Using a modified Delphi procedure to select a PRO-CTCAE-based subset for patient-reported symptomatic toxicity monitoring in rectal cancer patients

9 September 2024

Evidence

Qual Life Res. 2024 Sep 8. doi: 10.1007/s11136-024-03767-0. Online ahead of print.

ABSTRACT

PURPOSE: Standardized patient-reported outcomes (PRO) monitoring during and after rectal cancer treatment provides insight into treatment-related toxicities patients experience and improves health-related quality-of-life as well as overall survival. We aimed to select a subset of the PRO version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) for standardized monitoring of treatment-related symptomatic toxicities in rectal cancer.

METHODS: We used a mixed methods approach including a literature review, and semi-structured interviews with health care providers (HCPs) involved in rectal cancer care and rectal cancer patients. Results from literature and interviews were summarized and used in a modified Delphi procedure to select a PRO-CTCAE subset specific for rectal cancer.

RESULTS: Twenty-six PRO-CTCAE symptomatic toxicities were identified from literature. Fifteen HCPs from multiple disciplines (medical, radiation and surgical oncology), and a heterogeneous group of fifteen rectal cancer patients treated with chemotherapy and/or radiotherapy and/or surgery, participated in semi-structured interviews. Ten HCPs (67%) and nine patients (90%) participated in the first Delphi round. The final selected PRO-CTCAE core-subset contained 16 symptomatic toxicities: ‘diarrhea’, ‘fecal incontinence’, ‘constipation’,’bloating of the abdomen’, ‘pain in the abdomen’, ‘vomiting’, ‘decreased libido’, ‘pain during vaginal sex’, ‘ability to achieve and maintain erection’, ‘fatigue’, ‘anxiety’, ‘feeling that nothing could cheer you up’, ‘urinary incontinence’, ‘painful urination’, ‘general pain’, and ‘hand-foot syndrome’.

CONCLUSION: Based on a comprehensive mixed methods study, a PRO-CTCAE subset for standardized treatment-related symptomatic toxicity monitoring in rectal cancer was identified. Assessment of the effectiveness and compliance of symptomatic toxicity monitoring using this subset is recommended.

PMID:39244711 | DOI:10.1007/s11136-024-03767-0

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Rakgadi G. Malapela
Cannabis use among hospitalised adolescents before and after decriminalisation in South Africa 26 July 2024
Background: Cannabis is the most widely used substance worldwide, and its use is much higher among adolescents. However, adolescents are at higher risk of negative sequelae secondary to this use, including the possible development of mental disorders. On 31 March 2017, the South African High Court ruled that cannabis use by an adult in a private […]
Michelle C. Swartz

Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course 14 September 2024
Molecular Psychiatry, Published online: 14 September 2024; doi:10.1038/s41380-024-02752-wPrenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course
Alexandra J. Noble
Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation 13 September 2024
Molecular Psychiatry, Published online: 13 September 2024; doi:10.1038/s41380-024-02736-wTranscriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation
Luca Sforzini
Spatio-temporal mechanisms of consolidation, recall and reconsolidation in reward-related memory trace 13 September 2024
Molecular Psychiatry, Published online: 13 September 2024; doi:10.1038/s41380-024-02738-8Spatio-temporal mechanisms of consolidation, recall and reconsolidation in reward-related memory trace
Adam Hamed

Plaudits for logits in sensory neuroscience
A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful examination of their choices. In this issue of , Carandini flips the script, showing how it can model how the brain makes sensory choices.A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful […]
Impacts beyond the brain: Unraveling molecular mechanisms linking psychiatric, metabolic, and inflammatory conditions
By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the publication by Nakanishi et al. provides new insight to how primary brain deficiency impacts physiological systems beyond the brain.By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the […]
Keep calm and carry H3K27me1 off
In this issue of , Torres-Berrío et al. show that stress-susceptible mice exhibit elevated H3K27me1 levels in nucleus accumbens neurons due to the action of the SUZ12 VEFS domain, strengthening the link between specific epigenetic changes and long-lasting stress-induced social, emotional, and cognitive alterations.In this issue of , Torres-Berrío et al. show that stress-susceptible mice exhibit elevated […]

The Earth, Brain, Health Commission: how to preserve mental health in a changing environment 16 September 2024
Nature Mental Health, Published online: 16 September 2024; doi:10.1038/s44220-024-00314-1Announced in this Comment and in collaboration with Nature Mental Health is the convening of the Earth Brain Health Commission, addressing innovative and multidisciplinary approaches to mitigating environment-related mental health harms and promoting wellbeing.
Gunter Schumann
The relation between cortical gene expression and the neural correlates of risky behavior 12 September 2024
Nature Mental Health, Published online: 12 September 2024; doi:10.1038/s44220-024-00311-4In a large dataset from the UK Biobank, the authors examine the relationships between regional gene expressions and structural and functional features of the cerebral cortex associated with risky behavior.
Shu Liu
Social identity processes as a vehicle for therapeutic success in psychedelic treatment 9 September 2024
Nature Mental Health, Published online: 09 September 2024; doi:10.1038/s44220-024-00302-5In this Perspective, authors overview the ‘social cure’ model employing group contexts, identity, and connections and argue for its use as a therapeutic framework for psychedelic treatment.
Martha Newson

Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways 16 September 2024
Translational Psychiatry, Published online: 16 September 2024; doi:10.1038/s41398-024-03095-4Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways
Jing Guo
DeepASD: a deep adversarial-regularized graph learning method for ASD diagnosis with multimodal data 14 September 2024
Translational Psychiatry, Published online: 14 September 2024; doi:10.1038/s41398-024-02972-2DeepASD: a deep adversarial-regularized graph learning method for ASD diagnosis with multimodal data
Wanyi Chen
Orexin receptor antagonists in the treatment of insomnia associated with psychiatric disorders: a systematic review 14 September 2024
Translational Psychiatry, Published online: 14 September 2024; doi:10.1038/s41398-024-03087-4Orexin receptor antagonists in the treatment of insomnia associated with psychiatric disorders: a systematic review
Taro Kishi

Imaging endolymphatic space of the inner ear in vestibular migraine 13 September 2024
BackgroundVestibular migraine (VM), the most frequent episodic vertigo, is difficult to distinguish from Ménière’s disease (MD) because reliable biomarkers are missing. The classical proof of MD was an endolymphatic hydrops (EH). However, a few intravenous gadolinium-enhanced MRI studies of the inner ear (iMRI) also revealed an EH in VM. The major questions were the frequency […]
Kirsch, V., Boegle, R., Gerb, J., Kierig, E., Ertl-Wagner, B. B., Becker-Bense, S., Brandt, T., Dieterich, M.
Investigating colour vision and its structural correlates 15 years following a first demyelinating event 12 September 2024
BackgroundWe investigated the long-term colour and contrast vision outcomes, 15 years after a first demyelinating event, with their structural correlates using optical coherence tomography (OCT) and brain MRI.MethodsPatients recruited with their first demyelinating event, were invited~15 years later to undergo clinical assessments, OCT and brain MRI and were clinically classified according to multiple sclerosis (MS) […]
Yam, C., Brownlee, W. J., Prados Carrasco, F., Toosy, A., Ciccarelli, O.
Distinct plasma lipids predict axonal injury and multiple sclerosis activity 12 September 2024
BackgroundLipids are of particular interest for the study of neuroinjury and neuroinflammation as structural lipids are major components of myelin, and a variety of lipid species modulate inflammation. In this study, we performed an in-depth lipidomics analysis to identify lipids associated with injury and disease activity.MethodsPlasma samples were collected from paediatric-onset multiple sclerosis (MS) cases […]
Schoeps, V. A., Bhargava, P., Virupakshaiah, A., Ladakis, D. C., Moseley, C., Chong, J., Aaen, G., Graves, J. S., Benson, L., Gorman, M. P., Rensel, M., Abrams, A., Mar, S., Lotze, T. E., Chitnis, T., Waldman, A., Krupp, L., Rodriguez, M., Tillema, J.-M., Rose, J., Schreiner, T., Qureshi, F., Peterson, S., Barcellos, L. F., Casper, T. C., Newman, J., Borkowski, K., Waubant, E., On behalf of the US Network of Pediatric MS Centers

Mendelian randomization: causal inference leveraging genetic data 19 April 2024
Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for […]
Chen, Lane G.
Interventions targeting social determinants of mental disorders and the Sustainable Development Goals: a systematic review of reviews 25 March 2024
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review […]
Oswald, Tassia Kate
Do metacognitive therapies for schizophrenia-spectrum disorders work? A meta-analytic investigation 21 March 2024
Recent reviews and meta-analyses of metacognitive therapy for schizophrenia-spectrum disorder (SSD) have included uncontrolled studies, single-session interventions, and/or analyses limited to a single form of metacognitive therapy. We sought to evaluate the efficacy of metacognitive therapies more broadly based on controlled trials (CT) of sustained treatments. We conducted a pre-registered meta-analysis of controlled trials that […]
Melville, Grace

A national evaluation of a multi‐modal, blended, digital intervention integrated within Australian youth mental health services 12 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
M. Alvarez‐Jimenez, J. Nicholas, L. Valentine, P. Liu, S. Mangelsdorf, S. Baker, T. Gilbertson, G. O'Loughlin, C. McEnery, P. D. McGorry, J. F. Gleeson, S. P. Cross
Relationship between nonexercise activity and mood in patients with eating disorders 8 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Robin Olfermann, Sabine Schlegel, Anna Vogelsang, Ulrich Ebner‐Priemer, Almut Zeeck, Markus Reichert
The impact of sex in the effectiveness of functional remediation in bipolar disorder 7 September 2024
Acta Psychiatrica Scandinavica, EarlyView.
Maria Serra‐Navarro, Derek Clougher, Brisa Solé, Jose Sánchez‐Moreno, Ana González‐Pinto, Esther Jiménez, Benedikt L. Amann, Vicent Balanzá‐Martínez, Rafael Tabarés‐Seisdedos, Celso Arango, Vivian Accardo, María Paz García‐Portilla, Ángela Ibáñez, José Manuel Crespo, José Luis Ayuso‐Mateos, Silvia Amoretti, Carla Torrent, Anabel Martínez‐Aran, Eduard Vieta, CIBERSAM Functional Remediation Group

