Assessing tilavonemab efficacy in early Alzheimer’s disease via longitudinal item response theory modeling

5 June 2024

Evidence

Alzheimers Dement (N Y). 2024 Jun 4;10(2):e12471. doi: 10.1002/trc2.12471. eCollection 2024 Apr-Jun.

ABSTRACT

INTRODUCTION: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by declines in cognitive and functional severities. This research utilized the Clinical Dementia Rating (CDR) to assess the influence of tilavonemab on these deteriorations.

METHODS: Longitudinal Item Response Theory (IRT) models were employed to analyze CDR domains in early-stage AD patients. Both unidimensional and multidimensional models were contrasted to elucidate the trajectories of cognitive and functional severities.

RESULTS: We observed significant temporal increases in both cognitive and functional severities, with the cognitive severity deteriorating at a quicker rate. Tilavonemab did not demonstrate a statistically significant effect on the progression in either severity. Furthermore, a significant positive association was identified between the baselines and progression rates of both severities.

DISCUSSION: While tilavonemab failed to mitigate impairment progression, our multidimensional IRT analysis illuminated the interconnected progression of cognitive and functional declines in AD, suggesting a comprehensive perspective on disease trajectories.

HIGHLIGHTS: Utilized longitudinal Item Response Theory (IRT) models to analyze the Clinical Dementia Rating (CDR) domains in early-stage Alzheimer’s disease (AD) patients, comparing unidimensional and multidimensional models.Observed significant temporal increases in both cognitive and functional severities, with cognitive severity deteriorating at a faster rate, while tilavonemab showed no statistically significant effect on either domain’s progression.Found a significant positive association between the baseline severities and their progression rates, indicating interconnected progression patterns of cognitive and functional declines in AD.Introduced the application of multidimensional longitudinal IRT models to provide a comprehensive perspective on the trajectories of cognitive and functional severities in early AD, suggesting new avenues for future research including the inclusion of time-dependent random effects and data-driven IRT models.

PMID:38835820 | PMC:PMC11148533 | DOI:10.1002/trc2.12471

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Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression 21 June 2024
Background Structural imaging holds great potential for precise targeting and stimulation for deep brain stimulation (DBS). The anatomical information it provides may serve as potential biomarkers for predicting the efficacy of DBS in treatment-resistant depression (TRD). Aims The primary aim is to identify preoperative imaging biomarkers that correlate with the efficacy of DBS in patients […]
Wang, F., Dai, L., Wang, T., Zhang, Y., Wang, Y., Zhao, Y., Pan, Y., Bian, L., Li, D., Zhan, S., Lai, Y., Voon, V., Sun, B.

Implementing AI models in clinical workflows: a roadmap 24 June 2024
Artificial Intelligence (AI) aims at mimicking human intelligence through computer programmes. Machine learning (ML), especially deep learning technologies, aiming at inferring insights from complex data through mathematical modelling, offers an effective way of achieving AI and has achieved great success in many disciplines, such as computer vision and natural language processing. Over the past decade, […]
Wang, F., Beecy, A.
Correction: Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial 14 June 2024
Kongkam P, Khongkha W, Lopimpisuth C, et al Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial BMJ Evidence-Based Medicine 2023;28:399-406.The journal received a rapid response that raised issues regarding the registration status of this trial and the methods. The journal investigated these issues with the collaboration of the authors, […]
iHealthFacts: a health fact-checking website for the public 14 June 2024
Introduction and backgroundUnreliable health information has been identified as a public health challenge. It may lead individuals to explore unproven and potentially harmful medical treatments1 or cause delays in seeking appropriate healthcare services.2Determining the accuracy of health information is especially challenging in the digital age.3 These challenges were underscored by the onset of the COVID-19 […]
Byrne, P., Daly, A., Mac Loughlin, D., Madden, C., Mc Donnell, T., O'Connell, C., Pope, J., Saif-Ur-Rahman, K. M., Taneri, P. E., Tierney, M., Toomey, E., Devane, D.

‘Before, we ended up in conflicts, now we can provide support’—Experiences of Community Reinforcement and Family Training (CRAFT) for parents of young adults with hazardous substance use 21 June 2024
The prevalence of hazardous substance use is highest in the age between 18 and 25, but few young adults enter treatment. Community Reinforcement and Family Training (CRAFT) is a support program for concerned s...
Ola Siljeholm, Joachim Eckerström, Olof Molander, Jennie Sundbye and Anders Hammarberg
Motives and modifying factors for giving or rejecting psychiatric diagnoses in general medicine and psychiatry – a qualitative interview study 20 June 2024
There is a discussion among general practitioners and psychiatrists regarding over-diagnosing versus under-reporting of psychiatric diagnoses. A deeper understanding of this topic is relevant for providing rea...
Hannah Tebartz van Elst, Claudia Niehoff and Jost Steinhäuser
Association of interleukin-2 and interleukin-10 with the pathophysiology and development of generalized anxiety disorder: a case-control study 20 June 2024
Generalized anxiety disorder (GAD) is a devastating mental health condition characterized by constant, uncontrolled worrying. Recent hypotheses indicate that pro-inflammatory cytokines and chemokines are poten...
Nisat Sarmin, A. S. M. Roknuzzaman, Rapty Sarker, Mamun -or-Rashid, MMA Shalahuddin Qusar, Sitesh Chandra Bachar, Eva Rahman Kabir, Md. Rabiul Islam and Zobaer Al Mahmud

King Charles III retains patronage of Royal College of Psychiatrists
The Royal College of Psychiatrists is thrilled to announce His Majesty The King has retained his patronage of the College.
www.rcpsych.ac.uk
Maternal Mental Health Awareness Week
This Maternal Mental Health Awareness Week, we’re highlighting our mental health leaflets for patients and their families.
www.rcpsych.ac.uk
‘Discrimination against people with severe mental illness is cutting lives short’
The President of the Royal College of Psychiatrists, Dr Lade Smith CBE, warns that prejudice against people with severe mental illness prevents them from seeking help and cuts lives short.
www.rcpsych.ac.uk

Capacity to Consent to Treatment of Substance Use Disorders at Ontario's Consent and Capacity Board: A Review of Past Reported Decisions 14 June 2024
The Canadian Journal of Psychiatry, Ahead of Print. Capacity to consent to treatment of substance use disorders at Ontario's Consent and Capacity Board: A review of past reported decisionsPlain Language Summary TitleAn Ontario review of legal cases which have considered patients' ability to consent to substance use treatmentsPlain Language SummaryIn general, prescribers must consider whether […]
Tanya S. Hauck
Effect of Bright Light Therapy on Perinatal Depression: A Systematic Review and Meta-Analysis: Effet de la luminothérapie sur la dépression périnatale: une revue systématique et une méta-analyse 12 June 2024
The Canadian Journal of Psychiatry, Ahead of Print. ObjectiveThis study represents the inaugural attempt to systematically review and analyse the efficacy of bright light therapy on depression among women experiencing major depressive disorder or depressive symptoms during the perinatal period, encompassing its efficacy on depression scores, remission rates, and response rates.MethodsWe searched 10 databases for […]
Yujia Chen
Commentary on the Canadian Network for Mood and Anxiety Treatments 2023 Clinical Guidelines for Management of Major Depressive Disorder in Adults – Capturing the State of the Art 10 June 2024
The Canadian Journal of Psychiatry, Ahead of Print.
Katherine Beck

