Evidence
Rev Med Suisse. 2023 Apr 26;19(824):807-809. doi: 10.53738/REVMED.2023.19.824.807.
ABSTRACT
Cerebral amyloid angiopathy (CAA) is a common and well-defined small vessel disease characterized by the deposition of amyloid β in the vascular wall. CAA causes devastating outcomes related to intracerebral hemorrhage and cognitive decline in older adults. The shared pathogenic pathway between CAA and Alzheimer’s disease, co-occuring frequently in the same subject, has important implications for cognitive outcomes and novel anti-amyloid-β immunotherapies. In this review, we present the epidemiology, pathophysiology, current diagnostic criteria of CAA, and future developments in the field.
PMID:37133940 | DOI:10.53738/REVMED.2023.19.824.807
Add to Google Keep
Estimated reading time: 2 minute(s)
Latest: Psychiatryai.com #RAISR4D
Cool Evidence: Engaging Young People and Students in Real-World Evidence ☀️
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Cerebral amyloid angiopathy-related cognitive decline: small vessels, big problems
🌐 90 Days
VR Related Evidence Matrix
- Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
- Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer's disease
- Profiling amyloid-β peptides as biomarkers for cerebral amyloid angiopathy
- Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology
- Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy
- Surgical intervention for cerebral amyloid angiopathy-related lobar intracerebral hemorrhage: a systematic review
- Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone
- D’un suicide à l’autre ?
- Violence envers les soignants : l’augmentation des primes a cristallisé les tensions
- Assistance au suicide : la spiritualité, à la fois un soutien et une contrainte
- Endothelial leakiness elicited by amyloid protein aggregation
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages
- Attention deficit disorder with/without hyperactivity and obesity in adolescence
- Investigating the impact of hypertension with and without diabetes on Alzheimer's disease risk: A clinico-pathological study
- Digital environment and population health
- The end of dialysis: the weariness to carry on
- Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease
- New horizons in the diagnosis and management of Alzheimer's Disease in older adults
- Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease
- Swiss healthcare system: a bulimic machine
- Asthma: a respiratory pathology with a high risk for mental health
- Ischemia-Reperfusion Programming of Alzheimer's Disease-Related Genes-A New Perspective on Brain Neurodegeneration after Cardiac Arrest
- Hypnosis: a complementary tool for managing adolescents affected by anorexia nervosa
- Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease
- Alzheimer's Disease: The Past, Present, and Future of a Globally Progressive Disease
- Contribution of Global Amyloid-PET Imaging for Predicting Future Cognition in the MEMENTO Cohort
- Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
- Court-ordered inpatient psychiatric care in Switzerland. Length of stay and treatment outcome
- ATN Classification and Clinical Progression of the Amyloid-Negative Group in Alzheimer's Disease Neuroimaging Initiative Participants
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology
- Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity
- Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2)
- CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration
- The Relationship Between First Presenting Neuropsychiatric Symptoms in Older Adults and Autopsy-Confirmed Memory Disorders
- Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change
- Genetic Determinants of Vascular Dementia
- Is Alzheimer disease a disease?
- Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia
- The Biochemistry Behind Cognitive Decline: Biomarkers of Alzheimer's Disease
- Quantitative Brain Amyloid PET
- Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability
- Human iPSC-derived retinal organoids develop robust Alzheimer's disease neuropathology
- Disentangling Sex-Dependent Effects of APOE on Diverse Trajectories of Cognitive Decline in Alzheimer's Disease
- Small-vessel disease in the brain
- How donanemab data address the coverage with evidence development questions
- Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology
- Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs
- Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults
- Cognitive and neuroscientific perspectives of healthy ageing
- Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease
- Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease
- Dominant CST3 variants cause adult onset leukodystrophy without amyloid angiopathy
- Brain structural indicators of beta-amyloid neuropathology
- Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis
- Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis
- Early onset diagnosis in Alzheimer's disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid
- Using Drosophila amyloid toxicity models to study Alzheimer's disease
- Ageing-Related Neurodegeneration and Cognitive Decline
- Controversial Past, Splendid Present, Unpredictable Future: A Brief Review of Alzheimer Disease History
- Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database
- Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals
- The Role of NRF2 in Cerebrovascular Protection: Implications for Vascular Cognitive Impairment and Dementia (VCID)
- Donanemab in Japanese Patients with Early Alzheimer's Disease: Subpopulation Analysis of the TRAILBLAZER-ALZ 2 Randomized Trial
Evidence Blueprint
Cerebral amyloid angiopathy-related cognitive decline: small vessels, big problems
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Cerebral amyloid angiopathy-related cognitive decline: small vessels, big problems
🌐 365 Days
VR Related Evidence Matrix
- When to look for rare causes of cerebral small vessel disease?
