Treatment-Resistant Schizophrenia: Evaluation and Management

13 July 2024

Evidence

Prim Care Companion CNS Disord. 2024 Jul 2;26(4):23f03692. doi: 10.4088/PCC.23f03692.

ABSTRACT

The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.

Prim Care Companion CNS Disord 2024;26(4):23f03692.

Author affiliations are listed at the end of this article.

PMID:38996400 | DOI:10.4088/PCC.23f03692

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The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveThe objective of this study was to identify longitudinal predictors of depressive symptoms in autistic children and youth.MethodsParticipants were youth with a diagnosis of autism who were part of the Province of Ontario Neurodevelopmental Disorders Network longitudinal substudy. Depressive symptoms were assessed using the child behaviour checklist […]
Avery Longmore
Efficacy and Safety of Modafinil for Treatment of Amphetamine-Type Stimulant Use Disorder: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials: Efficacité et innocuité du modafinil pour le traitement des troubles liés à l'usage de stimulants de type amphétamine : revue systématique et méta-analyse d'essais randomisés contrôlés par placebo 21 July 2024
The Canadian Journal of Psychiatry, Ahead of Print. IntroductionAmphetamine-type stimulants (ATSs) are related to significant harm worldwide, with limited effective pharmacological treatments for ATS use disorder (ATSUD). Modafinil has been explored as a potential treatment for ATSUD. This systematic review and meta-analysis (PROSPERO ID: CRD42023388487) aimed to evaluate the efficacy and safety of modafinil for […]
Laurent Elkrief

Bullying within specialist medical training in Australia: Analysis of the medical training survey, 2020–2023 3 August 2024
Australasian Psychiatry, Ahead of Print. ObjectiveBullying is common in medical specialist training in Australia. To understand bullying rates across medical specialist training programs, we analyse the recent Medical Training Survey, administered by the Medical Board of Australia to all registered medical practitioners.MethodsMedical Training Survey data were extracted and averaged from 2020 to 2023.ResultsMany speciality trainees […]
Fiona A Wilkes
Respectful scientific debate in Australasian Psychiatry 3 August 2024
Australasian Psychiatry, Ahead of Print.
Jeffrey CL Looi
The 2024-2025 Commonwealth Budget for Mental Health: Funding unproven initiatives and stings in the tail 2 August 2024
Australasian Psychiatry, Ahead of Print. We discuss the ramifications of the Commonwealth of Australia Budget allocations for mental healthcare for 2024–2025. There is funding for population-based mental health initiatives for milder anxiety and depression but no direct funding of services for the most severe and disabling forms of mental illness, other than pre-existing state/territory disbursements […]
Jeffrey CL Looi

Evaluating counselling skills of community health workers for pregnant adolescents in Limpopo province 30 July 2024
Background: Adolescent pregnancy carries significant global ramifications. Community health workers (CHWs) play a role in empowering adolescents through counselling skills, thereby promoting informed decision-making for better outcomes.Aim: The study aims to evaluate the counselling skills of CHWs in their efforts to support pregnant adolescents (PA) in Limpopo province.Setting: The research was carried out with CHWs in the Mopani […]
Rakgadi G. Malapela
Cannabis use among hospitalised adolescents before and after decriminalisation in South Africa 26 July 2024
Background: Cannabis is the most widely used substance worldwide, and its use is much higher among adolescents. However, adolescents are at higher risk of negative sequelae secondary to this use, including the possible development of mental disorders. On 31 March 2017, the South African High Court ruled that cannabis use by an adult in a private […]
Michelle C. Swartz
The prevalence of anxiety in pregnant women at Chris Hani Baragwanath Academic Hospital 23 July 2024
Background: Non-psychotic mental disorders are common during the perinatal period. In South Africa, there are few studies on antenatal anxiety and these results vary. Antenatal anxiety does not only add to the burden of perinatal co-morbidity but has subsequent immediate and long-term effects on the mother, birth outcomes and her offspring.Aim: The aim of this study was […]
Lisha Narayan

Rasd2 regulates depression-like behaviors via DRD2 neurons in the prelimbic cortex afferent to nucleus accumbens core circuit 3 August 2024
Molecular Psychiatry, Published online: 03 August 2024; doi:10.1038/s41380-024-02684-5Rasd2 regulates depression-like behaviors via DRD2 neurons in the prelimbic cortex afferent to nucleus accumbens core circuit
Ziqian Cheng
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents 2 August 2024
Molecular Psychiatry, Published online: 02 August 2024; doi:10.1038/s41380-024-02668-5Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents
Zhikun Li
Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits 2 August 2024
Molecular Psychiatry, Published online: 02 August 2024; doi:10.1038/s41380-024-02675-6Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits
Ashutosh Tripathi

Thalamic cells and pathway for social memory processing and storage
In this issue of , Wang et al. demonstrate that parvalbumin interneurons in the sensory thalamic reticular nucleus are necessary and sufficient for regulating social memory in mice, identify a novel cortico-reticular thalamic-parafascicular pathway for social cognition, and highlight an essential role of GABAergic inhibitory neurons in social memory engrams.In this issue of , Wang et al. […]
Pupil constriction by contrast for contrast
The pupil is the eye’s adjustable aperture. Fitzpatrick et al. find that visual contrast constricts the pupil, increasing contrast. This process improves behavioral performance. Its retinal origin has unorthodox elements, like interneurons that make connections in unusual locales and photoreceptive ganglion cells.The pupil is the eye’s adjustable aperture. Fitzpatrick et al. find that visual contrast constricts the […]
Dissecting attention: Rate modulation vs. phase locking
In this issue of , Spyropoulos et al. report direct top-down modulation of neuronal firing rates underlying selective visual attentional modulation.In this issue of , Spyropoulos et al. report direct top-down modulation of neuronal firing rates underlying selective visual attentional modulation.

Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression 5 August 2024
Nature Mental Health, Published online: 05 August 2024; doi:10.1038/s44220-024-00298-yPsilocybin and escitalopram create significantly different reconfigurations in the global functional hierarchy of brain dynamics with opposite statistical effect responses in people with major depressive disorder.
Gustavo Deco
Lessons on targeting family mental health and improving outcomes for children of parents with a mental illness 1 August 2024
Nature Mental Health, Published online: 01 August 2024; doi:10.1038/s44220-024-00285-3Children of parents with a mental illness are at risk of adverse mental health outcomes. This Perspective discusses lessons learned from the European projects targeting family mental health and, on the basis of identified problems and barriers, provides recommendations to guide the development of future projects and […]
Elena Toffol
From diagnostic conformity to co-narration of self-insight in mental health care 30 July 2024
Nature Mental Health, Published online: 30 July 2024; doi:10.1038/s44220-024-00284-4This Perspective seeks to identify the limitations of the ‘clinical insight’ construct discussing an alternative narrative approach for individuals with psychosis.
N. J. Ermers

Pharmacogenomic scores in psychiatry: systematic review of current evidence 6 August 2024
Translational Psychiatry, Published online: 06 August 2024; doi:10.1038/s41398-024-02998-6Pharmacogenomic scores in psychiatry: systematic review of current evidence
Nigussie T. Sharew
Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation 6 August 2024
Translational Psychiatry, Published online: 06 August 2024; doi:10.1038/s41398-024-03041-4Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation
Rui Ni
Association of lifestyle with sleep health in general population in China: a cross-sectional study 4 August 2024
Translational Psychiatry, Published online: 04 August 2024; doi:10.1038/s41398-024-03002-xAssociation of lifestyle with sleep health in general population in China: a cross-sectional study
Yong-Bo Zheng

WFP News Section 21 May 2024
Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial 16 May 2024
AbstractIntroduction: Loneliness poses a significant health problem and existing psychological interventions have shown only limited positive effects on loneliness. Based on preliminary evidence for impaired oxytocin signaling in trait-like loneliness, the current proof-of-concept study used a randomized, double-blind, placebo-controlled design to probe intranasal oxytocin (OT) as an adjunct to a short-term modular-based group intervention for […]
Efficacy of an Internet- and Mobile-Based Intervention for Subclinical Anxiety and Depression (ICare Prevent) with Two Guidance Formats: Results from a Three-Armed Randomized Controlled Trial 30 April 2024
AbstractIntroduction: Limited research exists on intervention efficacy for comorbid subclinical anxiety and depressive disorders, despite their common co-occurrence. Internet- and mobile-based interventions (IMIs) are promising to reach individuals facing subclinical symptoms. Objective: This study aimed to evaluate the efficacy of a transdiagnostic and self-tailored IMI in reducing subclinical anxiety and depressive symptom severity with either […]

Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study 6 August 2024
BackgroundThe pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic and environmental factors. This study investigates associations between metal measures in plasma and urine, ALS risk and survival and exposure sources.MethodsParticipants with and without ALS from Michigan provided plasma and urine samples for metal measurement via inductively coupled plasma mass spectrometry. ORs and HRs for […]
Jang, D.-G., Dou, J. F., Koubek, E. J., Teener, S., Zhou, L., Bakulski, K. M., Mukherjee, B., Batterman, S. A., Feldman, E. L., Goutman, S. A.
Implications for driving based on the risk of seizures after ischaemic stroke 2 August 2024
BackgroundIn addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke.MethodsWe analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT2.0 prognostic model. We considered […]
Schubert, K. M., Bicciato, G., Sinka, L., Abraira, L., Santamarina, E., Alvarez-Sabin, J., Ferreira-Atuesta, C., Katan, M., Scherrer, N., Terziev, R., Döhler, N., Erdelyi-Canavese, B., Felbecker, A., Siebel, P., Winklehner, M., von Oertzen, T. J., Wagner, J. N., Gigli, G. L., Nilo, A., Janes, F., Merlino, G., Valente, M., Zafra-Sierra, M. P., Mayor-Romero, L. C., Conrad, J., Evers, S., Lochner, P., Roell, F., Brigo, F., Bentes, C., Peralta, R., Pinho e Melo, T., Keezer, M. R., Duncan, J. S., Sander, J. W., Tettenborn, B., Koepp, M., Galovic, M.
Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study) 31 July 2024
BackgroundData on cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited to studies with small sample sizes. Therefore, we aimed to analyse the extent, characteristics and the longitudinal course of potential cognitive deficits in patients with MOGAD.MethodsThe CogniMOG-Study is a prospective, longitudinal and multicentre observational study of 113 patients with MOGAD. Individual […]
Passoke, S., Stern, C., Häussler, V., Kümpfel, T., Havla, J., Engels, D., Jarius, S., Wildemann, B., Korporal-Kuhnke, M., Senel, M., Stellmann, J.-P., Warnke, C., Grothe, M., Schülke, R., Gingele, S., Kretschmer, J. R., Klotz, L., Walter, A., Then Bergh, F., Aktas, O., Ringelstein, M., Ayzenberg, I., Schwake, C., Kleiter, I., Sperber, P. S., Rust, R., Schindler, P., Bellmann-Strobl, J., Paul, F., Kopp, B., Trebst, C., Hümmert, M. W., on behalf of the Neuromyelitis Optica Study Group (NEMOS), The Neuromyelitis Optica Study Group (NEMOS), Albrecht, Angstwurm, Asseyer, Bayas, Bednarz, Behnke, Berthele, Bittner, Bütow, Buttmann, Dawin, Dersch, Duchow, Etgen, Finke, Fischer, Förster, Fousse, Frank, Freitag, Gahlen, Gass, Gehrig, Geis, Giglhuber, Goereci, Gold, Galvao Ribeiro Gomes, Graf, Groppa, Gutbrod, Guthke, Haarmann, Hastermann, Hellwig, Hemmer, Herfurth, Herwerth, Hoffmann, Hoffmann, Oy, Husseini, Ingenhoven, Junghans, Kaste, Kern, Kern, Kermer, Kleinschnitz, Köhler, Körbel, Kowarik, Krämer, Krumbholz, Kunzmann, Kurka, Ladopoulos, Landwehr, Langel, Lauenstein, Laurent, Lee, Lehrieder, Leypoldt, Liebetrau, Lindenblatt, Linker, Lohmann, Lüdemann, Luessi, Maiworm, Marziniak, Mayer, Meister, Melms, Mering, Metz, Meuth, Naumann, Nenkov, Neuhaus, Neziraj, Niederschweiberer, Niehaus, Oertel, Otto, Pache, Pakeerathan, Paryjas, Pawlitzki, Pepping, Pfeuffer, Pompsch, Pretzsch, Proebstel, Protopapa, Puhlmann, Pul, Rauer, Rehfeldt, Retzlaff, Riedlinger, Rommer, Rostasy, Rothhammer, Rückriem, Ruprecht, Ruschil, Saggau, Schraad, Schwab, Schwarz, Seipelt, Sieb, Soloroza, Sommer, Stefanou, Steinbrecher, Stephanik, Steuerwald, Stoppe, Stürner, Süsse, Tarampanis, Tauber, Tkachenko, Tsaktanis, Tumani, Wallwitz, Walz, Wandinger, Weber, Weise, Wickel, Wiendl, Winkelmann, Wohlrab, Yalachkov, Zettl, Ziemann, Zipp