Integrating exercise into depression care 17 June 2024
Send us a Text Message.On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole discuss the evidence supporting exercise as an effective treatment option for mild to moderate depression. They explore how exercise might be used effectively and the challenges involved in implementing it for patients.Dr. Nicholas Fabiano, a second-year psychiatry […]
Canadian Medical Association Journal
Responding to rising measles rates in Canada 3 June 2024
Send us a Text Message.On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole tackle an unexpected yet urgent topic: the resurgence of measles. With rising cases globally and in Canada, they discuss the implications and necessary actions for healthcare professionals.Dr. Sarah Wilson, a public health physician at Public Health Ontario, […]
Canadian Medical Association Journal
Constructive conversations on CanMEDS revisions 20 May 2024
Send us a Text Message.On this episode of the CMAJ Podcast, Dr. Blair Bigham and Dr. Mojola Omole discuss the heated debate over proposed updates to the CanMEDS framework. The controversy ignited when an interim report placed principles of equity, social justice, and anti-racism at the heart of the framework, rather than medical expertise.Dr. Kannin […]
Canadian Medical Association Journal

Bioethical implications of cosmetic psychiatry: Distributive justice versus utilitarianism 21 June 2024
Australasian Psychiatry, Ahead of Print.
Michael James Weightman
Bloom’s taxonomy—Can evidence-based teaching improve junior medical officers’ knowledge of the mental health and guardianship acts? 15 June 2024
Australasian Psychiatry, Ahead of Print. ObjectiveTo determine whether a brief educational intervention for Junior Medical Officers (JMOs), using teaching methods aimed at achieving higher outcomes on Bloom’s Taxonomy, significantly improved participant confidence and knowledge in decision making about restrictive care.MethodJMOs received a teaching session on restrictive medical and mental health care. Groups were randomly assigned […]
Trent Koessler
Any psychiatric assessment of a drowsy patient must be preliminary 15 June 2024
Australasian Psychiatry, Ahead of Print.
Mathew Coleman

Caregiver burden and its sociodemographic determinants in family caregivers of patients with schizophrenia attending a psychiatric tertiary hospital in South Africa 21 June 2024
Background: Chronic mental illnesses such as schizophrenia affect patients’ functioning, making caregiving necessary although burdensome.Aim: This study aimed to determine caregiver burden and its sociodemographic determinants in family caregivers of patients with schizophrenia attending a Psychiatric Outpatient Department (POD).Setting: Tertiary hospital in Northern Pretoria, South Africa.Methods: In this cross-sectional study conducted over 3 months, 300 consecutive family caregivers who […]
Chioma O. Onyia
The effects of inpatient suicide on nurses at Weskoppies Hospital: A qualitative study 21 May 2024
Background: Inpatient suicide is a serious adverse event in psychiatric wards. Suicide can cause severe trauma to both patients and health professionals, who may develop maladaptation with poor coping skills. Healthcare practitioners are the second victims and historically, this concept has been overlooked. The psychological effects and lack of support have not been sufficiently explored.Aim: The emotional […]
Nomthandazo Zola
Clinical profile of children and adolescents with autism spectrum disorder in Durban, South Africa 14 May 2024
Background: There are often delays in accessing care and diagnosing autism spectrum disorders (ASDs), with little data from Southern Africa on the clinical profile of affected children and adolescents.Aim: To describe the socio-demographic and clinical variables of children and adolescents with ASD attending psychiatric services at two state hospitals in eThekwini Municipality, KwaZulu-Natal province, South Africa.Setting: Two state […]
Manisharani Gangai

Standards for randomized controlled trials of efficacy of psychological treatments 10 May 2024
World Psychiatry, Volume 23, Issue 2, Page 286-287, June 2024.
David C. Mohr
The future of dynamic networks in research and clinical practice 10 May 2024
World Psychiatry, Volume 23, Issue 2, Page 288-289, June 2024.
Laura F. Bringmann
Algorithm‐based modular psychotherapy vs. cognitive‐behavioral therapy for patients with depression, psychiatric comorbidities and early trauma: a proof‐of‐concept randomized controlled trial 10 May 2024
World Psychiatry, Volume 23, Issue 2, Page 257-266, June 2024.
Elisabeth Schramm, Moritz Elsaesser, Carolin Jenkner, Martin Hautzinger, Sabine C. Herpertz

Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review 24 June 2024
Molecular Psychiatry, Published online: 24 June 2024; doi:10.1038/s41380-024-02638-xPlacebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review
Nathan T. M. Huneke
Comment on: Antidepressants act by directly binding to TRKB neurotrophin receptors 22 June 2024
Molecular Psychiatry, Published online: 22 June 2024; doi:10.1038/s41380-024-02615-4Comment on: Antidepressants act by directly binding to TRKB neurotrophin receptors
Philip W. Gold
Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 21 June 2024
Molecular Psychiatry, Published online: 21 June 2024; doi:10.1038/s41380-024-02635-0Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19
Guangting Zeng

Eyes on glutamate in angiogenesis and barrier formation
In this issue of , Biswas et al. demonstrate the roles of glutamatergic neuronal activity in the regulation of angiogenesis and retinal vascular endothelial barrier maturation using three different knockout mouse models. Their findings shed light on how aberrant glutamatergic activity can impact neural vascular function and barrier integrity.In this issue of , Biswas et al. demonstrate […]
Fuse mitochondria to win peer competition
In this issue of , Kochan et al. report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity in adult-born neurons during the critical period, thus supporting their competition with neurons of similar age for survival.In this issue of , Kochan et al. report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity […]
Tracking defensive states with prefrontal dynorphin-expressing neurons
The dynamic suppression of threat-related behavior as a function of environmental constraint is critical for survival in mammals, yet the neurobiological underpinnings remain largely unknown. In this issue of , Wang et al. identified prefrontal dynorphin-expressing neurons as key elements for tracking threat-related behavioral states and regulating fear suppression.The dynamic suppression of threat-related behavior as a […]

Gamma oscillations of visual cortex underlying emotion and cognition deficits associated with suicide attempt in major depressive disorder 21 June 2024
Nature Mental Health, Published online: 21 June 2024; doi:10.1038/s44220-024-00269-3The authors investigate neural oscillations, measured by magnetoencephalography, in response to emotionally valenced stimuli as a potential biomarker characterizing individuals with major depressive disorder who had previously made a suicide attempt.
Zhongpeng Dai
Stress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions 21 June 2024
Nature Mental Health, Published online: 21 June 2024; doi:10.1038/s44220-024-00266-6The authors evaluated and integrated compositional and functional microbiota data using fecal samples taken from healthy individuals and multimodal neuroimaging.
Eric An
The shortage of child psychiatrists in mainland China 18 June 2024
Nature Mental Health, Published online: 18 June 2024; doi:10.1038/s44220-024-00273-7This Comment was conducted to clarify the current number of child psychiatrists in mainland China, to analyze the reasons for the shortages and to provide constructive suggestions for solving the current shortage.
Zhongliang Jiang

Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets 21 June 2024
Translational Psychiatry, Published online: 21 June 2024; doi:10.1038/s41398-024-02970-4Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets
Kelly Perlman
Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder 20 June 2024
Translational Psychiatry, Published online: 20 June 2024; doi:10.1038/s41398-024-02976-yQuantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder
Jurjen Heij
Identifying the role of (dis)inhibition in the vicious cycle of substance use through ecological momentary assessment and resting-state fMRI 19 June 2024
Translational Psychiatry, Published online: 19 June 2024; doi:10.1038/s41398-024-02949-1Identifying the role of (dis)inhibition in the vicious cycle of substance use through ecological momentary assessment and resting-state fMRI
Valentine Chirokoff

