Evidence
PLoS One. 2024 Feb 9;19(2):e0289248. doi: 10.1371/journal.pone.0289248. eCollection 2024.
ABSTRACT
BACKGROUND: Agomelatine (AGO) is an antidepressant with unique pharmacological effects; however, its underlying mechanisms remain unknown. In this study, we examined agomelatine’s effects on catalase activity, oxidative stress, and inflammation.
METHODS: Chronic restraint stress (CRS) model mice were established over 4 weeks, and AGO 50 mg/kg was administered to different groups alongside a deferasirox (DFX) 10 mg/kg gavage treatment. Behavioral tests were performed to assess the effect of AGO on the remission of depression-like behaviors. Meanwhile, the expression of CAT, the oxidative stress signaling pathway and inflammatory protein markers were assessed using ELISA, qRT-PCR, Western blot, and immunohistochemistry.
RESULTS: Four weeks of AGO treatment significantly improved depression-like behavior in mice through the activation of catalase in the hippocampus and serum of the model mice, increased superoxide dismutase expression, reduced malondialdehyde expression, and reduced oxidative stress damage. Deferasirox was found to offset this therapeutic effect partially. In addition, the inflammatory pathway (including nuclear factor-κB and nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha) was not significantly altered.
CONCLUSIONS: AGO can exert antidepressant effects by altering oxidative stress by modulating catalase activity.
PMID:38335199 | DOI:10.1371/journal.pone.0289248
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Agomelatine prevented depression in the chronic restraint stress model through enhanced catalase activity and halted oxidative stress
🌐 90 Days
VR Related Evidence Matrix
- Effects of Nostoc commune extract on the cerebral oxidative and neuroinflammatory status in a mice model of schizophrenia
- PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
- Network pharmacology and experimental evidence: ERK/CREB/BDNF signaling pathway is involved in the antidepressive roles of Kaiyu Zhishen decoction
- The protective effect of Astaxanthin on scopolamine - induced Alzheimer's model in mice
- Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation
- Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation
- Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation
- Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD
- Protective Effects of Lycium ruthenicum Murray against Acute Alcoholic Liver Disease in Mice via the Nrf2/HO-1/NF-kappaB Signaling Pathway
- Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation
- Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
- Misophonia is related to stress but not directly with traumatic stress
- Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer's Disease and the Assessment of the Protective Potential of D-Galactose
- Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
- Albumin-fused thioredoxin ameliorates high-fat diet-induced non-alcoholic steatohepatitis
- Apigenin Alleviates Autistic-like Stereotyped Repetitive Behaviors and Mitigates Brain Oxidative Stress in Mice
- Poria cocos polysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation
- Neuronal and molecular mechanisms underlying chronic pain and depression comorbidity in the paraventricular thalamus
- Neuronal and molecular mechanisms underlying chronic pain and depression comorbidity in the paraventricular thalamus
- The role of nitric oxide and hormone signaling in chronic stress, anxiety, depression and post traumatic stress disorder
- Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl3-induced zebrafish (Danio rerio) model of Alzheimer's disease
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress
- Are anxiety, depression, and stress distinguishable in Italian adolescents? an examination through the Depression Anxiety Stress Scales-21
- Panax notoginseng saponins prevent dementia and oxidative stress in brains of SAMP8 mice by enhancing mitophagy
- The Effect of Propofol on the Hippocampus in Chronic Cerebral Hypoxia in a Rat Model Through Klotho Regulation
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Sex-dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain-gut axis in a VPA-induced autistic-like model of rats
- Investigating the impact of Psidium guajava leaf hydroalcoholic extract in improving glutamatergic toxicity-induced oxidative stress in Danio rerio larvae
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia
- Isolation of the differential effects of chronic and acute stress in a manner that is not confounded by stress severity
- The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism
- Towards a natural treatment for mania: red onion husk extract modulates neuronal resilience, redox signalling, and glial activation
- PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway
- The Role of Oxidative Stress in Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies
- Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer's disease
- PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer's disease mouse model by activating Nrf2 signaling pathway
- Metabolic dysfunction-associated steatohepatitis treated by poly(ethylene glycol)-block-poly(cysteine) block copolymer-based self-assembling antioxidant nanoparticles
- Edaravone dexborneol attenuates cognitive impairment in a rat model of vascular dementia by inhibiting hippocampal oxidative stress and inflammatory responses and modulating the NMDA receptor signaling pathway
- Alleviating Stress in Parkinson's Disease: Symptomatic Treatment, Disease Modification, or Both?
- Frontal alpha asymmetry is associated with chronic stress and depression, but not with somatoform disorders
- The endoplasmic reticulum stress protein GRP94 modulates cathepsin L activity in M2 macrophages in conditions of obesity-associated inflammation and contributes to their pro-inflammatory profile
- Effects of Ganjianglingzhu Decoction on Lean Non-Alcoholic Fatty Liver Disease in Mice Based on Untargeted Metabolomics
- Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with a2o-1 in rats
- Growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) mediates feeding produced by chronic social defeat stress in male mice
- Therapeutic potential of Lingjiao Gouteng decoction in acute alcohol intoxication and alcohol-induced brain injury involving the RhoA/ROCK2/NF-κB signaling pathway
- Effects of Interleukin-19 Overexpression in the Medial Prefrontal Cortex on Anxiety-Related Behaviors, BDNF Expression and p38/JNK/ERK Pathways
- Bi-directional neuro-immune dysfunction after chronic experimental brain injury
- Common and divergent molecular mechanisms of fasting and ketogenic diets
- Activation of CRF/CRFR1 signaling in the central nucleus of the amygdala contributes to chronic stress-induced exacerbation of neuropathic pain by enhancing GluN2B-NMDA receptor-mediated synaptic plasticity in adult male rats
- Neonatal stress disrupts the glymphatic system development and increases the susceptibility to Parkinson's disease in later life
- Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice
- Exposure to Progestin 17-OHPC Induces Gastrointestinal Dysfunction through Claudin 1 Suppression in Female Mice with Increased Anxiety-Like Behaviors
- Pebble to the Metal: A Boulder Approach to Enrichment for Danio rerio
- Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study
- Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle
- Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle
- ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
- Effects of chronic social equality and inequality conditions on passive avoidance memory and PTSD-like behaviors in rats under chronic empathic stress
- Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress
- Amelioration of Neurochemical Alteration and Memory and Depressive Behavior in Sepsis by Allopurinol, a Tryptophan 2,3-Dioxygenase Inhibitor
- The relationship between interoceptive emotional awareness, neuroticism, and depression, anxiety, and stress
- Ferulago Angulata methanolic extract ameliorates scopolamine-induced memory impairment through the inhibition of hippocampal monoamine oxidase activity
- Mindfully and confidently digital: A mixed methods study on personal resources to mitigate the dark side of digital working
Evidence Blueprint
Agomelatine prevented depression in the chronic restraint stress model through enhanced catalase activity and halted oxidative stress
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Agomelatine prevented depression in the chronic restraint stress model through enhanced catalase activity and halted oxidative stress
🌐 365 Days
VR Related Evidence Matrix
- Targeting the Endoplasmic Reticulum Stress-Linked PERK/GRP78/CHOP Pathway with Magnesium Sulfate Attenuates Chronic-Restraint-Stress-Induced Depression-like Neuropathology in Rats
- Effects of Nostoc commune extract on the cerebral oxidative and neuroinflammatory status in a mice model of schizophrenia
- Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats
- A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE-/- mice
- A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE-/- mice
- Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator
- PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
- 11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E2 /ERβ signaling pathways
- Network pharmacology and experimental evidence: ERK/CREB/BDNF signaling pathway is involved in the antidepressive roles of Kaiyu Zhishen decoction
- Adulthood effects of developmental exercise in rats
- The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study
- Agomelatine improves memory and learning impairments in a rat model of LPS-induced neurotoxicity by modulating the ERK/SorLA/BDNF/TrkB pathway
- The protective effect of Astaxanthin on scopolamine - induced Alzheimer's model in mice
- Lateralization of the 5-HT1A receptors in the basolateral amygdala in metabolic and anxiety responses to chronic restraint stress
- Canagliflozin Ameliorates Oxidative Stress and Autistic-like Features in Valproic-Acid-Induced Autism in Rats: Comparison with Aripiprazole Action
- Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation
- Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation
- Coprococcus eutactus screened from healthy adolescent attenuates chronic restraint stress-induced depression-like changes in adolescent mice: Potential roles in the microbiome and neurotransmitter modulation
- Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission
- Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD
- Feeding crocin ameliorate cognitive dysfunction, oxidative stress and neuroinflammation induced by unpredictable chronic mild stress in rats
- Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis
- Perceived stress, mental health symptoms, and deleterious behaviors during the transition to college
- Protective Effects of Lycium ruthenicum Murray against Acute Alcoholic Liver Disease in Mice via the Nrf2/HO-1/NF-kappaB Signaling Pathway
- Suppressive effects of bilobalide on depression-like behaviors induced by chronic unpredictable mild stress in mice
- Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function
- Date palm spathe extract reverses chronic stress-induced changes in dendritic arborization in the amygdala and impairment of hippocampal long-term potentiation
- Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation
- Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation
- Meloxicam Targets COX-2/NOX1/NOX4/Nrf2 Axis to Ameliorate the Depression-like Neuropathology Induced by Chronic Restraint Stress in Rats
- Oxidative stress in Alzheimer's disease: current knowledge of signaling pathways and therapeutics
- Efficacy and safety of agomelatine in epilepsy patients with sleep and mood disorders: An observational, retrospective cohort study
- Geniposide improves depression-like behavior in prenatal stress male offspring through restoring HPA axis- and glucocorticoid receptor-associated dysfunction
- Pterin metabolism, inflammation and oxidative stress biochemical markers in schizophrenia: Factor analysis and assessment of clinical symptoms associations
- Chronic social and psychological stress impact select neuropathologies in the PS19 mouse model of tauopathy
- Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
- (+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease
- Misophonia is related to stress but not directly with traumatic stress
- Effects of different maternal diets on adipose tissue inflammation and liver tissue oxidative stress in dams and their female offspring
- The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
- Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer's Disease and the Assessment of the Protective Potential of D-Galactose
- Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer's Disease Is Associated with Activation of HIF-1 Signaling Pathway
- Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways
- Use of sertraline and agomelatine in hemodialysis patients: A case series report
- Gender-related Characteristics of Oxidative Stress Severity and Cognitive Impairment in Patients With Schizophrenia
- Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
- A novel Zebrafish model of Alzheimer's disease by Aluminium chloride; involving nitro-oxidative stress, neuroinflammation and cholinergic pathway
- DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress
- The Chronic Pharmacological Antagonism of the CB1 Receptor is not Involved in the Behavioral Effects of Antidepressants Administered in Mice Submitted to Chronic Unpredictable Stress
- Lactobacillus plantarum ST-III culture supernatant protects against acute alcohol-induced liver and intestinal injury
- Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice
- Albumin-fused thioredoxin ameliorates high-fat diet-induced non-alcoholic steatohepatitis
- Walnut (Juglans regia L.) Oligopeptides Alleviate Alcohol-Induced Acute Liver Injury through the Inhibition of Inflammation and Oxidative Stress in Rats
- Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat
- Effect of acute stress on working memory in pilots: Investigating the modulatory role of memory load
- 8-Iso-prostaglandin F2α as a potential biomarker in patients with unipolar and bipolar depression
- Apigenin Alleviates Autistic-like Stereotyped Repetitive Behaviors and Mitigates Brain Oxidative Stress in Mice
- Neuroprotective Effects of Virgin Coconut Oil Supplemented Diet against Sodium Benzoate-induced Acetylcholinesterase Dysfunction and Cognitive Impairment: Role of Nrf2/NfKb Signaling Pathway
- Poria cocos polysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation
- Biological rhythms are correlated with Na+K+-ATPase and oxidative stress biomarkers: A translational study on bipolar disorder
- Neuronal and molecular mechanisms underlying chronic pain and depression comorbidity in the paraventricular thalamus
- Neuronal and molecular mechanisms underlying chronic pain and depression comorbidity in the paraventricular thalamus
- The role of nitric oxide and hormone signaling in chronic stress, anxiety, depression and post traumatic stress disorder
- Changes in social, sexual, and hedonic behaviors in rats in response to stress and restoration by a negative allosteric modulator of α5-subunit containing GABA receptor