Mendelian randomization: causal inference leveraging genetic data 19 April 2024
Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for […]
Chen, Lane G.
Interventions targeting social determinants of mental disorders and the Sustainable Development Goals: a systematic review of reviews 25 March 2024
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review […]
Oswald, Tassia Kate
Do metacognitive therapies for schizophrenia-spectrum disorders work? A meta-analytic investigation 21 March 2024
Recent reviews and meta-analyses of metacognitive therapy for schizophrenia-spectrum disorder (SSD) have included uncontrolled studies, single-session interventions, and/or analyses limited to a single form of metacognitive therapy. We sought to evaluate the efficacy of metacognitive therapies more broadly based on controlled trials (CT) of sustained treatments. We conducted a pre-registered meta-analysis of controlled trials that […]
Melville, Grace

Electroconvulsive therapy in the maintenance phase of psychotic unipolar depression 2 August 2024
Acta Psychiatrica Scandinavica, Volume 150, Issue 3, Page 148-159, September 2024.
Ahmed Al‐Wandi, Mikael Landén, Axel Nordenskjöld
Early specialised treatment for bipolar disorder: Long‐term follow‐up from the early intervention in affective disorders (EIA) randomised controlled trial 2 August 2024
Acta Psychiatrica Scandinavica, Volume 150, Issue 3, Page 138-147, September 2024.
Klaus Munkholm, Lars Vedel Kessing
Drug survival and risk factors for ADHD medication discontinuation in adults: A Danish Nationwide Registry‐based cohort study 2 August 2024
Acta Psychiatrica Scandinavica, Volume 150, Issue 3, Page 160-173, September 2024.
Pelle Lau Ishøy, Kim Berg Engersgaard Johannessen, Tine Houmann, Eline Levin, Per Hove Thomsen

Considering challenges for the new Alzheimer's drugs: Clinical, population, and health system perspectives 6 August 2024
Alzheimer's &Dementia, EarlyView.
Sebastian Walsh, Richard Merrick, Richard Milne, Shirley Nurock, Edo Richard, Carol Brayne
Evaluation of the Effects of Optokinetic Stimuli and Dual‐Task Performance on Vestibulo‐Ocular Reflex Function in Children With Attention Deficit and Hyperactivity Disorder 6 August 2024
Clinical Otolaryngology, EarlyView.
Hanifi Korkmaz, Emine Aydin, Fatma Ceyda Akin Ocal, Bulent Satar
A Month of Vestibular Migraine: Symptom Characterization Using Ecological Momentary Assessment 6 August 2024
The Laryngoscope, EarlyView.
Jasmeet Saroya, Max Humwell, Adam Gardi, Ricky Chae, Daniel Wong, Isabel Allen, Jeffrey D. Sharon

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Evolving Perspectives on Wellness and Stress
Renewing the Teaching of Clinical Reasoning in Psychiatry: An Opportunity for Advancing Mental Health Training and Care
Assaults and Microaggressions Against Psychiatric Residents: Findings from a US Survey
Psychiatric physicians may experience higher rates of assault than those in other fields. For many reasons, residents may be especially vulnerable. This study updates rates of assaults among US psychiatry residents as well as the reporting rates and emotional effects of these incidents. Little data exists to examine rates of microaggressions against psychiatry residents.A cross-sectional […]

