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Cellular specificity of mitochondrial and immunometabolic features in major depression
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Pathogenesis or a response to lithium? A novel perspective for mitochondrial mass fluctuation of naive T cells in patients with bipolar disorder Relationship between Cellular Oxygen Consumption and Atherosclerosis-Associated Mitochondrial Mutations (Variants of the Mitochondrial Genome) Relationship between Cellular Oxygen Consumption and Atherosclerosis-Associated Mitochondrial Mutations (Variants of the Mitochondrial Genome) Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan Leveraging new methods for comprehensive characterization of mitochondrial DNA in esophageal squamous cell carcinoma Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice Adiposity, immunity, and inflammation: interrelationships in health and disease: A report from 24th annual Harvard nutrition obesity symposium, June 2023 A current view of mitochondria damage and the diversity of lipopigment inclusions in neuronal ceroid lipofuscinose type 2 from rectal biopsy Imbalanced mitochondrial dynamics contributes to the pathogenesis of X-linked adrenoleukodystrophy Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks TRABD modulates mitochondrial homeostasis and tissue integrity TRABD modulates mitochondrial homeostasis and tissue integrity Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids Gut microbiota regulates the nutrient sensing enteroendocrine cell maturation and mitochondrial function Gut microbiota regulates the nutrient sensing enteroendocrine cell maturation and mitochondrial function Elimination of damaged mitochondria during UVB-induced senescence is orchestrated by NIX-dependent mitophagy SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux Piracetam reduces oxidative stress and mitochondrial function impairment in an in vitro model of vascular dementia Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy Rapamycin alleviates mitochondrial dysfunction in anti-NMDAR encephalitis mice Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease Inhibition of DAPK3 suppresses radiation-induced cellular senescence by activation of a PGC1alpha-dependent metabolism pathway in brain endothelial cells Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver Transcriptomic Evaluation of a Stress Vulnerability Network using Single Cell RNA-Seq in mouse Prefrontal Cortex Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury Parental status and markers of brain and cellular age: A 3D convolutional network and classification study mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming Mitophagy, from genetics to biology, and back (rescheduled date) Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease Paraoxonase-2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non-alcoholic steatohepatitis Driving Mitochondrial Fission Improves Cognitive, but not Motor Deficits in a Mouse Model of Ataxia of Charlevoix-Saguenay Radiomics analysis of ultrasound images to discriminate between benign and malignant adnexal masses with solid ultrasound morphology Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis Real-time monitoring of abnormal mitochondrial viscosity in glioblastoma with a novel mitochondria-targeting fluorescent probe A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria Delta opioid peptide [D-ala2, D-leu5]-Enkephalin's ability to enhance mitophagy via TRPV4 to relieve ischemia/reperfusion injury in brain microvascular endothelial cells Research progress in mitochondrial quality control in schizophrenia PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium CHCHD10(S59L/+) mouse model: Behavioral and neuropathological features of frontotemporal dementia Polygenic Risk Scores Validated in Patient-Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease Pleasurable emotions and internalizing psychopathology: A multi-study examination of specificity and alternative explanations SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity Exploration of mitochondrial autophagy related genes in the diagnosis model construction and molecular marker mining of Alzheimer's disease based on multi-omics integration Syrian child carrying multiple pathogenic variants in MBOAT7 and MT-TS1 genes: a case report on neurodevelopmental phenotypes and mitochondrial inheritance Syrian child carrying multiple pathogenic variants in MBOAT7 and MT-TS1 genes: a case report on neurodevelopmental phenotypes and mitochondrial inheritance Unveiling the Role of Novel miRNA PC-5P-12969 in Alleviating Alzheimer's Disease Identifying suicide attempter in major depressive disorder through machine learning: the importance of pain avoidance, event-related potential features of affective processing Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas Artificial intelligence-based, semi-automated segmentation for the extraction of ultrasound-derived radiomics features in breast cancer: a prospective multicenter study Validity of the DSM-5 Mixed Features Specifier Interview AI algorithm combined with RNA editing-based blood biomarkers to discriminate bipolar from major depressive disorders in an external validation multicentric cohort Validity of the DSM-5 Mixed Features Specifier Interview HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis l-Ornithine-l-Aspartate (LOLA) Normalizes Metabolic Parameters in Models of Steatosis, Insulin Resistance and Metabolic Syndrome PGC-1α integrates insulin signaling with mitochondrial physiology and behavior in a Drosophila model of Fragile X Syndrome
