Evidence
Front Psychiatry. 2024 Apr 4;15:1386984. doi: 10.3389/fpsyt.2024.1386984. eCollection 2024.
ABSTRACT
Adolescent major depressive disorder (MDD) is associated with altered resting-state connectivity between the default mode network (DMN) and the salience network (SN), which are involved in self-referential processing and detecting and filtering salient stimuli, respectively. Using spectral dynamical causal modelling, we investigated the effective connectivity and input sensitivity between key nodes of these networks in 30 adolescents with MDD and 32 healthy controls while undergoing resting-state fMRI. We found that the DMN received weaker inhibition from the SN and that the medial prefrontal cortex and the anterior cingulate cortex showed reduced self-inhibition in MDD, making them more prone to external influences. Moreover, we found that selective serotonin reuptake inhibitor (SSRI) intake was associated with decreased and increased self-inhibition of the SN and DMN, respectively, in patients. Our findings suggest that adolescent MDD is characterized by a hierarchical imbalance between the DMN and the SN, which could affect the integration of emotional and self-related information. We propose that SSRIs may help restore network function by modulating excitatory/inhibitory balance in the DMN and the SN. Our study highlights the potential of prefrontal-amygdala interactions as a biomarker and a therapeutic target for adolescent depression.
PMID:38638415 | PMC:PMC11024787 | DOI:10.3389/fpsyt.2024.1386984
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Sex differences in aberrant functional connectivity of three core networks and subcortical networks in medication-free adolescent-onset major depressive disorder
- Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study
- Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure
- Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
- EEG coherences of the default mode network among patients comorbid with major depressive disorder and anxiety symptoms
- Aberrant associations between neuronal resting-state fluctuations and working memory-induced activity in major depressive disorder
- Functional connectivity is linked to working memory differences in children with reading learning disability
- Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions
- Self-construal modulates default mode network connectivity in refugees with PTSD
- Self-construal modulates default mode network connectivity in refugees with PTSD
- Sleep and physical activity measures are associated with resting-state network segregation in non-demented older adults
- Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders
- Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A
- Functional integration and segregation during semantic cognition: Evidence across age groups
- Uncovering Effects of Schizophrenia upon a Maximally Significant, Minimally Complex Subset of Default Mode Network Connectivity Features
- Altered intra- and inter-network connectivity in autism spectrum disorder
- Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults
- The mediating role of trait impulsivity in the relation between cue-induced craving and functional connectivity within the salience network among abstinent patients with methamphetamine use disorder
- A longitudinal evaluation of personalized intrinsic network topography and cognitive decline in Parkinson's disease
- Shared and Distinctive Brain Networks Underlying Trait and State Rumination
- Active suicidal ideation associated with dysfunction in default mode network using resting-state EEG and functional MRI - Findings from the T-RAD Study
- Predicting Clinical Improvement in Early Psychosis Using Circuit-Based Resting-State Functional Magnetic Resonance Imaging
- The relationship between changes in functional networks and cognitive changes and PTSD symptoms in maltreated children before and after TF-CBT
- Decreased gray matter volume in the anterior cerebellar of attention deficit/hyperactivity disorder comorbid oppositional defiant disorder children with associated cerebellar-cerebral hyperconnectivity: insights from a combined structural MRI…
- Default mode network shows distinct emotional and contextual responses yet common effects of retrieval demands across tasks
- The effects of cannabis abstinence on cognition and resting state network activity in people with multiple sclerosis: A preliminary study
- Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia
- Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder
- Disrupted dynamic brain functional connectivity in male cocaine use disorder: Hyperconnectivity, strongly-connected state tendency, and links to impulsivity and borderline traits
- EEG based functional connectivity in resting and emotional states may identify major depressive disorder using machine learning
- Callousness, exploitativeness, and tracking of cooperation incentives in the human default network
- Callousness, exploitativeness, and tracking of cooperation incentives in the human default network
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder
- Static and Dynamic Cross-Network Functional Connectivity Shows Elevated Entropy in Schizophrenia Patients
- Functional connectivity of the posterior cingulate cortex in autism spectrum disorder
- The Role of Occipitotemporal Network for Speed-Reading: An fMRI Study
- Functional connectivity of the posterior cingulate cortex in autism spectrum disorder
- Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes
- Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder
- Causal relationship between resting-state networks and depression: a bidirectional two-sample mendelian randomization study
- Causal relationship between resting-state networks and depression: a bidirectional two-sample mendelian randomization study
- Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea
- Neural and psychological correlates of post-traumatic stress symptoms in a community adult sample
- Aberrant resting-state functional connectivity of major depressive disorder with higher risk of suicide
- Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial
- A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression
- A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer's disease using resting-state functional network connectivity
- Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination
- The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study
- Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia
- Perinatal stress modulates glutamatergic functional connectivity: A post-synaptic density immediate early gene-based network analysis
- Perinatal stress modulates glutamatergic functional connectivity: A post-synaptic density immediate early gene-based network analysis
- Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study
- Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study
- Information-based TMS to mid-lateral prefrontal cortex disrupts action goals during emotional processing
- Coactivation pattern analysis reveals altered whole-brain functional transient dynamics in autism spectrum disorder
- A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
- A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
- Giftedness and atypical sexual differentiation: enhanced perceptual functioning through estrogen deficiency instead of androgen excess