Glymphatic System Impairment in the Advanced Stage of Moyamoya Disease 16 September 2024
Journal of Neuroscience Research, Volume 102, Issue 9, September 2024.
Lingji Jin, Junwen Hu, Guangxu Han, Yin Li, Jun Zhu, Yuhan Zhu, Xuchao He, Duo Xu, Leilei Zheng, Ruiliang Bai, Lin Wang
Work‐Related Strain, Sense of Coherence and Intercultural Sensitivity Among Mental Health Nurses in Qatar: A Cross‐Sectional Study 16 September 2024
International Journal of Mental Health Nursing, EarlyView.
Ashishkumar Badanapurkar, Deborah Nelson, Ananth Nazarene, Katja Warwick Smith, Lazarus Phiri, Sejo Varghese, Shiju Ramapurath
Lost in translation? Qualitative interviews with Australian psychedelic‐assisted therapy trial clinicians 16 September 2024
Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Michaela Barber, John Gardner, Paul Liknaitzky, Adrian Carter

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Evolving Perspectives on Wellness and Stress
Renewing the Teaching of Clinical Reasoning in Psychiatry: An Opportunity for Advancing Mental Health Training and Care
Assaults and Microaggressions Against Psychiatric Residents: Findings from a US Survey
Psychiatric physicians may experience higher rates of assault than those in other fields. For many reasons, residents may be especially vulnerable. This study updates rates of assaults among US psychiatry residents as well as the reporting rates and emotional effects of these incidents. Little data exists to examine rates of microaggressions against psychiatry residents.A cross-sectional […]

Climate Change and Aging: Implications for Psychiatric Care
We reviewed recent evidence regarding the impact of climate change (specifically, high ambient temperatures, heatwaves, weather-related disasters, and air pollution) on older adults’ mental health. We also summarized evidence regarding other medical problems that can occur in aging adults in connection with climate change, resulting in psychiatric manifestations or influencing psychopharmacological management.Older adults can experience […]
The Role of Inflammation in Depression and Beyond: A Primer for Clinicians
We evaluate available evidence for the role of inflammation in depression. We reappraise literature involving systemic inflammation, neuroinflammation and neurotransmission and their association with depression. We review the connection between depression, autoimmunity and infectious diseases. We revise anti-inflammatory treatments used in depression.Peripheral inflammatory markers are present in a subset of patients with depression and can […]
Early Life Trauma, Emotion Dysregulation and Hormonal Sensitivity Across Female Reproductive Life Events
To explore the relationship between early life trauma, hormonal sensitivity, and psychiatric disorders across female-reproductive life events, with a focus on the neurobiological mechanisms.Childhood trauma significantly increases the risk of subsequent mood disorders during periods of intense hormonal fluctuation such as premenstrual, pregnancy, postpartum, and perimenopause. Neurobiological changes resulting from early trauma influence emotion regulation, […]

Editorial introductions
No abstract available
journals.lww.com
Sex and gender differences in cancer in individuals with severe mental disorders
Purpose of review Although cancer incidence is similar between individuals with severe mental disorders (SMD) and the general population (GP), survival rates are lower, particularly in those with schizophrenia. While the scientific and medical communities acknowledge sex differences in cancer mechanisms, including risk factors and cancer types, less is known about sex and gender disparities […]
Bajić, Žarko; Vuk-Pisk, Sandra; Filipčić, Igor; Šimunović Filipčić, Ivona
The role of human involvement and support in digital mental health interventions for people with schizophrenia spectrum disorders: a critical review
Purpose of review Schizophrenia spectrum disorders (SDD) are characterized by a complex array of psychosis symptoms, and typically require ongoing and long-term support, including pharmacological and nonpharmacological management. Digital mental health interventions (DMHIs) have been suggested as a novel therapeutic approach to enable low-cost, scalable improvements in quality of care for adults living with SSD. […]
Arnautovska, Urska; Milton, Alyssa; Trott, Mike; Soole, Rebecca; Siskind, Dan

Daily-life reactivity and emotion regulation in children with social anxiety disorder
Little is known about maintaining factors of child social anxiety disorder (SAD).High daily-life reactivity and use of suppression are specific to child SAD.Maladaptive emotion regulation predicts trait social anxiety one year later.Treatment should put more focus on reducing maladaptive emotion regulation. Prominent models of adult social anxiety disorder emphasize the role of hyperreactivity and emotion […]
Correlates of treatment-seeking in DSM-5 generalized anxiety disorder: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions‐III
47 % of those with lifetime GAD received therapy or medication for GAD.PTSD, depression, and panic disorder were associated with treatment seeking.Fatigue, panic attacks, reassurance seeking, and interpersonal avoidance were also related. Generalized Anxiety Disorder (GAD) presents a significant personal and societal burden and is associated with chronic medical comorbidities and markedly lower quality of life. […]
Scaling up psychological interventions into the daily lives of patients with anxiety and related disorders

Issue Information 13 September 2024
Journal of Child Psychology and Psychiatry, Volume 65, Issue 10, Page i-iv, October 2024.
Moving forward. Use of the START NOW skills training program for female youth with ODD and CD – a commentary on Stadler et al. (2024) 13 September 2024
Journal of Child Psychology and Psychiatry, Volume 65, Issue 10, Page 1401-1402, October 2024.
Gail Tripp
Editorial: Qualitative contributions to translational science – Practical pointers towards methodological pluralism in child psychology and psychiatry 13 September 2024
Journal of Child Psychology and Psychiatry, Volume 65, Issue 10, Page 1255-1257, October 2024.
Edmund J. S. Sonuga‐Barke