WFP News Section 21 May 2024
Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial 16 May 2024
AbstractIntroduction: Loneliness poses a significant health problem and existing psychological interventions have shown only limited positive effects on loneliness. Based on preliminary evidence for impaired oxytocin signaling in trait-like loneliness, the current proof-of-concept study used a randomized, double-blind, placebo-controlled design to probe intranasal oxytocin (OT) as an adjunct to a short-term modular-based group intervention for […]
Efficacy of an Internet- and Mobile-Based Intervention for Subclinical Anxiety and Depression (ICare Prevent) with Two Guidance Formats: Results from a Three-Armed Randomized Controlled Trial 30 April 2024
AbstractIntroduction: Limited research exists on intervention efficacy for comorbid subclinical anxiety and depressive disorders, despite their common co-occurrence. Internet- and mobile-based interventions (IMIs) are promising to reach individuals facing subclinical symptoms. Objective: This study aimed to evaluate the efficacy of a transdiagnostic and self-tailored IMI in reducing subclinical anxiety and depressive symptom severity with either […]

Neurocognitive and psychiatric outcomes associated with postacute COVID-19 infection without severe medical complication: a meta-analysis 24 June 2024
BackgroundCognitive symptoms are often reported by those with a history of COVID-19 infection. No comprehensive meta-analysis of neurocognitive outcomes related to COVID-19 exists despite the influx of studies after the COVID-19 pandemic. This study meta-analysed observational research comparing cross-sectional neurocognitive outcomes in adults with COVID-19 (without severe medical/psychiatric comorbidity) to healthy controls (HCs) or norm-referenced […]
Knapp, S. A. B., Austin, D. S., Aita, S. L., Caron, J. E., Owen, T., Borgogna, N. C., Del Bene, V. A., Roth, R. M., Milberg, W. P., Hill, B. D.
Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case-control study 21 June 2024
BackgroundThe underlying risk factors for young-onset cryptogenic ischaemic stroke (CIS) remain unclear. This multicentre study aimed to explore the association between heavy alcohol consumption and CIS with subgroup analyses stratified by sex and age.MethodsAltogether, 540 patients aged 18–49 years (median age 41; 47.2% women) with a recent CIS and 540 sex-matched and age-matched stroke-free controls […]
Martinez-Majander, N., Kutal, S., Ylikotila, P., Yesilot, N., Tulkki, L., Zedde, M., Sarkanen, T., Junttola, U., Nordanstig, A., Fromm, A., Ryliskiene, K., Licenik, R., Ferdinand, P., Jatuzis, D., Korv, L., Korv, J., Pezzini, A., Tuohinen, S., Sinisalo, J., Lehto, M., Gerdts, E., Ryödi, E., Autere, J., Hedman, M., Fonseca, A. C., Waje-Andreassen, U., von Sarnowski, B., Redfors, P., Sairanen, T., Tatlisumak, T., Roine, R. O., Huhtakangas, J., Numminen, H., Jäkälä, P., Putaala, J., The SECRETO Study Group
First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study 14 June 2024
BackgroundAntiseizure medications (ASMs) during the first trimester of pregnancy have been associated with an increased risk of miscarriage.MethodsWe carried out a population-based cohort study using routinely collected healthcare data from the UK, 1995–2018. Pregnancies were identified in the Clinical Practice Research Datalink and we estimated the HR of miscarriage associated with prescriptions of ASMs during […]
Forbes, H., Madley-Dowd, P., Ahlqvist, V., Campbell, J., Davies, N. M., Liebling, R., Lyall, K., Newschaffer, C., Rast, J., Tomson, T., Zhong, C., Magnusson, C., Rai, D., Lee, B. K.

Mendelian randomization: causal inference leveraging genetic data 19 April 2024
Mendelian randomization (MR) leverages genetic information to examine the causal relationship between phenotypes allowing for the presence of unmeasured confounders. MR has been widely applied to unresolved questions in epidemiology, making use of summary statistics from genome-wide association studies on an increasing number of human traits. However, an understanding of essential concepts is necessary for […]
Chen, Lane G.
Interventions targeting social determinants of mental disorders and the Sustainable Development Goals: a systematic review of reviews 25 March 2024
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review […]
Oswald, Tassia Kate
Do metacognitive therapies for schizophrenia-spectrum disorders work? A meta-analytic investigation 21 March 2024
Recent reviews and meta-analyses of metacognitive therapy for schizophrenia-spectrum disorder (SSD) have included uncontrolled studies, single-session interventions, and/or analyses limited to a single form of metacognitive therapy. We sought to evaluate the efficacy of metacognitive therapies more broadly based on controlled trials (CT) of sustained treatments. We conducted a pre-registered meta-analysis of controlled trials that […]
Melville, Grace

Sleep–wake variations of electrodermal activity in bipolar disorder 19 June 2024
Acta Psychiatrica Scandinavica, EarlyView.
Clàudia Valenzuela‐Pascual, Ariadna Mas, Roger Borràs, Gerard Anmella, Miriam Sanabra, Meritxell González‐Campos, Marc Valentí, Isabella Pacchiarotti, Antoni Benabarre, Iria Grande, Michele De Prisco, Vincenzo Oliva, Anna Bastidas, Isabel Agasi, Allan H. Young, Marina Garriga, Andrea Murru, Filippo Corponi, Bryan M. Li, Peter de Looff, Eduard Vieta, Diego Hidalgo‐Mazzei
Knowledge graphs in psychiatric research: Potential applications and future perspectives 18 June 2024
Acta Psychiatrica Scandinavica, EarlyView.
Sebastian Freidel, Emanuel Schwarz
Why does problem gambling in psychotic disorders pose such a challenge for comprehension? 17 June 2024
Acta Psychiatrica Scandinavica, EarlyView.
Thalles Rodrigues Alves Leite, Tainá Conrado Ferreira, Lucas Lima Menezes Albuquerque, Fábio Gomes de Matos e Souza, Luísa Weber Bisol

Advancing polypharmacological drug design: A dual‐targeted approach for treating psychiatric disorders 25 June 2024
MedComm – Biomaterials and Applications, Volume 3, Issue 2, June 2024.
Yawen Pan, Yinghao Zhi, Jianliang Shen
Multiparameter neuroimaging study of neurovascular coupling changes in patients with end‐stage renal disease 25 June 2024
Brain and Behavior, Volume 14, Issue 6, June 2024.
Wei Sun, Chen Li, Zhuqing Jiao, Tongqiang Liu, Haifeng Shi
Unified Protocol Versus Self‐Acceptance Group Therapy for Emotional Disorders in People With Severe Shame 25 June 2024
Clinical Psychology &Psychotherapy, Volume 31, Issue 3, May/June 2024.
Banafsheh Mohajerin, Richard C. Howard

A role for Shugoshin in human cilia?
We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array […]
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether sut-2 LOF also protects against shortened lifespan of tau transgenic C. […]
Evidence Based Clinical Analytics Supporting the Genetic Addiction Risk Severity (GARS) Assessment to Early Identify Probands in Preaddiction.
No abstract supplied.

