Evidence
Autophagy. 2024 Mar 18. doi: 10.1080/15548627.2024.2330032. Online ahead of print.
ABSTRACT
Conjugation of ATG8 to single membranes (CASM) at endolysosomal compartments has attracted attention as the non-autophagic function of the Atg8-family protein conjugation system, and the V-ATPase-ATG16L1 axis has emerged as a core mechanism. Our recent research has revealed that this mechanism contributes to the lysosomal recruitment and activation of LRRK2, a Parkinson disease-associated kinase that phosphorylates a subset of RAB GTPases. The activated LRRK2 under CASM-causing lysosomal stress acts to regulate lysosomal morphology and stimulate extracellular secretion of lysosomal contents, thereby promoting the lysosomal stress response.
PMID:38497477 | DOI:10.1080/15548627.2024.2330032
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CASM mediates LRRK2 recruitment and activation under lysosomal stress
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CASM mediates LRRK2 recruitment and activation under lysosomal stress
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