Dietary omega-3 intake and cognitive function in older adults 15 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveDietary habits have long been known to be a critical factor influencing cognitive health, especially among older adults. Despite extensive research on various dietary components, the impact of omega-3 polyunsaturated fatty acids (PUFAs) on cognitive function has not yet been thoroughly investigated. This research seeks […]
Bingdian Wang
Clinical correlates of medication adherence in individuals with bipolar disorder and comorbid hypertension 14 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveIndividuals with bipolar disorder (BD) have high rates of suboptimal medication adherence, medical illness, and premature mortality, largely from cardiovascular causes. This analysis examined the association between adherence to antihypertensive and BD medications and clinical symptoms in patients with BD and comorbid hypertension (HTN) from […]
Jennifer B. Levin
Elder abuse and neglect, novel factors affecting depression risk, SARS-CoV-2 Omicron-induced anxiety, and provider flourishing in pediatric palliative care 7 September 2024
The International Journal of Psychiatry in Medicine, Ahead of Print.
Harold G. Koenig

Research landscape analysis on dual diagnosis of substance use and mental health disorders: key contributors, research hotspots, and emerging research topics 30 August 2024
Substance use disorders (SUDs) and mental health disorders (MHDs) are significant public health challenges with far-reaching consequences on individuals and society. Dual diagnosis, the coexistence of SUDs and...
Waleed M. Sweileh
Association between rTMS-induced changes in inflammatory markers and improvement in psychiatric diseases: a systematic review 27 August 2024
Repetitive transcranial magnetic stimulation (rTMS) has recently gained relevance in treating different psychiatric disorders. Limited evidence suggests that the beneficial effects of rTMS on psychopathology c...
Bruno Pedraz-Petrozzi, Shrabon Insan, Moritz Spangemacher, Jonathan Reinwald, Eva Kathrin Lamadé, Maria Gilles, Michael Deuschle and Alexander Sartorius
Maternal depression and early childhood development among children aged 24–59 months: the mediating effect of responsive caregiving 20 August 2024
This study examined whether maternal depression is related to Early Childhood Developmental (ECD) delay among children by quantifying the mediating contribution of responsive caregiving. We used data from 1235...
Siyu Zou, Xinye Zou, Ruolin Zhang, Kefan Xue, Angela Y. Xiao, Mo Zhou, Ziyuan Fu and Hong Zhou

Sexual Orientation Microaggression Rating Scale (SOMRS): Development and association with alliance ruptures. 8 August 2024
Sexual minority clients report experiencing frequent microaggressions during therapy, however, therapists may not recognize those microaggressions or may be reluctant to self-report them. The main aim of the present study was thus to develop an observational measure of in-session therapist-committed microaggressions related to the sexual orientation of sexual minority individuals (e.g., those who identify as […]
Should we feel the same? Mutual recognition and congruence between therapist and client regarding ruptures and repairs. 8 July 2024
The pattern of rupture and repair within therapeutic alliances has been associated with improved outcome. The present study adds to this body of research by examining rupture and repair from a dyadic perspective. First, we examined the relationship between mutual recognition of ruptures, rupture intensity, and client ratings of session helpfulness. We then examined client–therapist […]
Preventing dropout in spiritually integrated psychotherapies: What are the effective methods of attending to clients’ spirituality? 30 May 2024
The purpose of this study was to examine associations between clinicians’ use of varying types of spiritual interventions in the first session of spiritually integrated psychotherapies (SIPs) and clients’ likelihood of returning for a second session. In total, 154 practitioners of SIPs from 33 settings in a practice-research network reported on their implementation of different […]

Ongoing Teacher Support for Data-Based Individualization: A Meta-Analysis and Synthesis 6 September 2024
Journal of Learning Disabilities, Ahead of Print. Although data-based individualization (DBI) has positive effects on learning outcomes for students with learning difficulties, this framework can be difficult for teachers to implement due to its complexity and contextual barriers. The first aim of this synthesis was to investigate the effects of ongoing professional development (PD) support […]
Emma Shanahan
A Family-Based Intervention for Early Elementary Students With Reading and Behavioral Difficulties: A Pilot Study 2 August 2024
Journal of Learning Disabilities, Ahead of Print. We created and tested a family-based intervention with families of children in Grades 1 and 2 with reading and behavioral difficulties to investigate its impact on text comprehension. Developed with input from parents, reading experts, and behavior specialists, Family-RISE (Reading Intervention with Supports for Engagement) integrates evidence-based practices […]
Garrett J. Roberts
Assessing Beliefs About Intrinsic and Extrinsic Determinants of SLD: Evaluating the Factor Structure of a Novel Instrument 26 July 2024
Journal of Learning Disabilities, Ahead of Print. Schools conduct comprehensive psychoeducational evaluations to identify students with specific learning disabilities (SLDs) and determine whether they qualify for special education services. This decision-making process is complex and research has documented many factors influencing SLD identification decisions. One such factor may be decision-makers’ beliefs about the underlying causes […]
Courtenay A. Barrett

