Evidence
Nat Commun. 2024 Jan 30;15(1):888. doi: 10.1038/s41467-024-44701-9.
ABSTRACT
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases.
PMID:38291025 | DOI:10.1038/s41467-024-44701-9
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
🌐 90 Days
VR Related Evidence Matrix
- The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study
- Thyroid function, adipokines and mitokines in metabolic dysfunction-associated steatohepatitis: A multi-centre biopsy-based observational study
- The association between neuroendocrine/glucose metabolism and clinical outcomes and disease course in different clinical states of bipolar disorders
- Thyroid allostasis in drug-free affective disorder patients
- THE RELATIONSHIP BETWEEN TSH LEVELS, THYROID AUTOANTIBODIES AND ATHEROGENIC INDEX OF PLASMA, AST TO PLATELET RATIO INDEX SCORE, AND FIBROSIS 4 INDEX IN PATIENTS WITH HYPOTHYROIDISM
- Serial multiple mediating roles of anxiety and thyroid-stimulating hormone in the relationship between depression and psychotic symptoms in young adults with anxious depression
- Genetic influences on circulating retinol and its relationship to human health
- The Intertwined Relationship Between an Overactive Thyroid and an Overactive Mind: A Case Report and Review of Literature
- Association of major depression, schizophrenia and bipolar disorder with thyroid cancer: a bidirectional two-sample mendelian randomized study
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
- Genome-wide characterization of circulating metabolic biomarkers
- Association between hypothyroidism subtypes and major depression: A two-sample Mendelian randomization study
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
- FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
- Genetic architecture distinguishes tinnitus from hearing loss
- Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression
- The genetic architecture of multimodal human brain age
- A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
- A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
- Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
- Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population
- Author Correction: Using rare genetic mutations to revisit structural brain asymmetry
- Publisher Correction: Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots
- Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease
- Dose response relationship between lithium serum levels during pregnancy and birth outcomes
- Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance
- Author Correction: ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells
- Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants
- Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance
- Causal effects from inflammatory bowel disease on liver function and disease: a two-sample Mendelian randomization study
- The causal relationship of female infertility and psychiatric disorders in the European population: a bidirectional two-sample Mendelian randomization study
- The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria
- Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
- Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
- Genome-wide association study identifies new loci associated with OCD
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
- Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease
- Using rare genetic mutations to revisit structural brain asymmetry
- The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study
- The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study
- Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
- Comprehensive Sex-Stratified Genetic Analysis of 28 Blood Biomarkers and Depression Reveals a Significant Association between Depression and Low Levels of Total Protein in Females
- Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence
- Investigating the shared genetic architecture between attention-deficit/hyperactivity disorder and risk taking behavior: A large-scale genomewide cross-trait analysis
- Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans
- Associations of externalizing polygenic scores with externalizing disorders among Mexican youth
- Relationship between autism and brain cortex surface area: genetic correlation and a two-sample Mendelian randomization study
- Connectome-based reservoir computing with the conn2res toolbox
- Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
- Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
- Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes
- Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis
- Association of chronic pain with suicide attempt and death by suicide: a two-sample Mendelian randomization
- Autistic traits and anthropomorphism: the case of vehicle fascia perception
Evidence Blueprint
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
Save Evidence Blueprint
Save as PDF
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
🌐 365 Days
VR Related Evidence Matrix
- Genetic determinants of thyroid function in children
- The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study
- Association of Gestational Thyroid Function and TPOAb Positivity with Postpartum Depression: a prospective cohort study and systematic literature review with meta-analysis
- Association of thyroid function with non-alcoholic fatty liver disease in recent-onset diabetes
- Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study
- Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence
- Anaemia-based screening for resistance to thyroid hormone alpha in children
- Association between thyroid function and psychotic symptoms in adolescents with major depressive disorder: A large sample sized cross-sectional study in China
- Thyroid function, adipokines and mitokines in metabolic dysfunction-associated steatohepatitis: A multi-centre biopsy-based observational study
- The association between neuroendocrine/glucose metabolism and clinical outcomes and disease course in different clinical states of bipolar disorders
- Thyroid allostasis in drug-free affective disorder patients
- X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
- THE RELATIONSHIP BETWEEN TSH LEVELS, THYROID AUTOANTIBODIES AND ATHEROGENIC INDEX OF PLASMA, AST TO PLATELET RATIO INDEX SCORE, AND FIBROSIS 4 INDEX IN PATIENTS WITH HYPOTHYROIDISM
- Association of gestational free and total triiodothyronine with gestational hypertension, preeclampsia, preterm birth and birth weight: an individual-participant data meta-analysis
- Prevalence of thyroid dysfunction among Iranian older adults: a cross-sectional study
- Thyroid function and opium use disorder: a cross-sectional study on the Fasa adults cohort study (FACS), 2017
- Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naïve patients with major depressive disorder with abnormal glucose metabolism
- Multi-ancestry genome-wide association meta-analysis of Parkinson's disease
- Serial multiple mediating roles of anxiety and thyroid-stimulating hormone in the relationship between depression and psychotic symptoms in young adults with anxious depression
- Genetic influences on circulating retinol and its relationship to human health
- Association between thyroid autoimmunity and clinical characteristics in first-episode and drug-naive depressed patients with suicide attempts
- Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients
- The Intertwined Relationship Between an Overactive Thyroid and an Overactive Mind: A Case Report and Review of Literature
- Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naïve young major depressive disorder patients with comorbid anxiety
- Association of major depression, schizophrenia and bipolar disorder with thyroid cancer: a bidirectional two-sample mendelian randomized study
- Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
- Cluster headache genome-wide association study and meta-analysis identifies eight loci and implicates smoking as causal risk factor
- Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
- Genome-wide characterization of circulating metabolic biomarkers
- Association between hypothyroidism subtypes and major depression: A two-sample Mendelian randomization study
- Genome-wide association studies: Utility and limitations for research in physiology
- Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
- Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk
- Chronic exposure to cortisone induces thyroid endocrine disruption and retinal dysfunction in adult female zebrafish (Danio rerio)
- The Interrelation Between Hypothyroidism and Non-alcoholic Fatty Liver Disease, a Cross-sectional Study
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
- Effect of physical exercise in people with hypothyroidism: systematic review and meta-analysis
- Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain
- Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
- Trans-ancestry meta-analysis of genome wide association studies of inhibitory control
- Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery
- FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
- Prevalence and factors associated with metabolic syndrome in first hospitalization for major depression disorder patients
- Cardiovascular morbidity and mortality in patients in Wales, UK with resistance to thyroid hormone β (RTHβ): a linked-record cohort study
- Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study
- Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits
- Prevalence and clinical correlates of psychotic symptoms in first-episode untreated female chinese patients with major depressive disorder
- Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
- Association between lithium treatment and renal, thyroid and parathyroid function: A cohort study of 6659 patients with bipolar disorder
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
- The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
- Prevalence and clinical correlates of thyroid dysfunction in first-episode and drug-naïve major depressive disorder patients with metabolic syndrome
- Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles
- Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes
- Investigating the shared genetic architecture between schizophrenia and body mass index