Enhancing Brain Health and Well-Being in Older Adults: Innovations in Lifestyle Interventions
This article will provide clinicians with guidance on helping older adult patients make lifestyle changes to enhance brain health and well-being.Evidence suggests that physical activity might be helpful in improving cognitive functioning. The data on the benefits of cognitive activity is inconsistent and not as robust. The MediDiet, DASH, and MIND diets have been associated […]
Management of MCI in the Outpatient Setting
We review current literature related to the clinical assessment of Mild Cognitive Impairment (MCI). We compile recommendations related to the evaluation of MCI and examine literature regarding the use of clinical biomarkers in this assessment, the role of non-pharmacologic therapy in the prevention of cognitive decline, and recent approval of anti-amyloid therapy in the treatment […]
Cross-Cultural Patient Counseling and Communication in the Integrative Medicine Setting: Respecting the Patient's Health Belief Model of Care
Communicating effectively with patients having a traditional, alternative or complementary medicine-related health-belief model is challenging in today’s cross-cultural society. This narrative review explores the integrative medicine setting of care, focusing on insights from the integrative oncology daily practice, while addressing the relevance to the mental health setting. The way in which healthcare providers can enhance […]

Editorial introductions
No abstract available
journals.lww.com
Sex and gender differences in cancer in individuals with severe mental disorders
Purpose of review Although cancer incidence is similar between individuals with severe mental disorders (SMD) and the general population (GP), survival rates are lower, particularly in those with schizophrenia. While the scientific and medical communities acknowledge sex differences in cancer mechanisms, including risk factors and cancer types, less is known about sex and gender disparities […]
Bajić, Žarko; Vuk-Pisk, Sandra; Filipčić, Igor; Šimunović Filipčić, Ivona
The role of human involvement and support in digital mental health interventions for people with schizophrenia spectrum disorders: a critical review
Purpose of review Schizophrenia spectrum disorders (SDD) are characterized by a complex array of psychosis symptoms, and typically require ongoing and long-term support, including pharmacological and nonpharmacological management. Digital mental health interventions (DMHIs) have been suggested as a novel therapeutic approach to enable low-cost, scalable improvements in quality of care for adults living with SSD. […]
Arnautovska, Urska; Milton, Alyssa; Trott, Mike; Soole, Rebecca; Siskind, Dan

Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood
Anhedonia is associated with aberrant predictions during Pavlovian fear acquisition.Anhedonia is associated with overgeneralization of predictions for novel stimuli.Anhedonia effects are evident at age 18-19 and again at age 21-22.Fear symptoms are associated with overgeneralized predictions only at age 21-22.General Distress symptoms are associated with overgeneralized predictions only at age 18-19. Pavlovian fear paradigms involve […]
Interventions to reduce adult state anxiety, dental trait anxiety, and dental phobia: A systematic review and meta-analyses of randomized controlled trials
For alleviating state anxiety (distress) during oral surgery, hypnosis and conscious sedation with benzodiazepines showed small effects.Psychotherapy for state anxiety is inconclusive; virtual reality distraction, music, aromatherapy, an information video, and acupuncture lack evidence.For the treatment of chronic dental (trait) anxiety, the use of Cognitive Behavioral Therapy (CBT) showed a moderate reducing effect.For dental phobia, […]
Testing predictions from the memory and identity theory of ICD-11 complex posttraumatic stress disorder: Measurement development and initial findings
The ‘Memory and Identity Theory’ of Complex Posttraumatic Stress Disorder (CPTSD) was recently published but has not yet been subjected to empirical testing. The objective of this study was to evaluate newly developed measures of memory and identity disturbances and test hypothesized structural relations between these constructs and CPTSD symptoms.Self-report data were collected from a […]

Characteristics of children with a psychiatric disorder in 1999, 2004 and 2017: an analysis of the national child mental health surveys of England 24 July 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Jessica M. Armitage, Tamsin Newlove‐Delgado, Tamsin Ford, Sally McManus, Stephan Collishaw
Issue Information 23 July 2024
Journal of Child Psychology and Psychiatry, Volume 65, Issue 8, Page i-iv, August 2024.
Editorial: For better or for worse? Intended and unintended consequences of science communication 23 July 2024
Journal of Child Psychology and Psychiatry, Volume 65, Issue 8, Page 995-997, August 2024.
Alice M. Gregory, Fatos Selita, Yulia Kovas

Adjuvant and Mainstream Treatments for Depression, Schizophrenia, Obsessive-Compulsive Disorder, and Cognitive Impairment 4 August 2024
The International Journal of Psychiatry in Medicine, Ahead of Print.
Harold G. Koenig
Building resilience: A specialty clinic tailored to older adults at risk of violence and abuse 4 August 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveBoth structural (e.g., ageism) and personal (e.g., stigma) barriers hinder older adult’s access to and engagement with mental health care). These barriers are particularly problematic for those vulnerable to interpersonal violence and abuse (e.g., due to social isolation). This study presents a quality improvement program […]
Melba A. Hernandez-Tejada
Prevalence and correlates of insomnia and fatigue in patients with type 2 diabetes in Jordan 26 July 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. Objective: The present study examined the prevalence and correlates of insomnia and fatigue in patients with type-2 diabetes in Jordan.Methods: This was a cross-sectional online study involving a convenience sample of 390 patients with type-2 diabetes. Insomnia was assessed by the Insomnia-Severity Index (ISI-A) and […]
Salam Shannag