What Approaches Described in Research Literature Enhance the Engagement of Children and Young People With Severe or Profound and Multiple Learning Disabilities? A Systematic Literature Review 16 September 2024
British Journal of Learning Disabilities, EarlyView.
Dominic Fitzpatrick, Richard Parker
Staff Perceptions of Mental Health Relapse Prevention Support in a Specialist Mental Health Service in an Intellectual Disability Setting 10 September 2024
British Journal of Learning Disabilities, EarlyView.
Shannon Sinnott, Cliodhna O'Donovan, Suzanne Guerin
Item reduction of the “Support Intensity Scale” for people with intellectual disabilities, using machine learning 19 August 2024
British Journal of Learning Disabilities, EarlyView.
Félix González‐Carrasco, Felipe Espinosa Parra, Izaskun Álvarez‐Aguado, Sebastián Ponce Olguín, Vanessa Vega Córdova, Miguel Roselló‐Peñaloza

The relationship between sense of security and suicide risk in male prison inmates: a chain mediating effect through intolerance of uncertainty and motor impulsiveness 13 September 2024
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Ruoheng Wang Jue Deng Yuanhua Ou Liqin Lu Yiduo Ye Zhi Chen Penghao Lu a Department of Penalty Execution, Fujian Police College, Fuzhou, Chinab Department of Forensic Science, Fujian Police College, Fuzhou, Chinac School of Psychology, Fujian Normal University, Fuzhou, China
Autism spectrum disorder, radicalization, and violence: a forensic perspective 30 August 2024
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Julian A.C. Gojer Kayla M. Gaw Kaileigh M. Chretien a Integrated Forensic Program, Royal Ottawa Mental Health Center and Institute of Mental Health Research, ON, Canadab Sexual Behaviours Clinic, Royal Ottawa Mental Health Center and Institute of Mental Health Research, ON, Canadac Integrated Forensic Program (IFP), Royal Ottawa Mental Health Center, ON, Canada
Childhood onset violence and early onset schizophrenia. A molecular diagnosis of 15q13.2-13.3 duplication syndrome and the effects on insight and engagement 28 August 2024
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Ed Silva Department missing for affiliation Rathbone Low Secure Unit, Rathbone Hospital, Mersey Care NHS FT, Liverpool, UK

Which diagnoses and arguments regarding severe mental disorder do forensic psychiatric experts in Sweden consider in different cases? A qualitative vignette study
The decision-making process of experts in forensic psychiatric investigations (FPI) is complex and reasoning regarding psychiatric diagnosis and (SMD, the judicial concept central to legal exemption in Swedish law) has severe ramifications. Nevertheless, the qualitative aspects of FPI experts' decision-making process have seldom been studied systematically. The participants ( = 41) were FPI experts: forensic psychiatrists ( = 15), […]
Editorial Board
Perceptions of bias and credibility of male and female clinical psychologist and psychiatrist expert witnesses presenting clinical information in the courtroom
The expert's gender and profession interaction can impact their perceived credibility.Psychiatrists were rated as more credible experts than clinical psychologists.Male experts were rated as more confident but less likeable than female experts.Perceptions of expert witness credibility can influence jurors' decision-making.Jurors were more likely to make decisions in line with highly credible sources. Expert witness credentials […]

Faithful and fearful: Does religion promote or reduce fear of crime in Germany?
This article complements existing victimological studies on religion by investigating whether religion promotes or reduces fear of crime in Germany. According to the generalized insecurity approach and the theory of social production functions, religion and fear of crime are linked via secularization-induced diffuse insecurities. It is expected that different facets of religion are tied to […]
Moral foundations in gender violence cases decided in Portuguese courts
Gender violence encompasses a multitude of morally problematic psychological, physical, and sexual behaviors that, in most countries, constitute criminal offenses. In this study, we investigate the association between moral foundations (, , , , and ) and punitive responses to gender violence offenses. Our case study focuses on gender violence in Portugal, a country in […]
Comparing the criminal careers of organized crime offenders in Italy and the Netherlands
The concept of organized crime has dynamically evolved, with researchers contending that it is a social construct or an umbrella concept encompassing different empirical manifestations. Scholars have often suggested classifying organized crime groups into those involved in “racketeering” or “governing” and those engaged in “transit crime” or “trading.” However, these propositions were never assessed at […]

The longitudinal associations between nonviolent/violent stressful life events, moral disengagement, and online aggression in Chinese young people through the lens of general aggression model. 18 July 2024
Objective: Online aggression (OA) in Chinese university students is a public health concern. Drawing on the general aggression model (GAM), this study examines the extent to which nonviolent and violent stressful life events predict OA through altering moral cognition (i.e., moral disengagement). It also examines whether the two types of stressful life events interactively predict […]
Adolescent relationship violence: Should pushes and hits always be considered violent? 18 July 2024
Objective: Research on adolescent relationship violence often involves having adolescents report on physically forceful acts, such as pushes and hits, that have occurred in the context of dating relationships. The present study compares: (a) adolescents who reported having experienced acts of physical force by a dating partner and attributed it solely to playfulness (playful only); […]
Internalized heterosexism magnifies the association of hazardous or harmful alcohol use on intimate partner violence perpetration rates of sexual minority and same-sex-attracted men. 20 June 2024
Objective: To test whether internalized heterosexism, a form of minority stress, heightens the effect of hazardous or harmful alcohol use on frequency of intimate partner violence (IPV) perpetration among sexual minority and same-sex-attracted men. Method: We recruited participants online via Amazon Mechanical Turk (MTurk). Inclusion criteria were adult cisgender men living in the United States […]