Addressing the Youth Mental Health Epidemic
A Model for Providing Psychological Support to Healthcare Leaders and Teams in Times of Crisis
Pre-pandemic, the healthcare workforce was already at risk for higher burnout than the general population and, in some roles (e.g., physicians, nurses), at higher risk for clinical distress and suicide. Studies of healthcare workforce well-being during and after past pandemics reflect that distress can persist after a pandemic subsides, if adequate support within the workplace […]
Assessment of Brief Online Approaches for Teaching Neuroscience in Psychiatry
The goal of this study was to assess an online collection of brief educational resources (videos, case studies, articles) for teaching a broad range of concepts relating to neuroscience in psychiatry.A national sample of 52 psychiatrists enrolled in the study. Forty (77%) completed an assessment before and after having access to the educational resources for […]

Vitamin B12 Supplementation in Psychiatric Practice
Vitamin B (B12, cobalamin) deficiency has been associated with neuropsychiatric symptoms, suggesting a role for B12 supplementation both as a treatment for psychiatric symptoms due to B12 deficiency and as an augmentation strategy for pharmacological treatments of psychiatric disorders. This critical review discusses the major causes of B12 deficiency, the range of psychiatric and non-psychiatric […]
Dignity in Medicine: Definition, Assessment and Therapy
Over the last 20 years, dignity and dignity-conserving care have become the center of investigation, in many areas of medicine, including palliative care, oncology, neurology, geriatrics, and psychiatry. We summarized peer-reviewed literature and examined the definition, conceptualization of dignity, potential problems, and suggested interventions.We performed a review utilizing several databases, including the most relevant studies […]
Metaverse in Mental Health: The Beginning of a Long History
We review the first pilot studies applying metaverse-related technologies in psychiatric patients and discuss the rationale for using this complex federation of technologies to treat mental diseases. Concerning previous virtual-reality applications in medical care, metaverse technologies provide the unique opportunity to define, control, and shape virtual scenarios shared by multi-users to exploit the “synchronized brains” […]

Editorial Board
The efficacy of psychotherapy for social anxiety disorder, a systematic review and meta-analysis
Largest meta-analysis about psychotherapy for SAD (66 studies with 98 comparisons).Psychotherapy is an effective treatment for SAD ( = 0.88, NNT = 3.8).Moderate to large effect sizes across all treatment types and formats.Self-help treatments can increase psychotherapy scalability in low-resource settings. Given the growth in research examining the effects of psychotherapy on social anxiety disorder […]
Metacognitive therapy versus exposure and response prevention for obsessive-compulsive disorder – A non-inferiority randomized controlled trial
Exposure with response prevention (ERP) is the first-line treatment for obsessive-compulsive disorder (OCD). However, refusals, dropouts and the required high time and logistic effort constitute barriers to the use of ERP. In a non-inferiority randomized controlled trial, we compared metacognitive therapy (MCT) to exposure with response prevention (ERP) as treatments for OCD.74 outpatients received 12 […]

Later (“evening”) circadian preference is associated with poorer executive, academic, and attentional functioning in adolescents with and without ADHD 21 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Stephen P. Becker, Aleah Brown, Joshua M. Langberg, Dean W. Beebe
Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records 15 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Louise Jane Hussey, Evan Kontopantelis, Pearl L. H. Mok, Darren M. Ashcroft, Matthew J. Carr, Shruti Garg, Carolyn A. Chew‐Graham, Nav Kapur, Karina Lovell, Roger T. Webb
Sex differences in attention‐deficit hyperactivity disorder diagnosis and clinical care: a national study of population healthcare records in Wales 12 June 2024
Journal of Child Psychology and Psychiatry, EarlyView.
Joanna Martin, Kate Langley, Miriam Cooper, Olivier Y. Rouquette, Ann John, Kapil Sayal, Tamsin Ford, Anita Thapar

COVID-19 and mental health treatment in primary care: Impacts of a global pandemic on a psychopharmacological collaborative care management program 22 June 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveThe COVID-19 pandemic has had a profound impact on individuals with mental health (MH) disorders and on the delivery of MH services. Studies examining treatment models which did not require substantial changes to the delivery of services during pandemic restrictions, such as collaborative care management […]
Zachary D Zuschlag
Calcium and vitamin D supplements and burnout of anesthesiologists: National cross-sectional study from China 21 June 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveJob burnout among anesthesiologists has been consistently high. This study evaluated the association of calcium and vitamin D supplementation with burnout among Chinese anesthesiologists.MethodA cross-sectional online survey was conducted during April and May 2023. Burnout was evaluated using the Maslach Burnout Inventory, which assesses emotional […]
Fu Zhang
Prevalence of the generalized anxiety disorder in Tunisia: A study of 707 primary care outpatients 20 June 2024
The International Journal of Psychiatry in Medicine, Ahead of Print. ObjectiveThis study examined the prevalence and correlates of generalized anxiety disorder (GAD) among primary care outpatients.MethodA multicenter, cross-sectional study was conducted that included 707 primary care outpatients being seen at 20 primary healthcare centers in Tunis and Sfax, Tunisia. The Mini International Neuropsychiatric Interview was […]
Jihene BEN THABET

Risk of major mental disorders in the offspring of parents with migraine 22 June 2024
Migraine has been associated with mental disorders, however whether parental migraine is associated with an increased risk of major mental disorders (MMDs) in offspring has not been investigated. We aimed to e...
Dian-Jeng Li, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang and Mu-Hong Chen
Children with ADHD and EEG abnormalities at baseline assessment, risk of epileptic seizures and maintenance on methylphenidate three years later 21 June 2024
This study aimed to assess the incidence of EEG abnormalities (EEG-ab) in children diagnosed with ADHD, investigate the risk of epileptic seizures (SZ) and maintenance on methylphenidate (MPH) over a three-yea...
Dobrinko Socanski, Geir Ogrim and Nezla Duric
Treating depression in patients with borderline personality disorder: clinical clues on the use of antidepressants 30 May 2024
Personality disorders (PD) are described as enduring patterns of markedly deviant and pervasive inner experiences and behaviors, with onset in adolescence, which lead to severe distress or impairment. Patients...
Carmine Tomasetti, G. Autullo, A. Ballerini, A. de Bartolomeis, B. Dell’Osso, A. Fiorentini, F. Tonioni, V. Villari and D. De Berardis

Blighted phenomena: Learning to work with the dark. 8 April 2024
Blighted phenomena are understood as derivatives of dark, lonely, injured experiences—those that are often difficult to put into words. These phenomena can manifest in innumerable configurations in patients’ presentations and in the specificity of their developmental struggles and language. The present article aims to describe ways of working with the darkness of blighted experience, through […]
Intimate partner violence: Narratives of attachment relationships and linguistic analysis of emotional schemas through a quali-quantitative approach. 18 January 2024
Intimate partner violence (IPV) is a concerning, widespread issue with serious health, social, and financial consequences. Previous studies highlighted the role of insecure attachment patterns in predicting IPV victimization. This study investigates attachment classifications among women survivors of IPV referred to antiviolence centers, as determined by the Adult Attachment Interview and compare them with a […]
Review of Reading French Psychoanalysis. 25 December 2023
Reviews the book, Reading French Psychoanalysis edited by Dana Birksted-Breen, Sara Flanders, and Alain Gibeault (2010). In this essay, the author discusses eight reviews of Reading French Psychoanalysis. The reviews considered are Cheshire (2010) in the British Journal of Psychotherapy, Forde (2010) in the Revista de Psicoanálisis, Glassgold (2014) in the Psychoanalytic Quarterly, Lefer (2011) […]