Global, regional, and national time trends in incidence for depressive disorders, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019 2 August 2024
Even with advances in primary health care, depressive disorders remain a major global public health problem. We conducted an in-depth analysis of global, regional and national trends in depressive disorders in...
Yuhang Wu, Luying Fan, Fan Xia, Yunzhe Zhou, Haiyan Wang, Lijuan Feng, Shudong Xie, Wendi Xu, Zhiqin Xie, Jing He, Dan Liu, Sui He, Yuting Xu, Jing Deng, Tingting Wang and Lizhang Chen
Predictors of continuation for asenapine from real-world data in patients with schizophrenia 2 August 2024
The continuation rates of pharmacotherapy in schizophrenia exhibit variability, a phenomenon influenced by the specific antipsychotic agent prescribed and patient-related factors such as age and duration of il...
Yoshiteru Takekita, Shuichi Hiraoka, Yasuhiro Iwama, Daisuke Matsui, Nobuatsu Aoki, Haruhiko Ogata, Toshiya Funatsuki, Toshiyuki Shimizu, Yuji Murase, Yutaro Shimamoto, Yosuke Koshikawa and Masaki Kato
Brain-derived neurotrophic factor and C-reactive protein (CRP) biomarkers in suicide attempter and non-attempter major depression disorder (MDD) patients 22 July 2024
In the available literature, levels of BDNF and CRP have been reported to correlate with suicide in depressive patients but there are inconsistencies in the results. We aimed to evaluate and compare BDNF and C...
Seyed Hassan Saadat, Mohammad Javanbakht and Shima Shahyad

Development and validation of the Gender Identity and Expression Microaggressions in Therapy Scale (GIEMTS). 18 April 2024
Developing affirming interventions for transgender and nonbinary (TNB) therapy clients requires understanding their experiences with microaggressions in psychotherapy, yet no self-report measure of anti-TNB microaggressions in this context exists. Moreover, few studies have tested the associations between anti-TNB microaggressions and therapy processes. To better address the burden of unmet mental health care needs among TNB […]
The evolution of feedback: Toward a multicultural orientation. 18 April 2024
There have been great strides in psychology regarding diversity, equity, inclusion, and multicultural competence, but a need remains to translate these values into actionable practices in psychotherapy. While the case has been made that measurement-based care is an evidence-based intervention that improves outcomes and reduces dropouts (de Jong et al., 2021) and recently that it […]
Beyond the dyad: Broadening the APA supervision guidelines to include group supervision. 28 March 2024
Group supervision is an extensively used format across many training agencies, yet it has been largely disregarded in theory and research within the supervision literature. In fact, the Guidelines for Clinical Supervision in Health Service Psychology (American Psychological Association, 2015a) mentions group supervision only one time, despite the fact that supervision within a group context […]

A Family-Based Intervention for Early Elementary Students With Reading and Behavioral Difficulties: A Pilot Study 2 August 2024
Journal of Learning Disabilities, Ahead of Print. We created and tested a family-based intervention with families of children in Grades 1 and 2 with reading and behavioral difficulties to investigate its impact on text comprehension. Developed with input from parents, reading experts, and behavior specialists, Family-RISE (Reading Intervention with Supports for Engagement) integrates evidence-based practices […]
Garrett J. Roberts
Assessing Beliefs About Intrinsic and Extrinsic Determinants of SLD: Evaluating the Factor Structure of a Novel Instrument 26 July 2024
Journal of Learning Disabilities, Ahead of Print. Schools conduct comprehensive psychoeducational evaluations to identify students with specific learning disabilities (SLDs) and determine whether they qualify for special education services. This decision-making process is complex and research has documented many factors influencing SLD identification decisions. One such factor may be decision-makers’ beliefs about the underlying causes […]
Courtenay A. Barrett
Do Mathematics and Reading Skills Impact Student Science Outcomes? 26 July 2024
Journal of Learning Disabilities, Ahead of Print. Establishing validated science programs for students with or at risk for learning disabilities requires testing treatment effects and exploring differential response patterns. This study explored whether students’ initial mathematics and reading skills influenced their treatment response to a whole-class, second-grade science program called Scientific Explorers (Sci2). The original […]
Christian T. Doabler

Bridging the digital divide for individuals with intellectual disabilities: Implications for well‐being and inclusion 25 July 2024
British Journal of Learning Disabilities, EarlyView.
Esther Murphy, Orla Shiels, Sara Fiori, Darren McCausland, Helena Bergström, Raphael Koster, Hanna Noorlandt, Ida Korfage, Eva Flygare Wallén
The role of lived experience eye care champions in improving awareness and access to eye care services for people with learning disabilities and/or autism 22 July 2024
British Journal of Learning Disabilities, Volume 52, Issue 3, Page 489-499, September 2024.
Marek Karas, Donna O'Brien, Lance Campbell, Rebecca Lunness, Joanne Kennedy, Grace McGill, Stephen Kill, Lisa Donaldson
Evaluation of a co‐designed Health Check‐in for adults with intellectual and developmental disabilities and family caregivers to support pandemic recovery 22 July 2024
British Journal of Learning Disabilities, Volume 52, Issue 3, Page 512-523, September 2024.
Yona Lunsky, Tiziana Volpe, Laura St. John, Anupam Thakur, Johanna Lake, the H‐CARDD COVID Program Team