Comparison of strength and adulteration between illicit drugs obtained from cryptomarkets versus off‐line 12 September 2024
Addiction, EarlyView.
Leigh Coney, Amy Peacock, Daan van der Gouwe, Laura Smit‐Rigter, Nadia Hutten, Mireia Ventura, Adrià Quesada, Monica J. Barratt
Wastewater‐based evaluation of the efficacy of oxycodone regulations in Australia 11 September 2024
Addiction, EarlyView.
Rory Verhagen, Cobus Gerber, Phong K. Thai, Jason Connor, Bill Loveday, Richard Bade, Jake O'Brien, Emma L. Jaunay, Bradley S. Simpson, Gary Chan, Wayne Hall, Kevin V. Thomas, Jochen F. Mueller, Benjamin J. Tscharke
Effectiveness of mobile smoking cessation treatment with 1‐week nicotine replacement therapy sampling at outdoor smoking hotspots: A cluster randomized controlled trial 11 September 2024
Addiction, EarlyView.
Wan Jia Aaron He, Qi Wang, Ching Han Helen Chan, Tzu Tsun Luk, Man Ping Wang, Siu Chee Sophia Chan, Tai Hing Lam, Yee Tak Derek Cheung

Former teachers’ perceptions of psychosocial supports leading to attrition 16 September 2024
The purpose of this study is to examine how former K-12 teachers’ perceptions of psychosocial support led to their decision to leave the profession. The researcher conducted eight interviews with former teachers who had been in the profession for 1.5–26 years and asked them about their thoughts on mental health interventions, leadership and collegial support […]
Lindsey Brown Gorham
A pilot study of “AKBAY” self-help intervention for university students with moderate symptoms of depression and anxiety 9 September 2024
Depression and anxiety are common mental health issues among young adults, particularly exacerbated by the COVID-19 pandemic. Research indicates a notable increase in global prevalence rates, especially in this demographic. Despite their prevalence, factors like stigma, cost and limited accessibility often prevent individuals from seeking professional help. Therefore, there is a pressing need for innovative […]
Sherna Bangalan
Defining mental health literacy: a systematic literature review and educational inspiration 2 September 2024
This paper aims to explore how the term “mental health literacy” (MHL) is defined and understand the implications for public mental health and educational interventions. An extensive search was conducted by searching PubMed, ERIC, PsycINFO, Scopus and Web of Science. Keywords such as “mental health literacy” and “definition” were used. The publication year ranges from […]
Shengnan Zeng

Mortality in the Victorian asylum: was it so high? Standardised Mortality Rate compared with historical methods 9 August 2024
History of Psychiatry, Ahead of Print. Mortality is closely linked to age, sex, and social and historical context. Standardised Mortality Rates (SMR) address these contextual factors by comparing mortality in a population under study with that in people of the same age and sex, the same period in history and from a similar cultural context. […]
Charlotte Richardson
The notion of excessive childhood restlessness in Spain at the beginning of the twentieth century 27 July 2024
History of Psychiatry, Ahead of Print. This study delves into the historical documentation from 1900 to 1936 by Spanish doctors and educators concerning children’s hyperactivity. By focusing on medical perspectives of the time, we aim to explore the conceptualisation of childhood phenomenology within the context of significant international literature of that era. The publications of […]
Joana Escamilla Lerner
Empathy or sympathy: a necessary distinction? 23 July 2024
History of Psychiatry, Ahead of Print. As a deeply hybrid discipline, psychiatry demands research that tackles the concepts constituting it and its objects. This is an essential prerequisite to empirical studies, the validity of which are directly dependent on a clear understanding of the underlying concepts. Empathy and sympathy are concepts used variably and inconsistently […]
Ivana S Marková

Childhood trauma distribution and behavioural problems among Pakistani adolescents 13 September 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Childhood trauma adversely impacts adolescents, and consequently, they develop behavioural problems. Understanding the distribution of childhood traumas and their association with behavioural problems among adolescents is paramount for the preventive efforts.Aim/Objective:The present research aimed to investigate this association among adolescents.Methods:This association was investigated among adolescents (N = 200) between […]
Zaryab Fatima
Prevalence of disturbance of body image perception and engagement in risky behaviors for eating disorders motivated by the Korean wave 12 September 2024
International Journal of Social Psychiatry, Ahead of Print. Background:the global expansion of the Korean wave (hallyu) has led to the idealization of Korean beauty standards among fans. Celebrities share extreme diets and exercise routines through social media that help them lose weight and adhere to this standard, which has been shown in some studies conducted […]
Valentina Belalcazar Vivas
The Mpox outbreak is a public health emergency of international concern: Implications for mental health and global preparedness 11 September 2024
International Journal of Social Psychiatry, Ahead of Print. Background:The Mpox, a zoonotic viral disease that has historically affected Central and West Africa, has been declared a Public Health Emergency of International Concern by the World Health Organization. Rapid transmission and recent dissemination in Africa may imply significant challenges to global health, including mental health.Methods:We reviewed […]
Julio Torales

