Evidence
Thyroid Res. 2024 Aug 19;17(1):19. doi: 10.1186/s13044-024-00206-7.
ABSTRACT
BACKGROUND: Hypothyroidism, a common worldwide syndrome caused by insufficient thyroid hormone secretion, affects number of people at different ages. Artemisinin (ART), a well-known effective agent in the treatment of malaria, also has anti-oxidative stress functions in various diseases. The L1 cell adhesion molecule exerts multiple protective roles in diseased systems. The aim of the present study was to evaluate the role of ART in adult male hypothyroid rats and the underlying mechanisms.
METHODS: The propylthiouracil (PTU) rat model was treated with or without 5 mg/kg ART and with or without L1 short-interfering RNA (siRNA), followed by the experiments to determine the effect of ART on thyroid function, depression and anxiety, cognition impairments, liver, kidney and heart functions, and oxidative stress.
RESULTS: In the current study, it was shown that ART can ameliorate thyroid function, mitigate depression and anxiety symptoms, attenuate cognition impairments, improve liver, kidney and heart functions, and inhibit oxidative stress; however, the effects exerted by ART could not be observed when L1 was silenced by L1 siRNA.
CONCLUSION: These results indicated that ART can upregulate the L1 cell adhesion molecule to ameliorate thyroid function and the complications in adult male hypothyroid rats, laying the foundation for ART to be a novel strategy for the treatment of hypothyroidism.
PMID:39155377 | DOI:10.1186/s13044-024-00206-7
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D Evidence
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Artemisinin ameliorates thyroid function and complications in adult male hypothyroid rats via upregulation of the L1 cell adhesion molecule
🌐 90 Days
AI Virtual Reality Related Evidence Matrix
- Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal hormones
- Artesunate improves learning and memory impairment in rats with vascular cognitive impairment by down-regulating the level of autophagy in cerebral cortex neurons
- Aldehyde dehydrogenase 1 family: A potential molecule target for diseases
- Serum Vascular Adhesion Protein-1 and Endothelial Dysfunction in Hepatic Cirrhosis: Searching for New Prognostic Markers
- TRIP13 - a potential drug target in cancer pharmacotherapy
- Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-naïve major depressive disorder: a large-scale cross-sectional study
- Three-needle electroacupuncture ameliorates depressive-like behaviors in a mouse model of post-stroke depression by promoting excitatory synapse formation via the NGL-3/L1cam pathway
- Three-needle electroacupuncture ameliorates depressive-like behaviors in a mouse model of post-stroke depression by promoting excitatory synapse formation via the NGL-3/L1cam pathway
- Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism
- Relationship between thyroid hormone levels and metabolic dysfunction associated steatotic liver disease in patients with type 2 diabetes: A clinical study
- Moderation of thyroid hormones for the relationship between amyloid and tau pathology
- ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats
- Targeting the Manifestations of Subclinical and Overt Hypothyroidism Within the Hippocampus
- ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats
- Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat
- Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-naive major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study
- Maternal thyroid function in early pregnancy and offspring school performance and neurodevelopmental disorders
- Maternal thyroid function in early pregnancy and offspring school performance and neurodevelopmental disorders
- Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models
- Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models
- Deep learning-based cell segmentation for rapid optical cytopathology of thyroid cancer
- Deep learning-based cell segmentation for rapid optical cytopathology of thyroid cancer
- Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs
- The crosstalk between neuropilin-1 and tumor necrosis factor-α in endothelial cells
- Gender difference in the relationship between clinical symptoms, thyroid hormones, and metabolic parameters in young, first-episode and drug-naive major depressive disorder patients with suicide attempts: A network analysis perspective
- Key Enzymes of the Serotonergic System - Tryptophan Hydroxylase 2 and Monoamine Oxidase A - In the Brain of Rats Selectively Bred for a Reaction toward Humans: Effects of Benzopentathiepin TC-2153
- Analysis and interpretability of machine learning models to classify thyroid disease
- Systemic inflammation, oxidative damage and neurocognition predict telomere length in a transdiagnostic sample stratified by global DNA methylation levels
- Including the Household: Individual, Community and Household Factors Affecting Antiretroviral Therapy Adherence After ART Initiation in Cape Town, South Africa
- Severe Post-partum Hypothyroidism Triggering Psychogenic Non-epileptiform Seizures, Myopathy, and Myxedema Coma
- CD177 on neutrophils engages stress-related behavioral changes in male mice
- Current and Future of Robotic Surgery in Thyroid Cancer Treatment
- Ginkgo biloba extract inhibits hippocampal neuronal injury caused by mitochondrial oxidative stress in a rat model of Alzheimer's disease