Police officers’ perception of mentally disordered people: a national survey in Japan 2 August 2024
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Akihiro Shiina Tomihisa Niitsu Aika Tomoto Masaomi Iyo Eiji Shimizu Chiyo Fujii a Center for Forensic Mental Health, Chiba University, Chiba-shi, Chiba, Japanb Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba-shi, Chiba, Japanc Department of Cognitive Behavioural Physiology, Chiba University Graduate School of Medicine, Chiba-shi, Chiba, Japand National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira-shi, Tokyo, Japan
“This place does a lot more than produce milk”: a reflexive thematic analysis of staff experiences of supporting prison dairy workers 1 August 2024
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Libby Payne Mary McMurran Clare Glennan Jenny Mercer Department of Applied Psychology, Cardiff Metropolitan University, Llandaff, Cardiff, Wales, UK
Correction 31 July 2024
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Therapeutic and non-therapeutic practices in the child justice system in Kenya: A therapeutic jurisprudence perspective
Child justice systems are specialized jurisdictions set up for the purpose of providing justice related services to children. In an effort to resolve many of the systemic injustices expereinced by justice involved children, Kenya recently legislated the Children Act 2022. This new law is viewed as a paradigm shift from previous children acts as it […]
Forensic criteria, clinical and theoretical issues of the indication of court-ordered treatment: A comparative survey among experts in forensic psychiatry and sentencing judges in France
Following the French law n° 98–468 of 17 June 1998 relative to the prevention of sexual offenses and the protection of minors, social and judicial follow-up and court-ordered treatment were introduced with the aim of reinforcing the prevention of recidivism. Court-ordered treatment is one of the possible obligatory measures provided for by social and judicial […]
Editorial Board

Changing environments to promote safety in libraries
The purpose of this article is to investigate how changes in the environment of a library affect the safety conditions of both visitors and staff. Using principles of Crime Prevention Through Environmental Design, crime and incidents of public disturbance from 2017 to 2020 from libraries in Stockholm, Sweden, are analyzed and later mapped using 3D […]
Revisiting the tautology problem in rational choice theory: What it is and how to move forward theoretically and empirically
Criminological rational choice theory is blighted by tautology—that if a crime occurs, then by definition the benefits must exceed the costs. The current analysis details the nature of this tautology as well as its theoretical and philosophical implications concerning the circumstances under which offenders make rational (thoughtful and reflective) or irrational (habitual, intuitive, or instinctual) […]
Experiences of fatherhood in prison: A thematic analysis of differences between fathers in a family approach programme and a comparison group
Various programmes have been implemented in prisons to strengthen parental involvement and parent–child relationships during imprisonment. In-depth insights into such programmes are limited. This qualitative study compared the experiences of two groups of imprisoned fathers in the Netherlands: fathers who participated in a family approach programme ( = 10) and fathers in a comparison group ( = 29). Based […]

“I just thought maybe this is [the] way of doing things”: Exploring lesbian-, gay-, and bisexual-specific intimate partner violence in Norway. 23 May 2024
Objective: Intimate partner violence (IPV) in lesbian, gay, and bisexual (LGB) relationships seems to be at least as high as in heterosexual relationships. However, there are uncertainties regarding how IPV is more specifically experienced in LGB relationships. We explore how LGB individuals exposed to IPV make sense of the potentially more specific ways in which […]
When childhood states become adult traits: Trait anxiety and anger as mediators linking childhood maltreatment to marital outcomes in midlife adults. 23 May 2024
Objective: Childhood maltreatment has been consistently linked to problematic marriages. The pathways, however, linking childhood maltreatment to marital problems over time remain understudied. The present study examined trait anger and trait anxiety as possible mediators linking childhood maltreatment to marital quality, support, and strain over a 9 year period. It was expected that both trait […]
Profiles of service-engaged intimate partner violence survivors: Considerations for service delivery and continuation. 16 May 2024
Objective: This study examined factors considered to influence service engagement among intimate partner violence (IPV) survivors. Specifically, it (a) investigated patterns of cultural beliefs, stigma related to attitudes about seeking formal help, and IPV experiences among service-engaged survivors and (b) explored their association with sociodemographic characteristics. Method: Mixture modeling was conducted using the Testing and […]

A feasibility evaluation of a peer support intervention for social participation in China 2 August 2024
This study aims to report on the feasibility, acceptability and outcomes of a peer support program designed to promote social participation for adults with serious mental illness (SMI) in China. The authors used a community-based participatory research approach to adapt and test a six-month, culturally responsive peer program with 68 participants. Peer supporters were trained […]
Xiyuan Chen
A community center to mobilize public policies and human rights in mental health: “the door is always open” 30 July 2024
This study aims to describe the perceptions of some participants from a community mental health center in the Department of Chocó, Colombia. A case study with a qualitative approach was carried out in 2023. Focus groups were conducted with mental health leaders and members of a community mental health center. The data were analyzed using […]
Felipe Agudelo-Hernández
Editorial: International perspectives in public mental health 5 June 2024
Editorial: International perspectives in public mental health
Neil Quinn

The notion of excessive childhood restlessness in Spain at the beginning of the twentieth century 27 July 2024
History of Psychiatry, Ahead of Print. This study delves into the historical documentation from 1900 to 1936 by Spanish doctors and educators concerning children’s hyperactivity. By focusing on medical perspectives of the time, we aim to explore the conceptualisation of childhood phenomenology within the context of significant international literature of that era. The publications of […]
Joana Escamilla Lerner
Empathy or sympathy: a necessary distinction? 23 July 2024
History of Psychiatry, Ahead of Print. As a deeply hybrid discipline, psychiatry demands research that tackles the concepts constituting it and its objects. This is an essential prerequisite to empirical studies, the validity of which are directly dependent on a clear understanding of the underlying concepts. Empathy and sympathy are concepts used variably and inconsistently […]
Ivana S Marková
A history of mental illness among women in the Straits Settlements in the nineteenth century 15 June 2024
History of Psychiatry, Ahead of Print. The Straits Settlements, a collective colony under the administration of British Malaya, was a very unhealthy area in the early years of the nineteenth century. One of the most common sicknesses was mental illness, which could not be cured by medicines. The number of women suffering from mental illness […]
Haszira Muhamad Yusof

