Evidence
Behav Processes. 2023 Jul 12:104915. doi: 10.1016/j.beproc.2023.104915. Online ahead of print.
ABSTRACT
Environmental enrichment (EE) is known to produce experience-dependent changes in the brains and behaviors of rodents, and it has therefore been widely used to study neurodevelopmental disorders, including autism. Current studies show significant protocol variation, such as the presence of running wheels, number of cagemates, duration of enrichment, and the age of the animals at the beginning and end of the enrichment interventions. EE has been shown to have prominent positive effects in animal models of idiopathic and syndromic autism, but little is known about the ideal type of EE and the most efficient protocols for reversing autism spectrum disorder (ASD) behaviors modeled in rodents. This review presents evidence that social enrichment is the most effective way to rescue typical behaviors, and that variables such as onset, duration, and type of induction in the ASD model are important for EE success. Understanding which EE protocols are most beneficial for reversing ASD behaviors modeled in rodents opens up possibilities for the potential treatment of neuropsychiatric disorders characterized by behavioral deficits, such as autism.
PMID:37451559 | DOI:10.1016/j.beproc.2023.104915
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Which form of environmental enrichment is most effective in rodent models of autism?
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice
- CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice
- Pebble to the Metal: A Boulder Approach to Enrichment for Danio rerio
- Zebrafish Maintenance Conditions Affect Behavioral and Biochemical Biomarkers: A Possible Interfering Factor on the Research Results
- Virtual Reality Environmental Enrichment Effects on Craving for Cigarette in Smokers
- Introduction of a model for the modification of masticatory activity to investigate induced neural and behavioral alterations in mice
- Phytocannabinoids in neuromodulation: from omics to epigenetics
- The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models
- A novel paradigm for measuring prediction abilities in a rat model using a speech-sound discrimination task
- Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models
- Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings
- Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders
- A multi-ancestry cerebral cortex transcriptome-wide association study identifies genes associated with smoking behaviors
- Establishment of animal models and behavioral studies for autism spectrum disorders
- Use of Clonidine in Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder Comorbidity: Report of 3 Cases
- A novel animal model for understanding secondary traumatic stress and visceral pain in male rats
- Incentive-salience attribution is attenuated in Spontaneously Hypertensive Rats, an animal model of ADHD
- Incentive-salience attribution is attenuated in Spontaneously Hypertensive Rats, an animal model of ADHD
- Targeting epigenetic dysregulation in autism spectrum disorders
- Bisphenol A (BPA) and neurological disorders: An Overview
- Bisphenol A (BPA) and neurological disorders: An Overview
- Bisphenol A (BPA) and neurological disorders: An Overview
- Association of Breastfeeding Duration with Neurodevelopmental Outcomes in an Enriched Familial Likelihood Cohort for Autism Spectrum Disorder
- Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles
- On-Chip Neural Induction Boosts Neural Stem Cell Commitment: Toward a Pipeline for iPSC-Based Therapies
- Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants
- Administration of Atosiban, an Oxytocin Receptor Antagonist, Ameliorates Autistic-like Behaviors in a Female Rat Model of Valproic Acid-induced Autism
- Microglial function interacts with the environment to affect sex-specific depression risk
- Microglial function interacts with the environment to affect sex-specific depression risk
- Diagnostic role of SPP1 and collagen IV in a rat model of type 2 diabetes mellitus with MASLD
- The contribution of silencer variants to human diseases
- The contribution of silencer variants to human diseases
- Graph Node Classification to Predict Autism Risk in Genes
- The circadian system: A neglected player in neurodevelopmental disorders
- Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models
- Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models
- Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism
- Perception and behavior toward neuropsychiatric disorders in Saudi Arabia: A systematic review and quality assessment
- Engineered lignocellulosic based biochar to remove endocrine-disrupting chemicals: Assessment of binding mechanism
- KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway
- Innate Immune Dysfunction and Neuroinflammation in Autism Spectrum Disorder (ASD)
- Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome
- Identification of differentially expressed genes of blood leukocytes for Schizophrenia
- The Role of Alpha-Synuclein in Neurodevelopmental Diseases
- Motor difficulties in 16p11.2 copy number variation
- A Longitudinal Analysis of Mothers' Parenting Stress and Internalizing and Externalizing Behavior of Young Children on the Autism Spectrum
- The association between prenatal oxidative stress levels measured by isoprostanes and offspring neurodevelopmental outcomes at 36 months
- The Role of Alpha-Synuclein in Neurodevelopmental Diseases
- The Role of Alpha-Synuclein in Neurodevelopmental Diseases
- Manganese in autism spectrum disorder and attention deficit hyperactivity disorder: The state of the art
- Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
- Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
- Manganese in autism spectrum disorder and attention deficit hyperactivity disorder: The state of the art
- Honey Added to Yogurt with Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 Supports Probiotic Enrichment but Does Not Reduce Intestinal Transit Time in Healthy Adults: A Randomized, Controlled, Crossover Trial
- Honey Added to Yogurt with Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 Supports Probiotic Enrichment but Does Not Reduce Intestinal Transit Time in Healthy Adults: A Randomized, Controlled, Crossover Trial
- Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
- A strike to the head: Parallels between the pediatric and adult human and the rodent in traumatic brain injury
- Autism Spectrum Disorders: Etiology, Epidemiology, and Challenges for Public Health
- Implementing a Uniform Outcome Measurement Approach for Early Interventions of Autism Spectrum Disorders
- Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers
- Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers
- Cell type specific roles of FOXP1 during early neocortical murine development
- Comparative efficacy of an early intervention "parent and me" program for infants showing signs of autism: The Baby JASPER model
- Reversal of electrophysiological and behavioral deficits mediated by 5-HT7 receptor upregulation following LP-211 treatment in an autistic-like rat model induced by prenatal valproic acid exposure
Evidence Blueprint
Which form of environmental enrichment is most effective in rodent models of autism?