- Cerebral small vessel disease
- Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
- Cognitive exergames: cognitive-motor synergies in neurorehabilitation
- Dementia with Lewy bodies: state of the art and perspectives for the clinician
- Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer's disease
- Profiling amyloid-β peptides as biomarkers for cerebral amyloid angiopathy
- Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology
- Treatment of the CRND8 mouse model for cerebral amyloid angiopathy, exhibited increased levels of neuron specific enolase in brain tissue following long-term treatment with a modified C5a receptor agonist, accompanied by improved cognitive function
- Similarities between amyotrophic lateral sclerosis and frontotemporal dementia
- Analysis of the prevalence of anticoagulant therapy in patients with cognitive disorders and cerebral amyloid angiopathy (CAA)
- Recovery of unilateral spatial neglect after stroke over the time
- Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer's disease
- Post-stroke aphasia recovery: what are the predictors?
- The histopathological correlates of lobar microbleeds in false-positive cerebral amyloid angiopathy cases
- Multidisciplinary assessment and management of neurocognitive complaints in people living with HIV
- Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
- Locus coeruleus pathology is associated with cerebral microangiopathy at autopsy
- Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy
- Phenotype and imaging features associated with APP duplications
- O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production
- Iatrogenic cerebral amyloid angiopathy rather than sporadic CAA in younger adults with lobar intracerebral haemorrhage
- Identifying individuals with non-Alzheimer's disease co-pathologies: A precision medicine approach to clinical trials in sporadic Alzheimer's disease
- Identifying diagnostic and prognostic factors in cerebral amyloid angiopathy-related inflammation: a systematic analysis of published and seven new cases
- Morphological characteristics differentiate dementia with Lewy bodies from Parkinson disease with and without dementia
- Surgical intervention for cerebral amyloid angiopathy-related lobar intracerebral hemorrhage: a systematic review
- Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy
- Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone
- Untangling Alzheimer's disease with spatial multi-omics: a brief review
- Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia
- D’un suicide à l’autre ?
- Violence envers les soignants : l’augmentation des primes a cristallisé les tensions
- Assistance au suicide : la spiritualité, à la fois un soutien et une contrainte
- Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy
- Neuropathologic correlates of cerebral microbleeds in community-based older adults
- Retinal arterial Aβ40 deposition is linked with tight junction loss and cerebral amyloid angiopathy in MCI and AD patients
- Psychiatric dimensions of post-COVID-19 condition : an overview
- Endothelial leakiness elicited by amyloid protein aggregation
- Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia: Dementia Series
- Integrative medicine and geriatrics : towards a convergence?
- Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages
- Attention deficit disorder with/without hyperactivity and obesity in adolescence
- Do we all suffer from imposter syndrome?
- Stockholm Syndrome and controlling relationships: to understand and act
- Emergency management of patients with autism spectrum disorder
- Neuropathology of Anti-Amyloid-β Immunotherapy: A Case Report
- Investigating the impact of hypertension with and without diabetes on Alzheimer's disease risk: A clinico-pathological study
- Borderline psychiatric disorder in the general hospital : specificity and clinical challenges
- Digital environment and population health
- In-hospital withdrawal of benzodiazepines in long term users : a bad idea with good intentions
- The end of dialysis: the weariness to carry on
- A patient-researcher in psychiatry: the role of lived experience in the production of knowledge
- Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology
- Non-Alcoholic Fatty Liver Disease and Diabetes: the bad marriage
- Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease
- New horizons in the diagnosis and management of Alzheimer's Disease in older adults
- Learning motivational interviewing to better support patient medication adherence
- Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease
- Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation
- Longitudinal changes in hippocampal texture from healthy aging to Alzheimer's disease
- Swiss healthcare system: a bulimic machine
- Asthma: a respiratory pathology with a high risk for mental health
- The supersaturation perspective on the amyloid hypothesis