Development and validation of the Gender Identity and Expression Microaggressions in Therapy Scale (GIEMTS). 18 April 2024
Developing affirming interventions for transgender and nonbinary (TNB) therapy clients requires understanding their experiences with microaggressions in psychotherapy, yet no self-report measure of anti-TNB microaggressions in this context exists. Moreover, few studies have tested the associations between anti-TNB microaggressions and therapy processes. To better address the burden of unmet mental health care needs among TNB […]
The evolution of feedback: Toward a multicultural orientation. 18 April 2024
There have been great strides in psychology regarding diversity, equity, inclusion, and multicultural competence, but a need remains to translate these values into actionable practices in psychotherapy. While the case has been made that measurement-based care is an evidence-based intervention that improves outcomes and reduces dropouts (de Jong et al., 2021) and recently that it […]
Beyond the dyad: Broadening the APA supervision guidelines to include group supervision. 28 March 2024
Group supervision is an extensively used format across many training agencies, yet it has been largely disregarded in theory and research within the supervision literature. In fact, the Guidelines for Clinical Supervision in Health Service Psychology (American Psychological Association, 2015a) mentions group supervision only one time, despite the fact that supervision within a group context […]

A Community Data Sharing Resource: The LDbase Data Repository 29 May 2024
Journal of Learning Disabilities, Ahead of Print. The purpose of this invited paper is to show the learning disabilities field what LDbase is, why it’s important for the field, what it offers the field, and examples of how you can leverage LDbase in your own work.
Sara A. Hart
Teaching Constant Rate-of-Change Problem-Solving to Secondary Students With or at Risk of Learning Disabilities 21 May 2024
Journal of Learning Disabilities, Ahead of Print. Rate of change (i.e., slope) is a critical mathematics concept for success in everyday life, academics, and professional careers. Students with or at risk of learning disabilities struggle with solving rate-of-change problems, especially word problems. Interventions that incorporate representations and problem-solving strategies are effective for improving the word […]
Kaitlin Bundock
Concept-Focused and Procedure-Focused Instruction on the Algebra Performance of Grade 9 Students With and Without Mathematics Difficulty 18 May 2024
Journal of Learning Disabilities, Ahead of Print. Developing both conceptual and procedural knowledge is important for students’ mathematics competence. This study examined whether Grade 9 general education mathematics teachers’ self-reported use of concept-focused instruction (CFI) and procedure-focused instruction (PFI) were associated differently with ninth graders’ algebra achievement after 2.5 years, depending on students’ mathematics difficulty […]
Jihyun Lee

Consumer decisions in virtual commerce: Predict good help-timing based on cognitive load. 10 June 2024
The retail sector is steadily moving toward virtual commerce (v-commerce), and the process has recently gained momentum. With the latest developments in headset technology and the rise of artificial intelligence, virtual shopping has become relevant for an increasing number of products. In this article, we present a study that combines consumer behavior research, eye tracking, […]
Correction to “Magnitude effects in preference reversals” by Lu and Nieznański (2021). 10 June 2024
Reports an error in "Magnitude effects in preference reversals" by Yong Lu and Marek Nieznański (Journal of Neuroscience, Psychology, and Economics, 2021[Sep], Vol 14[3], 149-184). In the article, the authors analyzed the data by applying an inappropriate statistical methodology, the Kruskal–Wallis analysis of variance by ranks, for mixed-subjects comparisons (i.e., one sample group of 57 […]
Fast and wrong: An eye-tracking exploration on how low “cognitive reflection” people analyze and choose commercial packages with multidimensional prices. 10 June 2024
Based on the literature on individual differences in cognitive processes, we analyzed gaze behavior during a purchase decision context to understand if the levels of cognitive reflection affect the type of price-information processing and, in turn, the quality of choice. The participants were presented with two websites selling the same commercial package and asked to […]

EJIHPE, Vol. 14, Pages 1868-1880: Online Games and Cognitive Distortions: A Comparative Analysis in Students with and without Disabilities 24 June 2024
Online games have experienced significant growth in recent years, with gaming becoming a popular form of entertainment for people of all ages. However, their impact on cognition, especially among vulnerable groups such as students with disabilities, is a topic that requires deeper exploration. The objectives of this study are twofold: firstly, to understand the typology […]
Raquel Suriá-Martínez
EJIHPE, Vol. 14, Pages 1881-1889: Violent Behaviour and Emotional Intelligence in Physical Education: The Effects of an Intervention Programme 24 June 2024
Violent behaviour in the secondary education stage is a serious concern that comes from low emotional control. Judo is a sport that requires self-control and high emotional competence to mitigate aggressive behaviours. This research presents the objectives of analysing the correlations of different types of aggressive behaviours before an intervention program with those after said […]
Manuel Ortiz-Franco
EJIHPE, Vol. 14, Pages 1853-1867: Network Analysis of the Association between Minority Stress and Activism in LGB People from Poland 21 June 2024
(1) Background: This paper presents an analysis of the associations between minority stressors and activism in the population of lesbian, gay, and bisexual individuals in Poland. (2) Methods: The cross-sectional online-based research was conducted among 192 lesbian, gay, and bisexual (LGB) people in two groups: activists (n = 51) and people not engaged in activism […]
Aleksandra Krok

Relationships between adverse childhood experiences, attachment, resilience, psychological distress and trauma among forensic mental health populations 12 June 2024
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Katie Finch Daniel Lawrence Marc O. Williams Andrew R. Thompson Christopher Hartwright a School of Psychology, Cardiff University, UKb Priory Group, Priory Healthcare, Monmouthshire, UKc Department of Applied Psychology, Cardiff Metropolitan University, UK
Unlocking a taboo topic: the sexuality of institutionalized men within a forensic psychiatric facility 29 May 2024
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Frédérique Fortin Jo-Annie Spearson Goulet Mathieu Goyette Ashley J. Lemieux a Department of Sexology, Université du Québec à Montréal, Canadab Research Center, Institut national de psychiatrie légale Philippe-Pinel, Montreal, Canadac Department of Psychiatry and Addiction, Université de Montréal, Canada
Evaluation of the Enhanced Engagement and Relational Support Service (EERSS) within the Offender Personality Disorder (OPD) pathway 26 May 2024
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Bardana Singh Roxanna Short Philip Minoudis a London Pathways Partnership, UKb Forensic Personality Disorder Psychology Department, East London NHS Foundation Trust, UKc Forensic and Neurodevelopmental Sciences, Kings College London, UK

The CRPD and mental health law reform in Scotland
Scotland's mental health and capacity legislation and its implementation is underpinned by European Convention on Human Rights (ECHR) informed principles, and such legislation and its implementation has remained largely ECHR compliant. It is designed to protect individuals' autonomy from inappropriate and disproportionate nonconsensual intrusions but its scope is largely limited to this. However, since the […]
Effects of entrapment, anger, psychological flexibility, and self-compassion on the ward climate and reactive aggression in forensic psychiatric hospital patients
This study aimed to investigate the double mediation effect of entrapment and anger, as well as the moderated mediation effect of psychological flexibility and self-compassion on the relationship between the forensic psychiatric hospital ward climate and reactive aggression perceived by patients. A self-reporting method was used to measure ward climate, entrapment, anger, reactive aggression, psychological […]
The violence profile of male mentally disordered offenders in a high secure unit in Turkiye
The severity of the offense was highest in the schizophrenia group and lowest in the ID group.The existence of comorbid substance misuse in the intellectual disability group and the existence of antisocial personality disorder in the BD group was associated with increased severity of offenses.The existence of comorbid personality disorder, substance misuse in the past […]