Feasibility of online psychosocial interventions to promote mental health recovery and well-being 6 August 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Amid the increasing trend and huge impact of mental illness, psychosocial support (PSS) has been asserted to support individuals’ recovery. Unfortunately, about 80% of affected people cannot access care as needed. Meanwhile, digital technology has a considerable role in closing service gaps.Aims:This convergent parallel mixed methods study […]
Peanchanan Leah
From asylums to deinstitutionalization and after: an analytic review 3 August 2024
International Journal of Social Psychiatry, Ahead of Print. Background:After a period of institution-based mental health care, in which the asylum system was the way in which the mental patients were treated, deinstitutionalization brought a set of significant changes and transformations in the conceptualization of mental illness and, by extension, the traditional therapeutic settings in which […]
Francisco Balbuena Rivera
Inequitable access to mental healthcare for socially excluded adolescents 31 July 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Adolescence is a critical period for mental health and social exclusion, a key social determinant of mental health. Early intervention approaches are key to mitigating the impact of mental ill-health during adolescence, however social exclusion can create additional barriers to accessing care.Aim:We aimed to better understand help-seeking […]
Kate Filia

Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes [version 2; peer review: 1 approved with reservations] 6 August 2024
Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein is beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, and is beneficial for liver, kidney, and respiratory health. Lutein protects against oxidative and nitrosative stress, both of which play a major role in […]
Anthony M Kyriakopoulos
Case Report: Peripartum periventricular leukomalacia resulting in cerebral palsy associated with placenta previa in Japan [version 5; peer review: 1 approved, 2 approved with reservations] 6 August 2024
Intrapartum fetal heart rate monitoring abnormalities had been reported to correlate with decreased umbilical artery base excess associated with neonatal seizures. However, we present an infant born at 35 weeks of gestation diagnosed with cerebral palsy associated with periventricular leukomalacia (PVL) without fetal heart rate (FHR) monitoring abnormalities, According to the summary reports of PVL […]
Shunji Suzuki
MirtronStructDB: A Comprehensive Database of Mirtrons with Predicted Secondary Structures [version 1; peer review: awaiting peer review] 6 August 2024
Motivation Mirtrons, a vital category of non-canonical microRNAs (miRNAs) originating from exon-intron boundaries through splicing mechanisms, play crucial roles in cellular processes. However, existing databases lack the latest data and structural information, hindering understandings of mirtron formation and functions. Results We introduce MirtronStructDB, an online database addressing these gaps by incorporating over 350 novel mirtrons. […]
Shumin Li

Coffee-Dementia Link Continues to Unfurl 5 August 2024
(MedPage Today) -- PHILADELPHIA -- Coffee and tea intake were associated with long-term cognitive changes in older adults, two prospective studies presented at the Alzheimer's Association International Conference (AAIC) suggested. Among 6,001...
Intermittent Fasting May Improve Memory, Executive Function, Early Trial Suggests 4 August 2024
(MedPage Today) -- PHILADELPHIA -- Intermittent calorie restriction improved executive function and memory measures in cognitively intact older adults, an exploratory pilot study suggested. The 8-week randomized clinical trial of 40 overweight...
The Promise of 'Magic Mushrooms' for Mental Health Is Real 3 August 2024
(MedPage Today) -- Looking for an election-year healthcare issue that could bring the two major political parties together? Think there is no such thing? Think again. A public opinion survey conducted last summer by the University of California...

Doctors, patients, algorithms, and avatars - University of Rochester 6 August 2024
In 2012, professor of psychiatry Caroline Easton had a eureka moment watching her son play video games: what if she could blend video-game technology ...
Suicide Rates in Children Continue to Climb | Newswise 6 August 2024
He established the medical-psychiatric unit at Medstar Washington Hospital Center, which focuses on providing holistic medical and mental health care ...
Pharmacogenomic scores in psychiatry: systematic review of current evidence - Nature 6 August 2024
... psychiatry have been developed based on psychiatric and medical diagnoses or trait variants, rather than pharmacogenomic variants. Among these PGx ...

New Guidance on Genetic Testing for Kidney Disease 6 August 2024
An expert group assembled by the National Kidney Foundation published recommendations and algorithms on who to test and which tests are best in which situations. Medscape Medical News
Do Private Equity Firms Really Save Troubled Hospitals? 6 August 2024
A new study suggested that from 2005 to 2018, private equity firms actually were more likely to buy institutions that had less debt. Medscape Medical News
Dental Costs Burden Many Patients With Head and Neck Cancer 6 August 2024
In this survey study, 39% of the patients with head and neck cancer experienced significant financial hardship owing to cancer treatment-related dental complications. Medscape Medical News

COVID-19 making worrying comeback WHO warns, amid summertime surge 6 August 2024
COVID-19 infections are surging worldwide - including at the Olympics - and are unlikely to decline anytime soon, the World Health Organization (WHO) warned on Tuesday.
More access to breastfeeding support could save 820,000 young lives annually, UN agencies say 31 July 2024
The heads of the UN Children’s Fund (UNICEF) and the World Health Organization (WHO) have called for greater access to breastfeeding support to both reduce health inequity and ensure mothers and babies can survive and thrive.
Healthcare in Sudan ‘hanging by a thread,’ warns UN agency 29 July 2024
The UN World Health Organization (WHO) on Monday strongly denounced the increasing attacks on healthcare facilities in Sudan, reporting over 20 such incidents in the last two months.

