Google Keep
Estimated reading time: 2 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Thiiranes: Intelligent Molecules for S-Persulfidation
🌐 90 Days
VR Related Evidence Matrix
- Optical Control of G-Actin with a Photoswitchable Latrunculin
- Artificial Intelligence for Retrosynthetic Planning Needs Both Data and Expert Knowledge
- Accelerating Computation of Acidity Constants and Redox Potentials for Aqueous Organic Redox Flow Batteries by Machine Learning Potential-Based Molecular Dynamics
- Serotonin Signaling through Lipid Membranes
- Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R
- SuFEx-Enabled Direct Deoxy-Diversification of Alcohols
- Deep Learning-Assisted Spectrum-Structure Correlation: State-of-the-Art and Perspectives
- Binding-Free Taste Visualization with Plasmonic Metasurfaces
- Protein-Based Tools for Studying Neuromodulation
- Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells
- Rapid Screening of New Psychoactive Substances Using pDART-QqQ-MS
- The Rational Design of Atomically Dispersed Catalysts via Spin Manipulation
- Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine
- Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine
- Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
- Exploring the Interactions between two Ligands, UCB-J and UCB-F, and Synaptic Vesicle Glycoprotein 2 Isoforms
- Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments?
- RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-N,N-diisopropyltryptamine
- Evaluating the Atypical Aging Potential Development in Sparkling Wines Can Be Achieved by Assessing the Base Wines at the End of the Alcoholic Fermentation
- Efficient Homojunction Tin Perovskite Solar Cells Enabled by Gradient Germanium Doping
- Deus Ex Machina? The Rise of Artificial Intelligence in Toxicology
- SDDSynergy: Learning Important Molecular Substructures for Explainable Anticancer Drug Synergy Prediction
- Ultrasensitive Nanofiber Biosensor: Rapid In Situ Chromatic Detection of Bacteria for Healthcare Innovation
- Single-Molecule-Resolution Approaches in Synaptic Biology
- RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
- Simultaneous SERS Sensing of Cysteine and Homocysteine in Blood Based on the CBT-Cys Click Reaction: Toward Precisive Diagnosis of Schizophrenia
- AI Personal Assistants and Sustainability: Risks and Opportunities
- Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress
- A Reconfigurable Bipolar Image Sensor for High-Efficiency Dynamic Vision Recognition
- AI in Pharma: Transforming Drug Discovery and Strategic Management with MYC-Modulating Compounds and BET Protein Inhibitors
- Prunin from Poncirus trifoliata (L.) Rafin Inhibits Aldose Reductase and Glucose-Fructose-Mediated Protein Glycation and Oxidation of Human Serum Albumin
- Correction to "Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T(1)-Weighted Contrast-Enhanced Brain Imaging"
- Impact of Sacrificial Hydrogen Bonds on the Structure and Properties of Rubber Materials: Insights from All-Atom Molecular Dynamics Simulations
- Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain
- Bringing Artificial Intelligence (AI) into Environmental Toxicology Studies: A Perspective of AI-Enabled Zebrafish High-Throughput Screening
- Spectroscopic and Computational Study of ZnCl2-Methanol Low-Melting-Temperature Mixtures
- Spatial Proteomics Reveals Alcohol-Induced Damages to the Crypts and Villi of the Mouse Small Intestine
- The role of extracellular vesicles in non-alcoholic steatohepatitis: Emerging mechanisms, potential therapeutics and biomarkers
- Size- and Shape-controlled Biodegradable Polymer Brushes Based on l-Amino Acid for Intracellular Drug Delivery and Deep-Tissue Penetration
- Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases
- Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases
- Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood-Brain Barrier
- Ratiometric Afterglow Luminescent Imaging of Matrix Metalloproteinase-2 Activity via an Energy Diversion Process
- Maximizing Electrochemical Information: A Perspective on Background-Inclusive Fast Voltammetry
- Unlocking mechanosensitivity: integrins in neural adaptation
- Protective Effect of Hop Ethyl Acetate Extract on Corticosterone-Induced PC12 and Improvement of Depression-like Behavior in Mice
- Regulatory pathways and therapeutic potential of PDE4 in liver pathophysiology
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions
- Patient-derived neuron model: capturing age-dependent adult-onset degenerative pathology in Huntington's disease
- Carbon Nanofibrous Aerogels Derived from Electrospun Polyimide for Multifunctional Piezoresistive Sensors
- Protein Engineering with Lightweight Graph Denoising Neural Networks
- Enrichment and MALDI-TOF MS Analysis of Phosphoinositides in Brain Tissue
- Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma
- Artificial Intelligence-Based, Wavelet-Aided Prediction of Long-Term Outdoor Performance of Perovskite Solar Cells
- Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation
- Boronic Acid-Linked Cell-Penetrating Peptide for Protein Delivery
- Deep Learning Bridged Bioactivity, Structure, and GC-HRMS-Readable Evidence to Decipher Nontarget Toxicants in Sediments
- Asymmetric Additions Empowered by OrganoCatalysts, Metal Catalysts, and Deep Natural Eutectic Solvents (NADES)
- Integration of Microfluidic Devices with Microelectrode Arrays to Functionally Assay Amyloid-β-Induced Synaptotoxicity
- Protein Corona Composition of Gold Nanocatalysts
- The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder
- Counting the days: Exploring the post-mortem interval factors in sexual homicides
Evidence Blueprint
Thiiranes: Intelligent Molecules for S-Persulfidation
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Thiiranes: Intelligent Molecules for S-Persulfidation
🌐 365 Days
VR Related Evidence Matrix
- Design of Tetrazolium Cations for the Release of Antiproliferative Formazan Chelators in Mammalian Cells
- Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches
- Optical Control of G-Actin with a Photoswitchable Latrunculin
- Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time
- Artificial Intelligence for Retrosynthetic Planning Needs Both Data and Expert Knowledge
- Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process
- Hydrodynamic Control of Alzheimer Aβ Fibrillation with Glucosaminic Acid Containing Click-Cyclized β-Bodies
- Accelerating Computation of Acidity Constants and Redox Potentials for Aqueous Organic Redox Flow Batteries by Machine Learning Potential-Based Molecular Dynamics
- Serotonin Signaling through Lipid Membranes
- Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R
- SuFEx-Enabled Direct Deoxy-Diversification of Alcohols
- Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain
- Customized Scaffolds for Direct Assembly of Functionalized DNA Origami
- Mechanism-Based Enzyme Inactivation Using an Allyl Sulfoxide-Allyl Sulfenate Ester Rearrangement1
- Deep Learning-Assisted Spectrum-Structure Correlation: State-of-the-Art and Perspectives
- Binding-Free Taste Visualization with Plasmonic Metasurfaces
- Protein-Based Tools for Studying Neuromodulation
- Global Neuropeptidome Profiling in Response to Predator Stress in Rat: Implications for Post-Traumatic Stress Disorder
- How is Membrane Permeation of Small Ionizable Molecules Affected by Protonation Kinetics?
- Concise and Scalable Radiosynthesis of (+)-[18F]MDL100907 as a Serotonin 5-HT2A Receptor Antagonist for PET
- Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells
- Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target
- Rapid Screening of New Psychoactive Substances Using pDART-QqQ-MS
- A Combin aed Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity
- The Rational Design of Atomically Dispersed Catalysts via Spin Manipulation
- Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine
- Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine
- Liquid-Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics
- Correction to "Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease"
- Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
- Hyperspectral Mapping of Human Primary and Stem Cells at Cell-Matrix Interfaces
- Dimerization of European Robin Cryptochrome 4a
- Exploring the Interactions between two Ligands, UCB-J and UCB-F, and Synaptic Vesicle Glycoprotein 2 Isoforms
- Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments?
- RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-N,N-diisopropyltryptamine
- Core-Labeling (Radio) Synthesis of Phenols
- Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer
- Evaluating the Atypical Aging Potential Development in Sparkling Wines Can Be Achieved by Assessing the Base Wines at the End of the Alcoholic Fermentation
- Efficient Homojunction Tin Perovskite Solar Cells Enabled by Gradient Germanium Doping
- Deus Ex Machina? The Rise of Artificial Intelligence in Toxicology
- Is Target-Based Drug Discovery Efficient? Discovery and "Off-Target" Mechanisms of All Drugs
- Infrared Spectroscopy for Rapid Triage of Cancer Using Blood Derivatives: A Reality Check
- Discovery of Orally Available and Brain Penetrant AEP Inhibitors
- SDDSynergy: Learning Important Molecular Substructures for Explainable Anticancer Drug Synergy Prediction
- Encapsulation of MCC950 in Liposomes Decorated with Anti-Frizzled 1 Improves Drug Bioavailability and Effectiveness in Fatty Liver Disease
- Distribution and Sensory Impact of (2E,4E,6Z)-nonatrienal and Trans-4,5-epoxy-(E)-2-decenal in Wines and Spirits
- Ultrasensitive Nanofiber Biosensor: Rapid In Situ Chromatic Detection of Bacteria for Healthcare Innovation
- Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene
- Single-Molecule-Resolution Approaches in Synaptic Biology
- Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist
- RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
- Simultaneous SERS Sensing of Cysteine and Homocysteine in Blood Based on the CBT-Cys Click Reaction: Toward Precisive Diagnosis of Schizophrenia
- AI Personal Assistants and Sustainability: Risks and Opportunities
- Cell-Free and In Vivo Characterization of the Inhibitory Activity of Lavado Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3
- 2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2
- Demonstrating the Analytical Potential of a Wearable Microneedle-Based Device for Intradermal CO2 Detection
- Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress
- A Reconfigurable Bipolar Image Sensor for High-Efficiency Dynamic Vision Recognition
- Novel Substituted Pyrimidine Derivatives as Potential Anti-Alzheimer's Agents: Synthesis, Biological, and Molecular Docking Studies
- Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
- AI in Pharma: Transforming Drug Discovery and Strategic Management with MYC-Modulating Compounds and BET Protein Inhibitors
- Prunin from Poncirus trifoliata (L.) Rafin Inhibits Aldose Reductase and Glucose-Fructose-Mediated Protein Glycation and Oxidation of Human Serum Albumin
- Correction to "Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T(1)-Weighted Contrast-Enhanced Brain Imaging"
- Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model
Indementia