- Abnormal Insula Network Characteristics in Panic Disorder
- Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli
- Functional connectivity of the auditory cortex in women with trauma-related disorders who hear voices
- Functional connectivity of the auditory cortex in women with trauma-related disorders who hear voices
Evidence Blueprint
Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
- Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
- Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
- Sex differences in aberrant functional connectivity of three core networks and subcortical networks in medication-free adolescent-onset major depressive disorder
- Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study
- Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study
- Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure
- Intrinsic functional connectivity between the anterior insular and retrosplenial cortex as a moderator and consequence of cocaine self-administration in rats
- Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
- EEG coherences of the default mode network among patients comorbid with major depressive disorder and anxiety symptoms
- Triple network connectivity changes in patients with major depressive disorder versus healthy controls via structural network imaging after electroconvulsive therapy treatment
- Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain-states during resting-state activity
- Aberrant associations between neuronal resting-state fluctuations and working memory-induced activity in major depressive disorder
- Functional connectivity is linked to working memory differences in children with reading learning disability
- Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions
- Self-construal modulates default mode network connectivity in refugees with PTSD
- Self-construal modulates default mode network connectivity in refugees with PTSD
- Heart rate variability, interoceptive accuracy and functional connectivity in middle-aged and older patients with depression
- Acute effects of Δ9-tetrahydrocannabinol (THC) on resting state connectivity networks and impact of COMT genotype: A multi-site pharmacological fMRI study
- Connectomics-based resting-state functional network alterations predict suicidality in major depressive disorder
- Functional connectivity in rumination: a systematic review of magnetic resonance imaging studies
- Sleep and physical activity measures are associated with resting-state network segregation in non-demented older adults
- Resting state functional connectivity as a predictor of brief intervention response in adults with alcohol use disorder: A preliminary study
- Aberrant brain dynamics of large-scale functional networks across schizophrenia and mood disorder
- Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders
- Neuroticism and openness exhibit an anti-correlation pattern to dissociable default mode network: using resting connectivity and structural equation modeling analysis
- Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia
- Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder
- Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats
- Functional connectivity of the default mode network predicts subsequent polysomnographically measured sleep in people with symptoms of insomnia
- Similarity and difference in large-scale functional network alternations between behavioral addictions and substance use disorder: a comparative meta-analysis
- Functional Brain Networks of Minor and Well-Structured Major Hallucinations in Parkinson's Disease
- Association of polygenic risk for bipolar disorder with resting-state network functional connectivity in youth with and without bipolar disorder
- Impaired topology and connectivity of grey matter structural networks in major depressive disorder: evidence from a multi-site neuroimaging data-set
- Large-scale network abnormality in behavioral addiction
- Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A
- Functional integration and segregation during semantic cognition: Evidence across age groups
- Uncovering Effects of Schizophrenia upon a Maximally Significant, Minimally Complex Subset of Default Mode Network Connectivity Features
- Sex differences of the triple network model in children with autism: A resting-state fMRI investigation of effective connectivity
- Distinctive and complementary roles of default mode network subsystems in semantic cognition
- Altered intra- and inter-network connectivity in autism spectrum disorder
- Altered resting-state functional connectivity and dynamic network properties in cognitive impairment: an independent component and dominant-coactivation pattern analyses study
- Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy
- Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults
- The mediating role of trait impulsivity in the relation between cue-induced craving and functional connectivity within the salience network among abstinent patients with methamphetamine use disorder
- A longitudinal evaluation of personalized intrinsic network topography and cognitive decline in Parkinson's disease
- Mindfulness-based cognitive therapy neurobiology in treatment-resistant obsessive-compulsive disorder: A domain-related resting-state networks approach
- Longitudinal changes in resting-state functional connectivity as markers of vulnerability or resilience in first-degree relatives of patients with bipolar disorder
- Disrupted topological organization of the default mode network in mild cognitive impairment with subsyndromal depression: A graph theoretical analysis
- Amygdala functional connectivity in borderline personality disorder
- Deficits in brain default mode network connectivity mediate the relationship between poor sleep quality and anxiety severity
- Unraveling how the adolescent brain deals with criticism using Dynamic Causal Modeling
- Distinct resting-state effective connectivity of large-scale networks in first-episode and recurrent major depression disorder: evidence from the REST-meta-MDD consortium
- Shared and Distinctive Brain Networks Underlying Trait and State Rumination
- Active suicidal ideation associated with dysfunction in default mode network using resting-state EEG and functional MRI - Findings from the T-RAD Study
- Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder
- I know why the caged bird sings: Greater ventromedial prefrontal cortex to right amygdala associated with elevated HRV in distress tolerant versus intolerant individuals
- The co-activation pattern between the DMN and other brain networks affects the cognition of older adults: evidence from naturalistic stimulation fMRI data
- Alterations of resting-state functional network connectivity in patients with noise-induced hearing loss: A study based on independent component analysis
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety
- Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks
- Electroconvulsive therapy regulates brain connectome dynamics in patients with major depressive disorder
- Reorganization of the cortical connectome functional gradient in age-related hearing loss
- Understanding and predicting future relapse in depression from resting state functional connectivity and self-referential processing