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Which form of environmental enrichment is most effective in rodent models of autism?
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats
- Semi-natural housing rescues social behavior and reduces repetitive exploratory behavior of BTBR autistic-like mice
- Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid
- Environmental interventions reduced repetitive behavior in a mouse model: Physiology and Behavior
- Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder
- A novel head-fixed assay for social touch in mice uncovers aversive responses in two autism models
- CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice
- CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice
- Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings
- Age-related brain atrophy and the positive effects of behavioral enrichment in middle-aged beagles
- Age-related brain atrophy and the positive effects of behavioral enrichment in middle-aged beagles
- Pebble to the Metal: A Boulder Approach to Enrichment for Danio rerio
- Zebrafish Maintenance Conditions Affect Behavioral and Biochemical Biomarkers: A Possible Interfering Factor on the Research Results
- Improved Estimation of Functional Enrichment in SNP Heritability Using Feasible Generalized Least Squares
- Virtual Reality Environmental Enrichment Effects on Craving for Cigarette in Smokers
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents
- Environmental Enrichment Cage for Laboratory Mice: A Downloadable Alternative
- Exploring key genes and pathways associated with sex differences in autism spectrum disorder: integrated bioinformatic analysis
- Environmental Enrichment Improves Motor Function and Muscle Transcriptome of Aged Mice
- Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons
- Enrichment and MALDI-TOF MS Analysis of Phosphoinositides in Brain Tissue
- Levels of BDNF and NGF in adolescent rat hippocampus neonatally exposed to methamphetamine along with environmental alterations
- Introduction of a model for the modification of masticatory activity to investigate induced neural and behavioral alterations in mice
- Rodent models for mood disorders - understanding molecular changes by investigating social behavior
- The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment
- Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment
- Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder
- Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus
- Phytocannabinoids in neuromodulation: from omics to epigenetics
- The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models
- Identification of Immune Infiltration and Iron Metabolism-Related Subgroups in Autism Spectrum Disorder
- A novel paradigm for measuring prediction abilities in a rat model using a speech-sound discrimination task
- Agmatine ameliorates valproic acid-induced depletion of parvalbumin-positive neuron
- Single-cell brain organoid screening identifies developmental defects in autism
- Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models
- From synapses to circuits: What mouse models have taught us about how autism spectrum disorder impacts hippocampal function
- Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings
- Enrichment of the local synaptic translatome for genetic risk associated with schizophrenia and autism spectrum disorder
- Microglial contribution to the pathology of neurodevelopmental disorders in humans
- Autism. Pharmacological treatment
- Mechanisms of copy number variants in neuropsychiatric disorders: From genes to therapeutics
- LAMP1 as a novel molecular biomarker to predict the prognosis of the children with autism spectrum disorder using bioinformatics approaches
- Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies
- Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons
- Minocycline improves autism-related behaviors by modulating microglia polarization in a mouse model of autism
- Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders
- An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period
- Bridging the translational gap: what can synaptopathies tell us about autism?
- DO AUTISTIC AND DEPRESSED RATS EXPRESS THE SAME TYPE OF MATERNAL CARE?
- Sex differences in the age of childhood autism diagnosis and the impact of co-occurring conditions
- The Impact of Audio-Visual, Visual and Auditory Cues on Multiple Object Tracking Performance in Children with Autism
- Animal-assisted therapies for autism
- A primer on the use of computational modelling to investigate affective states, affective disorders and animal welfare in non-human animals
- Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder
- A multi-ancestry cerebral cortex transcriptome-wide association study identifies genes associated with smoking behaviors
- Establishment of animal models and behavioral studies for autism spectrum disorders
- A bridge to recovery: Acute amantadine prior to environmental enrichment after brain trauma augments cognitive benefit
- Neurotoxicity of Pyrethroids in exacerbating neurodegenerative diseases: From animals' models to humans' studies
- Program for the Education and Enrichment of Relational Skills (PEERS®) for Italy: A Randomized Controlled Trial of a Social Skills Intervention for Autistic Adolescents
- Use of Clonidine in Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder Comorbidity: Report of 3 Cases
- TrkB-dependent regulation of molecular signaling across septal cell types
- A novel animal model for understanding secondary traumatic stress and visceral pain in male rats
- Autism Spectrum Disorder in Children With Perinatal Ischemic Stroke Varies by Stroke Type
- Incentive-salience attribution is attenuated in Spontaneously Hypertensive Rats, an animal model of ADHD