Evidence Blueprint
Cellular specificity of mitochondrial and immunometabolic features in major depression
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Cellular specificity of mitochondrial and immunometabolic features in major depression
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Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease Features of immunometabolic depression as predictors of antidepressant treatment outcomes: pooled analysis of four clinical trials Pathogenesis or a response to lithium? A novel perspective for mitochondrial mass fluctuation of naive T cells in patients with bipolar disorder Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6 Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals IGF‑1 inhibits palmitic acid‑induced mitochondrial apoptosis in macrophages Increasing autobiographical memory specificity: Using kindness meditation to impact features of memory retrieval Selecting cases of major psychiatric and substance use disorders in Swedish national registries on the basis of clinical features to maximize the strength or specificity of the genetic risk Elevated susceptibility to exogenous seizure triggers and impaired interneuron excitability in a mouse model of Leigh syndrome epilepsy Relationship between Cellular Oxygen Consumption and Atherosclerosis-Associated Mitochondrial Mutations (Variants of the Mitochondrial Genome) Relationship between Cellular Oxygen Consumption and Atherosclerosis-Associated Mitochondrial Mutations (Variants of the Mitochondrial Genome) Multifaceted Roles of AFG3L2, a Mitochondrial ATPase in Relation to Neurological Disorders Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration Quantitative assessment of mitochondrial morphology relevant for studies on cellular health and environmental toxicity Teratogenic Effects of Drugs on Primary Lymphocytes Assessed by Flow Cytometry Depression and anxiety have distinct and overlapping language patterns: Results from a clinical interview Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids Effects of arginine on coenzyme-Q10 micelle uptake for mitochondria-targeted nanotherapy in phenylketonuria Metabolic features of treatment-refractory major depressive disorder with suicidal ideation Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy Mitochondrial DNA Disorders: the (long and winding) road to treatment Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan Leveraging new methods for comprehensive characterization of mitochondrial DNA in esophageal squamous cell carcinoma Mitochondrial health, NLRP3 inflammasome activation, and white matter integrity in adolescent mood disorders: A pilot study Neuroendocrine and cellular mechanisms in stress resilience: From hormonal influence in the CNS to mitochondrial dysfunction and oxidative stress Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria Differentiation between depression and bipolar disorder in child and adolescents by voice features Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency Integrating mitoepigenetics into research in mood disorders: a state-of-the-art review Insights of mitochondrial involvement in alcoholic fatty liver disease Antioxidants and mitochondrial/lysosomal protective agents reverse toxicity induced by titanium dioxide nanoparticles on human lymphocytes Astroglial calcium signaling and homeostasis in tuberous sclerosis complex Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice Adiposity, immunity, and inflammation: interrelationships in health and disease: A report from 24th annual Harvard nutrition obesity symposium, June 2023 The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors A current view of mitochondria damage and the diversity of lipopigment inclusions in neuronal ceroid lipofuscinose type 2 from rectal biopsy Imbalanced mitochondrial dynamics contributes to the pathogenesis of X-linked adrenoleukodystrophy Prediction of early improvement of major depressive disorder to antidepressant medication in adolescents with radiomics analysis after ComBat harmonization based on multiscale structural MRI Cellular senescence in liver diseases: From mechanisms to therapies Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models Maintenance of mitochondrial function by sinapic acid protects against tramadol-induced toxicity in isolated mitochondria obtained from rat brain Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury TRABD modulates mitochondrial homeostasis and tissue integrity TRABD modulates mitochondrial homeostasis and tissue integrity ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice Depersonalization depression in young female patients Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids ICA-based Individualized Differential Structure Similarity Networks for Predicting Symptom Scores in Adolescents with Major Depressive Disorder Gut microbiota regulates the nutrient sensing enteroendocrine cell maturation and mitochondrial function Gut microbiota regulates the nutrient sensing enteroendocrine cell maturation and mitochondrial function Mitochondrial transplantation combined with coenzyme Q10 induces cardioprotection and mitochondrial improvement in aged male rats with reperfusion injury Mitochondrial dysfunction: A promising therapeutic target for liver diseases Stress response silencing by an E3 ligase mutated in neurodegeneration The Association between Depression Severity, Prosody, and Voice Acoustic Features in Women with Depression Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons Second-generation antipsychotics and metabolic syndrome: a role for mitochondria