Evidence
Toxics. 2023 Jun 11;11(6):525. doi: 10.3390/toxics11060525.
ABSTRACT
Heated tobacco products (HTPs) produce aerosol using a different mechanism than tobacco cigarettes, leading to lower emissions of some harmful substances, but also of nicotine as reported by some independent studies. Lower nicotine delivery could lead to compensatory puffing when product use does not sufficiently satisfy cravings. Thus, this three-arm crossover study was conducted to characterize the potential of two different HTPs to deliver nicotine and satisfy cravings compared with conventional cigarettes in users who had already switched to HTPs. Fifteen active, non-exclusive HTP users consumed the study products according to a pre-directed puffing protocol. At predetermined time points, venous blood was sampled and the subjective effects of consumption were assessed. Nicotine delivery by both HTPs was comparable, but significantly lower than that by conventional cigarettes, suggesting a lower addictive potential. Cravings were reduced by all products, with no statistically significant differences between them, despite the different nicotine deliveries. This indicated that HTPs do not necessarily need high nicotine deliveries with high addictive potential, as are characteristic of tobacco cigarettes. These results were followed up on with an ad libitum use study.
PMID:37368625 | DOI:10.3390/toxics11060525
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Two Different Heated Tobacco Products vs. Cigarettes: Comparison of Nicotine Delivery and Subjective Effects in Experienced Users
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Smokers' perception of the comparative health risks of cigarettes, e-cigarettes and heated tobacco products: a survey among the German population
- Heated tobacco product marketing: a mixed-methods study examining exposure and perceptions among US and Israeli adults
- Comparison of emissions across tobacco products: A slippery slope in tobacco control
- Reasons for multiple tobacco product and cannabis co-use among Texas young adults
- Depression screening outcomes among adolescents, young adults, and adults reporting past 30-day tobacco and cannabis use
- An observational human laboratory assessment of nicotine delivery, vaping topography and subjective effects of usual brand electronic cigarette use among young adults
- Perceived relative harm and addictiveness compared with cigarettes and intentions to use modified risk tobacco products utilizing FDA-authorized marketing claims among adults in the United States
- Breaking the habit: isolating nicotine-degrading bacteria in undergraduate microbiology teaching labs
- Cigarette smoking and cognitive task performance: Experimental effects of very-low nicotine-content cigarettes
- Reinforcing and adverse observable effects of nicotine and minor tobacco alkaloids in squirrel monkeys
- Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial
- Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial
- Understanding the nicotine dose delivered by electronic nicotine delivery systems in a single puff: the importance of nicotine flux and puff duration
- Online quantification of nicotine in e-cigarette aerosols by vacuum ultraviolet photoionization mass spectrometry
- Menthol and filter ventilation in cigarettes: prevalence estimates and relationships with harm perception and smoking exposure
- Vaping: Public Health, Social Media, and Toxicity
- More than a "characterizing flavor": Menthol at subliminal levels in tobacco products
- More than a "characterizing flavor": Menthol at subliminal levels in tobacco products
- Menthol versus tobacco e-liquid flavor: Impact on acute subjective effects, puff patterns, and intentions for use among Black and White menthol smokers
- Nicotine information disclosed online by e-cigarette brands popular with young people
- Prevalence of Electronic Cigarette Smoking Among Students of Shaqra University, Saudi Arabia
- Does e-cigarette use predict short-term smoking cessation behaviors among adults who smoke in Mexico? A longitudinal study
- Does e-cigarette use predict short-term smoking cessation behaviors among adults who smoke in Mexico? A longitudinal study
- Unveiling the Impact of Electronic Cigarettes (EC) on Health: An Evidence-Based Review of EC as an Alternative to Combustible Cigarettes
- Interactions between ENDS and cigarette use: evidence from a 2022 national telephone survey in South Africa
- Eating Disorder Symptomatology Among Young Adult Cigarette and E-Cigarette Users
- Harm perceptions across vaping product features: An on-line cross-sectional survey of adults who smoke and/or vape in the United Kingdom
- The Role of e-Cigarette Packaging as a Health Communications Tool: A Focus Group Study With Adolescents and Adults in England and Scotland
- Methoxsalen inhibits the acquisition of nicotine self-administration: attenuation by cotinine replacement in male rats
- Poly-tobacco use and mental health in South Korean adolescents
- Direct Extraction and Determination of Free Nicotine in Cigarette Smoke
- Perceptions of a reduced nicotine policy and predictors of policy support: A nationally representative U.S. survey
- New Research: E-Cigarette Content on Instagram Violates Policies, Is Marketed to Teens
- Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board
- Cigarette and E-Cigarette Perceptions About Harm During Pregnancy
- E-cigarette use, perceived risks, attitudes, opinions of e-cigarette policies, and associated factors among Thai university students
- Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart
- Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
- E-cigarette use among university students in Palestine: Prevalence, knowledge, and determinant factors
- Prevalence, Habit Pattern, and Awareness on Harmful Effects of Tobacco/Areca Nut Use among Patients Visiting a Tertiary Care Center in Sri Lanka
- Switching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence relief
- Risk of Adverse Neonatal Outcomes After Combined Prenatal Cannabis and Nicotine Exposure
- Risk of Adverse Neonatal Outcomes After Combined Prenatal Cannabis and Nicotine Exposure
- Associations between vaping and self-reported respiratory symptoms in young people in Canada, England and the US
- Associations between vaping and self-reported respiratory symptoms in young people in Canada, England and the US
- Assisting young people aged 12-25 years to cease e-cigarette use in general practice
- Evaluation of a smoking cessation program for adults with severe mental illness in a public mental health service
- Discordance Between Insurance Coverage of Antiviral Medications and Nicotine Replacement Therapy Among Individuals With Human Immunodeficiency Virus Who Smoke
- Not-so-disposable e-cigarettes: Methods young people use to discard single-use e-cigarettes
- From Impression to Addiction: The Pathways of Adolescent Tobacco Use
- Do Australians use the prescription pathway when using nicotine vaping products to quit smoking?