Desired support system to eradicate urban homelessness: an exploratory descriptive study [version 2; peer review: 2 approved with reservations] 16 September 2024
Background - The new increasing homeless lately consist of women, children, youth, the elderly and marginalized ethnic or migrant groups. Some of them are working and earn salaries, however, the income is not sufficient to live modestly. Purpose – The purpose of this research is to establish a desired support system to eradicate urban homelessness […]
Noor Ashikin Mohd Rom
PASS: A scoring system to evaluate persistent kidney injury in critically ill ICU adult patients [version 3; peer review: 1 approved, 1 not approved] 16 September 2024
Background We evaluated if the course of recovery from sepsis-induced acute kidney injury (AKI) can be predicted using variables collected at admission. Methods A total of 63 patients admitted for sepsis-induced AKI in our Mangalore ICU were evaluated and baseline demographic and clinical/laboratory parameters, including serum creatinine (SCr), base excess (BE), Plethysmographic Variability Index (PVI), […]
Dattatray Prabhu
The effects of multifactorial pharmacist-led intervention protocol on medication optimisation and adherence among patients with type 2 diabetes: A randomised control trial [version 2; peer review: 2 approved with reservations] 16 September 2024
Background Patient-related factors and limited medication adherence in patients with chronic diseases, are associated with poor clinical outcomes, long-term complications, and increased overall disease costs. Many methods have been tested with mixed results, and innovative approaches are needed to encourage patients to adhere to their prescribed drug regimens. Methods This randomised controlled trial examined a […]
Marwan El-Deyarbi

Severe Sleep Issues May Tell of Later Suicidal Behavior in Preteens 16 September 2024
(MedPage Today) -- Sleep disturbance may portend suicidal behavior among preteens, according to a longitudinal cohort study. A study of more than 8,000 kids found that those who reported severe sleep disturbances at age 10 had a higher odds of...
Brain Health Risks: Digital Quality Measures and the Future of Neurological Care 16 September 2024
(MedPage Today) -- As the American Academy of Neurology's (AAN) Brain Health Summit convenes in September, it's an opportune moment to explore the future of neurology and the role that digital quality measures (dQMs) will play in the evolution...
Conviction for Fatal COVID Spread; Who Is Alleged Trump Shooter? BMI & Schizophrenia 16 September 2024
(MedPage Today) -- Note that some links may require registration or subscription. A woman in Austria was found guilty of grossly negligent homicide after fatally infecting her neighbor with COVID. (AP) COVID levels in the U.S. remain elevated...

4-question CAGE assessment may reveal alcohol problem: doctor - New York Post 16 September 2024
A UK psychiatrist recommends undergoing the four-question CAGE assessment, a screening tool that may identify a substance abuse problem.
Center for Youth Advocacy and Well-Being a Model for Youth Mental Health Support 16 September 2024
Dr. Stewart serves as president of the American Association for Community Psychiatry and was the first Black president of the American Psychiatric ...
Bidirectional link seen for psychiatric disorders with chronic rhinosinusitis - Medical Xpress 16 September 2024
There is a bidirectional association for anxiety and depression with chronic rhinosinusitis (CRS), according to a study published online Sept.

Perioperative Regional Anesthesia: Less Pain, Fewer Pills 16 September 2024
Regional anesthesia reduced acute and chronic postoperative pain and decreased the incidence of prolonged opioid use after surgery. Medscape Medical News
ALS Blood Test Promises Accurate, Earlier Diagnosis 16 September 2024
A blood test has been shown to accurately identify patients with amyotrophic lateral sclerosis at early stages, which could speed diagnosis and treatment. Medscape Medical News
LPA1 Receptor Affects Biomarkers in Pulmonary Fibrosis 16 September 2024
Analysis from a phase 2 study showed potential to monitor treatment response in future trials. Medscape Medical News

Sanitary disaster in Gaza ‘worsening by the day’, warns UNRWA 16 September 2024
Overcrowded shelters in Gaza, a lack of running water and the constant threat of disease are making conditions worse by the day for people in the enclave, the UN agency for Palestine refugees, UNRWA, warned on Monday.
Health teams brave war conditions in Sudan to save newborn babies 15 September 2024
The civil war in Sudan has brought to country’s health system to its knees. UN mobile health teams are attempting to plug the gaps, crossing conflict zones to help pregnant women to give birth in safety.
WHO approves first mpox vaccine to boost access in Africa 13 September 2024
The World Health Organization (WHO) has approved the use of an mpox vaccine for the first time, which it says should facilitate “timely and increased access” for millions at risk in Africa where the latest outbreak has infected more than 20,000 so far this year.