- Prevalence of drugs used for chronic conditions after diagnosis of thyroid cancer: A register-based cohort study
- MNMST: topology of cell networks leverages identification of spatial domains from spatial transcriptomics data
- Evolutionary Multiobjective Molecule Optimization in an Implicit Chemical Space
- Evolutionary Multiobjective Molecule Optimization in an Implicit Chemical Space
- Lithium carbonate-induced giant goiter and subclinical hyperthyroidism in a patient with schizophrenia: A case report and review of literature
- Effect of Interactive Media-Based Music and Art Therapies on Reduction in PTSD Symptoms in Children and Adult Victims of Abduction
- The effectiveness of expressive art therapy on infertile women undergoing surgery: study protocol for a randomized controlled trial
- Association between subclinical thyroid dysfunction and cognitive decline: findings from the ELSA-Brasil study
- Association between subclinical thyroid dysfunction and cognitive decline: findings from the ELSA-Brasil study
- The Effect of Bone Marrow Mesenchymal Stem Cells on Nestin and Sox-2 Gene Expression and Spatial Learning (Percent Alternation Y-Maze Test) against AlCl3-Induced Alzheimer's-like Pathology in a Rat Model
- The Effect of Bone Marrow Mesenchymal Stem Cells on Nestin and Sox-2 Gene Expression and Spatial Learning (Percent Alternation Y-Maze Test) against AlCl3-Induced Alzheimer's-like Pathology in a Rat Model
- Associations of sex-related and thyroid-related hormones with risk of metabolic dysfunction-associated fatty liver disease in T2DM patients
- Associations of sex-related and thyroid-related hormones with risk of metabolic dysfunction-associated fatty liver disease in T2DM patients
- Exploring the therapeutic potential: Apelin-13's neuroprotective effects foster sustained functional motor recovery in a rat model of Huntington's disease
- Evaluation of the Effects of Opium on the Expression of SOX2 and OCT4 in Wistar Rat Bladder
- Hippocampal neurogenesis modulated by Quinic acid: A therapeutic strategy for the neurodegenerative disorders
- Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board
- Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
- Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
- Shared genetic links between hypothyroidism and psychiatric disorders: evidence from a comprehensive genetic analysis
- Shared genetic links between hypothyroidism and psychiatric disorders: evidence from a comprehensive genetic analysis
- Chiglitazar attenuates high-fat diet-induced nonalcoholic fatty liver disease by modulating multiple pathways in mice
- DEL-Thyroid: deep ensemble learning framework for detection of thyroid cancer progression through genomic mutation
- Integrated analysis of the role of PR/SET domain 14 in gastric cancer
- Integrated analysis of the role of PR/SET domain 14 in gastric cancer
- Differential Impact of Serotonin Signaling Methylphenidate on Young versus Adult: Insights from Behavioral and Dorsal Raphe Nucleus Neuronal Recordings from Freely Behaving Rats
- Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet
- Apilarnil exerts neuroprotective effects and alleviates motor dysfunction by rebalancing M1/M2 microglia polarization, regulating miR-155 and miR-124 expression in a rotenone-induced Parkinson's disease rat model
- Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood
- Perioperative complications of middle cerebral artery occlusion in rats alleviated by human umbilical cord mesenchymal stem cells
- Inhibiting the JNK Signaling Pathway Attenuates Hypersensitivity and Anxiety-Like Behavior in a Rat Model of Non-specific Chronic Low Back Pain
Evidence Blueprint
Artemisinin ameliorates thyroid function and complications in adult male hypothyroid rats via upregulation of the L1 cell adhesion molecule
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Artemisinin ameliorates thyroid function and complications in adult male hypothyroid rats via upregulation of the L1 cell adhesion molecule
🌐 365 Days
AI Virtual Reality Related Evidence Matrix
- Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase
- Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior
- Severity of hypothyroidism is inversely associated with impaired quality of life in patients referred to an endocrine clinic
- Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal hormones
- Prevalence of thyroid dysfunction among Iranian older adults: a cross-sectional study
- Co-Morbid Hypothyroidism and Liver Dysfunction: A Review
- THE RELATIONSHIP BETWEEN TSH LEVELS, THYROID AUTOANTIBODIES AND ATHEROGENIC INDEX OF PLASMA, AST TO PLATELET RATIO INDEX SCORE, AND FIBROSIS 4 INDEX IN PATIENTS WITH HYPOTHYROIDISM
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
- Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence
- Maternal Thyroid Dysfunction During Pregnancy as an Etiologic Factor in Autism Spectrum Disorder: Challenges and Opportunities for Research
- Artesunate improves learning and memory impairment in rats with vascular cognitive impairment by down-regulating the level of autophagy in cerebral cortex neurons
- Chronic exposure to cortisone induces thyroid endocrine disruption and retinal dysfunction in adult female zebrafish (Danio rerio)
- Aldehyde dehydrogenase 1 family: A potential molecule target for diseases