Changing environments to promote safety in libraries
The purpose of this article is to investigate how changes in the environment of a library affect the safety conditions of both visitors and staff. Using principles of Crime Prevention Through Environmental Design, crime and incidents of public disturbance from 2017 to 2020 from libraries in Stockholm, Sweden, are analyzed and later mapped using 3D […]
Revisiting the tautology problem in rational choice theory: What it is and how to move forward theoretically and empirically
Criminological rational choice theory is blighted by tautology—that if a crime occurs, then by definition the benefits must exceed the costs. The current analysis details the nature of this tautology as well as its theoretical and philosophical implications concerning the circumstances under which offenders make rational (thoughtful and reflective) or irrational (habitual, intuitive, or instinctual) […]
Experiences of fatherhood in prison: A thematic analysis of differences between fathers in a family approach programme and a comparison group
Various programmes have been implemented in prisons to strengthen parental involvement and parent–child relationships during imprisonment. In-depth insights into such programmes are limited. This qualitative study compared the experiences of two groups of imprisoned fathers in the Netherlands: fathers who participated in a family approach programme ( = 10) and fathers in a comparison group ( = 29). Based […]

Correction to “Gentrification’s association with police violence and the moderating effects of race” by Harmon-Darrow et al. (2023). 2 May 2024
Reports an error in "Gentrification’s association with police violence and the moderating effects of race" by Caroline Harmon-Darrow, Hyun-Jin Jun and Charlotte Lyn Bright (Psychology of Violence, 2023[May], Vol 13[3], 183-193). In the article, corrections to some findings were needed. For the Gentrification Revitalization × Race and the Gentrification Disruption × Race interactions (reported in […]
Perceived victimhood shapes support for interpartisan political violence in the United States. 21 March 2024
Objective: Understanding the drivers of political violence is critical, given the destructive consequences it has on the fabric of society. Prior work has established the importance of situational and dispositional predictors of political violence, such as search for significance and meaning and experiencing trauma. However, these predictors do not fully account for one of its […]
Sexual victimization of autistic college students. 18 March 2024
Objective: Researchers have demonstrated a link between autism and victimization, but less research has explored rates of sexual victimization among autistic college students. Informed by lifestyle-routine activity theory, certain features of autism may enhance vulnerability to sexual victimization and may lead autistic individuals to be targeted by potential perpetrators. Method: Using data from the American […]

Nicotine pouch use by sex, school type and tobacco product use among Finnish adolescents during the 2023 change in regulatory scheme with deregulated sales 24 June 2024
Addiction, EarlyView.
Otto Ruokolainen, Hanna Ollila, Tommi Härkänen
Young adults' visual attention to features of social media marketing for disposable e‐cigarettes and associated perceptions 24 June 2024
Addiction, EarlyView.
Julia Chen‐Sankey, Caitlin Weiger, Kathryn La Capria, Julia Vassey, Michelle Jeong, Lilianna Phan, Jennifer B. Unger, Jon‐Patrick Allem, Carla J. Berg, Kelvin Choi
Quitting intentions and behaviours among young Australian e‐cigarette users 23 June 2024
Addiction, EarlyView.
Michelle I. Jongenelis, Melissa Gill, Nicole Lawrence, Claire E. Wakefield

Does socioeconomic position moderate the associations between the content and delivery features of digital behaviour change interventions for smoking cessation and intervention effectiveness? A systematic review and meta-analysis 19 June 2024
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Corinna Leppin Tosan Okpako Jamie Brown Claire Garnett Olga Perski a Department of Behavioural Science and Health, University College London, London, UKb School of Psychological Science, University of Bristol, Bristol, UKc Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USAd Faculty of Social Sciences, Tampere University, Tampere, Finland
App-based interventions to improve cancer outcomes rely on informational support from professionals: a systematic review 17 May 2024
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Karoline Villinger Corina Berli Urte Scholz a Department of Psychology, University of Zurich, Zurich, Switzerlandb Institute of Psychology, University of Bern, Bern, Switzerland
Tobacco use, trauma exposure and PTSD: a systematic review 7 May 2024
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Alina Shevorykin Bridget M. Hyland Daniel Robles Mengjia Ji Darian Vantucci Lindsey Bensch Hannah Thorner Matthew Marion Amylynn Liskiewicz Ellen Carl Jamie S. Ostroff Christine E. Sheffer a Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USAb Department of Psychology, Faculty of Science, University of Alberta, Edmonton, Canadac Department of Psychology, The City College of New York (CUNY), New York, NY, USAd Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Editorial: International perspectives in public mental health 5 June 2024
Editorial: International perspectives in public mental health
Neil Quinn
Mental Health First Aid™ for Deaf communities: responses to a lack of national Deaf mental health service provision 17 May 2024
For over 15 years, Mental Health First Aid™ (MHFA) has successfully been delivered in Wales, United Kingdom, with growing interest in the MHFA programme and increasing course attendees. Trainers, aware of the need for support, know the importance of MHFA being accessible for different communities and learner groups. MHFA has always focused on increasing mental […]
Julia Terry
Prevalence of cosmetic surgery and its relationship with psychosocial status: a population based study in Sulaymaniyah, Iraq 16 May 2024
This study aims to investigate the prevalence of cosmetic surgery and its relationship with the level of mental health and socioeconomic variables in Sulaymaniyah city in Iraq. This descriptive-analytical and cross-sectional study was conducted on 941 subjects who were selected using multistage sampling method. Data were collected using a checklist as well as a questionnaire. […]
Farman Zahir Abdullah

A history of mental illness among women in the Straits Settlements in the nineteenth century 15 June 2024
History of Psychiatry, Ahead of Print. The Straits Settlements, a collective colony under the administration of British Malaya, was a very unhealthy area in the early years of the nineteenth century. One of the most common sicknesses was mental illness, which could not be cured by medicines. The number of women suffering from mental illness […]
Haszira Muhamad Yusof
Social issues relating to Vladimir Bekhterev’s concept of reflexology: a hitherto underestimated aspect of his work 12 June 2024
History of Psychiatry, Ahead of Print. This article investigates the diversity of social and political assertions in the work of Vladimir M Bekhterev. Its findings reveal that he drew social and political conclusions based on his doctrine of reflexology. Moreover, he propagated the use of statistical investigations by scientific and governmental institutions to estimate the […]
Birk Engmann
Phrenitis and the pathology of the mind in western medical thought (fifth century BCE to twentieth century cE) 11 June 2024
History of Psychiatry, Ahead of Print. Phrenitis is ubiquitous in ancient medicine and philosophy. Galen mentions the disease innumerable times, Patristic authors take it as a favourite allegory of human flaws, and no ancient doctor fails to diagnose it and attempt its cure. Yet the nature of this once famous disease has not been properly […]
Chiara Thumiger

Interventions to promote mental health in the Occupied Palestinian Territories and Palestinian refugees: A scoping review 19 June 2024
International Journal of Social Psychiatry, Ahead of Print. Background:The long history of the Palestinian-Israeli conflict has resulted in a public and mental health crisis. Despite the significant mental health burdens facing the Palestinian population in the Occupied Palestinian Territories (OPT) and refugee camps, this issue remains comprehensively unexplored.Aims:This scoping review identified mental health interventions and […]
Wahiba Abu-Ras
Goodbyes without farewells under the rubble: A phenomenological study of earthquake victim’s methods of coping with ambiguous loss 8 June 2024
International Journal of Social Psychiatry, Ahead of Print. Introduction:Ambiguous loss refers to the lack of clear information about the fate of a missing person or object.Aim:This study aims to examine in-depth the experiences of earthquake victims regarding the methods of coping with the uncertain losses they experienced after the Kahramanmaraş-based earthquake disaster on February 6, […]
Kübra Gülırmak Güler
Proxy consultations for severe mental illnesses: An exploratory cross-sectional study from a tertiary care hospital 8 June 2024
International Journal of Social Psychiatry, Ahead of Print. Background:Non-adherence to medication leading to a break in continuity of care poses significant challenges in severe mental illness (SMI), leading to poor outcomes. In India, proxy consultation, wherein caregivers consult on behalf of patients, is a commonly adopted but insufficiently researched area to address these challenges.Aims:To explore […]
Prakyath Ravindranath Hegde

When my neighborhood woke up: Knitting collective action in disadvantaged areas amid the 2019 Chilean uprising. 15 April 2024
October 2019 saw the birth of the largest wave of demonstrations to hit Chile in the last 50 years. Protesters, the length of the country, soon joined in, voicing a broad range of demands and driving what has been described as a true “awakening” at the local level. This local dimension of the protests—that is, […]
Clarification notice to “The geography of military occupation and its effect on Palestinian community cohesion, norms, and resistance motivation” by Penić et al. (2023). 15 April 2024
Reports a clarification to "The Geography of Military Occupation and its Effect on Palestinian Community Cohesion, Norms, and Resistance Motivation" by Sandra Penić, Johanna Ray Vollhardt, Karsten Donnay, Mai Albzour and Ravi Bhavnani (Peace and Conflict: Journal of Peace Psychology, Advanced Online Publication, Jun 22, 2023, np). The authors wish to clarify the relationship between […]
School as a contested territory for citizenship: An ethnographic study of illegal occupation and protest processes at a popular vocational education school in the chilean october. 15 April 2024
The sociopolitical crisis that flared up in Chile starting in October 2019 laid bare tensions in how different social groups understand citizenship and political mobilization. These tensions evinced clear generational differences coupled with the emergence of new forms of understanding and doing politics among youth. This article presents the results of an ethnographic study conducted […]

Coronavirus pandemic dreams in China: A qualitative research on the effect of the Wuhan lockdown on dream contents. 15 April 2024
This study investigated the “coronavirus pandemic dream” phenomenon in Chinese including residing in Wuhan city based on the continuity hypothesis, which states that dream contents reflect waking life. We analyzed the effects of lockdown due to coronavirus disease-2019 (COVID-19) on dream reported from Chinese university students and workers residing in inside and outside of Hubei […]
Dreaming about the pandemic: A thematic content analysis of COVID-19-related dreams during the outbreak in Portugal. 4 April 2024
The COVID-19 pandemic has affected the mental health of people around the world, altering sleep patterns and dream experiences. Since dream content is associated with waking-life experiences, one would expect pandemic-related concerns to pervade dreams. Building upon previous research efforts, this study aims to contribute to the ongoing debate on dream function and to address […]
Prolonged changes in the perception of dreaming behaviors resulting from the COVID-19 pandemic. 18 March 2024
Reports of changes in dreaming behaviors emerged immediately after the onset of the COVID-19 pandemic. However, it is unclear if these changes persisted long term, after initial lockdowns were lifted and people became accustomed to pandemic life. The current study measured dreaming behaviors known to have changed immediately after the pandemic onset and other behaviors […]

Supreme Court Will Take Up State Bans on Gender Care for Minors: Here's What to Know 24 June 2024
(MedPage Today) -- The Supreme Court on Monday jumped into the fight over transgender rights, agreeing to hear an appeal from the Biden administration seeking to block state bans on gender-affirming care. The justices' action comes as Republican...
A Closer Look at Medetomidine and Its 'Unusual' Patient Presentations 22 June 2024
(MedPage Today) -- "The drug sample contained multiple different nitazenes, a bunch of fentanyl analogues, xylazine, diphenhydramine, caffeine, and medetomidine." That last word, medetomidine, stuck out to me. This was the preliminary report I...
Prenatal Maternal Distress During Pandemic Tied to Newborn Brain Development 20 June 2024
(MedPage Today) -- Left amygdalar volumes were smaller in newborns whose mothers had high psychological distress during the COVID-19 pandemic, a small cross-sectional study suggested. Infants of mothers with elevated maternal distress during the...

Association between negative life events through mental health and non-suicidal self-injury ... 25 June 2024
JAMA Psychiatry. 2022;79(7):718–26. Article PubMed PubMed Central Google Scholar. Lim KS, Wong CH, McIntyre RS, et al. Global lifetime and 12-month ...
Some Social Psychoexemplaries - Psychiatric Times 25 June 2024
PSYCHIATRIC VIEWS ON THE DAILY NEWS. Back in my column on February 23, 2024, I wondered if we needed a potential classification of social ...
'Serious concern' for patients in psychiatric units as more fail to meet standards, new report finds 25 June 2024
Serious concerns have emerged for patients in psychiatric units across the country with many centres going in the “wrong direction” and ...

Half the world now following doctors’ orders on cutting trans fats: WHO 24 June 2024
A total of 53 countries had best practice policies in place for tackling industrial trans fats in food as of last year, vastly improving the food environment for 3.7 billion people, or 46 per cent of the world’s population, according to a milestone report published by the UN World Health Organization on Monday.
UN health agency issues alert on falsified semaglutides used for diabetes treatment, weight loss 20 June 2024
The World Health Organization (WHO) on Thursday issued a medical product alert on the release of three batches of falsified semaglutides – brand name Ozempic – the type of medicines primarily used to treat type 2 diabetes and obesity in some countries.
WHO announces global resurgence of cholera cases in 2024 20 June 2024
The UN World Health Organization (WHO) has announced a spike in cholera in several regions of the world, with almost 195,000 cases and over 1,900 deaths reported in 24 countries since the start of this year.