- Determining the Short-term Effects of Smoking Cessation Using Nicotine Gum on Oral Health-Related Quality of Life: A Pilot Study
- Nicotine inhalant via E-cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF-TrkB signalling in traumatic brain injury
- Distinct patterns of cigarette smoking intensity and other substance use among women who experience housing instability
- Brain antioxidant status and gene expressions of nicotinic and dopamine receptors are improved by black seed oil administration in cigarette smoke or nicotine vapour-exposed rats
- Change in vaping, smoking and dual-use identities predicts quit success and cigarette usage: A prospective study of people quitting smoking with electronic cigarette support
- Change in vaping, smoking and dual-use identities predicts quit success and cigarette usage: A prospective study of people quitting smoking with electronic cigarette support
- Factors associated with the use of benzodiazepine and opioid prescription drug in the student population: a cross-sectional study
- Social networks of people with serious mental illness who smoke: potential role in a smoking cessation intervention
- Opportunistic smoking cessation interventions for people accessing financial support settings: A scoping review
- Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell
- N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice
- Bidirectional relationships between nicotine vaping and maladaptive eating behaviors among young adults
- Intake of the different types of dairy products, genetic predisposition, and the risks of nonalcoholic fatty liver disease and cirrhosis: a prospective cohort study
Evidence Blueprint
Two Different Heated Tobacco Products vs. Cigarettes: Comparison of Nicotine Delivery and Subjective Effects in Experienced Users
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Two Different Heated Tobacco Products vs. Cigarettes: Comparison of Nicotine Delivery and Subjective Effects in Experienced Users
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Is "tobacco harm reduction" possible? Other countries' experiences and perspectives, and how they could inform tobacco control in Japan
- Research progress on the prevalence and harm of heated tobacco products
- Smokers' perception of the comparative health risks of cigarettes, e-cigarettes and heated tobacco products: a survey among the German population
- Effect of nicotine corrective messaging on nicotine-related beliefs in US adults: a randomised controlled trial
- Heated tobacco product marketing: a mixed-methods study examining exposure and perceptions among US and Israeli adults
- Nicotine and Cardiovascular Health: When Poison is Addictive - a WHF Policy Brief
- Expanding on cross-price elasticity: Understanding tobacco product demand and substitution from the cross-price purchase task
- Comparison of emissions across tobacco products: A slippery slope in tobacco control
- Reasons for multiple tobacco product and cannabis co-use among Texas young adults
- Depression screening outcomes among adolescents, young adults, and adults reporting past 30-day tobacco and cannabis use
- Underreporting of non-study cigarette use by study participants confounds the interpretation of results from ambulatory clinical trial of reduced nicotine cigarettes
- Underreporting of non-study cigarette use by study participants confounds the interpretation of results from ambulatory clinical trial of reduced nicotine cigarettes
- Effects of Modified Tobacco Risk Products with Claims and Nicotine Features on Perceptions among Racial and Ethnic Groups
- Tobacco Free Nicotine Vaping Products: A Study of Health Halo Effects Among Middle School Youth
- Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- Patterns and perceptions of nicotine use among U.S. adolescents and young adults receiving medication treatment for opioid use disorder
- Young Adults' Exposure to and Engagement With Tobacco-Related Social Media Content and Subsequent Tobacco Use
- Testing messaging strategies to correct beliefs about nicotine and relative harm perceptions of non-cigarette tobacco products compared to cigarettes: A 2 × 2 factorial experiment of factsheets
- Experiences and Perceptions of E-Cigarette Cessation for Young Adults in Rural Communities
- Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial
- An observational human laboratory assessment of nicotine delivery, vaping topography and subjective effects of usual brand electronic cigarette use among young adults
- Preliminary study on the E-liquid and aerosol on the neurobehavior of C. elegans
- An 8-year longitudinal study of long-term, continuous users of electronic cigarettes