- Serum Vascular Adhesion Protein-1 and Endothelial Dysfunction in Hepatic Cirrhosis: Searching for New Prognostic Markers
- The Potential Role of Thyroid Hormone Therapy in Neural Progenitor Cell Differentiation and Its Impact on Neurodevelopmental Disorders
- TRIP13 - a potential drug target in cancer pharmacotherapy
- The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study
- Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017
- Social-Single Prolonged Stress affects contextual fear conditioning in male and female Wistar rats: Molecular insights in the amygdala
- Cellular adhesion molecules in drug-naive and previously medicated patients with schizophrenia-spectrum disorders
- The role of cell adhesion molecule IgSF9b at the inhibitory synapse and psychiatric disease
- Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-naïve major depressive disorder: a large-scale cross-sectional study
- Quetiapine and Valproic Acid-induced Central Hypothyroidism in a Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case Report
- Three-needle electroacupuncture ameliorates depressive-like behaviors in a mouse model of post-stroke depression by promoting excitatory synapse formation via the NGL-3/L1cam pathway
- Three-needle electroacupuncture ameliorates depressive-like behaviors in a mouse model of post-stroke depression by promoting excitatory synapse formation via the NGL-3/L1cam pathway
- Study of Auditory Brainstem Evoked Response at Varying Frequencies in Subclinical Hypothyroid Subjects
- Radiological evolution of pituitary hyperplasia in primary hypothyroidism and its differentiation from nonfunctioning pituitary adenoma coexisting with primary hypothyroidism
- Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid
- Relationship between thyroid hormone levels and metabolic dysfunction associated steatotic liver disease in patients with type 2 diabetes: A clinical study
- The Intertwined Relationship Between an Overactive Thyroid and an Overactive Mind: A Case Report and Review of Literature
- Thyroid function, adipokines and mitokines in metabolic dysfunction-associated steatohepatitis: A multi-centre biopsy-based observational study
- Hypothyroidism and subclinical hypothyroidism are associated with fatty pancreas (Non-Alcoholic Fatty Pancreas Disease)
- Assisted Reproductive Technology and Disease Management in Infertile Women with Multiple Sclerosis
- The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats
- Advances in artificial intelligence in thyroid-associated ophthalmopathy
- Moderation of thyroid hormones for the relationship between amyloid and tau pathology
- Clinical correlates and thyroid hormones of metabolic syndrome in first-episode and drug-naïve major depressive disorder outpatients with and without hyperglycemia: a comprehensive cross-sectional study
- ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats
- Targeting the Manifestations of Subclinical and Overt Hypothyroidism Within the Hippocampus
- ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats
- Resting heart rate, cognitive function, and inflammation in older adults: a population-based study
- Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat
- Synaptic adhesion molecule protocadherin-γC5 mediates β-amyloid-induced neuronal hyperactivity and cognitive deficits in Alzheimer's disease
- Synaptic adhesion molecule protocadherin-γC5 mediates β-amyloid-induced neuronal hyperactivity and cognitive deficits in Alzheimer's disease
- Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-naive major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study
- Maternal thyroid function in early pregnancy and offspring school performance and neurodevelopmental disorders
- Maternal thyroid function in early pregnancy and offspring school performance and neurodevelopmental disorders
- Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats
- Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models
- Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models
- Association of thyroid disease and risk of fatty liver disease: an exposure-wide Mendelian randomization study
- Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice
- Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice
- Common changes in rat cortical gene expression after antidepressant drug treatment: impacts on metabolism of polyamines, mRNA splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding
- Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
- Endocrine manifestations in adults with 22q11.2 deletion syndrome: a retrospective single-center cohort study
- Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats
- Epidemiology of alcohol use and alcohol use disorders among people living with HIV on antiretroviral therapy in Northwest Tanzania: implications for ART adherence and case management
- Deep learning-based cell segmentation for rapid optical cytopathology of thyroid cancer
- Deep learning-based cell segmentation for rapid optical cytopathology of thyroid cancer
- A Bayesian approach for investigating the pharmacogenetics of combination antiretroviral therapy in people with HIV
- Association of thyroid function with non-alcoholic fatty liver disease in recent-onset diabetes
- Serial multiple mediating roles of anxiety and thyroid-stimulating hormone in the relationship between depression and psychotic symptoms in young adults with anxious depression
- Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis