Evidence
Hum Brain Mapp. 2024 May;45(7):e26694. doi: 10.1002/hbm.26694.
ABSTRACT
Schizophrenia (SZ) is a debilitating mental illness characterized by adolescence or early adulthood onset of psychosis, positive and negative symptoms, as well as cognitive impairments. Despite a plethora of studies leveraging functional connectivity (FC) from functional magnetic resonance imaging (fMRI) to predict symptoms and cognitive impairments of SZ, the findings have exhibited great heterogeneity. We aimed to identify congruous and replicable connectivity patterns capable of predicting positive and negative symptoms as well as cognitive impairments in SZ. Predictable functional connections (FCs) were identified by employing an individualized prediction model, whose replicability was further evaluated across three independent cohorts (BSNIP, SZ = 174; COBRE, SZ = 100; FBIRN, SZ = 161). Across cohorts, we observed that altered FCs in frontal-temporal-cingulate-thalamic network were replicable in prediction of positive symptoms, while sensorimotor network was predictive of negative symptoms. Temporal-parahippocampal network was consistently identified to be associated with reduced cognitive function. These replicable 23 FCs effectively distinguished SZ from healthy controls (HC) across three cohorts (82.7%, 90.2%, and 86.1%). Furthermore, models built using these replicable FCs showed comparable accuracies to those built using the whole-brain features in predicting symptoms/cognition of SZ across the three cohorts (r = .17-.33, p < .05). Overall, our findings provide new insights into the neural underpinnings of SZ symptoms/cognition and offer potential targets for further research and possible clinical interventions.
PMID:38727014 | DOI:10.1002/hbm.26694
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence
Real-Time Evidence Search [Psychiatry]
AI Research
Cross-cohort replicable resting-state functional connectivity in predicting symptoms and cognition of schizophrenia
🌐 90 Days
VR Related Evidence Matrix
- Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping
- Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping
- Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia
- Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome
- Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis
- A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry
- Cerebellar dysconnectivity in schizophrenia and bipolar disorder is associated with cognitive and clinical variables
- Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety
- Association between homotopic connectivity and clinical symptoms in first-episode schizophrenia
- Association between homotopic connectivity and clinical symptoms in first-episode schizophrenia
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (muCAPs)
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)
- Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months
- Amygdala functional connectivity in borderline personality disorder
- The relationship between the resting state functional connectivity and social cognition in schizophrenia: Results from the Italian Network for Research on Psychoses
- Mindfulness-based cognitive therapy neurobiology in treatment-resistant obsessive-compulsive disorder: A domain-related resting-state networks approach
- Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia
- Altered intersubject functional variability of brain white-matter in major depressive disorder and its association with gene expression profiles
- Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders
- Functional connectivity is linked to working memory differences in children with reading learning disability
- Functional connectivity changes of the hippocampal subregions in anti-N-methyl-D-aspartate receptor encephalitis
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations
- Resting-state functional connectivity of amygdala subregions predicts treatment outcome for cognitive behavioral therapy in obsessive-compulsive disorder at a 4-month follow-up
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns
- Preliminary study on early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging
- Longitudinal changes in resting-state functional connectivity as markers of vulnerability or resilience in first-degree relatives of patients with bipolar disorder
- Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN-LSTM model
- Autism spectrum disorder diagnosis with EEG signals using time series maps of brain functional connectivity and a combined CNN-LSTM model
- Association between urban upbringing and functional brain connectivity in schizophrenia
- Functional connectivity in rumination: a systematic review of magnetic resonance imaging studies
- Predicting Treatment Outcome Based on Resting-State Functional Connectivity in Internalizing Mental Disorders: A Systematic Review and Meta-Analysis
- Correlation Between Prefrontal Functional Connectivity and the Degree of Cognitive Impairment in Alzheimer's Disease: A Functional Near-Infrared Spectroscopy Study
- Correlations between developmental trajectories of brain functional connectivity, neurocognitive functions, and clinical symptoms in patients with attention-deficit hyperactivity disorder
- Correlations between developmental trajectories of brain functional connectivity, neurocognitive functions, and clinical symptoms in patients with attention-deficit hyperactivity disorder
- A novel method for PET connectomics guided by fibre-tracking MRI: Application to Alzheimer's disease
- Resting-state fMRI is associated with trauma experiences, mood and psychosis in Afro-descendants with bipolar disorder and schizophrenia
- The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study
- Global MEG Resting State Functional Connectivity in Children with Autism and Sensory Processing Dysfunction
- Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder
- Daily Functional Characteristics and Health Among Older Adults During COVID-19: A Structural Equation Modeling Approach
- Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions
- Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions
- Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions
- Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD Study
- Risk factors for internalizing symptoms: The influence of empathy, theory of mind, and negative thinking processes
- Lost in space(s): Multimodal neuroimaging of disorientation along the Alzheimer's disease continuum
- Structural and functional changes of anterior cingulate cortex subregions in migraine without aura: relationships with pain sensation and pain emotion
- Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study
- Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia
- Multivariate association between psychosocial environment, behaviors, and brain functional networks in adolescent depression
- Multivariate association between psychosocial environment, behaviors, and brain functional networks in adolescent depression
- Sensory over-responsivity and orbitofrontal cortex connectivity in obsessive-compulsive disorder
- Neuroimaging alterations and relapse in early-stage psychosis
- Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension
- Association of cytokines levels, psychopathology and cognition among CR-TRS patients with metabolic syndrome
- Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links through Daily Activity Patterns and Brain Connectivity Analysis
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder
- Continuous theta burst stimulation to dorsomedial prefrontal cortex in young adults with depression: Changes in resting frontostriatal functional connectivity relevant to positive mood
- Distinguishing schizophrenia and bipolar disorder through a Multiclass Classification model based on multimodal neuroimaging data
- Dynamic functional network connectivity analysis in schizophrenia based on a spatiotemporal CPD framework
Evidence Blueprint
Cross-cohort replicable resting-state functional connectivity in predicting symptoms and cognition of schizophrenia
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Cross-cohort replicable resting-state functional connectivity in predicting symptoms and cognition of schizophrenia
🌐 365 Days
VR Related Evidence Matrix
- Functional brain connectivity predicts sleep duration in youth and adults
- Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder
- Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping
- Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping
- Altered patterns of dynamic functional connectivity of brain networks in deficit and non-deficit schizophrenia
- Altered thalamic volumes and functional connectivity in the recovered patients with psychosis
- Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
- Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia
- Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome
- Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions
- Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment
- A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry
- Neuroimaging profiles of the negative affective network predict anxiety severity in patients with chronic insomnia disorder: A machine learning study
- Multi-model order spatially constrained ICA reveals highly replicable group differences and consistent predictive results from resting data: A large N fMRI schizophrenia study
- Cerebellar dysconnectivity in schizophrenia and bipolar disorder is associated with cognitive and clinical variables
- Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings
- Whole-brain resting-state connectivity underlying impaired inhibitory control during early versus longer-term abstinence in cocaine addiction
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features
- Longitudinal developmental trajectories of functional connectivity reveal regional distribution of distinct age effects in infancy
- Preferential signal pathways during the perception and imagery of familiar scenes: An effective connectivity study
- Default mode network functional connectivity strength in utero and the association with fetal subcortical development
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety
- Association between homotopic connectivity and clinical symptoms in first-episode schizophrenia
- Association between homotopic connectivity and clinical symptoms in first-episode schizophrenia
- The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (muCAPs)
- Effects of integrated hospital treatment on the default mode, salience, and frontal-parietal networks in anorexia nervosa: A longitudinal resting-state functional magnetic resonance imaging study
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)
- Connectome-based predictive modeling of Internet addiction symptomatology
- Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months
- Amygdala functional connectivity in borderline personality disorder
- The relationship between the resting state functional connectivity and social cognition in schizophrenia: Results from the Italian Network for Research on Psychoses
- Mindfulness-based cognitive therapy neurobiology in treatment-resistant obsessive-compulsive disorder: A domain-related resting-state networks approach
- Cumulative Effects of Resting-state Connectivity Across All Brain Networks Significantly Correlate with ADHD Symptoms
- Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome
- Stability of specific personality network features corresponding to openness trait across different adult age periods: A machine learning analysis
- Abnormal dynamic functional network connectivity in patients with early-onset bipolar disorder
- Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia
- Intrinsic network abnormalities in children with autism spectrum disorder: an independent component analysis
- Altered Temporal Dynamics of Resting-State Functional Magnetic Resonance Imaging in Adolescent-Onset First-Episode Psychosis
- Altered intersubject functional variability of brain white-matter in major depressive disorder and its association with gene expression profiles
- Daily Cannabidiol Administration for 10 Weeks Modulates Hippocampal and Amygdalar Resting-State Functional Connectivity in Cannabis Users: A Functional Magnetic Resonance Imaging Open-Label Clinical Trial
- Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders
- Thalamo-cortical and cerebello-cortical functional connectivity in development
- Functional connectivity is linked to working memory differences in children with reading learning disability
- Perifocal Edema in Patients with Meningioma is Associated with Impaired Whole-Brain Connectivity as Detected by Resting-State fMRI
- Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks
- Effects of family income on brain functional connectivity in US children: associations with cognition
- Basolateral Amygdala Functional Connectivity in Alexithymia: Linking Interoceptive Sensibility and Cognitive Empathy
- Functional connectivity changes of the hippocampal subregions in anti-N-methyl-D-aspartate receptor encephalitis
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations
- Delineating disorder-general and disorder-specific dimensions of psychopathology from functional brain networks in a developmental clinical sample
- Functional reorganization of brain activity in children with attention-deficit/hyperactivity disorder: Evidence from the modulatory effect of cognitive demand during visuospatial attention task
- A Deep Learning Approach for Psychosis Spectrum Label Noise Detection from Multimodal Neuroimaging Data
- Edge time series components of functional connectivity and cognitive function in Alzheimer's disease
- Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury
- Resolving heterogeneity in dynamics of synchronization stability within the salience network in autism spectrum disorder
- Altered functional connectivity of the amygdala across variants of callous-unemotional traits: A resting-state fMRI study in children and adolescents
- Resting-state functional connectivity of amygdala subregions predicts treatment outcome for cognitive behavioral therapy in obsessive-compulsive disorder at a 4-month follow-up
- The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns
- Longitudinal development of thalamocortical functional connectivity in 22q11.2 deletion syndrome