- "Tobacco-free nicotine" electronic cigarette perceptions and use among adolescents and adults in five New England states
- Addiction to Tobacco Smoking and Vaping
- Perceived relative harm and addictiveness compared with cigarettes and intentions to use modified risk tobacco products utilizing FDA-authorized marketing claims among adults in the United States
- Effects of flavour and modified risk claims on nicotine pouch perceptions and use intentions among young adults who use inhalable nicotine and tobacco products: a randomised controlled trial
- Sexual and Gender Identity Disparities in Nicotine and Tobacco Use Susceptibility and Prevalence: Disaggregating Emerging Identities Among Adolescents from California, USA
- Breaking the habit: isolating nicotine-degrading bacteria in undergraduate microbiology teaching labs
- Dual and poly-nicotine and tobacco use among adolescents in the United States from 2011 to 2022
- Heterogeneity of Harmful Constituent Profiles in Smokeless Tobacco Products from Five African Countries
- Cigarette smoking and cognitive task performance: Experimental effects of very-low nicotine-content cigarettes
- Foods and beverages associated with smoking craving in heated tobacco product and cigarette smokers: A cross-sectional study
- Motives for using electronic nicotine delivery systems (ENDS) as a cessation tool are associated with tobacco abstinence at 1-year follow-up: A prospective investigation among young adults in the United States Air Force
- Electronic Nicotine-Delivery Systems for Smoking Cessation
- Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials
- Cigarette and ENDS dual use longitudinal transitions among adults in the Population Assessment of Tobacco and Health (PATH) Study, Waves 4-5 (2016-2019)
- Reinforcing and adverse observable effects of nicotine and minor tobacco alkaloids in squirrel monkeys
- Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial
- Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial
- E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs
- Associations between smokers' knowledge of causes of smoking harm and related beliefs and behaviors: Findings from the International Tobacco Control (ITC) Four Country Smoking and Vaping Survey
- Understanding the nicotine dose delivered by electronic nicotine delivery systems in a single puff: the importance of nicotine flux and puff duration
- Genetic regulation and manipulation of nicotine biosynthesis in tobacco: Strategies to eliminate addictive alkaloids
- E-cigarette Unit Sales by Product and Flavor Type, and Top-Selling Brands, United States, 2020-2022
- Online quantification of nicotine in e-cigarette aerosols by vacuum ultraviolet photoionization mass spectrometry
- Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits
- Menthol and filter ventilation in cigarettes: prevalence estimates and relationships with harm perception and smoking exposure
- Advances in regulatory mechanism(s) and biotechnological approaches to modulate nicotine content in tobacco
- Vaping: Public Health, Social Media, and Toxicity
- More than a "characterizing flavor": Menthol at subliminal levels in tobacco products
- More than a "characterizing flavor": Menthol at subliminal levels in tobacco products
- Including the term 'tobacco-free nicotine' in the nicotine addiction warning label mandated by the US Food and Drug Administration alters risk perceptions and use intentions
- Menthol versus tobacco e-liquid flavor: Impact on acute subjective effects, puff patterns, and intentions for use among Black and White menthol smokers
- Concurrent E-cigarette Use While Enrolled in a Smoking Cessation Program: Associations between Frequency of use, Motives for Use and Smoking Cessation
- Nicotine Transport across Calu-3 Cell Monolayer: Effect of Nicotine Salts and Flavored E-liquids
- Oral nicotine pouches with an aftertaste? Part 2: in vitro toxicity in human gingival fibroblasts
- Effect of Third Party Components on Emissions from a Pod Style Electronic Cigarette
- Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model
- HPLC-MS/MS Method for Measuring Cotinine and Trans-3'-Hydroxycotinine in Bronchoalveolar Lavage Fluid of Patients with e-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI)
- Nicotine information disclosed online by e-cigarette brands popular with young people
- Use of Tobacco Products and Suicide Attempts Among Elementary School-Aged Children
- Prevalence of Underreported Nicotine Exposure Among US Non-Smoking Adults: A Comparison of Self-Reported Exposure and Serum Cotinine Levels from NHANES 2013-2020
- Why and how should children be protected from the deluge of vaping related media and marketing overexposure?