Strengthening HIV testing services in francophone countries from West and Central Africa and the Indian Ocean sub-region 25 June 2024
Meeting of Francophone countries from West and Central Africa and the Indian Ocean sub-region to strengthen HIV testing services and integration. It aims to support the identification of solutions to address existing testing gaps and to strengthen testing and linkage services.
who.int
Six partners on a global journey to celebrate excellence in public health 20 June 2024
Chronology of how six global health awards, established by the founders through the Executive Board and administered by WHO, have been recognizing outstanding contributions to public health throughout decades.
who.int
Health in All Policies: Advancing Multisectoral Collaboration for Health Equity 19 June 2024
Join the WHO Global Knowledge Network for Health Equity and the Global Network for Health in All Policies for a webinar exploring Health in All Policies (HiAP) and its potential for advancing equity across various sectors.
who.int

WHO concerned about escalating health crisis in West Bank 15 June 2024
15 June 2024, Jerusalem/Cairo/Geneva WHO remains concerned about the escalating health crisis in the occupied Palestinian territory, including the West Bank, where attacks on health infrastructure and increased restrictions on movement are obstructing access to health care. A spike in violence in the West Bank, including East Jerusalem, since the war in Gaza started has […]
World Elder Abuse Awareness Day 2024: ensuring older people’s safety in emergencies 12 June 2024
15 June 2024, Cairo, Egypt – On World Elder Abuse Awareness Day 2024, the spotlight is on older people in emergencies. Older people often face mobility issues, chronic health conditions or social isolation –some of the factors that can hinder their ability to access aid, evacuate safely or receive timely medical care and support services. […]
Unsafe food makes 100 million people ill each year in the Region 6 June 2024
6 June 2024, Cairo, Egypt – “Prepare for the unexpected” is the theme of the sixth World Food Safety Day, marked today by the United Nations. Food businesses, governments and consumers can all help prevent food contamination and foodborne illnesses. Food must be protected at every stage from production to consumption. WHO and the Food […]

Research protocol - Evaluating data quality in the Netherlands Perinatal Registry (Perined): A data comparison study using hospital records from the IUGR Risk Selection (IRIS) study [version 1; peer review: awaiting peer review] 24 June 2024
Background The quality of registry based studies depends largely on the data accuracy of the registries. The Dutch Perinatal Registry (Perined) is a nationwide database comprising perinatal data digitally provided by different healthcare providers. Perined data are used for comparing outcomes across regions and healthcare institutions as well as for quality analyses and research purposes. […]
Hilde Plomp
Predictors of mortality for blunt trauma patients in intensive care: A retrospective cohort study [version 2; peer review: 2 approved with reservations] 24 June 2024
Background: Major trauma places substantial demand on critical care services, is a leading cause of death in under 40-year-olds and causes significant morbidity and mortality across all age groups. Various factors influence patient outcome and predefining these could allow prognostication. The aim of this study was to identify predictors of mortality from major trauma in […]
Michael Jennings
Unravelling the devaluation puzzle: Empirical insights into the transmission channel on balance of payments and output in Ethiopia [version 1; peer review: awaiting peer review] 24 June 2024
Background Empirical studies on the impact of devaluation in developing countries, including Ethiopia, have revealed diverse and mixed results. The effects can be positive or negative depending on the specific economic context and policies in place.This study addresses the devaluation puzzle by providing a more comprehensive and nuanced understanding of how devaluation affects the balance […]
Yigermal Maru Ayinewa

GALENOS in the BMJ 9 June 2024
Today the British Medical Journal shared their perspective on GALENOS.
galenos.org.uk
Welcoming the New Chair and Vice-Chair of GLEAB 16 May 2024
We are delighted to welcome a brand new Chair and Vice Chair of the GLEAB.
galenos.org.uk
In Memory Of Lea Milligan 30 April 2024
Lea Milligan, CEO of MQ Mental Health Research and a founding member of the GALENOS leadership team passed away unexpectedly on the 15th of April following a sudden illness.
galenos.org.uk

Medicines eligible for Northern Ireland MHRA Authorised Route 21 June 2024
Sets out medicines that can be moved to Northern Ireland to meet patient need.
HM Government
Child death overview panels: contacts 21 June 2024
Contact details of the people in child death overview panels (CDOPs) who are responsible for receiving child death notifications.
HM Government
National flu immunisation programme plan 2024 to 2025 18 June 2024
The annual flu letter describes the national flu immunisation programme and outlines which groups are eligible for flu vaccination.
HM Government

Artificial Intelligence (AI): The Future of Data 20 May 2024
With the public release of large language models like Chat GPT putting Artificial Intelligence (AI) firmly on our radar, the...
stevemilne
Measuring wellbeing and going ‘Beyond GDP’ 9 May 2024
A new ONS publication out today, aims to give an holistic view on how society is doing, beyond purely economic measures. Here, Tim Vizard explores what we have done so far on Beyond GDP and outlines our next steps on this important work.
samcollin
Understanding the new income statistics for local areas: Different measures for better insights 30 April 2024
The ONS has been busy producing faster, more detailed statistics using new data sources. Providing clearer insights at the local level is an important aspect of this work. Ainslie Woods explains how our local income statistics compare and why they offer a complementary picture of local areas.
croydl

Long covid: I’d rather have a well researched and well informed doctor than “become my own physician” 24 June 2024
My husband and I have both been diagnosed with long covid and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). I developed long covid in 2020, my husband in 2022. These days I am more functional but still have to limit exertion. My husband is severely affected.There is much I can relate to in Jreidini’s account,1 not least […]
Karen L Hargrave
Doctors are under attack from all sides, BMA chair tells annual meeting 24 June 2024
The medical profession is under attack financially, professionally, and morally, and must continue to fight to preserve itself, the BMA’s chair of council has said.In a speech to the association’s annual representative meeting in Belfast, Philip Banfield took aim at the government over industrial action, funding cuts, and the state of general practice. He also […]
Gareth Iacobucci
Sixty seconds on . . . space hairdryers 24 June 2024
What’s the Buzz?A new device that researchers are calling a “space hairdryer” has been used to help mend broken hearts.Surely only time can heal a broken heart?Perhaps where emotions are concerned. But researchers in Austria have tried using shockwave therapy—sonic (sound) waves—to regenerate heart tissue in patients undergoing coronary bypass graft surgery (CABG).Sounds goodThe researchers […]
Ingrid Torjesen

Semaglutide Equally Effective in Women With HFpEF, Obesity 24 June 2024
Two new analyses of the STEP-HFpEF trials show that semaglutide led to more weight loss in women than in men and that the GLP-1 therapy also improves NYHA class. Medscape Medical News
Subcutaneous efgartigimod alfa hyaluronidase-qvfc (Vyvgart Hytrulo, argenx) has been shown to reduce relapse risk in chronic inflammatory demyelinating polyneuropathy (CIDP). 24 June 2024
Medscape Medical News
Experts Advise on Early-Risk Monitoring for Type 1 Diabetes 24 June 2024
New consensus statement on monitoring people with positive autoantibodies is aimed at pediatric and adult primary care and endocrinology providers. Medscape Medical News

Federal Experts Talk Bird Flu ‘What Ifs’ in WebMD Live Event 16 May 2024
WebMD brought together experts from four federal agencies to talk prevention, monitoring, and what the “what ifs” of bird flu might look like.
What’s Next in Health Care for Older Adults: Questions and Answers With John Whyte, MD 16 May 2024
As WebMD’s chief medical officer, John Whyte, MD, is in a unique position to see both the current state of medical care for America’s older adults and the way things are trending for the future. We asked him to share his insight on a few topics, along with a bit of advice.
Get the Care You Need in a COVID-19 World 16 May 2024
What to expect at the doctor’s office, hospitals, and long-term care facilities, the future of telemedicine, and how to get the best care during COVID-19.

Alison Henley: family speak out after long delays to inquest into self-inflicted death in Derbyshire 24 June 2024
24 June 2024
Inquest
Megan Davison: second inquest into death to open in Hertfordshire this month 21 June 2024
21 June 2024
Inquest
Deaths in prison 19 June 2024
In this country we do not give a death sentence, but for everyone who has taken their life in prison that is exactly what they got - Mark Saunders, whose son Dean died in HMP & YOI Chelmsford in 2016 Below is a breakdown of deaths in prison in England and Wales by calendar year […]
Inquest