Launch of the Global Coalition for Evidence 13 September 2024
The Global Coalition for Evidence will be launched on 13th September during the second Global Evidence Summit in Prague.The COVID-19 pandemic underscored the critical role of evidence-informed decision-making (EIDM), where the rapid uptake and effective implementation of evidence were pivotal in guiding decision-making processes. Accurate and timely translation of evidence remains essential for promoting population […]
who.int
Suicide prevention in Thailand: A whole-of-society approach 10 September 2024
In recent years, Thailand has seen a concerning rise in suicide rates, with a 32% increase in the suicide mortality rate from 2017 to 2022. The highest rates are observed among older individuals (aged 55 and above) , while teenagers (15-19) have the highest rates of suicide attempts. In 2023, there were 31,402 suicide attempts […]
who.int
Results from the 2024 Tracking Antimicrobial Resistance Country Self-Assessment Survey (TrACSS): Quadripartite webinar 10 September 2024
Agenda:1. Overview and introduction to the Tracking Antimicrobial Resistance Country Self-Assessment Survey (TrACSS): Anand Balachandran (WHO)2. Results of the 8th round of TrACSS and relevant trends from the previous seven years by sector:- Zlatina Dobreva (WHO): Multisector results and human health related results - Yohane Soko (WOAH): Animal health related results- Ozge Kara (FAO): Food and […]
who.int

Race, Gender, and Donor Heart Acceptance—Reply 10 September 2024
In Reply Ms Majeed and colleagues pose important questions regarding our study. First, the COVID-19 pandemic had several possible implications for transplant care. To explore these implications, we reexamined the number of donor heart offers until acceptance as in the original article but censored observations after February 29, 2020, to exclude the COVID-19 period. For […]
The Valediction in Poetry and Medicine 10 September 2024
Valedictions are essential in poetry (from those of Catullus to Donne and, in more recent times, from Seamus Heaney to Adrienne Rich), expressing as much devotion and renewal as they do sorrow and the elegiac. So at this difficult moment of transition in medicine, when many physicians are leaving the profession for a variety of […]
Extent of Drug Patents With Terminal Disclaimers and Obviousness-Type Double Patenting Rejections 10 September 2024
This study evaluates the frequency of terminal disclaimers filed by drug patent holders to obviate obviousness-type double patenting rejections associated with drug patent thickets.

Barriers to investigating and reporting research misconduct: prioritising publication integrity 16 September 2024
Bouter’s editorial1 on the UK Research Integrity Office (UKRIO) report Barriers to investigating and reporting research misconduct2 highlights protecting patients from consequences of research misconduct.Waiting for publishers to correct publications affected by misconduct or errors can take years. In the meantime, these papers influence clinical guidelines and patient care. Delays have been so concerning that […]
Alison Avenell, Andrew A Klein, Jennifer A Byrne, Peter Wilmshurst, Mark J Bolland, Andrew Grey
Assisted dying: Quebec allows advance directives, defying federal ban 16 September 2024
Quebec will allow people with incurable diseases or in the early stages of dementia to make advance directives specifying conditions under which they could receive medical assistance in dying without giving further consent.Such directives will be accepted from 30 October, although medical staff providing assistance in such cases would technically be guilty of homicide under […]
Owen Dyer
Four in five general practices are already taking collective action, says BMA 16 September 2024
Over 80% of general practices in England are already taking some form of collective action over their contractual terms and insufficient funding for general practice, the BMA has said.In a ballot over the summer GP partners in England voted overwhelmingly in favour of collective action, with 98.3% of members voting yes.12 The BMA called on […]
Jacqui Wise

Do infographics 'spin the findings of health and medical research? 12 September 2024
ObjectiveTo compare the prevalence of ‘spin’, and specific reporting strategies for spin, between infographics, abstracts and full texts of randomised controlled trials (RCTs) reporting non-significant findings in the field of health and medicine and to assess factors associated with the presence of spin.DesignCross-sectional observational study.Data sourcePublications in top quintile health and medical journals from August […]
Muller, R., Ferreira, G., Bejarano, G., Gamble, A. R., Kirk, J., Sindone, J., Zadro, J. R.
How to best convey continuous outcomes in patient decision aids 10 September 2024
IntroductionThe work of transforming scientific publications into tools that can support people in comparing treatments, tests and other interventions has been driven by efforts to support shared decision-making. The International Patient Decision Aids Standards (IPDAS) Collaboration has published many articles that guide this process. IPDAS, and others in this field, have considered the challenges of […]
Elwyn, G., Durand, M. A., Agoritsas, T., Mayer, M.
Development of a competency framework for health technology assessment in India 5 September 2024
IntroductionHealth technology assessment (HTA) has become a key part of assessing evidence to determine which treatments are funded. Early applications were within the centrally funded health systems of high-income countries. Recent years have seen increased use within low-income and middle-income countries, including India.1–6Increased application of HTAs has required corresponding increases in the systems’ resources that […]
Dixon, S., Tyagi, K., Singh, M., Kar, S. S., Bagepally, B. S., Prinja, S., Booth, A., Carroll, C., Sohail, A., Mehndiratta, A.

Deaths in prison 10 September 2024
In this country we do not give a death sentence, but for everyone who has taken their life in prison that is exactly what they got - Mark Saunders, whose son Dean died in HMP & YOI Chelmsford in 2016 Below is a breakdown of deaths in prison in England and Wales by calendar year […]
inquest.org.uk
Deaths in police custody 10 September 2024
To date there have been 1901 deaths in police custody or otherwise following contact with the police in England & Wales since 1990 Below is a breakdown of deaths in police custody or following other forms of contact with the police, as well as vehicular pursuits and road traffic incidents (RTIs) since 1990, by calendar […]
Inquest
Podcast 6 September 2024
Every year hundreds of people die preventable deaths at the hands of police, whilst in prison, or in the care of mental health services in the UK. Some of the names you’ll know. Most of them you won’t. Bereaved families are left fighting for answers, demanding justice, and campaigning for change, in a system that […]
inquest.org.uk