Strength in numbers – how monitoring breastfeeding policies and programmes creates accountability and empowers change 6 August 2024
Among the number of events during World Breastfeeding Week, on the 6th of August, WHO, UNICEF, and Global Breastfeeding Collective will be hosting the webinar
who.int
New Lancet Series: Maternal health in the perinatal period and beyond, Asia-Pacific Region 5 August 2024
Join this webinar for the launch of a new Lancet four-part Series on Maternal health in the Perinatal Period and Beyond.
who.int
Children in Gaza are now at risk of polio as well as bombs – we need a ceasefire now 1 August 2024
The polio virus was detected in wastewater samples in Gaza last week, an alarming yet unsurprising development given the dismantled state of the territory’s health systems after nine relentless months of war.
who.int

WHO and United Arab Emirates evacuate 85 patients from Gaza 30 July 2024
30 July 2024 Jerusalem, Cairo, Geneva Today, 85 sick and severely injured patients from Gaza were evacuated to Abu Dhabi, United Arab Emirates (UAE), for specialized care. This extremely complex joint evacuation was supported by the the World Health Organization (WHO) in partnership with the Government of the UAE and other partners. This is the […]
World Hepatitis Day 2024: It’s Time for Action 28 July 2024
28 July 2024, Cairo, Egypt – “It’s Time for Action”, urges WHO’s campaign to mark World Hepatitis Day 2024. In the Eastern Mediterranean Region and globally, WHO is calling on governments and communities to intensify efforts to combat hepatitis, emphasizing the need for urgent action. Fighting hepatitis in the Eastern Mediterranean Region raises both significant […]
Launch of the National Guidelines Programme of Egypt 27 July 2024
28 July 2024 – Egypt has officially launched the Egyptian National Guidelines programme. Thirty public health and clinical care guidelines are now available, covering 15 health issues. This is a great start to a remarkable initiative. “I had the honour of Joining H.E. Dr Khaled Abdul Ghafar, Deputy Prime Minster and Minister of Health in the […]

Low-Dose Corticosteroids for Adults With Severe Pulmonary Infections 23 July 2024
This Review discusses whether treatment with low-dose corticosteroids may benefit critically ill patients with respiratory infections who have septic shock, acute respiratory distress syndrome, or both.
LGBTQI+ Data Collection in Medicaid to Advance Health Equity 23 July 2024
This Viewpoint explores Centers for Medicare & Medicaid Services guidance on the collection of sexual orientation and gender identity data and how these data could be used to advance health equity for LGBTQI+ people.
Addressing Ableism in Physician Well-Being Planning 23 July 2024
This Viewpoint discusses the importance of physician well-being for optimizing patient care and current efforts to improve physician well-being, describes how structural ableism affects the well-being of physicians with disabilities, and calls for further efforts to address ableism in the health care workforce.

Let’s end corporate sponsorship of sporting events 6 August 2024
Mega sporting events matter. They inspire athletes and the general public, they inspire national pride, and they inspire corporate advertisers. The latter is not surprising, as over one billion people were estimated to have tuned into the Paris Olympics last week—a truly global captive audience.Olympic spectators will have been subject to a deluge of advertising […]
Kent Buse, Simon Barquera, Maggie Wetzel
Collective action could become norm, warns head of England’s GPs 6 August 2024
The collective action being undertaken by general practices could be maintained in the long term to protect services and staff, the head of England’s GPs has told The BMJ.Katie Bramall-Stainer, chair of the BMA’s General Practitioners Committee for England, emphasised that the collective action voted for by GP partners last week could be undertaken at […]
Gareth Iacobucci
UN fires nine staff members over potential involvement in 7 October Hamas attack on Israel 6 August 2024
The United Nations has said it will be terminating contracts with nine staff members who have been working for the United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA), after an investigation found they may have been involved in the Hamas led attacks on Israel on 7 October.1The investigation by […]
Elisabeth Mahase

Risk ratios, odds ratios and the risk difference 31 July 2024
The risk ratioScenarioAs a heart surgeon, you regularly perform aortic valve replacement, using a median sternotomy technique. However, you are aware that less-invasive options are available, and you wonder whether these may be as effective and safe as your current practice. After searching the Cochrane Library, you find a systematic review, ‘Limited versus full sternotomy […]
Richardson, R., Kanellopoulou, A., Dwan, K.
Successes, shortcomings and learning opportunities for evidence-based medicine from the COVID-19 pandemic 31 July 2024
The COVID-19 pandemic represents the largest public health crisis of the past century. Faced with a global threat, public health officials, professional societies, clinicians and patients have appropriately sought strategies to prevent SARS-CoV-2 transmission, reduce progression to severe and critical illness, and mitigate short-term and long-term sequelae. Efforts have extended to drug therapies, non-pharmacological interventions […]
Agarwal, A., Guyatt, G.
Simple tool implementing Buchers method for indirect treatment comparisons in meta-analyses 31 July 2024
StandfirstHealthcare practitioners and patients are often required to make choices between two treatment options which may have never been compared directly. When performing standard ‘pairwise’ meta-analysis, it is common to find trials comparing one of two experimental treatments against a common control (standard of care or placebo) but no head-to-head trials. Statistical methods are available […]
Tingle, S. J., Kourounis, G., Liu, F., Wilson, C. H., Richardson, R., Sandercock, J.

My sister, Ruth Perry 6 August 2024
FAMILY BLOG: Julia Waters talks about her sister Ruth, the Ofsted inspection that led to her death and what needs to change to protect others.
Inquest
Instagram Links 2 August 2024
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inquest.org.uk
Deaths in women’s prisons 31 July 2024
Below is a breakdown of deaths in women’s prisons in England and Wales by calendar year (January-December) since 2013. Figures for the current calendar year and for 2021-2023 may be incomplete as they are based on INQUEST casework and monitoring. The data for previous calendar years are derived from official sources. For data going back […]
Inquest